公开(公告)号：JOP20210129A1

公开(公告)日：2023-01-30

申请号：JOP20210129

申请日：2019-12-17

Applicant: VERTEX PHARMA

Inventor： SHI YI ,  MEDEK ALES ,  BRODNEY MICHAEL ,  DAKIN LESLIE A ,  DORSCH WARREN A ,  DENIS FRANCOIS ,  ROSE PETER ,  SENTER TIMOTHY J ,  SHRESTHA MUNA ,  SAYEGH CAMIL ,  GAGNON KEVIN ,  FORTIER ANNE ,  CAO JINGRONG ,  KRUEGER ELAINE B ,  COME JON H ,  LEDFORD BRIAN ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  HAMEL MARTINE ,  HU KAN-NIAN ,  WANG TIANSHENG ,  WITKOS FAITH

Abstract: غيرمتوفر

公开(公告)号：AU2021213758A1

公开(公告)日：2022-09-01

申请号：AU2021213758

申请日：2021-01-28

Applicant: VERTEX PHARMA

Inventor： CAO JINGRONG ,  COME JON H ,  DAKIN LESLIE A ,  DENIS FRANCOIS ,  DORSCH WARREN A ,  FORTIER ANNE ,  HAMEL MARTINE ,  KRUEGER ELAINE B ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  SAYEGH CAMIL E ,  SENTER TIMOTHY J ,  WANG TIANSHENG

IPC: C07D209/12 ,  A61K31/404 ,  A61P13/12 ,  C07D209/18 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12

Abstract: The disclosure provides at least one entity chosen from compounds of Formula (I) pharmaceutically acceptable salts thereof, solvates of any of the foregoing, and deuterated derivatives of any of the foregoing, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.

公开(公告)号：MX2021007152A

公开(公告)日：2021-11-03

申请号：MX2021007152

申请日：2019-12-17

Applicant: VERTEX PHARMA

Inventor： LEDFORD BRIAN ,  WANG TIANSHENG ,  SHI YI ,  COME JON H ,  MEDEK ALES ,  SHRESTHA MUNA ,  BRODNEY MICHAEL ,  GAGNON KEVIN ,  HU KAN - NIAN ,  ROSE PETER ,  WITKOS FAITH ,  CAO JINGRONG ,  DAKIN LESLIE A ,  DENIS FRANCOIS ,  DORSCH WARREN A ,  FORTIER ANNE ,  HAMEL MARTINE ,  KRUEGER ELAINE B ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  SAYEGH CAMIL ,  SENTER TIMOTHY J

IPC: A61P13/12 ,  A61K31/4025 ,  C07D403/12

Abstract: La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula (I), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).

公开(公告)号：ECSP21052184A

公开(公告)日：2021-08-31

申请号：ECDI202152184

申请日：2021-07-15

Applicant: VERTEX PHARMA

Inventor： COME JON H ,  DENIS FRANCOIS ,  HU KAN-NIAN ,  DORSCH WARREN A ,  MEDEK ALES ,  DAKIN LESLIE A ,  HAMEL MARTINE ,  LEDFORD BRIAN ,  WANG TIANSHENG ,  SHI YI ,  ROSE PETER ,  WITKOS FAITH ,  GAGNON KEVIN ,  NANTHAKUMAR SUGANTHINI S ,  KRUEGER ELAINE B ,  NICOLAS OLIVIER ,  CAO JINGRONG ,  SENTER TIMOTHY J ,  SHRESTHA MUNA ,  FORTIER ANNE ,  BRODNEY MICHAEL ,  SAYEGH CAMIL

IPC: A61P13/12 ,  A61K31/4025 ,  C07D403/12

Abstract: La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula (I), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).

公开(公告)号：CO2021009053A2

公开(公告)日：2021-08-09

申请号：CO2021009053

申请日：2021-07-09

Applicant: VERTEX PHARMA

Inventor： MEDEK ALES ,  SHI YI ,  BRODNEY MICHAEL ,  GAGNON KEVIN ,  HU KAN-NIAN ,  ROSE PETER ,  SHRESTHA MUNA ,  WITKOS FAITH ,  CAO JINGRONG ,  COME JON H ,  DAKIN LESLIE A ,  DENIS FRANCOIS ,  DORSCH WARREN A ,  FORTIER ANNE ,  HAMEL MARTINE ,  KRUEGER ELAINE B ,  LEDFORD BRIAN ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  SAYEGH CAMIL ,  SENTER TIMOTHY J ,  WANG TIANSHENG

IPC: A61P13/12 ,  A61K31/4025 ,  C07D403/12

Abstract: La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula (I), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).

公开(公告)号：AU2010341573B2

公开(公告)日：2016-10-13

申请号：AU2010341573

申请日：2010-12-21

Applicant: VERTEX PHARMA

Inventor： ARONOV ALEX ,  COME JON H ,  DAVIES ROBERT J ,  PIERCE ALBERT C ,  WANG JIAN ,  NANTHAKUMAR SUGANTHINI ,  CAO JINGRONG ,  BANDARAGE UPUL K ,  KRUEGER ELAINE ,  TIRAN AMAUD LE ,  LIAO YUSHENG ,  MESSERSMITH DAVID ,  COLLIER PHILIP N ,  GREY RONALD ,  O'DOWD HARDWIN ,  HENDERSON JAMES A ,  GRILLOT ANNE-LAURE

IPC: C07D401/04 ,  A61K31/352 ,  A61K31/424 ,  A61K31/429 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/20 ,  C07D491/20

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：NZ574097A

公开(公告)日：2012-01-12

申请号：NZ57409707

申请日：2007-06-13

Applicant: VERTEX PHARMA

Inventor： GUTIERREZ COREY ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  JOSHI PRAMOD ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG

IPC: C07D277/14 ,  A61K31/4468 ,  A61K31/517 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D498/10 ,  C07D513/10

Abstract: Disclosed is a thiazolidine compound of formula (I) where the substituents are as disclosed in the specification. Example of compound of formula (I) include: 1-(1-(2-(4-Oxo-2-phenyl-3-((pyridin-4-yl)methyl)thiazolidin-5-yl)acetyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 3,4-Dihydro-3-(1-(2-(3-methyl-4-oxo-2-phenylthiazolidin-5-yl)acetyl)piperidin-4-yl)quinazolin-2(1H)-one and 3-(1-(2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one. Also disclosed is the pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula9I) in the manufacture of a medicament for treating or preventing headache; migraine; cluster headache; chronic tension type headache; pain; chronic pain; neurogenic inflammation and inflammatory pain; neuropathic pain; eye pain; tooth pain; diabetes; non-insulin dependent diabetes mellitus; vascular disorders; inflammation; arthritis; bronchial hyperactivity, asthma; shock; sepsis; opiate withdrawal syndrome; morphine tolerance; hot flashes in men and women; allergic dermatitis; encephalitis; brain trauma; epilepsy; neurodegenerative diseases; skin diseases; neurogenic cutaneous redness, skin rosaceous and erythema; tinnitus; inflammatory bowel disease, irritable bowel syndrome, or cystitis.

公开(公告)号：CA2381882C

公开(公告)日：2011-01-25

申请号：CA2381882

申请日：2000-08-11

Applicant: VERTEX PHARMA

Inventor： GREEN JEREMY ,  BEMIS GUY ,  GRILLOT ANNE-LAURE ,  LEDEBOER MARK ,  SALITURO FRANCIS ,  HARRINGTON EDMUND ,  GAO HUAI ,  BAKER CHRISTOPHER ,  CAO JINGRONG ,  HALE MICHAEL

IPC: C07D413/04 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P3/10 ,  A61P7/02 ,  A61P7/04 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/02 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/14

Abstract: The present invention provides compounds of formula (I) where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

公开(公告)号：CA2764989A1

公开(公告)日：2010-12-16

申请号：CA2764989

申请日：2010-06-09

Applicant: VERTEX PHARMA

Inventor： COTTRELL KEVIN MICHAEL ,  ARONOV ALEX ,  DAVIES ROBERT J ,  COME JON H ,  MESSERSMITH DAVID ,  XU JINGWANG ,  BANDARAGE UPUL K ,  CAO JINGRONG

IPC: C07D417/06 ,  A61K31/427 ,  A61P25/00

Abstract: The present invention relates to compounds useful as inhibitors of PBK, particularly of PBK?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AT469895T

公开(公告)日：2010-06-15

申请号：AT07796984

申请日：2007-07-23

Applicant: VERTEX PHARMA

Inventor： GUTIERREZ COREY ,  TERMIN ANDREAS ,  JOSHI PRAMOD ,  HADIDA RUAH SARA ,  BERGERON DANIELE ,  YOO SANGHEE ,  CAO JINGRONG

IPC: C07D413/12 ,  A61K31/536 ,  A61K31/5415 ,  A61P25/06 ,  C07D417/12