公开(公告)号：AU2016204286A1

公开(公告)日：2016-08-11

申请号：AU2016204286

申请日：2016-06-23

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

Abstract: Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG11201507203RA

公开(公告)日：2015-10-29

申请号：SG11201507203R

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  COTTRELL KEVIN M ,  MORRIS MARK A ,  WAAL NATHAN D ,  COURT JOHN J ,  GU WENXIN ,  DENG HONGBO

IPC: A61K31/517 ,  A61P35/00 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：SG10201503833SA

公开(公告)日：2015-06-29

申请号：SG10201503833S

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：SG10201405827PA

公开(公告)日：2014-11-27

申请号：SG10201405827P

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  JONES STEVEN ,  GERMANN URSULA A ,  FRANCESCO G SALITURO ,  ANN DAK-YEE KWONG

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：HK1194736A1

公开(公告)日：2014-10-24

申请号：HK14108107

申请日：2014-08-07

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S PS ,  CLARK MICHAEL P MP ,  BANDARAGE UPUL K UK ,  BETHIEL RANDY S RS ,  BOYD MICHAEL J MJ ,  DAVIES IOANA I ,  DENG HONGBO ,  DUFFY JOHN P JP ,  FARMER LUC J LJ ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M JM ,  LEDFORD BRIAN B ,  LEDEBOER MARK W MW ,  MALTAIS FRANCOIS F ,  PEROLA EMANUELE E ,  WANG TIANSHENG

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：CL2014000245A1

公开(公告)日：2014-08-18

申请号：CL2014000245

申请日：2014-01-31

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  DAVIS IOANA

IPC: C07D471/04 ,  A61K31/506 ,  A61P31/16

公开(公告)号：AU2011343647A1

公开(公告)日：2013-05-02

申请号：AU2011343647

申请日：2011-12-16

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  DENG HONGBO ,  DAVIES IOANA ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANNAMAKER MARION W ,  WANG TIANSHENG ,  SALITURO FRANCESCO G

IPC: C07D471/04 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：HUE057527T2

公开(公告)日：2022-05-28

申请号：HUE18207382

申请日：2014-03-12

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN ,  CHARIFSON PAUL ,  TANG QING ,  RONKIN STEVEN ,  JACKSON KATRINA ,  PIERCE ALBERT ,  LAUFFER DAVID ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  MORRIS MARK ,  COURT JOHN ,  COTTRELL KEVIN ,  DENG HONGBO ,  WAAL NATHAN ,  GU WENXIN

IPC: C07D403/12 ,  A61P35/00 ,  C07D241/44 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12

公开(公告)号：ES2763535T3

公开(公告)日：2020-05-29

申请号：ES16181564

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL ,  BANDARAGE UPUL ,  BETHIEL RANDY ,  BOYD MICHAEL ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH ,  LEDFORD BRIAN ,  LEDEBOER MARK ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Un compuesto de Fórmula (IV):**Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde: X1 es -F, -Cl, -CF3, -CN o -CH3; X2 es -H, -F o -Cl; Z1 es N o CH; Z2 es N o CR0; R0 es -H, -F o -CN; R1, R2 y R3 son cada uno independientemente -CH3, -CH2F, -CF3, -C2H5, -CH2CH2F o -CH2CF3; R4 y R5 son cada uno independientemente -H; Q es -C(O)OR; y R es -H o alquilo C1-4, con la condición de que el compuesto de Fórmula (IV) no sea el compuesto n.º 2 o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：CY1121360T1

公开(公告)日：2020-05-29

申请号：CY191100217

申请日：2019-02-20

Applicant: VERTEX PHARMA

Inventor： MAXWELL JOHN PATRICK ,  CHARIFSON PAUL S ,  TANG QING ,  RONKIN STEVEN M ,  JACKSON KATRINA LEE ,  PIERCE ALBERT CHARLES ,  LAUFFER DAVID J ,  LI PAN ,  GIROUX SIMON ,  XU JINWANG ,  MORRIS MARK A ,  COURT JOHN J ,  COTTRELL KEVIN M ,  DENG HONGBO ,  WAAL NATHAN D ,  GU WENXIN

IPC: C07D403/12 ,  A61K31/517 ,  A61P35/00 ,  C07D405/12 ,  C07D413/04 ,  C07D417/12 ,  C07D491/052

Abstract: Ηπαρούσαεφεύρεσηαναφέρεταισεενώσεις (I) χρήσιμεςωςαναστολείς DNA-PK. Ηεφεύρεση, επίσης, παρέχειφαρμακευτικώςαποδεκτέςσυνθέσεις, οιοποίεςαποτελούνταιαπότιςενλόγωενώσειςκαιμεθόδουςχρήσηςτωνσυνθέσεωνστηθεραπευτικήαγωγήδιαφόρωνασθενειών, καταστάσεων, ήδιαταραχών.