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公开(公告)号：DK1278747T3
公开(公告)日：2007-01-02
申请号：DK01935065
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , ALTENBACH ROBERT J , AGRIOS KONSTANTINOS A , DRIZIN IRENE , KORT MICHAEL J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：NO318628B1
公开(公告)日：2005-04-18
申请号：NO20012100
申请日：2001-04-27
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , CARROLL WILLIAM A , KORT MICHAEL E , AGRIOS KONSTANTINOS A , DRIZIN IRENE
IPC: C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：PT1040097E
公开(公告)日：2004-08-31
申请号：PT98963249
申请日：1998-12-16
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , DRIZIN IRENE , SULLIVAN JAMES P , HOLLADAY MARK W , ZHANG HENRY Q
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/44 , A61K31/38
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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公开(公告)号：DE60103615D1
公开(公告)日：2004-07-08
申请号：DE60103615
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , ALTENBACH J , CARROLL A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
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公开(公告)号：SK283580B6
公开(公告)日：2003-09-11
申请号：SK71799
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are 'alpha'-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are 'alpha'-1 antagonist compositions and a method for antagonising 'alpha'-1 adrenoreceptors and treating BPH.
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Patent Agency Ranking
公开(公告)号：CA2476936A1
公开(公告)日：2003-08-28
申请号：CA2476936
申请日：2003-02-11
Applicant: ABBOTT LAB
Inventor： ZHENG GUO ZHU , SCHMIDT ROBERT G , PERNER RICHARD J , LEE CHIH-HUNG , BAYBURT EROL K , KOENIG JOHN R , WHITE TAMMIE K , TURNER SEAN C , DRIZIN IRENE , GOMTSYAN ARTHUR R , DIDOMENICO STANLEY JR
IPC: A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/56 , C07D237/28 , C07D401/12 , C07D405/12 , C07D521/00 , C07D417/02 , A61K31/502 , C07D403/12
Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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公开(公告)号：PT942911E
公开(公告)日：2002-04-29
申请号：PT97951555
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , MEYER MICHAEL D , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：GR3036560T3
公开(公告)日：2001-12-31
申请号：GR20010401414
申请日：2001-09-06
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA Z , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , PRATT JOHN K , SIPPY KEVIN B , TIETJE KARIN R , YAMAMOTO DIANE M
IPC: C07D491/056 , C07D495/04 , C07D498/04 , A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D487/02 , C07D495/02 , C07D487/00
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：SK5242001A3
公开(公告)日：2001-12-03
申请号：SK5242001
申请日：1999-10-28
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , AGRIOS KONSTANTINOS A , ALTENBACH ROBERT J , DRIZIN IRENE , KORT MICHAEL E
IPC: C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00 , A61K31/47 , A61P13/10 , A61P21/00 , A61P29/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：TR200001715T2
公开(公告)日：2000-12-21
申请号：TR200001715
申请日：1998-12-16
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , HOLLADAY MARK W , SULLIVAN JAMES P , DRIZIN IRENE , ZHANG HENRY Q
IPC: A61K31/4365 , A61K31/47 , A61K31/4743 , A61P1/00 , A61P1/14 , A61P9/08 , A61P9/12 , A61P11/06 , A61P13/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , C07C45/29 , C07D215/36 , C07D221/04 , C07D495/04 , C07D495/14 , C07D211/84 , A61K31/44 , A61K31/38
Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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