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    Inhibitors of influenza viruses replication
    32.
    发明专利
    Inhibitors of influenza viruses replication 未知

    公开(公告)号：AU2011343646A1

    公开(公告)日：2013-05-02

    申请号：AU2011343646

    申请日：2011-12-16

    Applicant: VERTEX PHARMA

    Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  DAVIES IOANA ,  GAO HUAI ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE

    IPC: C07D471/04 ,  A61K31/16

    Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

    INHIBITORS OF INFLUENZA VIRUSES REPLICATION
    34.
    发明专利
    INHIBITORS OF INFLUENZA VIRUSES REPLICATION 未知

    公开(公告)号：CA2822059A1

    公开(公告)日：2012-06-21

    申请号：CA2822059

    申请日：2011-12-16

    Applicant: VERTEX PHARMA

    Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  DAVIES IOANA ,  GAO HUAI ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE

    IPC: C07D471/04 ,  A61K31/16

    Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

    2-AMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS
    36.
    发明专利
    2-AMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS 未知

    公开(公告)号：NZ578744A

    公开(公告)日：2012-02-24

    申请号：NZ57874408

    申请日：2008-01-30

    Applicant: VERTEX PHARMA

    Inventor： JIMENEZ JUAN-MIGUEL ,  BEMIS GUY ,  MALTAIS FRANCOIS ,  WANG TIANSHENG ,  KNEGTEL RONALD ,  DAVIS CHRIS ,  FRAYSSE DAMIEN ,  BOYALL DEAN ,  SETTIMO LUCA ,  YOUNG STEPHEN ,  MORTIMORE MICHAEL

    IPC: A61K31/444 ,  C07D213/73 ,  A61P25/00 ,  A61P35/00 ,  C07D401/14 ,  C07D409/06 ,  C07D417/06 ,  C07D487/04

    Abstract: Disclosed are (2-aminopyridin-3-yl)(heteroaryl)methanone derivatives as represented by the general formula, wherein B is a monocyclic heteroaromatic ring, a 6,6 bicyclic heteroaromatic ring, or a 6,5 bicyclic heteroaromatic ring wherein B is optionally and independently substituted with R12' and independently optionally and independently substituted with one or more R12 groups in addition to R3; Z is O or S; R1 is hydrogen, halogen, cyano, nitro, or -T1-Q1; R2 is hydrogen, halogen, cyano, nitro or optionally and independently substituted alkyl; R3 is halogen, cyano, nitro, or -T2-Q2; and wherein the remaining substituents are as defined herein. Further disclosed is a composition which comprises a compound of pharmaceutically acceptable salt thereof as defined above, and a pharmaceutically acceptable carrier, adjuvant, or vehicle for treating or preventing a protein kinase-mediated condition and particularly a GSK 3 mediated condition such as diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, and rheumatoid arthritis.

    40.
    发明专利
    未知

    公开(公告)号：UA84929C2

    公开(公告)日：2008-12-10

    申请号：UAA200613207

    申请日：2005-05-13

    Applicant: VERTEX PHARMA

    Inventor： MARTINEZ-BOTELLA GABRIEL ,  HALE MICHAEL R ,  MALTAIS FRANCOIS ,  TANG QING ,  STRAUB JUDITH

    IPC: C07D403/04 ,  A61K31/506 ,  A61P35/00

    Abstract: Этоизобретениекасаетсясоединений, которыеиспользуютсякакингибиторыпротеинкиназ.Изобретениепредлагаеттакжефармацевтическиприемлемыекомпозиции, которыесодержатуказанныесоединения, испособыприменениятакихкомпозицийв леченииразныхболезней, состоянийилирасстройств.

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