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公开(公告)号：AU2004290666A1
公开(公告)日：2005-06-02
申请号：AU2004290666
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： TU NOAH , KUNZER AARON R , BRUNCKO MILAN , WANG XILU , LYNCH CHRISTOPHER L , DING HONG , MCCLELLAN WILLIAM , SONG XIAOHONG , ELMORE STEVEN , PETROS ANDREW , WENDT MICHAEL D , PARK CHEOL-MIN
IPC: A61K31/635 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
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公开(公告)号：BR0112028A
公开(公告)日：2004-02-17
申请号：BR0112028
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：NO20032471A
公开(公告)日：2003-07-25
申请号：NO20032471
申请日：2003-05-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：UY26942A1
公开(公告)日：2002-04-26
申请号：UY26942
申请日：2001-09-19
Applicant: ABBOTT LAB
Inventor： AUGERI DAVID J , DICKMAN DANIEL A , WANG XILU , MCCLELLAN WILLIAM , FESIK STEPHEN W , NETTESHEIM DAVID G , SHEN WANG , OOST THORSTEN , DING HONG , HAJDUK PHILIP J , PETROS ANDREW M , THOMAS SHEELA A , BRUNCKO MILAN , BAUMEISTE STEVEN A , DINGES JURGEN , KUNZER AARON R , ROSEMBERG SAUL H , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07C311/16 , C07D207/00 , C07D211/00 , C07D307/02 , C07D309/00 , C07D333/02 , C07D335/02
Abstract: Las N - benzoilarilsulfonamidas de la fórmula son inhibidoras de BCL - XI y resultan útiles para promover la apoptosis. Asimismo se revelan composiciones inhibidoras de BCL - XI y métodos para promover la apoptosis en un mamífero.
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公开(公告)号：AU9115101A
公开(公告)日：2002-04-02
申请号：AU9115101
申请日：2001-09-20
Applicant: ABBOTT LAB
Inventor： MCCLELLAN WILLIAM , OOST THORSTEN , BRUNCKO MILAN , WANG XILU , AUGERI DAVID J , BAUMEISTER STEVEN A , DICKMAN DANIEL A , DING HONG , DINGES JURGEN , FESIK STEPHEN W , HAJDUK PHILIP J , KUNZER AARON R , NETTESHEIM DAVID G , PETROS ANDREW M , ROSENBERG SAUL H , SHEN WANG , THOMAS SHEELA A , WENDT MICHAEL D
IPC: A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107 , C07C311/00
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Patent Agency Ranking
公开(公告)号：AU5921801A
公开(公告)日：2001-11-07
申请号：AU5921801
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , CURTIN MICHAEL L , FAKHOURY STEPHEN A , GWALTNEY STEPHEN L II , HASVOLD LISA A , HUTCHINS CHARLES W , LI QUI , LIN NAN-HORNG , NELSON LISSA TAKA JENNINGS , O'CONNOR STEPHEN J , SHAM HING L , SULLIVAN GERALD M , WANG GARY T , WANG XILU
IPC: C07D233/22 , A61K31/381 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/4406 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61P17/06 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07D213/30 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/82 , C07D213/84 , C07D213/85 , C07D231/12 , C07D233/26 , C07D233/54 , C07D249/04 , C07D249/08 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/30 , C07D333/16 , C07D333/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D233/00
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公开(公告)号：BRPI0110101B1
公开(公告)日：2016-08-23
申请号：BR0110101
申请日：2001-09-20
Applicant: ABBOTT LAB , ABBVIE INC
Inventor： KUNZER AARON R , PETROS ANDREW M , DICKMAN DANIEL A , NETTESHEIM DAVID G , AUGERI DAVID J , DING HONG , DINGES JURGEN , WENDT MICHAEL D , BRUNCKO MILAN , HAJDUK PHILIP J , ROSENBERG SAUL H , THOMAS SHEELA A , FESIK STEPHEN W , BAUMEISTER STEVEN A , OOST THORSTEN , SHEN WANG , MCCLELLAN WILLIAM , WANG XILU
IPC: C07C311/00 , A61K31/18 , A61K31/428 , A61K31/63 , A61K31/635 , A61P9/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/02 , C07C311/46 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/43 , C07C323/44 , C07C323/48 , C07C323/58 , C07C323/60 , C07D203/10 , C07D205/04 , C07D205/12 , C07D207/09 , C07D207/24 , C07D207/40 , C07D207/404 , C07D209/08 , C07D209/52 , C07D209/54 , C07D209/96 , C07D211/14 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D233/60 , C07D235/08 , C07D235/26 , C07D241/08 , C07D241/16 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D333/70 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D417/12 , C07D451/02 , C07D491/107
Abstract: "n-acil-sulfonamidas promotoras de apoptose". descreve-se n-benzoil-aril-sulfonamidas que têm a fórmula (i), são inibidores de bcl-x1, e úteis para promover apoptose. descreve-se também composições e métodos inibidores de bcl-xl para promover apoptose em um mamífero.
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68.发明专利
公开(公告)号：BR112012012918A2
公开(公告)日：2015-09-08
申请号：BR112012012918
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： KUNZER AARON , SOUERS ANDREW J , PETROS ANDREW M , PARK CHANG H , PARK CHEOL-MIN , WANG GARY T , DOHERTY GEORGE A , SULLIVAN GERARD M , DING HONG , HEXAMER LAURA , WANG LE , HASVOLD LISA , WENDT MICHAEL D , BRUNCKO MILAN , MANTEI ROBERT A , ELMORE STEVEN W , HANSEN TODD M , MCCLELLAN WILLIAM J , SONG XIAOHONG , WANG XILU , DAÍ YUJIA , TAO ZHI-FU
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: agente indutor de apoptose para o tratamento de câncer e de doenças imunes e autoimunes. a presente invenção descreve compostos que inibem a atividade de proteínas anti-apoptóticas da família bcl-2, além de composições contendo os compostos e métodos para tratar doenças que cursam com a expressão da proteína antiapoptótica bcl-2.
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公开(公告)号：BRPI0810365A2
公开(公告)日：2014-10-29
申请号：BRPI0810365
申请日：2008-04-16
Applicant: ABBOTT LAB
Inventor： ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG XILU , HASVOLD LISA A , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , MADAR DAVID
IPC: C07D209/34 , A61K31/404 , A61P35/00 , C07D401/12 , C07D413/06 , C07D417/04
Abstract: 7-substituted indole derivatives which inhibit the activity of anti-apoptotic Mcl-1 protein and compositions containing the compounds are disclosed.
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70.发明专利
公开(公告)号：ZA201208727B
公开(公告)日：2013-07-31
申请号：ZA201208727
申请日：2012-11-20
Applicant: ABBOTT LAB
Inventor： TAO ZHI-FU , SOUERS ANDREW J , SULLIVAN GERARD , WANG XILU , CATRON NATHANIEL D
IPC: A01N20060101 , A61K20060101
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