公开(公告)号：SMT201400124B

公开(公告)日：2014-11-10

申请号：SM201400124

申请日：2014-09-05

Applicant: VERTEX PHARMA

Inventor： BOTFIELD MARTYN ,  FANNING LEV T D ,  BINCH HAYLEY ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL ,  AURLEY DENNIS

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

公开(公告)号：SI2349263T1

公开(公告)日：2014-09-30

申请号：SI200930982

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: A61K31/00 ,  C07D453/00 ,  C12Q1/00

公开(公告)号：DK2349263T3

公开(公告)日：2014-07-21

申请号：DK09822784

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL ,  SILINA ALINA

IPC: A61K31/439 ,  C07D453/04 ,  C12Q1/02

公开(公告)号：CA2829803A1

公开(公告)日：2012-09-20

申请号：CA2829803

申请日：2012-03-13

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  BINCH HAYLEY MARIE ,  DENINNO MICHAEL PAUL ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER DIEDERIK JAN ,  HILGRAF NICOLE ,  JOSHI PRAMOD ,  KALLEL EDWARD ADAM ,  PONTILLO JOSEPH ,  SILINA ALINA ,  SHETH URVI JAGDISHBHAI ,  HURLEY DENNIS JAMES ,  ARUMUGAM VIJAYALAKSMI ,  MILLER MARK THOMAS

IPC: C07D498/10 ,  A61K31/424 ,  A61P29/00

Abstract: The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2743134A1

公开(公告)日：2010-05-14

申请号：CA2743134

申请日：2009-11-10

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  BINCH HAYLEY MARIE ,  CLEVELAND THOMAS ,  FANNING LEV T D ,  HURLEY DENNIS J ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

公开(公告)号：CA2741718A1

公开(公告)日：2010-04-29

申请号：CA2741718

申请日：2009-10-23

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: C07D471/12 ,  A61K31/4709 ,  A61P11/00 ,  C07D451/02 ,  C12Q1/02

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:

公开(公告)号：NO20084007L

公开(公告)日：2008-10-07

申请号：NO20084007

申请日：2008-09-19

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  DRUTU IOANA ,  BERGERON DANIELE M ,  TERMIN ANDREAS P ,  RAFFAI GABRIEL ,  SILINA ALINA ,  HURLEY DENNIS J

IPC: C07D471/10 ,  C07D519/00

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：AU2021358063A9

公开(公告)日：2025-03-13

申请号：AU2021358063

申请日：2021-10-06

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  ABELA ALEXANDER RUSSELL ,  ABRAHAM SUNNY ,  ANDERSON COREY DON ,  ARUMUGAM VIJAYALAKSMI ,  CHAU JACLYN ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  DWIGHT TIMOTHY A ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER (DECEASED) ,  GULEVICH ANTON V ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KHATUYA HARIPADA ,  KRENITSKY PAUL ,  MELILLO VITO ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SILINA ALINA ,  TRAN JOE A ,  UY JOHNNY ,  VALDEZ LINO ,  ZHOU JINGLAN

IPC: C07D515/04 ,  A61K31/519 ,  A61P43/00

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：SI3946595T1

公开(公告)日：2024-02-29

申请号：SI202030331

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/00 ,  C07D515/00

公开(公告)号：RS65132B1

公开(公告)日：2024-02-29

申请号：RSP20240085

申请日：2020-04-02

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  SILINA ALINA ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08