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公开(公告)号：AU8005100A
公开(公告)日：2001-04-30
申请号：AU8005100
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , WANG GARY T , KRUEGER ALLAN C , CHEN YUANWEI , DEGOEY DAVID A , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , LIN ZHEN , MADIGAN DONALD L , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , WANG SHELDON , YEUNG MING C
IPC: A61K31/195 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04 , C07C233/00
Abstract: Disclosed are compounds of the formula:which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CA2388859A1
公开(公告)日：2001-04-26
申请号：CA2388859
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , WAGENAAR FRANK L , WANG SHELDON , GIRANDA VINCENT L , LIN ZHEN , FLOSI WILLIAM J , DEGOEY DAVID A , KLEIN LARRY L , KEMPF DALE J , STOLL VINCENT S , KATI WARREN M , GRAMPOVNIK DAVID J , KENNEDY APRIL L , WIEDEMAN PAUL E , MCDANIEL KEITH F , TU NOAH P , XU YIBO , HANESSIAN STEPHEN , STEWART KENT D , SHAM HING L , MUCHMORE STEVEN W , WANG GARY T , BAYRAKDARIAN MALKEN , LUO XUEHONG , CHEN YUANWEI , MADIGAN DAROLD L , YEUNG MING C , ZHAO CHEN , KRUEGER ALLAN C , GU YU GUI , CHEN HUI-JU , SUN MINGHUA
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of t he formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CZ20003872A3
公开(公告)日：2001-03-14
申请号：CZ20003872
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-YU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/40 , A61P31/16 , C07D207/16 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
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公开(公告)号：BR9909870A
公开(公告)日：2000-12-19
申请号：BR9909870
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：CA2329660A1
公开(公告)日：1999-10-28
申请号：CA2329660
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , SUN MINGHUA , SHAM HING L , ZHAO CHEN , CHEN YUANWEI , WANG GARY T , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KENNEDY APRIL , YEUNG MING , MUCHMORE STEVEN W , MADIGAN DAROLD L , LIN ZHEN , STEWART KENT D , GU YU-GUI , WANG SHELDON , STOLL VINCENT S , MARING CLARENCE J , KEMPF DALE J , KATI WARREN M
IPC: A61K31/196 , A61K31/215 , A61K31/341 , A61K31/4164 , A61K31/421 , A61P31/16 , A61P43/00 , C07C233/47 , C07C233/52 , C07C237/24 , C07C271/22 , C07C271/24 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/32 , C07D405/04 , C07D493/08 , A61K31/16 , A61K31/33
Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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Patent Agency Ranking
公开(公告)号：GEP20053657B
公开(公告)日：2005-11-10
申请号：GEAP2000004605
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： JAE WOO PARK , LINK JAMES , LIU GANG , PEI ZHONGHUA , VON GELDERN TOM , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA ; INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07C323/62 , C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: 1. Technical Result Increase in treatment efficiency of inflamma¬tory and immune diseases. 2. Essence The present invention relates to compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal. 3. Field of Application Medicine.
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公开(公告)号：NZ523445A
公开(公告)日：2004-10-29
申请号：NZ52344501
申请日：2001-06-22
Applicant: ABBOTT LAB
Inventor： WANG GARY T , WANG SHELDON , GENTLES ROBERT
IPC: A61K31/425 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/506 , C07D239/42 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/551 , A61P9/10 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/74 , C07D263/48 , C07D265/30 , C07D277/20 , C07D277/42 , C07D279/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/04
Abstract: Heterocycyl-containing diaryl sulfide compounds of formula (I) useful for treating inflammatory and immune diseases, pharmaceutical compositions comprising such compounds and the use of such compounds in the preparation of a medicament for inhibiting inflammation or suppressing immune response in a mammal in need thereof.
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公开(公告)号：AU2004205260A1
公开(公告)日：2004-09-23
申请号：AU2004205260
申请日：2004-08-25
Applicant: ABBOTT LAB
Inventor： LIU GANG , LINK JAMES , LYNCH JOHN K , JAE HWAN-SOO , STAEGER MICHAEL A , GUNAWARDANA INDRANI W , FREEMAN JENNIFER C , ZHU GUI-DONG , BOYD STEVEN A , WANG SHELDON , XIN ZHILI , WINN MARTIN , GELDERN THOMAS W VON , PEI ZHONGHUA
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：AU774564B2
公开(公告)日：2004-07-01
申请号：AU4194400
申请日：2000-04-03
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN THOMAS W VON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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公开(公告)号：AU6871801A
公开(公告)日：2002-01-14
申请号：AU6871801
申请日：2001-06-22
Applicant: ABBOTT LAB
Inventor： WANG GARY T , WANG SHELDON , GENTLES ROBERT
IPC: C07D239/42 , A61K31/425 , A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/551 , A61P9/10 , A61P29/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/74 , C07D263/48 , C07D265/30 , C07D277/20 , C07D277/42 , C07D279/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/04 , C07D239/00 , C07D233/00
Abstract: The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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