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公开(公告)号：CO2022002634A2
公开(公告)日：2022-06-21
申请号：CO2022002634
申请日：2022-03-04
Applicant: VERTEX PHARMA
Inventor： SHI YI , MEDEK ALES , WALDO MICHAEL , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , GROOTENHUIS PETER (DECEASED) , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN , SHRESTHA MUNA , GAGNON KEVIN J , LI JICONG , LU JENNIFER , ZHANG BEILI , ZWICKER CARL L
IPC: C07D513/22 , A61K31/435 , A61P11/00
Abstract: Se describen formas cristalinas del Compuesto I: I, sales farmacéuticamente aceptables de este, y solvatos e hidratos de estas. También se describen composiciones farmacéuticas que comprenden las mismas, métodos para tratar la fibrosis quística mediante el uso de las mismas y métodos para fabricar las mismas.
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公开(公告)号：AU2020286424A1
公开(公告)日：2022-01-06
申请号：AU2020286424
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：EA039280B1
公开(公告)日：2021-12-28
申请号：EA201991403
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TIMOTHY JOHN , ZHOU JINGLAN
Abstract: Визобретенииописанымодуляторрегуляторатрансмембраннойпроводимостипримуковисцидозе (CFTR) формулы 1, атакжеегодейтерированноепроизводное, фармацевтическиекомпозиции, содержащиеуказанныймодулятор, испособылечениямуковисцидоза.
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公开(公告)号：BR112021011564A2
公开(公告)日：2021-08-31
申请号：BR112021011564
申请日：2019-12-17
Applicant: VERTEX PHARMA
Inventor： MEDEK ALES , FORTIER ANNE , LEDFORD BRIAN , SAYEGH CAMIL , ELAINE B KRUEGER , WITKOS FAITH , DENIS FRANCOIS , CAO JINGRONG , JON H COME , HU KAN-NIAN , GAGNON KEVIN , LESLIE A DAKIN , HAMEL MARTINE , BRODNEY MICHAEL , SHRESTHA MUNA , NICOLAS OLIVIER , ROSE PETER , SUGANTHINI S NANTHAKUMAR , WANG TIANSHENG , TIMOTHY J SENTER , WARREN A DORSCH , SHI YI
IPC: C07D403/12 , A61K31/4025 , A61P13/12
Abstract: inibidores de apol1 e métodos de uso dos mesmos. trata-se de pelo menos uma entidade escolhida dentre os compostos de fórmula (i), formas de estado sólido dos mesmos, composições que compreendem os mesmos e métodos para usar os mesmos, incluindo o uso no tratamento de glomeruloesclerose segmentar focal (gesf) e/ou doença renal não diabética (ndkd).
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公开(公告)号：CO2021005884A2
公开(公告)日：2021-05-20
申请号：CO2021005884
申请日：2021-05-05
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , ECCLES MARY ELIZABETH , GAGNON KEVIN JAMES , HOOD SARAH CAROL , HUSSEY JOSHUA KENNEDY , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , WALDO MICHAEL , BANDARAGE UPUL KEERTHI , BOUCHER DIANE M , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , DEWEY FANNING LEV TYLER , FIMOGNARI JR ROBERT FRANCIS , GARCIA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , XU JINWANG , MAXWELL BRAD D , COTTRELL KEVIN MICHAEL
IPC: A61P1/16 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Nuevos compuestos, composiciones y métodos para usar y preparar los mismos, los cuales pueden ser útiles para tratar la deficiencia de alfa-1 antitripsina (AATD).
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Patent Agency Ranking
公开(公告)号：HUE052205T2
公开(公告)日：2021-04-28
申请号：HUE17826629
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL , BAEK MINSON , CLEMENS JEREMY , CLEVELAND THOMAS , FERRIS LORI , GROOTENHUIS PETER DIEDERIK , GROSS RAYMOND , GULEVICH ANTON , HADIDA RUAH SARA , HSIA CLARA , HUGHES ROBERT , JOSHI PRAMOD , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL , MCCARTNEY JASON , MILLER MARK , PARASELLI PRASUNA , PIERRE FABRICE JEAN , SHI YI , SHRESTHA MUNA , SIESEL DAVID , STAVROPOULOS KATHY , TERMIN ANDREAS , UY JOHNNY , VAN GOOR FREDRICK , YOUNG TOMOTHY , ZHOU JINGLAN
IPC: A61P11/00
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公开(公告)号：CA3150162A1
公开(公告)日：2021-02-18
申请号：CA3150162
申请日：2020-08-13
Applicant: VERTEX PHARMA
Inventor： SHI YI , GAGNON KEVIN J , LI JICONG , LU JENNIFER , MEDEK ALES , SHRESTHA MUNA , WALDO MICHAEL , ZHANG BEILI , ZWICKER CARL L , ANDERSON COREY DON , CLEMENS JEREMY J , CLEVELAND THOMAS , COON TIMOTHY RICHARD , FRIEMAN BRYAN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE , SWIFT SARA E , ZHOU JINGLAN , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA
IPC: A61K31/435 , A61P11/00 , C07D513/22
Abstract: Crystalline forms of Compound I: Formula (I) pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：UY38403A
公开(公告)日：2020-04-30
申请号：UY38403
申请日：2019-10-07
Applicant: VERTEX PHARMA
Inventor： JONES PETER , NUHANT PHILIPPE MARCEL , BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE M , DEWEY FANNING LEV TYLER , ECCLES MARY ELIZABETH , FIMOGNARI JR ROBERT FRANCIS , GAGNON KEVIN JAMES , BOYD MICHAEL JOHN , GARCÍA BARRANTES PEDRO M , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , HUSSEY JOSHUA KENNEDY , JOHNSON JR , KESAVAN SARATHY , LOOKER ADAM , MAXWELL BRAD D , MAXWELL JOHN PATRICK , MEDEK ALES , NAVAMAL METTACHIT , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , WALDO MICHAEL , XU JINWANG , DAMAGNEZ VERONIQUE , BRODNEY MICHAEL AARON
IPC: A61P1/16 , A61K31/4162 , A61K31/437 , A61K31/497 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07F5/04
Abstract: Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
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公开(公告)号：MA49235A
公开(公告)日：2019-10-16
申请号：MA49235
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: A61P11/00 , A61K31/455 , C07D231/20 , C07D401/04 , C07D401/14
Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.
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公开(公告)号：SI3068776T1
公开(公告)日：2019-09-30
申请号：SI201431295
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： NTI-ADDAE KWAME W , WALDO MICHAEL , O'NEIL SIMON ADAM , VAN ALSTEN JOHN GREGG , MACIKENAS DAINIUS , MUDUNURI PRAVEEN , SHI YI , LEDEBOER MARK WILLEM , JURKAUSKAS VALDAS , MEDEK ALES , JONES STEVEN , BYRN RANDAL , ASMAL MOHAMMED , ROBERTSON SARAH MARIE , TSAI WANJUNG
IPC: C07D403/00 , A61K31/00 , A61P31/00 , C07D471/00
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