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公开(公告)号：BR112021022832A2
公开(公告)日：2022-01-18
申请号：BR112021022832
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM , MEDEK ALES , AMY BETH HALL , MAXWELL BRAD , CAVAN MCKEON BLIGH , DENNIS JAMES HURLEY , BOUCHER DIANE , GABRIELLE SIMONE FLEMING , XU JINWANG , JOHN PATRICK MAXWELL , STAVROPOULOS KATHY , KEVIN JAMES GAGNON , KEVIN MICHAEL COTTRELL , KIRK ALAN OVERHOFF , LEV TYLER DEWEY FANNING , MAC ARTHUR JOHNSON JR , ZAKY MARIAM , SPOSATO MARISA , LAI MEI-HSIU , MICHAEL AARON BRODNEY , MICHAEL JOHN BOYD , MICHAEL PHILIP CLARK , SHRESTHA MUNA , PEDRO MANUEL GARCIA BARRANTES , JONES PETER , PHILIPPE MARCEL NUHANT , TANG QING , REBECCA JANE SWETT , ROBERT DANIEL GIACOMETTI , ROBERT FRANCIS FIMOGNARI , RONALD LEE GREY JR , SAWANT RUPA , GUIDO SAMANTHA , SARAH CAROL HOOD , KESAVAN SARATHY , RODAY SETU , GIROUX SIMON , LIU SIYING , ROEPER STEFANIE , THOMSON STEPHEN , STEVEN M RONKIN , TIMOTHY LEWIS TAPLEY , UPUL KEERTHI BANDARAGE , DAMAGNEZ VERONIQUE , SHI YI
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: pirrois tricíclicos condensados como moduladores da alfa-1 antitripsina. a divulgação fornece compostos úteis para tratar a deficiência de alfa-1 antitripsina (aatd), de acordo com a fórmula (i), seus tautômeros, sais farmaceuticamente aceitáveis dos compostos, sais farmaceuticamente aceitáveis dos tautômeros, derivados deuterados dos compostos, derivados deuterados dos tautômeros e derivados deuterados dos sais, formas sólidas desses compostos e processos para produzir esses compostos.
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公开(公告)号：PE20212302A1
公开(公告)日：2021-12-10
申请号：PE2021000896
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
IPC: A61P13/12 , A61K31/4025 , C07D403/12
Abstract: Referido a un compuesto de formula I, en donde: cada R1 se selecciona, de modo independiente, de grupos halogeno, hidroxi, tiol, amino, entre otros; cada R2 se selecciona, de modo independiente, de grupos halogeno, hidroxi, tiol, ciano, entre otros; m se selecciona de 0, 1, 2, 3 y 4; n se selecciona de 0, 1, 2, 3, 4 y 5; (v) Y se selecciona de grupos alquilo divalentes C1-C8 lineales y ramificados ciclicos, grupos alcoxi divalentes C1-C8 lineales y ramificados, entre otros; cada de R3 y R4 se selecciona, de modo independiente, de H, hidroxi, tiol, entre otros; cada de R5 y R6 se selecciona, de modo independiente, de H, tiol, amino, entre otros; cada de R7, R8 y R9 se selecciona, de modo independiente, de H, grupos alquilo C1-C6 lineales, ramificados y ciclicos, grupos hidroxialquilo C1-C6 lineales, ramificados y ciclicos, entre otros; sus sales farmaceuticamente aceptables, solvatos y derivados deuterados de los mismos. Estos compuestos son inhibidores de la actividad de apolipoproteina L1 (APOL1). Tambien se refiere a metodos de preparacion de dichos compuestos, formas en estado solido de ellos, composicion farmaceutica que los comprenden y metodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabetica (NDKD).
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公开(公告)号：CL2021001561A1
公开(公告)日：2021-11-26
申请号：CL2021001561
申请日：2021-06-15
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
IPC: A61K31/4025 , A61P13/12 , C07D403/12
Abstract: La descripción proporciona al menos una entidad seleccionada de compuestos de la fórmula (I), formas en estado sólido de ellos, composiciones que los comprenden y métodos que los usan, incluyendo el uso en el tratamiento de glomeruloesclerosis segmentaria focal (FSGS) y/o enfermedad renal no diabética (NDKD).
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公开(公告)号：AU2021211993A1
公开(公告)日：2021-08-26
申请号：AU2021211993
申请日：2021-08-03
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOND VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Abstract Compounds of Formula (I): )S 0 0 x y 1 N (R), R1 (R3 (R4)(, pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：SG11202105769XA
公开(公告)日：2021-07-29
申请号：SG11202105769X
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
IPC: A61P13/12 , A61K31/4025 , C07D403/12
Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
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Patent Agency Ranking
公开(公告)号：AU2019405477A1
公开(公告)日：2021-06-24
申请号：AU2019405477
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： BRODNEY MICHAEL , GAGNON KEVIN , HU KAN-NIAN , MEDEK ALES , ROSE PETER , SHI YI , SHRESTHA MUNA , WITKOS FAITH , CAO JINGRONG , COME JON H , DAKIN LESLIE A , DENIS FRANCOIS , DORSCH WARREN A , FORTIER ANNE , HAMEL MARTINE , KRUEGER ELAINE B , LEDFORD BRIAN , NANTHAKUMAR SUGANTHINI S , NICOLAS OLIVIER , SAYEGH CAMIL , SENTER TIMOTHY J , WANG TIANSHENG
IPC: A61P13/12 , A61K31/4025 , C07D403/12
Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
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公开(公告)号：MA49235B1
公开(公告)日：2021-02-26
申请号：MA49235
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： FERRIS LORI , ANDERSON COREY , CLEVELAND THOMAS , KHATUYA HARIPADA , MCCARTNEY JASON , UY JOHNNY , ZHOU JINGLAN , ALCACIO TIMOTHY , BAEK MINSON , HADIDA RUAH SARA , HUGHES ROBERT , KESHAVARZ-SHOKRI ALI , MILLER MARK , JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , ABELA ALEXANDER , PARASELLI PRASUNA , SIESEL DAVID , ANGELL PAUL , CLEMENS JEREMY , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HSIA CLARA , KANG PING , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , STAVROPOULOS KATHY , VAN GOOR FREDRICK , YOUNG TOMOTHY
IPC: A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04 , C07D401/14
Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.
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公开(公告)号：DK3551622T3
公开(公告)日：2020-11-23
申请号：DK17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：UA121376C2
公开(公告)日：2020-05-25
申请号：UAA201606307
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
Abstract: ПоліморфнаформаСполуки (1) абоїїфармацевтичноприйнятнасіль, деСполука (1) представленанаступноюструктурноюформулою: , (1) ФормиА соліНСl Сполуки (1) 1/2Н2О, Форми F соліНСl Сполуки (1) 3Н2Оі Форми D соліНС1 Сполуки (1), ФормиА Сполуки (1) іФормиА тозилатуСполуки (1). Такіполіморфніформивикористовуютьсядлялікуваннягрипу, інгібуванняреплікаціївірусівгрипуабозменшеннякількостівірусівгрипув біологічномузразкуабоу індивіда.
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公开(公告)号：CA3114672A1
公开(公告)日：2020-04-23
申请号：CA3114672
申请日：2019-10-04
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: C07D487/04 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/437 , A61K31/4985 , A61K31/5377 , A61K31/7056 , C07D471/14 , C07D487/14 , C07D519/00 , C07H13/02
Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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