公开(公告)号：MX2011006333A

公开(公告)日：2011-06-27

申请号：MX2011006333

申请日：2009-12-22

Applicant: ABBOTT LAB

Inventor： DONNER PAMELA L ,  RANDOLPH JOHN T ,  DEGOEY DAVID A ,  KRUEGER ALLAN C ,  HUTCHINS CHARLES W ,  MOTTER CHRISTOPHER E ,  PILOT-MATIAS TAMI J ,  KATI WARREN M ,  NELSON LISSA T ,  PATEL SACHIN V ,  SOLTWEDEL TODD N ,  KRISHNAN PREETHI ,  MISTRY NEETA C ,  LI XIAOYAN

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/519 ,  A61P31/14

Abstract: Se describen compuestos efectivos para inhibir la réplica de virus de Hepatitis C ("HCV"). La presente invención también se refiere a procesos para elaborar dichos compuestos, composiciones que comprenden dichos compuestos, y métodos para utilizar dichos compuestos, para tratar infección HCV.

公开(公告)号：NZ552276A

公开(公告)日：2011-03-31

申请号：NZ55227605

申请日：2005-06-29

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GRAMPOVNIK DAVID J ,  KLEIN LARRY L ,  KEMPF DALE J ,  WANG XIU C

IPC: A61K31/661 ,  A61P35/00 ,  C07F9/09

Abstract: Disclosed are phosphor-ester prodrugs having formula (I), (II) or (III) where A is the substituent (i) and the rest of the variables are as disclosed in the description. Also disclosed are processes for making prodrugs of formula (I); pharmeacutical composistions containing a prodrug having formula (I), (II), or (III) and the use of a prodrug of formula (I), (II) or (III) in the preparation of a medicament for inhibiting HIV protease, for treating HIV infection, for improving the pharmacokinetics of a drug or for increasing human blood levels of a drug.

公开(公告)号：MX2010002905A

公开(公告)日：2010-07-05

申请号：MX2010002905

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： BARNES DAVID M ,  PRATT JOHN K ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  MARING CLARENCE J ,  WAGNER ROLF ,  RANDOLPH JOHN T ,  DEGOEY DAVID A ,  FLENTGE CHARLES A ,  HUANG PEGGY P ,  HUTCHINSON DOUGLAS K ,  KRUEGER ALLAN C ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  HAIGHT ANTHONY R ,  GAO YI ,  STEWART KENT D ,  LONGENECKER KENTON L ,  ROCKWAY TODD W ,  MOTTER CHRISTOPHER E ,  TUFANO MICHAEL D ,  LIU DACHUN ,  ZHANG GEOFF G Z ,  LOU XIAOCHUN ,  SARRIS KATHY ,  CHEN SHUANG ,  KATI WARREN M ,  LIU YAYA ,  FRANCZYK THADDEUS S II ,  HENGEVELD JOHN E

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: Esta invención se relaciona con: (a) compuestos y sales de los mismos que, entre otros, inhiben el HCV; (b) intermediarios de utilidad para la preparación de dichos compuestos y sales; (c) composiciones que comprenden tales compuestos y sales; (d) métodos para preparar tales intermediarios, compuestos, sales y composiciones; (e) métodos de uso de tales compuestos, sales y composiciones; y (f) conjuntos de elementos que comprenden tales compuestos, sales y composiciones.

公开(公告)号：CA2740195A1

公开(公告)日：2010-07-01

申请号：CA2740195

申请日：2009-12-22

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  KRISHNAN PREETHI ,  MISTRY NEETA C ,  PILOT-MATIAS TAMI J ,  PATEL SACHIN V ,  LI XIAOYAN ,  SOLTWEDEL TODD N ,  NELSON LISSA T

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/519 ,  A61P31/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：BRPI0620440A2

公开(公告)日：2010-06-29

申请号：BRPI0620440

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J ,  COOPER CURT S

IPC: C07D471/04

公开(公告)号：CA2699986A1

公开(公告)日：2009-03-26

申请号：CA2699986

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：CA2633757A1

公开(公告)日：2007-07-05

申请号：CA2633757

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KRUEGER ALLAN C ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  ROCKWAY TODD W ,  WAGNER ROLF ,  ANDERSON DAVID D ,  IWASAKI NOBUHIKO ,  DONNER PAMELA L ,  ZHANG RONG ,  HE WEPING ,  MOTTER CHRISTOPHER E ,  GRAMPOVNIK DAVID J ,  MOLLA AKHTERUZZAMAN ,  LU LIANGJUN ,  BETEBENNER DAVID A ,  GREEN BRIAN E ,  CARRICK ROBERT J ,  COOPER CURT S ,  KEMPF DALE J ,  PILOT-MATIAS TAMI J ,  LIU DACHUN ,  MO HONGMEI ,  SHANLEY JASON P ,  MASSE SHERIE VL ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  PRATT JOHN K ,  TUFANO MICHAEL D

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：AU2006330924A1

公开(公告)日：2007-07-05

申请号：AU2006330924

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  WAGNER ROLF ,  KRUEGER ALLAN C ,  GREEN BRIAN E ,  PILOT-MATIAS TAMI J ,  ANDERSON DAVID D ,  GRAMPOVNIK DAVID J ,  PRATT JOHN K ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  MADIGAN DAROLD L ,  LU LIANGJUN ,  TUFANO MICHAEL D ,  ZHANG RONG ,  MASSE SHERIE VL ,  HE WEPING ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  SHANLEY JASON P ,  COOPER CURT S ,  CARRICK ROBERT J ,  ROCKWAY TODD W ,  LIU DACHUN ,  DONNER PAMELA L ,  IWASAKI NOBUHIKO ,  DEGOEY DAVID A ,  BETEBENNER DAVID A

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：CA2571726A1

公开(公告)日：2006-02-09

申请号：CA2571726

申请日：2005-06-29

Applicant: ABBOTT LAB

Inventor： FLOSI WILLIAM J ,  GRAMPOVNIK DAVID J ,  KLEIN LARRY L ,  DEGOEY DAVID A ,  KEMPF DALE J ,  WANG XIU C

IPC: C07F9/09 ,  A61K31/661 ,  A61P35/00

Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.

公开(公告)号：HU0101224A2

公开(公告)日：2001-08-28

申请号：HU0101224

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  GU YU-GUI ,  KATI WARREN M ,  KEMPF DALE J ,  KENNEDY APRIL ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MARING CLARENCE J ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572