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公开(公告)号：UA97639C2
公开(公告)日：2012-03-12
申请号：UAA200811465
申请日：2007-02-16
Applicant: ABBOTT LAB
Inventor： COWART MARLON D , ZHAO CHEN , SUN MINGHUA , BLACK LAWRENCE A , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
IPC: C07D487/04 , A61K31/407
Abstract: Раскрытыоктагидропирроло[3,4-b]пиррольныепроизводныеформулы I и II, пригодныедлялечениясостоянийилирасстройств, которыепредотвращаютсяилиоблегчаютсяс помощьюлигандоврецепторагистамина-3.Раскрытыоктагидропирроло[3,4-b]пиррольныесоединения, применениетакихсоединений, композиции, содержащиеэтисоединения, испособыполучениятакихсоединений.
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42.发明专利
公开(公告)号：UA94242C2
公开(公告)日：2011-04-26
申请号：UAA200805050
申请日：2006-09-19
Applicant: ABBOTT LAB
Inventor： COWART MARLON D , SUN MINGHUA , ZHAO CHEN , ZHENG GUO ZHU
IPC: C07D417/04 , A61K31/428 , A61K51/04 , A61P9/10 , C07D277/64 , C07D417/08 , C07D417/12 , C07D487/04
Abstract: Соединенияформулы (I) пригодныдлялечениясостоянийилирасстройств, которыепредотвращаютсяилиоблегчаютсяс помощьюлигандоврецепторовгистамина-3.Раскрытытакжефармацевтическиекомпозиции, которыесодержатлигандырецепторовгистамина-3, применениетакихсоединенийи композицийи способыполучениясоединенийформулы (I).
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公开(公告)号：DE602004024830D1
公开(公告)日：2010-02-04
申请号：DE602004024830
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC: C07D417/06 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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44.发明专利
公开(公告)号：AU2007220889A1
公开(公告)日：2007-09-07
申请号：AU2007220889
申请日：2007-02-16
Applicant: ABBOTT LAB
Inventor： FICKES MICHAEL G , SUN MINGHUA , ZHAO CHEN , SHEIKH AHMAD Y , HENRY RODGER F , BARNES DAVID M , GREGG ROBERT J , HAIGHT ANTHONY R , KOLACZKOWSKI LAWRENCE , WITTENBERGER STEVEN J , ZHANG GEOFF G Z , COWART MARLON D , LOU XIAOCHUN , ZHENG GUO ZHU , BLACK LAWRENCE A , CHANG SOU-JEN
IPC: C07D487/04 , A61K31/407
Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
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公开(公告)号：CA2549389A1
公开(公告)日：2005-07-07
申请号：CA2549389
申请日：2004-11-10
Applicant: ABBOTT LAB
Inventor： MADIGAN DAROLD L , RANDOLPH JOHN T , ZHAO CHEN , DEGOEY DAVID A , GRAMPOVNIK DAVID J , YEUNG MING C , SUN MINGHUA , FLOSI WILLIAM J , KEMPF DALE J , CHEN HUI-JU , FLENTGE CHARLES A , HUANG PEGGY P , KLEIN LARRY L , KRUEGER ALLAN C
IPC: C07D417/06 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/14 , C07D471/04 , C07D493/04
Abstract: A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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Patent Agency Ranking
公开(公告)号：SK15092000A3
公开(公告)日：2001-05-10
申请号：SK15092000
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VICENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：AU8005100A
公开(公告)日：2001-04-30
申请号：AU8005100
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , WANG GARY T , KRUEGER ALLAN C , CHEN YUANWEI , DEGOEY DAVID A , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , LIN ZHEN , MADIGAN DONALD L , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , WANG SHELDON , YEUNG MING C
IPC: A61K31/195 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04 , C07C233/00
Abstract: Disclosed are compounds of the formula:which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CA2388859A1
公开(公告)日：2001-04-26
申请号：CA2388859
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , WAGENAAR FRANK L , WANG SHELDON , GIRANDA VINCENT L , LIN ZHEN , FLOSI WILLIAM J , DEGOEY DAVID A , KLEIN LARRY L , KEMPF DALE J , STOLL VINCENT S , KATI WARREN M , GRAMPOVNIK DAVID J , KENNEDY APRIL L , WIEDEMAN PAUL E , MCDANIEL KEITH F , TU NOAH P , XU YIBO , HANESSIAN STEPHEN , STEWART KENT D , SHAM HING L , MUCHMORE STEVEN W , WANG GARY T , BAYRAKDARIAN MALKEN , LUO XUEHONG , CHEN YUANWEI , MADIGAN DAROLD L , YEUNG MING C , ZHAO CHEN , KRUEGER ALLAN C , GU YU GUI , CHEN HUI-JU , SUN MINGHUA
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of t he formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CZ20003872A3
公开(公告)日：2001-03-14
申请号：CZ20003872
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-YU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/40 , A61P31/16 , C07D207/16 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
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公开(公告)号：BR9909870A
公开(公告)日：2000-12-19
申请号：BR9909870
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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