公开(公告)号：HK1142882A1

公开(公告)日：2010-12-17

申请号：HK10108367

申请日：2010-10-11

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN J ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  C07D471/04 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：NZ549880A

公开(公告)日：2010-04-30

申请号：NZ54988005

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed is a compound of formula (IB) or pharmaceutically acceptable salts thereof wherein the substituents are disclosed within the specification. Also disclosed is the use of a compound of formula (IB) in the manufacture of a medicament for inhibiting JAK-3, ROCK or Aurora kinase activity.

公开(公告)号：CA2422354C

公开(公告)日：2009-12-08

申请号：CA2422354

申请日：2001-09-14

Applicant: VERTEX PHARMA

Inventor： GOLEC JULIAN ,  BINCH HAYLEY ,  PATEL SANJAY ,  CHARRIER JEAN-DAMIEN ,  KAY DAVID ,  KNEGTEL RONALD ,  BEBBINGTON DAVID ,  FORSTER CORNELIA ,  PIERCE ALBERT ,  LI PAN ,  WANNAMAKER MARION ,  DAVIES ROBERT

IPC: C07D401/12 ,  C07D403/12 ,  A61K31/415 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/00 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P3/14 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P25/18 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D239/26 ,  C07D239/36 ,  C07D239/70 ,  C07D239/88 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D475/10 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D491/107 ,  C07D491/113 ,  C07D491/20 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D521/00

Abstract: This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula (V) wherein Z1 is N, CRa, or CH, and Z2 is N or CH, provided one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidiny l, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substitutents independently selected from -R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selecte d from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; and R1, R2, R2', R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such a s cancer, diabetes and Alzheimer's disease.

公开(公告)号：AT420883T

公开(公告)日：2009-01-15

申请号：AT06734381

申请日：2006-02-02

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK ,  PIERCE ALBERT ,  BEMIS GUY ,  FARMER LUC ,  WANG TIANSHENG ,  MESSERSMITH DAVID ,  DUFFY JOHN ,  WANG JIAN ,  SALITURO FRANCESCO

IPC: C07D487/04 ,  A61K31/519 ,  A61P7/00 ,  A61P11/00 ,  A61P19/00 ,  A61P37/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：NO20084652A

公开(公告)日：2008-12-03

申请号：NO20084652

申请日：2008-11-05

Applicant: VERTEX PHARMA

Inventor： FORSTER CORNELIA J ,  CAO JINGRONG ,  PIERCE ALBERT ,  MALTAIS FRANCOIS ,  LEDEBOER MARK ,  MESSERSMITH DAVID ,  WANG TIANSHENG ,  GAO HUAI ,  MARTINEZ-BOTELLA GABRIEL ,  SALITURO FRANCESCO ,  FARMER LUC ,  WANNAMAKER MARION ,  DUFFY JOHN ,  MARONE VALERIE

IPC: C07D487/04

CPC classification number: C07D487/04

公开(公告)号：NO20083501A

公开(公告)日：2008-10-14

申请号：NO20083501

申请日：2008-08-13

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  WANG JIAN ,  MARTINEZ-BOTELLA GABRIEL ,  SALITURO FRANCESCO ,  FARMER LUC ,  PIERCE ALBERT ,  WANNAMKER MARION

IPC: C07D471/04

CPC classification number: A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D495/10 ,  C07D519/00 ,  C12N9/12 ,  C12Y207/10002

公开(公告)号：NZ545284A

公开(公告)日：2007-06-29

申请号：NZ54528401

申请日：2001-09-14

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT ,  BEBBINGTON DAVID ,  KNEGTEL RONALD ,  WANNAMAKER MARION ,  LI PAN ,  FORESTER CORNELIA ,  PIERCE ALBERT ,  KAY DAVID

IPC: C07D403/12 ,  A61K31/415 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/00 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P3/14 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P25/18 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D239/26 ,  C07D239/36 ,  C07D239/70 ,  C07D239/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D475/10 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D491/107 ,  C07D491/113 ,  C07D491/20 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D521/00 ,  A61K31/4155

Abstract: Disclosed are 4-chloropyrimidine compounds of formula (B) are disclosed, wherein the variables are as defined in the specification. Also described are certain pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

公开(公告)号：CA2623032A1

公开(公告)日：2007-04-12

申请号：CA2623032

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： FARMER LUC ,  WANG JIAN ,  WANG TIANSHENG ,  BETHIEL RANDY ,  WANNAMAKER MARION ,  SALITURO FRANCESCO ,  MARTINEZ-BOTELLA GABRIEL ,  DUFFY JOHN ,  ARONOV ALEXANDER ,  PIERCE ALBERT ,  LAUFFER DAVID

IPC: C07D487/04 ,  A61K31/495 ,  A61P29/00 ,  C07D519/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorder.

公开(公告)号：AU2006297351A1

公开(公告)日：2007-04-12

申请号：AU2006297351

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： WANNAMAKER MARION ,  BETHIEL RANDY ,  FARMER LUC ,  SALITURO FRANCESCO ,  LAUFFER DAVID ,  WANG JIAN ,  DUFFY JOHN ,  ARONOV ALEXANDER ,  MARTINEZ-BOTELLA GABRIEL ,  PIERCE ALBERT ,  WANG TIANSHENG

IPC: C07D487/04 ,  A61K31/495 ,  A61P29/00 ,  C07D519/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorder.

公开(公告)号：AU2006201396A1

公开(公告)日：2006-05-04

申请号：AU2006201396

申请日：2006-04-04

Applicant: VERTEX PHARMA

Inventor： LI PAN ,  CHARRIER JEAN-DAMIEN ,  BEBBINGTON DAVID ,  KAY DAVID ,  DAVIES ROBERT ,  PATEL SANJAY ,  WANNAMAKER MARION ,  BINCH HAYLEY ,  PIERCE ALBERT ,  FORSTER CORNELIA ,  GOLEC JULIAN ,  KNEGTEL RONALD

IPC: C07D401/14 ,  C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D521/00