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公开(公告)号：AU2012203382A8
公开(公告)日：2012-08-02
申请号：AU2012203382
申请日：2012-06-08
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , WANG JIAN , PINDER JOANNE , WANG TIANSHENG , PIERCE ALBERT
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：NZ579485A
公开(公告)日：2012-02-24
申请号：NZ57948508
申请日：2008-03-10
Applicant: VERTEX PHARMA
Inventor： PIERCE ALBERT , COME JON , COURT JOHN , GAO HUAI , HENKEL GREGORY , LIU MICHAEL , NEUBERGER TIMOTHY
IPC: A61P9/00 , A61K31/506 , A61P3/10 , A61P25/00 , C07D471/04
Abstract: A compound of formula I e.g. N-(2-(2-chlorophenyl)-S,6-dimethylpyrimidin-4-yl)-S-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine or a pharmaceutically acceptable salt thereof, wherein: RX is alkyl and RY is alkyl for treating or lessening the severity of a disease or condition selected from diabetes, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), schizophrenia, leukocytopenia, stroke, and rheumatoid arthritis, stroke, spinal cord injury, traumatic brain injury, Charcot-Marie- Tooth, and diabetic neuropathy.
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公开(公告)号：ES2374335T3
公开(公告)日：2012-02-15
申请号：ES08731839
申请日：2008-03-10
Applicant: VERTEX PHARMA
Inventor： PIERCE ALBERT , COME JON , COURT JOHN , GAO HUAI , HENKEL GREGORY , LIU MICHAEL , NEUBERGER TIMOTHY
IPC: C07D471/04
Abstract: Un compuesto de fórmula I: o una sal farmacéuticamente aceptable del mismo, en la que: RX es alquilo C1-3 y RY es alquilo C1-3
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公开(公告)号：HRP20110566T1
公开(公告)日：2011-09-30
申请号：HRP20110566
申请日：2011-07-29
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , PINDER JOANNE , WANG TIANSHENG , PIERCE ALBERT
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：AU2008226466A1
公开(公告)日：2008-09-18
申请号：AU2008226466
申请日：2008-03-10
Applicant: VERTEX PHARMA
Inventor： COME JON , PIERCE ALBERT , COURT JOHN , HENKEL GREGORY , GAO HUAI , LIU MICHAEL , NEUBERGER TIMOTHY
IPC: C07D471/04 , A61K31/506 , A61P3/10 , A61P9/00 , A61P25/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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Patent Agency Ranking
公开(公告)号：ZA200607981B
公开(公告)日：2008-06-25
申请号：ZA200607981
申请日：2005-03-30
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , WANG JIAN , PINDER JOANNE , WANG TIANGSHENG , PIERCE ALBERT
IPC: C07D20090101
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公开(公告)号：HUE057527T2
公开(公告)日：2022-05-28
申请号：HUE18207382
申请日：2014-03-12
Applicant: VERTEX PHARMA
Inventor： MAXWELL JOHN , CHARIFSON PAUL , TANG QING , RONKIN STEVEN , JACKSON KATRINA , PIERCE ALBERT , LAUFFER DAVID , LI PAN , GIROUX SIMON , XU JINWANG , MORRIS MARK , COURT JOHN , COTTRELL KEVIN , DENG HONGBO , WAAL NATHAN , GU WENXIN
IPC: C07D403/12 , A61P35/00 , C07D241/44 , C07D405/12 , C07D413/04 , C07D417/12
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公开(公告)号：LT3141252T
公开(公告)日：2018-11-12
申请号：LT16181549
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL , BANDARAGE UPUL , BETHIEL RANDY , COURT JOHN , DENG HONGBO , DRUTU IOANA , DUFFY JOHN , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN , KENNEDY JOSEPH , LEDEBOER MARK , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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公开(公告)号：AU2012203384A8
公开(公告)日：2012-08-02
申请号：AU2012203384
申请日：2012-06-08
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , WANG JIAN , PINDER JOANNE , WANG TIANSHENG , PIERCE ALBERT
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：AU2012203384A1
公开(公告)日：2012-06-28
申请号：AU2012203384
申请日：2012-06-08
Applicant: VERTEX PHARMA
Inventor： SALITURO FRANCESCO , FARMER LUC , BETHIEL RANDY , HARRINGTON EDMUND , GREEN JEREMY , COURT JOHN , COME JON , LAUFFER DAVID , ARONOV ALEX , BINCH HAYLEY , BOYALL DEAN , CHARRIER JEAN-DAMIEN , EVERITT SIMON , FRAYSSE DAMIEN , MORTIMORE MICHAEL , PIERARD FRANCOISE , ROBINSON DANIEL , WANG JIAN , PINDER JOANNE , WANG TIANSHEN , PIERCE ALBERT
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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