公开(公告)号：CA2672737A1

公开(公告)日：2008-11-06

申请号：CA2672737

申请日：2007-12-19

Applicant: ABBOTT LAB

Inventor： ANDERSON DAVID D ,  WAGNER ROLF ,  CARRICK ROBERT J ,  ZHANG RONG ,  HE WENPING ,  ROCKWAY TODD W ,  MARING CLARENCE J ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE V L ,  COOPER CURT S ,  BETEBENNER DAVID A ,  MO HONGMEI ,  MOLLA AKHTERUZZAMAN ,  LU LIANGJUN

IPC: A01N43/42 ,  A61K31/44

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to composi tions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and interme diates for the syntheses of such compounds, and methods of using such compou nds for the treatment of HCV or other viral infections.

公开(公告)号：CA2633752A1

公开(公告)日：2007-07-19

申请号：CA2633752

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J ,  CARRICK ROBERT J ,  HE WEPING ,  KRUEGER ALLAN C ,  BETEBENNER DAVID A ,  TUFANO MICHAEL D ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  WAGNER ROLF ,  MCDANIEL KEITH F ,  IWASAKI NOBUHIKO ,  DEGOEY DAVID A ,  LIU DACHUN ,  ROCKWAY TODD W ,  MO HONGMEI ,  COOPER CURT S ,  DONNER PAMELA L ,  ANDERSON DAVID D ,  MOLLA AKHTERUZZAMAN ,  MOTTER CHRISTOPHER E ,  ZHANG RONG ,  GREEN BRIAN E ,  MADIGAN DAROLD L ,  PRATT JOHN K ,  KEMPF DALE J ,  SHANLEY JASON P

IPC: C07D495/04 ,  C07D471/04 ,  C07D513/04

公开(公告)号：BR0010525A

公开(公告)日：2002-11-26

申请号：BR0010525

申请日：2000-09-22

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GIRANDA VINCENT L ,  KEMPF DALE J ,  STOLL VINCENT S ,  SUN MINGHUA ,  ZHAO CHEN ,  GU YU GUI ,  HANESSIAN STEPHEN ,  STEWART KENT D ,  WANG GARY T ,  WANG JIANCHIO ,  MADIGAN DAROLD L

IPC: A61K31/16 ,  A61K31/19 ,  C07C233/52 ,  C07C247/12 ,  C07D303/38

公开(公告)号：NO20005301L

公开(公告)日：2000-12-08

申请号：NO20005301

申请日：2000-10-20

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU-GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VINCENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40

公开(公告)号：CA1328258C

公开(公告)日：1994-04-05

申请号：CA601931

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04 ,  A61K31/71

Abstract: 9-R-AZACYCLIC ERYTHROMYCIN ANTIBIOTICS Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：DK276289D0

公开(公告)日：1989-06-06

申请号：DK276289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：CA2755348C

公开(公告)日：2017-12-12

申请号：CA2755348

申请日：2010-03-25

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  PRATT JOHN K ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  LIU DACHUN

IPC: C07D239/54 ,  A61K31/18 ,  A61K31/27 ,  A61K31/4015 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61P31/14 ,  C07D213/64 ,  C07D233/66 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：CA2755023C

公开(公告)日：2016-12-13

申请号：CA2755023

申请日：2010-03-25

Applicant: ABBOTT LAB

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LONGENECKER KENTON L ,  PRATT JOHN K ,  STEWART KENT D ,  WAGNER ROLF ,  MARING CLARENCE J

IPC: C07D405/04 ,  A61K31/513 ,  A61K31/517 ,  A61P31/12 ,  C07D401/04 ,  C07D403/04 ,  C07D409/14

Abstract: This invention relates to: (a) compounds, for example, the compound of formula (I): (see formula I) wherein R1, R2, R3 and R4 are as described in the specification, and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：ZA201204223B

公开(公告)日：2015-12-23

申请号：ZA201204223

申请日：2012-06-08

Applicant: ABBOTT LAB

Inventor： LOU XIAOCHUN ,  ZHANG GEOFF G Z ,  KOTECKI BRIAN J ,  HENGEVELD JOHN E ,  GAO YI ,  CHEN SHUANG ,  BETEBENNER DAVID A ,  DONNER PAMELA L ,  HUANG PEGGY P ,  KATI WARREN M ,  LIU YAYA ,  MARING CLARENCE J ,  PRATT JOHN K ,  ROCKWAY TODD W ,  TUFANO MICHAEL D ,  LIU DACHUN ,  SARRIS KATHY ,  HENRY RODGER F ,  HAIGHT ANTHONY R ,  FRANCZYK II THADDEUS S ,  BARNES DAVID M ,  DEGOEY DAVID A ,  HUTCHINSON DOUGLAS K ,  KRUEGER ALLAN C ,  LONGENECKER KENTON L ,  RANDOLPH JOHN T ,  STEWART KENT D ,  WEGNER ROLF

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; and (e) use of such compounds, salts, and compositions.

公开(公告)号：IN5113DEN2012A

公开(公告)日：2015-10-23

申请号：IN5113DEN2012

申请日：2012-06-08

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2- ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs I and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4- dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-pheny1)naphthalen-2- yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-method-styryl-phemyl)methanesulfonamide.