公开(公告)号：CA2658573A1

公开(公告)日：2008-01-24

申请号：CA2658573

申请日：2007-07-23

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  TERMIN ANDREAS ,  JOSHI PRAMOD ,  GUTIERREZ COREY DON ,  BERGERON DANIELE ,  YOO SANGHEE ,  CAO JINGRONG

IPC: C07D413/12 ,  A61K31/536 ,  A61K31/5415 ,  A61P25/06 ,  C07D417/12

Abstract: The present invention relates to CGRP receptor antagonists, pharmaceutica l compositions thereof, and methods therewith for treating CGRP receptor-med iated diseases and conditions.

公开(公告)号：HK1104544A1

公开(公告)日：2008-01-18

申请号：HK07109785

申请日：2007-09-07

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS J ,  SHETH URVI ,  BOGER JOSHUA S

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2007258313A1

公开(公告)日：2007-12-21

申请号：AU2007258313

申请日：2007-06-12

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  ZHANG YULIAN ,  FANNING LEV T D ,  WILSON DEAN ,  TERMIN ANDREAS

IPC: A61K31/519 ,  A61P25/00

Abstract: The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：MA49235B1

公开(公告)日：2021-02-26

申请号：MA49235

申请日：2017-12-08

Applicant: VERTEX PHARMA

Inventor： FERRIS LORI ,  ANDERSON COREY ,  CLEVELAND THOMAS ,  KHATUYA HARIPADA ,  MCCARTNEY JASON ,  UY JOHNNY ,  ZHOU JINGLAN ,  ALCACIO TIMOTHY ,  BAEK MINSON ,  HADIDA RUAH SARA ,  HUGHES ROBERT ,  KESHAVARZ-SHOKRI ALI ,  MILLER MARK ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  ABELA ALEXANDER ,  PARASELLI PRASUNA ,  SIESEL DAVID ,  ANGELL PAUL ,  CLEMENS JEREMY ,  GROOTENHUIS PETER DIEDERIK ,  GROSS RAYMOND ,  GULEVICH ANTON ,  HSIA CLARA ,  KANG PING ,  PIERRE FABRICE JEAN ,  SHI YI ,  SHRESTHA MUNA ,  STAVROPOULOS KATHY ,  VAN GOOR FREDRICK ,  YOUNG TOMOTHY

IPC: A61K31/455 ,  A61P11/00 ,  C07D231/20 ,  C07D401/04 ,  C07D401/14

Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.

公开(公告)号：NZ603477A

公开(公告)日：2014-09-26

申请号：NZ60347711

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： STORCK PIERRE-HENRI ,  KAY DAVID ,  BINCH HAYLEY MARIE ,  FANNING LEV TYLER DEWEY ,  REAPER PHILIP MICHAEL ,  CHARRIER JEAN-DAMIEN ,  YOUNG STEPHEN CLINTON ,  HURLEY DENNIS JAMES ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  JOSHI PRAMOD ,  O’DONNELL MICHAEL ,  CLEVELAND THOMAS ,  VIRANI ANISA NIZARALI ,  GROTE MATTHEW PAUL ,  PINDER JOANNE ,  DURRANT STEVEN JOHN

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: The disclosure relates to pyrazine and pyridine derivatives of formula (I), wherein the variables are as defined in the specification. These compounds are useful as inhibitors of ATR protein kinase involved in cellular responses to DNA damage, and are suitable for treating various diseases, disorders, and conditions that are mediated by the particular protein kinase, particularly suitable for treating cancer selected from lung cancer, head and neck cancer, pancreatic cancer, gastric cancer, and brain cancer. Processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors are also disclosed.

公开(公告)号：MX2012013081A

公开(公告)日：2013-05-09

申请号：MX2012013081

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  KAY DAVID ,  JOSHI PRAMOD ,  YOUNG STEPHEN CLINTON ,  O'DONNELL MICHAEL ,  PINDER JOANNE ,  VIRANI ANISA NIZARALI ,  REAPER PHILIP MICHAEL ,  BINCH HAYLEY MARIE ,  CLEVELAND THOMAS ,  DURRANT STEVEN JOHN ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  FANNING LEV TYLER DEWEY ,  HURLEY DENNIS JAMES ,  STORCK PIERRE-HENRI ,  GROTE MATTHEW PAUL

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: La presente invención se refiere a compuestos de pirazina y piridina útiles como inhibidores de la proteína cinasa ATR. La invención también se refiere a composiciones farmacéuticamente aceptables que comprenden los compuestos de esta invención; métodos para tratar diversas enfermedades, trastornos y afecciones usando los compuestos de esta invención; procesos para preparar los compuestos de esta invención; intermedios para la preparación de los compuestos de esta invención; y métodos para usar los compuestos en aplicaciones in vitro, tales como el estudio de cinasas en fenómenos biológicos y patológicos; el estudio de vías de transducción de señales intracelulares mediadas por tales cinasas y la evaluación comparativa de nuevos inhibidores de cinasas. Los compuestos de la presente invención tienen la fórmula I donde las variables son tal como se describen en la presente.

公开(公告)号：AU2011253025A1

公开(公告)日：2012-11-29

申请号：AU2011253025

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HALEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

公开(公告)号：ZA201103411B

公开(公告)日：2012-09-26

申请号：ZA201103411

申请日：2011-05-10

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA ,  YOUNG STEPHEN ,  BINCH HAYLEY ,  CLEVELAND THOMAS ,  FANNING LEV T D ,  HURLEY DENNIS J ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA ,  REAPER PHILIP MICHAEL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：NZ568393A

公开(公告)日：2011-08-26

申请号：NZ56839306

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  FANNING LEV T D ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  JOSHI PRAMOD ,  SHETH URVI

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: Disclosed are substituted quinazoline compound of formula (IA) or formula (IB), wherein the variables are as defined in the specification, which have the activity as inhibitors of voltage-gate sodium channels, and are suitable for use in the treatment of disease, condition, or disorder that is implicated in the activation or hyperactivity of voltage-gated sodium channels, wherein the disease, condition, or disorder is selected from acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or epilepsy conditions, neurodegenerative disorders, psychiatric disorders such as anxiety and depression, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, postherpetic neuralgia, diabetic neuropathy, radicular pain, sciatica, back pain, head or neck pain, severe or intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, or cancer pain.

公开(公告)号：ZA200808751B

公开(公告)日：2009-12-30

申请号：ZA200808751

申请日：2008-10-14

Applicant: VERTEX PHARMA

Inventor： GONZALEZ JESUS ,  TERMIN ANDREAS ,  WANG JIAN ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  WILSON DEAN

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.