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公开(公告)号：AT194141T
公开(公告)日：2000-07-15
申请号：AT96903340
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA Z , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F JR , LEBOLD SUZANNE A , LEE EDMUND L , ELMORE STEVEN W , SIPPY KEVIN B , TIETJE KARIN R , WENDT MICHAEL D , YAMAMOTO DIANE M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , C07D487/16
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：SK174899A3
公开(公告)日：2000-06-12
申请号：SK174899
申请日：1998-07-24
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: C07D295/08 , A61K31/155 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/5375 , A61P15/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/47 , C07C323/56 , C07C323/62 , C07D207/08 , C07D207/337 , C07D209/08 , C07D213/56 , C07D213/58 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D237/20 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/54 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/08 , C07D261/14 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/42 , C07D277/44 , C07D295/092 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/58 , C07D317/66 , C07D317/68 , C07D333/24 , C07D405/12 , C07D521/00 , C07C249/00 , A61K31/136
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
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公开(公告)号：BR9713682A
公开(公告)日：2000-03-28
申请号：BR9713682
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANG WEIJIANG
IPC: A61K31/415 , C07D491/04
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公开(公告)号：CZ194499A3
公开(公告)日：1999-11-17
申请号：CZ194499
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , ALTENBACH ROBERT J , BASHA FATIMA , CARROLL WILLIAM A , DRIZIN IRENE , KERWIN JAMES F , WENDT MICHAEL D , HAIGHT ANTHONY R , ZHANGH WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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35.发明专利
公开(公告)号：HK1177202A1
公开(公告)日：2013-08-16
申请号：HK13104084
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC: C07D20060101
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking36.发明专利
公开(公告)号：ECSP12012020A
公开(公告)日：2012-08-31
申请号：ECSP12012020
申请日：2012-07-03
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , SULLIVAN GERARD M , WANG GARY , WANG XILU , MANTEI ROBERT A , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , DAI YUJIA , DING HONG , HEXAMER LAURA , MCCLELLAN WILLIAM J , PARK CHANG H , PETROS ANDREW M , HANSEN TODD M , DOHERTY GEORGE A , TAO ZHI FU
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D235/06 , C07D277/24 , C07D309/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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37.发明专利
公开(公告)号：CR20120347A
公开(公告)日：2012-08-14
申请号：CR20120347
申请日：2012-06-25
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHNG , SOUERS ANDREW J , SULLIVAN GERARD , TAO ZHI-GU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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公开(公告)号：SG181491A1
公开(公告)日：2012-07-30
申请号：SG2012040820
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.
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39.发明专利
公开(公告)号：ZA201103807B
公开(公告)日：2012-02-29
申请号：ZA201103807
申请日：2011-05-24
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , ELMORE STEVEN W , HEXAMER LAURA , MANTEI ROBERT A , PARK CHANG HEE , PETROS ANDREW J , SOUERS ANDREW J , TAO ZHI-FU , WANG LE , WENDT MICHAEL D , DAI YUJIA , DOHERTY GEORGE A , HASVOLD LISA A , KUNZER AARON R , MCCLELLAN WILLIAM J , PARK CHEOL-MIN , SONG XIAOHONG , SULLIVAN GERARD M , WANG GARY T , WANG XILU
IPC: A61K20060101 , A61P20060101 , C07D20060101
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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40.发明专利
公开(公告)号：UY32681A
公开(公告)日：2011-02-28
申请号：UY32681
申请日：2010-06-02
Applicant: ABBOTT LAB
Inventor： MANTEI ROBERT A , MILAN BRUNCKO , HONG DING , DOHERTY GEORGE A , ELMORE STEVEN W , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SOUERS ANDREW J , SULLIVAN GERARD M , XILU WANG , WENDT MICHAEL D , WANG GARY T , LE WANG , HANSEN TODD M , XIAOHLONG SONG , YUJIA DAI , TAO ZHI-FU
IPC: A61P35/00 , C07D207/04 , C07D209/04 , C07D211/06 , C07D215/02 , C07D217/00 , C07D231/54 , C07D235/04 , C07D241/10 , C07D277/60 , C07D295/04 , C07D305/02 , C07D309/04 , C07D319/10 , C07D403/00 , C07D405/00 , C07D417/10
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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