公开(公告)号：CA2628461A1

公开(公告)日：2007-05-24

申请号：CA2628461

申请日：2006-11-15

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJ B ,  THOMAS SHEELA A ,  PENNING THOMAS D ,  ZHU GUI-DONG ,  GIRANDA VINCENT L ,  GONG JIANCHUN

IPC: C07D235/18 ,  A61K31/4184 ,  A61P35/00 ,  C07D409/04 ,  C07D417/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).

公开(公告)号：PT1276722E

公开(公告)日：2006-07-31

申请号：PT01934906

申请日：2001-04-25

Applicant: ABBOTT LAB

Inventor： MILAN BRUNCKO ,  DALTON CHRISTOPHER R ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  MCCLELLAN WILLIAM J ,  NIENABER VICKI L ,  ROCKWAY TODD W ,  SAUER DARYL R ,  MOSHE WEITZBERG

IPC: A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P15/16 ,  A61P15/18 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/26 ,  C07D401/06 ,  C07D405/04 ,  C07D405/10 ,  C07D217/00 ,  C07D401/00 ,  C07D405/00

公开(公告)号：BR0010622A

公开(公告)日：2003-07-15

申请号：BR0010622

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  WANG JIANCHIO ,  KRUEGER ALLAN C

IPC: A61P31/12 ,  C07D309/28 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/351

公开(公告)号：PL343678A1

公开(公告)日：2001-08-27

申请号：PL34367899

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

公开(公告)号：BG104962A

公开(公告)日：2001-07-31

申请号：BG10496200

申请日：2000-11-17

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YCANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims

公开(公告)号：AU7990000A

公开(公告)日：2001-04-30

申请号：AU7990000

申请日：2000-10-02

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  WANG GARY T ,  WANG JIANCHIO ,  KRUEGER ALLAN C

IPC: A61P31/12 ,  C07D309/28 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/351

公开(公告)号：AU7831200A

公开(公告)日：2001-04-30

申请号：AU7831200

申请日：2000-09-22

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  KENNEDY APRIL ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  MCDANIEL KEITH F ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN

IPC: A61P31/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4353 ,  A61K31/5383 ,  C07D209/00 ,  C07D221/00 ,  C07D265/00

公开(公告)号：CA2329422A1

公开(公告)日：1999-10-28

申请号：CA2329422

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MADIGAN DAROLD L ,  LIN ZHEN ,  KRUEGER ALLAN C ,  MARING CLARENCE J ,  DEGOEY DAVID A ,  XU YIBO ,  YEUNG MING C ,  FLOSI WILLIAM J ,  ZHAO CHEN ,  KENNEDY APRIL ,  MUCHMORE STEVEN W ,  STEWART KENT D ,  KEMPF DALE J ,  SHAM HING L ,  GRAMPOVNIK DAVID J ,  STOLL VINCENT S ,  KATI WARREN M ,  WANG GARY T ,  GU YU-GUI ,  SUN MINGHUA ,  WANG SHELDON ,  MCDANIEL KEITH F ,  GIRANDA VINCENT L ,  KLEIN LARRY L ,  CHEN YUANWEI ,  CHEN HUI-JU

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：CA2672868C

公开(公告)日：2015-11-24

申请号：CA2672868

申请日：2007-12-20

Applicant: ABBOTT LAB

Inventor： GANDHI VIRAJ B ,  GIRANDA VINCENT L ,  GONG JIANCHUN ,  PENNING THOMAS D ,  ZHU GUI-DONG

IPC: C07D403/10 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/55 ,  A61P35/00 ,  C07D237/32 ,  C07D401/10 ,  C07D471/04

Abstract: The present invention relates to compounds of formula (Ik) or pharmaceutical acceptable salts, (see formula Ik) wherein R101, R102, R103, R104, and R105 are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting poly(ADP-ribose)polymerase (PARP).

公开(公告)号：CA2641776C

公开(公告)日：2014-04-08

申请号：CA2641776

申请日：2007-02-15

Applicant: ABBOTT LAB

Inventor： PENNING THOMAS D ,  ZHU GUI-DONG ,  GANDHI VIRAJKUMAR B ,  GONG JIANCHUN ,  GIRANDA VINCENT L

IPC: C07D471/04 ,  A61K31/438 ,  A61P35/00 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).