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31.发明专利
公开(公告)号：HU0101224A2
公开(公告)日：2001-08-28
申请号：HU0101224
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , GU YU-GUI , KATI WARREN M , KEMPF DALE J , KENNEDY APRIL , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MARING CLARENCE J , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572
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公开(公告)号：AU1076001A
公开(公告)日：2001-04-30
申请号：AU1076001
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , TU NOAH P , WAGENAAR FRANK L , WANG SHELDON , WIEDEMAN PAUL E , XU YIBO , YEUNG MING C , BAYRAKDARIAN MALKEN , LUO XUEHONG
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
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公开(公告)号：NO20005301A
公开(公告)日：2000-12-08
申请号：NO20005301
申请日：2000-10-20
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40
CPC classification number: C07D207/327 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06 , C07F9/5722
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公开(公告)号：NO20005301D0
公开(公告)日：2000-10-20
申请号：NO20005301
申请日：2000-10-20
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , C07D
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公开(公告)号：AU3554599A
公开(公告)日：1999-11-08
申请号：AU3554599
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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Patent Agency Ranking
公开(公告)号：EA005563B1
公开(公告)日：2005-04-28
申请号：EA200101036
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K , XIN ZHILI
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: Настоящееизобретениеотноситсяк новымциннамиднымсоединениямформулы (I)вкоторыхпокрайнеймереодиниз R-Rпредставляетцис-циннамид (а) илитранс-циннамид (b), адругиерадикалыопределеныв формулеизобретения, икоторыемогутбытьиспользованыдлялечениявоспалительныхи иммунныхзаболеваний; кфармацевтическимкомпозициям, содержащимуказанныесоединения; ик способамингибированиявоспаленияилиподавленияиммунногоответау млекопитающих.
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公开(公告)号：NZ515237A
公开(公告)日：2004-11-26
申请号：NZ51523700
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , WINN MARTIN , XIN ZHILI , WANG SHELDON , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K , VON GELDERN THOMAS W , BOYD STEVEN A
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: Described are cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" or a "trans-cinnamide" that are useful for treating inflammatory and immune diseases, pharmaceutical compositions containing these compounds and methods of inhibiting inflammation or suppressing immune response in a non-human mammal; Wherein R1, R2, R3, R4, and R5 are independently selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, cyano, nitro, carboxaldehyde, and with the proviso that at least one of R1 or R3 is a "cis-cinnamide" or a "trans-cinnamide", and Ar is a substituted aryl or substituted heteroaryl group, where substitutions are independently selected from hydrogen, halogen, alkyl, aryl, haloalkyl, hydroxy, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkyl, aminoalkyl, aminocarbonyl, alkyl (alkoxycarbonylalkyl)aminoalkyl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, substituted heterocyclylalkyl, carboxaldehyde, carboxaldehyde hydrazone, carboxamide, alkoxycarbonylalkyl, carboxy, carboxyalkyl, carboxyalkoxy, carboxythioalkoxy, carboxycycloalkoxy, thioalkyl, hydroxycarbonylalkyl (carboxyalkyl), hydroxyalkylaminocarbonyl, cyano, amino, heterocyclylalkylamino, carboxyalkylamino, heterocyclylalkylaminocarbonyl, and a "trans-cinnamide", or a pharmaceutically-acceptable salt or prodrug thereof.
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公开(公告)号：AT275543T
公开(公告)日：2004-09-15
申请号：AT00921654
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN THOMAS W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：BR0010555A
公开(公告)日：2003-09-23
申请号：BR0010555
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , TU NOAH P , WAGENAAR FRANK L , WANG SHELDON , WIEDEMAN PAUL E , XU YIBO , YEUNG MING C , BAYRAKDARIAN MALKEN , LUO XUEHONG
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
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公开(公告)号：PL352018A1
公开(公告)日：2003-07-14
申请号：PL35201800
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN THOMAS W , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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