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公开(公告)号：PT942911E
公开(公告)日：2002-04-29
申请号：PT97951555
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , MEYER MICHAEL D , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：CA2423103A1
公开(公告)日：2002-03-28
申请号：CA2423103
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： THOMAS SHEELA A , PETROS ANDREW M , DING HONG , BAUMEISTER STEVEN A , AUGERI DAVID J , DICKMAN DANIEL A , MCCLELLAN WILLIAM , SHEN WANG , FESIK STEPHEN W , WENDT MICHAEL D , WANG XILU , BRUNCKO MILAN , NETTESHEIM DAVID G , KUNZER AARON R , DINGES JURGEN , ROSENBERG SAUL H , HAJDUK PHILIP J , OOST THORSTEN
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07D295/14 , C07D317/58
Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
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公开(公告)号：DK0808318T3
公开(公告)日：2000-10-16
申请号：DK96903340
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： SIPPY KEVIN B , MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA Z , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , ELMORE STEVEN W , TIETJE KARIN R , WENDT MICHAEL D , YAMAMOTO DIANE M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/395 , C07D487/16
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：NO992661L
公开(公告)日：1999-07-30
申请号：NO992661
申请日：1999-06-02
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , C07D311/00 , C07D209/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：AU8587498A
公开(公告)日：1999-02-16
申请号：AU8587498
申请日：1998-07-24
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: C07D295/08 , A61K31/155 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/5375 , A61P15/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/47 , C07C323/56 , C07C323/62 , C07D207/08 , C07D207/337 , C07D209/08 , C07D213/56 , C07D213/58 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D237/20 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/54 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/08 , C07D261/14 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/42 , C07D277/44 , C07D295/092 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/58 , C07D317/66 , C07D317/68 , C07D333/24 , C07D405/12 , C07D521/00 , C07C249/00
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
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Patent Agency Ranking
公开(公告)号：ZA9806594B
公开(公告)日：1999-01-27
申请号：ZA9806594
申请日：1998-07-23
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: C07D295/08 , A61K31/155 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/5375 , A61P15/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/47 , C07C323/56 , C07C323/62 , C07D207/08 , C07D207/337 , C07D209/08 , C07D213/56 , C07D213/58 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D237/20 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/54 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/08 , C07D261/14 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/42 , C07D277/44 , C07D295/092 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/58 , C07D317/66 , C07D317/68 , C07D333/24 , C07D405/12 , C07D521/00 , C07D , A61K
CPC classification number: C07D249/08 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C311/13 , C07C311/16 , C07C323/56 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07D207/08 , C07D209/08 , C07D213/58 , C07D213/74 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D233/56 , C07D237/20 , C07D239/34 , C07D239/42 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/14 , C07D263/32 , C07D277/34 , C07D277/42 , C07D295/088 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/68 , C07D333/24 , C07D405/12
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公开(公告)号：ZA9710926B
公开(公告)日：1998-09-16
申请号：ZA9710926
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJTANG
IPC: C07D491/04 , C07D , A61K
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and tr
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公开(公告)号：AU5516998A
公开(公告)日：1998-06-29
申请号：AU5516998
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：CA2211212A1
公开(公告)日：1996-08-01
申请号：CA2211212
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , LEE EDMUND L , CARROLL WILLIAM A , LEBOLD SUZANNE A , WENDT MICHAEL D , KERWIN JAMES F JR , YAMAMOTO DIANE M , DRIZIN IRENE , ALTENBACH ROBERT J , SIPPY KEVIN B , ELMORE STEVEN W , TIETJE KARIN R , BASHA FATIMA Z
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/505
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
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公开(公告)号：BRPI0110101B1
公开(公告)日：2016-08-23
申请号：BR0110101
申请日：2001-09-20
Applicant: ABBOTT LAB , ABBVIE INC
Inventor： KUNZER AARON R , PETROS ANDREW M , DICKMAN DANIEL A , NETTESHEIM DAVID G , AUGERI DAVID J , DING HONG , DINGES JURGEN , WENDT MICHAEL D , BRUNCKO MILAN , HAJDUK PHILIP J , ROSENBERG SAUL H , THOMAS SHEELA A , FESIK STEPHEN W , BAUMEISTER STEVEN A , OOST THORSTEN , SHEN WANG , MCCLELLAN WILLIAM , WANG XILU
IPC: C07C311/00 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
Abstract: "n-acil-sulfonamidas promotoras de apoptose". descreve-se n-benzoil-aril-sulfonamidas que têm a fórmula (i), são inibidores de bcl-x1, e úteis para promover apoptose. descreve-se também composições e métodos inibidores de bcl-xl para promover apoptose em um mamífero.
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