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公开(公告)号：PE20020687A1
公开(公告)日：2002-08-03
申请号：PE2001001198
申请日：2001-11-29
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU , WANG WEIBO , WANG LE , TONG YUNSONG , SHAM HING L , MANTEI ROBERT A , LI TONGMEI , HASVOLD LISA A
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D401/01
Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES
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公开(公告)号：SK15092000A3
公开(公告)日：2001-05-10
申请号：SK15092000
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VICENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：AU8005100A
公开(公告)日：2001-04-30
申请号：AU8005100
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , WANG GARY T , KRUEGER ALLAN C , CHEN YUANWEI , DEGOEY DAVID A , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , LIN ZHEN , MADIGAN DONALD L , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , WANG SHELDON , YEUNG MING C
IPC: A61K31/195 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04 , C07C233/00
Abstract: Disclosed are compounds of the formula:which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CA2388859A1
公开(公告)日：2001-04-26
申请号：CA2388859
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , WAGENAAR FRANK L , WANG SHELDON , GIRANDA VINCENT L , LIN ZHEN , FLOSI WILLIAM J , DEGOEY DAVID A , KLEIN LARRY L , KEMPF DALE J , STOLL VINCENT S , KATI WARREN M , GRAMPOVNIK DAVID J , KENNEDY APRIL L , WIEDEMAN PAUL E , MCDANIEL KEITH F , TU NOAH P , XU YIBO , HANESSIAN STEPHEN , STEWART KENT D , SHAM HING L , MUCHMORE STEVEN W , WANG GARY T , BAYRAKDARIAN MALKEN , LUO XUEHONG , CHEN YUANWEI , MADIGAN DAROLD L , YEUNG MING C , ZHAO CHEN , KRUEGER ALLAN C , GU YU GUI , CHEN HUI-JU , SUN MINGHUA
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
Abstract: Enantiomerically enriched compounds having the absolute stereochemistry of t he formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：CZ20003872A3
公开(公告)日：2001-03-14
申请号：CZ20003872
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-YU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/40 , A61P31/16 , C07D207/16 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
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Patent Agency Ranking
公开(公告)号：BR9909870A
公开(公告)日：2000-12-19
申请号：BR9909870
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
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公开(公告)号：CA2329660A1
公开(公告)日：1999-10-28
申请号：CA2329660
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： DEGOEY DAVID A , SUN MINGHUA , SHAM HING L , ZHAO CHEN , CHEN YUANWEI , WANG GARY T , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KENNEDY APRIL , YEUNG MING , MUCHMORE STEVEN W , MADIGAN DAROLD L , LIN ZHEN , STEWART KENT D , GU YU-GUI , WANG SHELDON , STOLL VINCENT S , MARING CLARENCE J , KEMPF DALE J , KATI WARREN M
IPC: A61K31/196 , A61K31/215 , A61K31/341 , A61K31/4164 , A61K31/421 , A61P31/16 , A61P43/00 , C07C233/47 , C07C233/52 , C07C237/24 , C07C271/22 , C07C271/24 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/32 , C07D405/04 , C07D493/08 , A61K31/16 , A61K31/33
Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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公开(公告)号：PT100304A
公开(公告)日：1993-06-30
申请号：PT10030492
申请日：1992-03-26
Applicant: ABBOTT LAB
Inventor： SHAM HING L , NORBECK DANIEL W , KEMPF DALE J , ZHAO CHEN
IPC: A61K38/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C217/48 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/16 , C07D217/26 , C07D233/84 , C07D239/38 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D295/088 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D417/12 , C07D487/04 , C07D521/00 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/06 , A61K37/64
Abstract: Compounds are disclosed which are retroviral protease inhibitors. Also disclosed are methods of using the compounds and compositions for inhibiting a retroviral protease and for treating an HIV infection.
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公开(公告)号：IE920714A1
公开(公告)日：1992-10-07
申请号：IE920714
申请日：1992-03-05
Applicant: ABBOTT LAB
Inventor： SHAM HING L , KEMPF DALE J , NORBECK DANIEL W , ZHAO CHEN
IPC: A61K38/00 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C217/48 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/16 , C07D217/26 , C07D233/84 , C07D239/38 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D295/088 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D417/12 , C07D487/04 , C07D521/00 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/06 , C07K5/00 , C07C229/00
Abstract: Compounds are disclosed which are retroviral protease inhibitors. Also disclosed are methods of using the compounds and compositions for inhibiting a retroviral protease and for treating an HIV infection.
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公开(公告)号：ITMI913081A1
公开(公告)日：1992-05-20
申请号：ITMI913081
申请日：1991-11-19
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , NORBECK DANIEL W , CODACOVI LYNN M , PLATTNER JACOB J , ZHAO CHEN , SHAM HING L , WITTENBERGER STEVEN J
IPC: A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K38/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C53/134 , C07C211/00 , C07C215/18 , C07C215/20 , C07C215/28 , C07C215/30 , C07C215/80 , C07C219/18 , C07C233/40 , C07C237/10 , C07C237/22 , C07C269/04 , C07C271/02 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D20060101 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/36 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D213/79 , C07D215/20 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D237/10 , C07D239/26 , C07D241/12 , C07D261/08 , C07D261/12 , C07D263/20 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/02 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/34 , C07D307/42 , C07D307/66 , C07D333/16 , C07D333/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D521/00 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
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