公开(公告)号：HUE052205T2

公开(公告)日：2021-04-28

申请号：HUE17826629

申请日：2017-12-08

Applicant: VERTEX PHARMA

Inventor： ABELA ALEXANDER ,  ALCACIO TIMOTHY ,  ANDERSON COREY ,  ANGELL PAUL ,  BAEK MINSON ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  FERRIS LORI ,  GROOTENHUIS PETER DIEDERIK ,  GROSS RAYMOND ,  GULEVICH ANTON ,  HADIDA RUAH SARA ,  HSIA CLARA ,  HUGHES ROBERT ,  JOSHI PRAMOD ,  KANG PING ,  KESHAVARZ-SHOKRI ALI ,  KHATUYA HARIPADA ,  KRENITSKY PAUL ,  MCCARTNEY JASON ,  MILLER MARK ,  PARASELLI PRASUNA ,  PIERRE FABRICE JEAN ,  SHI YI ,  SHRESTHA MUNA ,  SIESEL DAVID ,  STAVROPOULOS KATHY ,  TERMIN ANDREAS ,  UY JOHNNY ,  VAN GOOR FREDRICK ,  YOUNG TOMOTHY ,  ZHOU JINGLAN

IPC: A61P11/00

公开(公告)号：ZA201208373B

公开(公告)日：2014-01-29

申请号：ZA201208373

申请日：2012-11-07

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HAYLEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：NZ596413A

公开(公告)日：2013-03-28

申请号：NZ59641307

申请日：2007-04-11

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  GONZALEZ JESUS ,  WANG JIAN ,  WILSON DEAN ,  TERMIN ANDREAS

IPC: C07D295/20 ,  A61K31/18 ,  A61P29/00 ,  C07C311/46 ,  C07C323/62 ,  C07D207/32 ,  C07D213/65 ,  C07D213/74 ,  C07D233/54 ,  C07D239/34 ,  C07D317/60

Abstract: ABSTRACT - 596413 The disclosure relates to phenylsulfinyl-3-sulfamoylphenyl-benzamide compounds of formula (I), which are useful as inhibitors of voltage-gated sodium channels, wherein the variables are as defined in the specification. The disclosure also provides pharmaceutically acceptable compositions comprising said compounds and their use for treating or lessening the severity in a subject of acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, epilepsy, neurodegenerative disorders, psychiatric disorders, anxiety, depression, dipolar disorder, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, visceral pain, osteoarthritis pain, back pain, head pain, neck pain, severe pain, intractable pain, nociceptive pain, breakthrough pain, postsurgical pain, cancer pain, stroke, cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, stress-induced angina, exercise induced angina, palpitations, hypertension, migraine, or abnormal gastro-intestinal motility.

公开(公告)号：CA2829803A1

公开(公告)日：2012-09-20

申请号：CA2829803

申请日：2012-03-13

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  BINCH HAYLEY MARIE ,  DENINNO MICHAEL PAUL ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER DIEDERIK JAN ,  HILGRAF NICOLE ,  JOSHI PRAMOD ,  KALLEL EDWARD ADAM ,  PONTILLO JOSEPH ,  SILINA ALINA ,  SHETH URVI JAGDISHBHAI ,  HURLEY DENNIS JAMES ,  ARUMUGAM VIJAYALAKSMI ,  MILLER MARK THOMAS

IPC: C07D498/10 ,  A61K31/424 ,  A61P29/00

Abstract: The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2798763A1

公开(公告)日：2011-11-17

申请号：CA2798763

申请日：2011-05-12

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  BINCH HAYLEY MARIE ,  HURLEY DENNIS JAMES ,  CLEVELAND THOMAS ,  JOSHI PRAMOD ,  FANNING LEV TYLER DEWEY ,  PINDER JOANNE ,  O'DONNELL MICHAEL ,  VIRANI ANISA NIZARALI ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  DURRANT STEVEN JOHN ,  YOUNG STEPHEN CLINTON ,  STORCK PIERRE-HENRI ,  KAY DAVID ,  REAPER PHILIP MICHAEL ,  GROTE MATTHEW PAUL

IPC: C07D413/14 ,  A61K31/444 ,  A61K31/497 ,  A61P35/00

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

公开(公告)号：MX2010003866A

公开(公告)日：2010-06-01

申请号：MX2010003866

申请日：2008-10-10

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  WILSON DEAN ,  TERMIN ANDREAS

IPC: C07D213/82 ,  A61K31/341 ,  A61P29/00 ,  C07D249/10 ,  C07D261/18 ,  C07D263/34 ,  C07D277/56 ,  C07D285/12 ,  C07D307/68 ,  C07D333/38

Abstract: La presente invención se refiere a compuestos de fórmula II", útiles como inhibidores de canales de sodio dependientes del voltaje. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de varias enfermedades.

公开(公告)号：CA2743134A1

公开(公告)日：2010-05-14

申请号：CA2743134

申请日：2009-11-10

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN ,  KAY DAVID ,  O'DONNELL MICHAEL ,  KNEGTEL RONALD ,  MACCORMICK SOMHAIRLE ,  PINDER JOANNE ,  VIRANI ANISA NIZARALI ,  YOUNG STEPHEN ,  BINCH HAYLEY MARIE ,  CLEVELAND THOMAS ,  FANNING LEV T D ,  HURLEY DENNIS J ,  JOSHI PRAMOD ,  SHETH URVI ,  SILINA ALINA

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

公开(公告)号：ZA200810791B

公开(公告)日：2010-03-31

申请号：ZA200810791

申请日：2007-06-13

Applicant: VERTEX PHARMA

Inventor： GUTIERREZ COREY ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  JOSHI PRAMOD ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG

IPC: A61K20100101 ,  C07D20100101

公开(公告)号：MX2008015908A

公开(公告)日：2009-01-28

申请号：MX2008015908

申请日：2007-06-12

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  WILSON DEAN ,  TERMIN ANDREAS ,  FANNING LEV T D ,  ZHANG YULIAN

IPC: A61K31/519 ,  A61P25/00

Abstract: La presente invención se refiere a compuestos de utilidad como inhibidores de canales iónicos. La invención también provee composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos de uso de las composiciones en el tratamiento de diversos trastornos.

公开(公告)号：MX2008013194A

公开(公告)日：2008-12-01

申请号：MX2008013194

申请日：2007-04-11

Applicant: VERTEX PHARMA

Inventor： WANG JIAN ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  GONZALEZ JESUS ,  WILSON DEAN ,  TERMIN ANDREAS

IPC: C07C311/46 ,  A61K31/18 ,  A61P29/00 ,  C07C323/62 ,  C07D207/32 ,  C07D213/65 ,  C07D213/74 ,  C07D233/54 ,  C07D239/34 ,  C07D295/20 ,  C07D317/60

Abstract: La presente invención se refiere a compuestos de utilidad como inhibidores de canales de sodio regulados por voltaje. La invención también provee composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos de uso de las composiciones en el tratamiento de diversos trastornos.