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51.发明专利
公开(公告)号：ECSP11011173A
公开(公告)日：2011-08-31
申请号：ECSP11011173
申请日：2011-07-04
Applicant: ABBOTT LAB
Inventor： DOHERTY GEORGE ANDREW , HASVOLD LISA A , SULLIVAN GERARD M , WANG GARY , WANG XILU , MANTEI ROBERT A , ELMORE STEVEN W , SOUERS ANDREW J , BRUNCKO MILAN , SONG XIAOHONG , WANG LE , KUNZER AARON R , PARK CHEOL-MIN , WENDT MICHAEL D , TAO ZHI-FU , DAI YUJIA , DING HONG , HEXAMER LAURA , MCCLELLAN WILLIAM J , PARK CHANG H , PETROS ANDREW M
IPC: A61P35/00 , A61K31/496 , C07D403/12
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
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公开(公告)号：UY32680A
公开(公告)日：2011-02-28
申请号：UY32680
申请日：2010-06-02
Applicant: ABBOTT LAB
Inventor： WANG GARY T , MANTEI ROBERT A , MILAN BRUNCKO , HONG DING , DOHERTY GEORGE A , ELMORE STEVEN W , LISA HASVOLD , LAURA HEXAMER , KUNZER AARON R , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , XIAOHONG SONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , XILU WANG , WENDT MICHAEL D , HANSEN TODD M , LE WANG
IPC: A61P35/00 , C07D205/00 , C07D205/08 , C07D207/04 , C07D209/04 , C07D215/00 , C07D217/00 , C07D231/54 , C07D235/04 , C07D241/10 , C07D295/00 , C07D309/04 , C07D333/02 , C07D499/00
Abstract: Compuestos que inhiben la actividad de las proteínas anti-apoptóticas Bcl-2 o Bcl-XL, composiciones que contienen dichos compuestos y métodos para tratar enfermedades durante las cuales se expresa la proteína anti-apoptótica Bcl-2.
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公开(公告)号：PT1339695E
公开(公告)日：2006-08-31
申请号：PT01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D233/00 , C07D401/00 , C07D405/00 , C07D409/00
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公开(公告)号：ZA200506760B
公开(公告)日：2006-06-28
申请号：ZA200506760
申请日：2005-08-23
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , LI GAOQUAN , SHAM HING , SULLIVAN GERARD M , XIA PING , HEXAMER LAURA , LIN NAN-HORNG , SOWIN TOM , WANG LE
IPC: A61K20060101 , A61P20060101 , C07D20060101
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公开(公告)号：AT323681T
公开(公告)日：2006-05-15
申请号：AT01273519
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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Patent Agency Ranking
公开(公告)号：PL378116A1
公开(公告)日：2006-03-06
申请号：PL37811604
申请日：2004-02-26
Applicant: ABBOTT LAB
Inventor： HASVOLD LISA A , HEXAMER LAURA , LI GAOQUAN , LIN NAN-HORNG , SHAM HING , SOWIN TOM , SULLIVAN GERARD M , WANG LE , XIA PING XIA
IPC: C07D243/38 , A61K31/551 , A61P35/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10
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公开(公告)号：PE06872002A1
公开(公告)日：2002-08-03
申请号：PE0011982001
申请日：2001-11-29
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY II STEPHEN L , LI QUN , LIN NAN-HORNG , ROCKWAY TODD W , SULLIVAN GERARD M , WANG GARY T , WANG XILU , WANG WEIBO , WANG LE , TONG YUNSONG , SHAM HING L , MANTEI ROBERT A , LI TONGMEI , HASVOLD LISA A
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D401/01
CPC classification number: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: SE REFIERE A IMIDAZOLES Y TIAZOLES DE FORMULA I DONDE E ES UN ANILLO CARBOCICLICO AROMATICO O NO AROMATICO DE CINCO, SEIS O SIETE MIEMBROS DONDE ENTRE 0-3 ATOMOS DE CARBONO ESTAN REEMPLAZADOS POR NITROGENO; F Y G SON C Y N CON LA SALVEDAD DE QUE CUANDO UNO DE F Y G ES N EL OTRO ES C; L1 Y L2 SON ALQUENILENO, ALQUINILENO, O, NR9, C(O), S, ENTRE OTROS; X ES S, NR7; R1 ES ARILO, ARILALQUILO, HETEROCICLO, (HETEROCICLO)ALQUILO; R2 ES H, ALCOXI, ALQUILO, AMINO, AMINOALQUILO, CIANO, CIANOALQUILO, ENTRE OTROS; R3 ES ARILO, HETEROCICLO Y CICLOALQUILO; R4-R6 SON H, NR9C(O), C(N)NR9, ALCANOILO, ALQUENILO, ENTRE OTROS; R7 ES H, ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS; R9 ES H, ALCOXIALQUILO, ALQUILO, AMIDOALQUILO, ENTRE OTROS; R12 ES H, ALCOXI, ALQUILO, ENTRE OTROS; m, n, p, q SON 0-4. SON COMPUESTOS PREFERIDOS 4-(((6-CLORO-2-(3-CLOROFENIL)-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, 4-(((2-(3-CLOROFENIL)-6-METIL-3-PIRIDINIL)METOXI)(1-METIL-1H-IMIDAZOL-5-IL)METIL)BENZONITRILO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FARNESIL TRANSFERASA Y SON UTILES PARA EL TRATAMIENTO DE TUMORES
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58.发明专利
公开(公告)号：GR3030342T3
公开(公告)日：1999-09-30
申请号：GR990401431
申请日：1999-05-27
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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59.发明专利
公开(公告)号：CA2152822A1
公开(公告)日：1995-05-11
申请号：CA2152822
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , C07C235/82 , A61K31/33 , C07D207/337 , C07D249/02 , C07D285/06 , C07D307/54 , C07D333/24
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
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60.发明专利
公开(公告)号：HK1177202A1
公开(公告)日：2013-08-16
申请号：HK13104084
申请日：2013-04-03
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DAI YUJIA , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHANG H , PARK CHEOL-MIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDREW J , SULLIVAN GERARD M , TAO ZHI-FU , WANG GARY T , WANG LE , WANG XILU , WENDT MICHAEL D , HANSEN TODD M
IPC: C07D20060101
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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