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    올레핀의 비대칭 에폭시화 반응에 유용한 고분자 키랄살렌 유도체
    21.
    发明公开
    올레핀의 비대칭 에폭시화 반응에 유용한 고분자 키랄살렌 유도체 失效
    聚合物乳酸盐衍生物有用的非对称环氧化烯烃

    公开(公告)号：KR1020020011678A

    公开(公告)日：2002-02-09

    申请号：KR1020000045098

    申请日：2000-08-03

    Applicant: 한국과학기술연구원 ,  한화화인케미칼 주식회사

    Inventor： 송충의 ,  노은주 ,  김수창 ,  채기병 ,  김근식

    IPC: C07C251/24

    Abstract: PURPOSE: Provided are a chiral salen derivative bonded to a polymer and a chiral salen-metal complex produced from the chiral salen derivative polymer, wherein the chiral salen-metal complex is used as a chiral catalyst in an asymmetric epoxidation of olefin. CONSTITUTION: The chiral salen derivative is represented by the formula 1 and the chiral salen-metal complex is represented by the formula 5, wherein m is 0 or 1, n is an integer of 0-24, Y is O, NH, or C(O)NH, p is a polymer insoluble in water and organic solvents, H(1) and H(2) are trans each other, M is a transition metal ion selected from the group consisting of Cr, Mn, V, Fe, Mo, W, Ru, Co, Ti, and Os, and A is an anion selected from the group consisting of Cl-, CH3COO-, PF6-, and SbF6-.

    Abstract translation: 目的：提供了结合到聚合物上的手性salen衍生物和由手性salen衍生物聚合物制备的手性salen-金属络合物，其中手性盐金属络合物用作烯烃不对称环氧化中的手性催化剂。 构成：手性盐酸衍生物由式1表示，手性盐金属络合物由式5表示，其中m为0或1，n为0-24的整数，Y为O，NH或C （O）NH，p是不溶于水和有机溶剂的聚合物，H（1）和H（2）彼此相互反转，M是选自Cr，Mn，V，Fe， Mo，W，Ru，Co，Ti和Os，A是选自Cl-，CH 3 COO-，PF 6 - 和SbF 6 - 的阴离子。

    실리카겔 지지체에 결합된 트리플루오로메틸케톤 유도체 및 그의 제조방법
    22.
    发明公开
    실리카겔 지지체에 결합된 트리플루오로메틸케톤 유도체 및 그의 제조방법 失效
    支持二氧化硅凝胶的三氟甲基酮衍生物及其制备方法

    公开(公告)号：KR1020010008779A

    公开(公告)日：2001-02-05

    申请号：KR1019990026769

    申请日：1999-07-03

    Applicant: 한국과학기술연구원

    Inventor： 송충의 ,  임진석 ,  노은주 ,  이기정 ,  지대윤

    IPC: C07G5/00

    CPC classification number: C07C49/167 ,  C07B2200/11

    Abstract: PURPOSE: The trifluoromethylketone derivatives supported on silica gel and a producing method thereof are provided to be used as a useful catalyst in the epoxidation reaction using olefin and Oxone oxidizing agent. CONSTITUTION: The trifluoromethylketone derivatives are represented by formula (3), in which R1 is C1 to C6 alkyl, R2, R3 and R4 are individually hydrogen or C1 to C6 alkyl, I is an integer from 0 to 1, m is methylene from 1 to 6, n is an integer from 0 to 2, and O is methylene from 0 to 16. The trifluoromethylketone derivatives of formula (3) supported on silica gel are produced by reacting trifluoromethylketone derivatives of formula (1) with mercaptoalkylsilanized silica gel of formula (2) in the presence of organic solvents such as azobisisobutyronitrile, benzene, toluene, acetonitrile or chloroform.

    Abstract translation: 目的：提供负载在硅胶上的三氟甲基酮衍生物及其制备方法，用作使用烯烃和氧化羰氧化剂的环氧化反应中的有用催化剂。 构成：三氟甲基酮衍生物由式（3）表示，其中R 1为C 1至C 6烷基，R 2，R 3和R 4各自为氢或C 1至C 6烷基，I为0至1的整数，m为1 至6，n为0至2的整数，O为0至16的亚甲基。通过使式（1）的三氟甲基酮衍生物与式（1）的巯基烷基硅烷化硅胶与式 （2）在有机溶剂如偶氮二异丁腈，苯，甲苯，乙腈或氯仿存在下进行。

    메틸리덴-헤테로싸이클릭 화합물
    27.
    发明授权
    메틸리덴-헤테로싸이클릭 화합물 有权
    亚甲基杂环化合物

    公开(公告)号：KR101319593B1

    公开(公告)日：2013-10-16

    申请号：KR1020110071653

    申请日：2011-07-19

    Applicant: 한국과학기술연구원

    Inventor： 노은주 ,  신계정 ,  송혜승 ,  양정은 ,  김남윤 ,  배애님 ,  남길수 ,  추현아 ,  지완근

    IPC: C07D417/10 ,  C07D417/12 ,  C07D277/36 ,  A61K31/427

    Abstract: 본 발명은 메틸리덴-헤테로싸이클릭 화합물과 이의 약학적으로 허용 가능한 염, 이 화합물의 제조방법 및 이 화합물을 유효성분으로 함유하는 약제조성물에 관한 것이다.
    본 발명의 화합물은 NF-κB의 활성 과정에 관여하는 IκB 키나제-b (IKK-b)에 대해 강한 저해활성을 가지고 있으므로 류마티스 관절염(rheumatoid arthritis), 유년기 관절염(juvenile arthritis), 천식(asthma), 척추성 관절염(spondyloarthopathies), 통풍(gout), 골관절염(osteoarthritis), 알러지성 비염, 아토피성 피부염, 담마진, 전신 홍반성 루푸스(systemic lupuserythematosus), 건선, 궤양성 대장염, 전신성 염증반응증후군, 폐혈증, 다발성근염, 결절다발성동맥염을 포함하는 각종 염증질환 치료를 위한 약제로써 유용하다.

    신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 항균 조성물
    29.
    发明公开
    신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 항균 조성물 有权
    新型3-苯基-4-吡喃酮，3-苯氧基-4-吡啶酮或4-吡啶酮衍生物，其制备方法和含有其作为活性成分的抗生物组合物

    公开(公告)号：KR1020110011271A

    公开(公告)日：2011-02-08

    申请号：KR1020090068834

    申请日：2009-07-28

    Applicant: 한국과학기술연구원 ,  서울대학교산학협력단

    Inventor： 신계정 ,  노은주 ,  정민경 ,  차현주 ,  서선희

    IPC: C07D309/34 ,  C07D213/06 ,  A61K31/351 ,  A61P31/00

    CPC classification number: C07D213/06 ,  A61K31/351 ,  C07D309/34

    Abstract: PURPOSE: A novel 3-phenoxy-4-pyrone, 3-penoxy-4-pyridone or 4-pyridoen derivative and an antibacterial composition are provided to effectively suppress enoyl-ACP reductase(Fabl). CONSTITUTION: A novel 3-penoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative is denoted by chemical formula 1. A method for preparing the novel 3-phenoxy-4-pyrone derivative of chemical formula 1 comprises: a step of performing Ullmann reaction of kojic acid compound of chemical formula 4 to obtain a compound of chemical formula 5; a step of substituting the compound of chemical formula 5 with a chloride group to prepare a compound of chemical formula 6; a step of performing Arbuzov reation of the compound of chemical formula 6 to obtain a compound of chemical formula 7; and a step of performing Horner-Emmons reaction of compound of chemical formula 7 to introduce a double bond structure to prepare a compound of chemical formula 1a. An antibacterial composition contains the novel 3-phenoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative or pharmaceutically acceptable salt thereof as an active ingredient.

    Abstract translation: 目的：提供新颖的3-苯氧基-4-吡喃酮，3-缩氧-4-吡啶酮或4-吡啶酮衍生物和抗菌组合物，以有效抑制烯酰-ACP还原酶（Fab1）。 构成：化学式1表示新的3-氧羰基-4-吡喃酮，3-苯氧基-4-吡啶酮或4-吡啶酮衍生物。制备化学式1的新型3-苯氧基-4-吡喃酮衍生物的方法包括 ：进行化学式4的曲酸化合物的乌尔曼反应以获得化学式5的化合物的步骤; 用氯化物基团取代化学式5的化合物制备化学式6的化合物的步骤; 进行化学式6的化合物的Arbuzov化合以获得化学式7的化合物的步骤; 并进行化学式7化合物的霍纳 - 埃蒙斯反应以引入双键结构以制备化学式1a的化合物的步骤。 抗菌组合物含有新型3-苯氧基-4-吡喃酮，3-苯氧基-4-吡啶酮或4-吡啶酮衍生物或其药学上可接受的盐作为活性成分。

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