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公开(公告)号：AU2008343115A1
公开(公告)日：2009-07-09
申请号：AU2008343115
申请日：2008-12-18
Applicant: ABBOTT LAB
Inventor： HSIEH GIN C , ZHAO CHEN , BLACK LAWRENCE A , LIU HUAQING , COWART MARLON D , WAKEFIELD BRIAN D , GFESSER GREGORY A , ALTENBACH ROBERT J
IPC: C07D413/14 , A61K31/423 , A61K31/428 , A61P3/10 , A61P25/00 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
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公开(公告)号：CA2502856C
公开(公告)日：2009-01-20
申请号：CA2502856
申请日：1993-12-16
Applicant: ABBOTT LAB
Inventor： NORBECK DANIEL W , COOPER ARTHUR J , SHAM HING LEUNG , RENO DANIEL S , SOWIN THOMAS J , ZHAO CHEN , HAIGHT ANTHONY R , KEMPF DALE J
IPC: C07D275/02 , C07F5/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/04 , C07K5/06 , C07K5/065
Abstract: Borooxazine compounds of the formula are used as intermediates in processes to compounds of the formula
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公开(公告)号：DE69133610D1
公开(公告)日：2009-01-08
申请号：DE69133610
申请日：1991-11-04
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , CODACOVI LYNN M , NORBECK DANIEL W , PLATTNER JACOB J , SHAM HING L , WITTENBERGER STEVEN J , ZHAO CHEN
IPC: A61K31/42 , C07D277/24 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
Abstract: An intermediate of the formula: and an intermediate of the formula: or an acid addition salt thereof.M
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44.发明专利
公开(公告)号：ECSP088326A
公开(公告)日：2008-04-28
申请号：ECSP088326
申请日：2008-03-28
Applicant: ABBOTT LAB
Inventor： ZHAO CHEN , COWART MARLON D , SUN MINGHUA , ZHENG GUO ZHU
IPC: C07D277/64
Abstract: Los compuestos de fórmula I son útiles para tratar condiciones o trastornos prevenidos por o mejorados por ligandos del receptor 3 de histamina. También se revelan composiciones farmacéuticas que comprenden los ligandos del receptor 3 de histamina, métodos para usar tales compuestos y composiciones, y un proceso para preparar compuestos dentro del alcance de la fórmula (I).
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公开(公告)号：HK1100037A1
公开(公告)日：2007-08-31
申请号：HK07103390
申请日：2007-03-29
Applicant: ABBOTT LAB DEPT
Inventor： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC: A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D20100101 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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Patent Agency Ranking
公开(公告)号：MXPA06006610A
公开(公告)日：2006-08-31
申请号：MXPA06006610
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： ZHAO CHEN
IPC: C07C311/17 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: Se describe un compuesto de la formula (I) como un inhibidor de proteasa de VIH. Tambien se describen metodos y composiciones para inhibir una infeccion de VIH.
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公开(公告)号：CA2792483A1
公开(公告)日：2005-07-07
申请号：CA2792483
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC: C07D277/20 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/4168 , A61K31/426 , A61K31/44 , A61K31/65 , A61K45/06 , A61P31/18 , C07C311/00 , C07C311/17 , C07D213/00 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号：CA2174000C
公开(公告)日：2005-05-24
申请号：CA2174000
申请日：1994-09-26
Applicant: ABBOTT LAB
Inventor： STUK TIMOTHY L , KERDESKY FRANCIS A J , LIJEWSKI LINDA M , NORBECK DANIEL W , SCARPETTI DAVID , TIEN JIEN-HEH J , ALLEN MICHAEL S , LANGRIDGE DENTON C , MELCHER LAURA , RENO DANIEL S , SHAM HING LEUNG , ZHAO CHEN , HAIGHT ANTHONY R , LEANNA M ROBERT , MORTON HOWARD E , ROBBINS TIMOTHY A , SOWIN THOMAS J
IPC: C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C233/36 , C07C217/58 , C07C233/78
Abstract: Intermediates and processes are disclosed which are useful for the preparati on of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd a nd Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected fr om loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken togethe r with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independent ly selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.
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公开(公告)号：BR0010525A
公开(公告)日：2002-11-26
申请号：BR0010525
申请日：2000-09-22
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , STEWART KENT D , WANG GARY T , WANG JIANCHIO , MADIGAN DAROLD L
IPC: A61K31/16 , A61K31/19 , C07C233/52 , C07C247/12 , C07D303/38
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公开(公告)号：HK1039612A1
公开(公告)日：2002-05-03
申请号：HK01107154
申请日：2001-10-11
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , SHAM HING LEUNG , ZHAO CHEN , SOWIN THOMAS J , RENO DANIEL S , HAIGHT ANTHONY R , COOPER ARTHUR J
IPC: C07D275/02 , A61K31/395 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K38/00 , A61K45/06 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/10 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/06 , C07D261/08 , C07D263/24 , C07D263/30 , C07D263/32 , C07D263/48 , C07D265/30 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D521/00 , C07F5/02 , C07F5/04 , C07K5/06 , C07K5/065 , C07D , C07F , A61K , A61P
Abstract: A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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