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公开(公告)号：AU9115101A
公开(公告)日：2002-04-02
申请号：AU9115101
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07C311/00
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公开(公告)号：AU5673196A
公开(公告)日：1996-11-21
申请号：AU5673196
申请日：1996-05-02
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROSENBERG SAUL H , FUNG K L ANTHONY , ROCKWAY TODD W , FAKHOURY STEPHEN A , GARVEY DAVID S , DONNER B GREGORY , O'CONNOR STEPHEN J , PRASAD RAJNANDAN N , SHEN WANG , STOUT DAVID M , SULLIVAN GERARD M
IPC: C07C65/24 , C07C65/28 , C07C65/40 , C07C69/94 , C07C229/38 , C07C233/22 , C07C233/65 , C07C233/69 , C07C233/73 , C07C233/87 , C07C235/16 , C07C235/34 , C07C235/42 , C07C235/48 , C07C235/60 , C07C235/84 , C07C237/08 , C07C237/20 , C07C237/32 , C07C251/48 , C07C255/57 , C07C259/10 , C07C271/48 , C07C275/42 , C07C311/08 , C07C311/29 , C07C311/51 , C07C323/59 , C07C327/48 , C07C333/04 , C07D209/16 , C07D213/40 , C07D231/12 , C07D271/10 , C07D271/113 , C07D307/88 , C07D307/89 , C07D309/32 , C07D311/68 , C07D319/06 , C07D333/20 , C07C235/38 , C07D257/04 , C07C335/22 , C07C233/12
Abstract: The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.
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13.发明专利
公开(公告)号：CA2218597A1
公开(公告)日：1996-10-24
申请号：CA2218597
申请日：1996-04-18
Applicant: ABBOTT LAB
Inventor： STEIN HERMAN H , FUND K L ANTHONY , AUGERI DAVID J , BAKER WILLIAM R , SULLIVAN GERARD M , ROSENBERG SAUL H , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , PRASAD RAJNANDAN N , STOUT DAVID M , SHEN WANG , ROCKWAY TODD W , MCCLELLAN WILLIAM J , GARVEY DAVIS S , ARENDSEN DAVID L
IPC: A61K31/195 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/433 , A61P3/06 , A61P9/00 , A61P9/08 , A61P31/04 , A61P35/00 , A61P43/00 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C235/82 , C07D271/06 , C07D271/10 , C07D285/10 , C07D333/20 , A61K38/04 , C07D215/14 , A61K31/16 , A61K31/19 , C07D333/24 , C07D263/32 , A61K31/33 , C07C323/40 , C07C317/44 , C07C311/45 , C07D307/54 , C07D213/56 , C07C233/57 , C07D317/60 , C07D333/60
Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
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公开(公告)号：CA2612260A1
公开(公告)日：2007-01-18
申请号：CA2612260
申请日：2006-07-07
Applicant: ABBOTT LAB
Inventor： WENDT MICHAEL D , AUGERI DAVID , ELMORE STEVEN W , SHEN WANG , DING HONG , THOMAS SHEELA A , DICKMAN DANIEL A
IPC: A61K31/192 , A61P35/00 , C07C15/12
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases durin g which are expressed the Mcl- 1 protein are disclosed.
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公开(公告)号：DK1318978T3
公开(公告)日：2006-06-06
申请号：DK01971244
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： WANG XILU , AUGERI DAVID J , DICKMAN DANIEL A , DINGES JUERGEN , FESIK STEPHEN W , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D , MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , BAUMEISTER STEVEN A , DING HONG , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M
IPC: C07C311/51 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/14 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
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Patent Agency Ranking
公开(公告)号：AT317382T
公开(公告)日：2006-02-15
申请号：AT01971244
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
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公开(公告)号：CA2423103A1
公开(公告)日：2002-03-28
申请号：CA2423103
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： THOMAS SHEELA A , PETROS ANDREW M , DING HONG , BAUMEISTER STEVEN A , AUGERI DAVID J , DICKMAN DANIEL A , MCCLELLAN WILLIAM , SHEN WANG , FESIK STEPHEN W , WENDT MICHAEL D , WANG XILU , BRUNCKO MILAN , NETTESHEIM DAVID G , KUNZER AARON R , DINGES JURGEN , ROSENBERG SAUL H , HAJDUK PHILIP J , OOST THORSTEN
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07D295/14 , C07D317/58
Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
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18.发明专利
公开(公告)号：GR3030342T3
公开(公告)日：1999-09-30
申请号：GR990401431
申请日：1999-05-27
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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公开(公告)号：ES2130452T3
公开(公告)日：1999-07-01
申请号：ES94931987
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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公开(公告)号：ZA963237B
公开(公告)日：1996-07-29
申请号：ZA963237
申请日：1996-04-23
Applicant: ABBOTT LAB
Inventor： SHEN WANG , ROSENBERG SAUL H , ARENDSEN DAVID L , O'CONNOR STEPHEN J , FAKHOURY STEPHEN A , GARVEY DAVID S , FUNG ANTHONY K L , STEIN HERMAN H
IPC: A61K20060101 , C07C20060101 , C07D20060101 , A61K , C07C , C07D
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