公开(公告)号：AU8005100A

公开(公告)日：2001-04-30

申请号：AU8005100

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  WANG GARY T ,  KRUEGER ALLAN C ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KENNEDY APRIL L ,  LIN ZHEN ,  MADIGAN DONALD L ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  WANG SHELDON ,  YEUNG MING C

IPC: A61K31/195 ,  C07C233/48 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07C279/16 ,  C07D233/54 ,  C07D263/32 ,  C07D307/24 ,  C07D317/30 ,  C07D405/04 ,  C07C233/00

Abstract: Disclosed are compounds of the formula:which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：CA2388859A1

公开(公告)日：2001-04-26

申请号：CA2388859

申请日：2000-10-10

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  WAGENAAR FRANK L ,  WANG SHELDON ,  GIRANDA VINCENT L ,  LIN ZHEN ,  FLOSI WILLIAM J ,  DEGOEY DAVID A ,  KLEIN LARRY L ,  KEMPF DALE J ,  STOLL VINCENT S ,  KATI WARREN M ,  GRAMPOVNIK DAVID J ,  KENNEDY APRIL L ,  WIEDEMAN PAUL E ,  MCDANIEL KEITH F ,  TU NOAH P ,  XU YIBO ,  HANESSIAN STEPHEN ,  STEWART KENT D ,  SHAM HING L ,  MUCHMORE STEVEN W ,  WANG GARY T ,  BAYRAKDARIAN MALKEN ,  LUO XUEHONG ,  CHEN YUANWEI ,  MADIGAN DAROLD L ,  YEUNG MING C ,  ZHAO CHEN ,  KRUEGER ALLAN C ,  GU YU GUI ,  CHEN HUI-JU ,  SUN MINGHUA

IPC: C07D401/12 ,  A61K31/357 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/66 ,  A61K31/662 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P43/00 ,  C07D20060101 ,  C07D207/00 ,  C07D207/12 ,  C07D207/16 ,  C07D207/26 ,  C07D207/32 ,  C07D207/327 ,  C07D207/38 ,  C07D207/46 ,  C07D303/16 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/06 ,  C07D407/12 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/40 ,  C07F9/572

Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of t he formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：CZ20003872A3

公开(公告)日：2001-03-14

申请号：CZ20003872

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-YU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/40 ,  A61P31/16 ,  C07D207/16 ,  C07D401/12 ,  C07D403/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

公开(公告)号：BR9909870A

公开(公告)日：2000-12-19

申请号：BR9909870

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04

公开(公告)号：BG103981A

公开(公告)日：2000-11-30

申请号：BG10398199

申请日：1999-12-10

Applicant: ABBOTT LAB

Inventor： GEYER ANDREW G ,  MCCLELLAN WILLIAM J ,  ROCKWAY TODD W ,  STEWART KENT D ,  WEITZBERG MOSHE ,  WENDT MICHAEL D

IPC: C07D295/08 ,  A61K31/155 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/5375 ,  A61P15/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C257/18 ,  C07C259/18 ,  C07C271/22 ,  C07C271/30 ,  C07C271/66 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/47 ,  C07C323/56 ,  C07C323/62 ,  C07D207/08 ,  C07D207/337 ,  C07D209/08 ,  C07D213/56 ,  C07D213/58 ,  C07D213/74 ,  C07D213/75 ,  C07D215/38 ,  C07D217/02 ,  C07D231/12 ,  C07D231/40 ,  C07D231/56 ,  C07D237/20 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D241/18 ,  C07D241/20 ,  C07D261/08 ,  C07D261/14 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/42 ,  C07D277/44 ,  C07D295/092 ,  C07D303/46 ,  C07D307/16 ,  C07D307/18 ,  C07D307/54 ,  C07D307/64 ,  C07D317/58 ,  C07D317/66 ,  C07D317/68 ,  C07D333/24 ,  C07D405/12 ,  C07D521/00 ,  C07C249/00 ,  C07D307/80 ,  C07D233/54 ,  C07D307/32 ,  C07D217/04 ,  C07D295/80 ,  C07D295/14

Abstract: The compounds with the formula are inhibitors of urokinase and are useful for the treatment of diseases where it is of basic importance. The invention also relates to pharmaceutical compositions as inhibitors of urokinase and to a method for its inhibition in mammals. 16 claims

公开(公告)号：NO996578D0

公开(公告)日：1999-12-30

申请号：NO996578

申请日：1999-12-30

Applicant: ABBOTT LAB

Inventor： GEYER ANDREW G ,  MCCLELLAN WILLIAM J ,  ROCKWAY TODD W ,  STEWART KENT D ,  WEITZBERG MOSHE ,  WENDT MICHAEL D

IPC: C07D295/08 ,  A61K31/155 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/5375 ,  A61P15/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C257/18 ,  C07C259/18 ,  C07C271/22 ,  C07C271/30 ,  C07C271/66 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/47 ,  C07C323/56 ,  C07C323/62 ,  C07D207/08 ,  C07D207/337 ,  C07D209/08 ,  C07D213/56 ,  C07D213/58 ,  C07D213/74 ,  C07D213/75 ,  C07D215/38 ,  C07D217/02 ,  C07D231/12 ,  C07D231/40 ,  C07D231/56 ,  C07D237/20 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D241/18 ,  C07D241/20 ,  C07D261/08 ,  C07D261/14 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/42 ,  C07D277/44 ,  C07D295/092 ,  C07D303/46 ,  C07D307/16 ,  C07D307/18 ,  C07D307/54 ,  C07D307/64 ,  C07D317/58 ,  C07D317/66 ,  C07D317/68 ,  C07D333/24 ,  C07D405/12 ,  C07D521/00 ,  C07C

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.

公开(公告)号：CA2329660A1

公开(公告)日：1999-10-28

申请号：CA2329660

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  SUN MINGHUA ,  SHAM HING L ,  ZHAO CHEN ,  CHEN YUANWEI ,  WANG GARY T ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KENNEDY APRIL ,  YEUNG MING ,  MUCHMORE STEVEN W ,  MADIGAN DAROLD L ,  LIN ZHEN ,  STEWART KENT D ,  GU YU-GUI ,  WANG SHELDON ,  STOLL VINCENT S ,  MARING CLARENCE J ,  KEMPF DALE J ,  KATI WARREN M

IPC: A61K31/196 ,  A61K31/215 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/421 ,  A61P31/16 ,  A61P43/00 ,  C07C233/47 ,  C07C233/52 ,  C07C237/24 ,  C07C271/22 ,  C07C271/24 ,  C07D233/54 ,  C07D263/32 ,  C07D307/24 ,  C07D317/32 ,  C07D405/04 ,  C07D493/08 ,  A61K31/16 ,  A61K31/33

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：CA2755023C

公开(公告)日：2016-12-13

申请号：CA2755023

申请日：2010-03-25

Applicant: ABBOTT LAB

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LONGENECKER KENTON L ,  PRATT JOHN K ,  STEWART KENT D ,  WAGNER ROLF ,  MARING CLARENCE J

IPC: C07D405/04 ,  A61K31/513 ,  A61K31/517 ,  A61P31/12 ,  C07D401/04 ,  C07D403/04 ,  C07D409/14

Abstract: This invention relates to: (a) compounds, for example, the compound of formula (I): (see formula I) wherein R1, R2, R3 and R4 are as described in the specification, and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：ZA201204223B

公开(公告)日：2015-12-23

申请号：ZA201204223

申请日：2012-06-08

Applicant: ABBOTT LAB

Inventor： LOU XIAOCHUN ,  ZHANG GEOFF G Z ,  KOTECKI BRIAN J ,  HENGEVELD JOHN E ,  GAO YI ,  CHEN SHUANG ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  HUANG PEGGY P ,  KATI WARREN M ,  LIU YAYA ,  MARING CLARENCE J ,  PRATT JOHN K ,  ROCKWAY TODD W ,  TUFANO MICHAEL D ,  LIU DACHUN ,  SARRIS KATHY ,  HENRY RODGER F ,  HAIGHT ANTHONY R ,  FRANCZYK II THADDEUS S ,  BARNES DAVID M ,  DEGOEY DAVID A ,  HUTCHINSON DOUGLAS K ,  KRUEGER ALLAN C ,  LONGENECKER KENTON L ,  RANDOLPH JOHN T ,  STEWART KENT D ,  WEGNER ROLF

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; and (e) use of such compounds, salts, and compositions.

公开(公告)号：IN5113DEN2012A

公开(公告)日：2015-10-23

申请号：IN5113DEN2012

申请日：2012-06-08

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2- ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs I and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4- dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-pheny1)naphthalen-2- yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-method-styryl-phemyl)methanesulfonamide.