公开(公告)号：AU2019200723A1

公开(公告)日：2019-02-21

申请号：AU2019200723

申请日：2019-02-04

Applicant: VERTEX PHARMA

Inventor： MEDEK ALES ,  SHAW DAVID MATTHEW ,  PANESAR MANINDER ,  ZHANG YUEGANG ,  ALEM NAZIHA ,  CHARRIER JEAN-DAMIEN ,  DAVIS CHRISTOPHER JOHN ,  FRAYSSE DAMIEN ,  ETXEBARRIA I JARDI GORKA ,  PEGG SIMON ,  PIERARD FRANCOISE ,  PINDER JOANNE ,  STUDLEY JOHN ,  ZWICKER CARL ,  SANGHVI TAPAN ,  WALDO MICHAEL

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  C07B59/00

Abstract: Nd x2 N F \N ye RI x -0 NH2 a .N F y1 ' V /1 N H R3k 'Y" I-A I-B The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：AU2015247850A1

公开(公告)日：2016-10-06

申请号：AU2015247850

申请日：2015-04-14

Applicant: VERTEX PHARMA

Inventor： PHENIX BRIAN DEAN ,  BAGNOL LAURENT JEAN-CLAUDE ,  BRODEUR GEOFFREY GLEN ,  CHANDRAN SACHIN ,  DOKOU ELENI ,  FERRIS LORI ANN ,  KNEZIC DRAGUTIN ,  MCCARTY KATIE LYNN ,  MEDEK ALES ,  WAGGENER SARA A

IPC: C07D209/04 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/404 ,  A61K31/47 ,  A61K45/06 ,  C07D215/00

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

公开(公告)号：CA2796642A1

公开(公告)日：2011-10-27

申请号：CA2796642

申请日：2011-04-22

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  ALCACIO TIM EDWARD ,  AREKAR SNEHA G ,  JOHNSTON STEVEN C ,  KADIYALA IRINA NIKOLAEVNA ,  KESHAVARZ-SHOKRI ALI ,  KRAWIEC MARIUSZ ,  LEE ELAINE CHUNGMIN ,  MEDEK ALES ,  MUDUNURI PRAVEEN ,  SULLIVAN MARK JEFFREY ,  ZAMAN NOREEN TASNEEM ,  ZHANG BEILI ,  ZHANG YUEGANG ,  ZLOKARNIK GREGOR

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/443

Abstract: The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：AU2023338957A1

公开(公告)日：2025-02-20

申请号：AU2023338957

申请日：2023-09-08

Applicant: VERTEX PHARMA

Inventor： ALLEN EMILY ELIZABETH ,  BOYD MICHAEL J ,  FIMOGNARI JR ,  GIROUX SIMON ,  GREY JR ,  LAI-CHEN MICHELLE ,  MEDEK ALES ,  LI MENGQI ,  POFF CHRISTOPHER DAVID ,  RICHTER DANIEL TYLER ,  SCOTT TONY Z ,  SOKOLOWSKY KATHLEEN PAIGE ,  SPERRY JEFFREY BRADEN ,  TSAY CHARLENE ,  WANG XIAOXU ,  ZAKY MARIAM ,  ZHANG CHENLONG ,  MAXWELL BRAD ,  GLADDING JEFFERY

IPC: C07D405/04 ,  A61K31/4162 ,  A61P1/16 ,  A61P11/00 ,  C07D487/04

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD). (Formula (I))

公开(公告)号：AU2023215372A1

公开(公告)日：2024-08-22

申请号：AU2023215372

申请日：2023-02-02

Applicant: VERTEX PHARMA

Inventor： ANGELL PAUL TIMOTHY ,  BAEK MINSON ,  GAGNON KEVIN ,  MACK DANIEL JAMES ,  MEDEK ALES ,  PERESYPKIN ANDREY ,  ROEPER STEFANIE ,  SHRESTHA MUNA ,  SIESEL DAVID A ,  ZHOU JINGLAN ,  SHI YI

IPC: C07D498/14 ,  A61K31/437 ,  A61P11/00 ,  C07D213/81 ,  C07D413/04

Abstract: Processes and methods of preparing Compound (I) are disclosed. Crystalline forms of Compound (I), pharmaceutically acceptable salts, solvates, hydrates, and cocrystals thereof, pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：CO2024006736A2

公开(公告)日：2024-07-18

申请号：CO2024006736

申请日：2024-05-27

Applicant: VERTEX PHARMA

Inventor： MEDEK ALES ,  GARCIA BARRANTES PEDRO M ,  DAKIN LESLIE A ,  SENTER TIMOTHY J ,  DOLGIKH ELENA ,  BRODNEY MICHAEL A ,  OLSEN JESSICA H ,  SHIMIZU AKIRA J ,  STONE STEVEN D ,  DANIEL KEVIN B ,  TSAY CHARLENE

IPC: C07D211/52 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61P13/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: La descripción proporciona al menos un compuesto, tautómero, derivado deuterado, o sal farmacéuticamente aceptable elegida de compuestos de Fórmula (I), tautómeros de estos, derivados deuterados de esos compuestos o tautómeros, y sales farmacéuticamente aceptables de cualquiera de los anteriores, composiciones que comprenden los mismos, y métodos de uso de los mismos, incluidos los usos en el tratamiento de enfermedades mediadas por APOL1, incluido el cáncer pancreático, la glomeruloesclerosis segmentaria focal (FSGS), y/o la enfermedad renal no diabética (NDKD). Fórmula (I)

公开(公告)号：AU2022402839A1

公开(公告)日：2024-05-30

申请号：AU2022402839

申请日：2022-11-30

Applicant: VERTEX PHARMA

Inventor： DAKIN LESLIE A ,  BRODNEY MICHAEL A ,  DOLGIKH ELENA ,  OLSEN JESSICA H ,  SENTER TIMOTHY J ,  SHIMIZU AKIRA J ,  STONE STEVEN D ,  DANIEL KEVIN B ,  GARCIA BARRANTES PEDRO M ,  MEDEK ALES ,  TSAY CHARLENE

IPC: C07D211/52 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61P13/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula (I), tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

公开(公告)号：AU2021381509A1

公开(公告)日：2023-06-22

申请号：AU2021381509

申请日：2021-11-17

Applicant: VERTEX PHARMA

Inventor： SHI YI ,  LAI MEI-HSIU ,  MEDEK ALES ,  HU KAN-NIAN ,  SONG ZHENGTIAN ,  TORRICO GUZMAN ELISA ,  SOKOLOWSKY KATHLEEN ,  GIROUX SIMON ,  LIU SIYING ,  OVERHOFF KIRK ,  RODAY SETU ,  SAWANT RUPA ,  SPOSATO MARISA

IPC: A61P1/16 ,  A61K31/416 ,  A61K31/4162 ,  A61P11/00 ,  C07D487/04

Abstract: Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD).

公开(公告)号：JOP20210130A1

公开(公告)日：2023-01-30

申请号：JOP20210130

申请日：2019-12-17

Applicant: VERTEX PHARMA

Inventor： SHI YI ,  MEDEK ALES ,  BRODNEY MICHAEL ,  DAKIN LESLIE A ,  DORSCH WARREN A ,  DENIS FRANCOIS ,  ROSE PETER ,  SENTER TIMOTHY J ,  SHRESTHA MUNA ,  SAYEGH CAMIL ,  GAGNON KEVIN ,  FORTIER ANNE ,  CAO JINGRONG ,  KRUEGER ELAINE B ,  COME JON H ,  LEDFORD BRIAN ,  NANTHAKUMAR SUGANTHINI S ,  NICOLAS OLIVIER ,  HAMEL MARTINE ,  HU KAN-NIAN ,  WANG TIANSHENG ,  WITKOS FAITH

Abstract: غيرمتوفر

公开(公告)号：CL2021002964A1

公开(公告)日：2022-08-05

申请号：CL2021002964

申请日：2021-11-09

Applicant: VERTEX PHARMA

Inventor： MEDEK ALES ,  SHI YI ,  SHRESTHA MUNA ,  STAVROPOULOS KATHY ,  ZAKY MARIAM ,  BANDARAGE UPUL KEERTHI ,  BLIGH CAVAN MCKEON ,  BOUCHER DIANE ,  BOYD MICHAEL JOHN ,  BRODNEY MICHAEL AARON ,  CLARK MICHAEL PHILIP ,  DAMAGNEZ VERONIQUE ,  FANNING LEV TYLER DEWEY ,  FIMOGNARI ROBERT FRANCIS ,  FLEMING GABRIELLE SIMONE ,  GAGNON KEVIN JAMES ,  GARCIA BARRANTES PEDRO MANUEL ,  GIACOMETTI ROBERT DANIEL ,  GIROUX SIMON ,  GREY JR RONALD LEE ,  GUIDO SAMANTHA ,  HALL AMY BETH ,  HOOD SARAH CAROL ,  HURLEY DENNIS JAMES ,  JOHNSON JR MAC ARTHUR ,  JONES PETER ,  KESAVAN SARATHY ,  LAI MEI-HSIU ,  LIU SIYING ,  LOOKER ADAM ,  MAXWELL BRAD ,  MAXWELL JOHN PATRICK ,  NUHANT PHILIPPE MARCEL ,  OVERHOFF KIRK ALAN ,  RODAY SETU ,  ROEPER STEFANIE ,  RONKIN STEVEN M ,  SAWANT RUPA ,  SPOSATO MARISA ,  SWETT REBECCA JANE ,  TANG QING ,  TAPLEY TIMOTHY LEWIS ,  THOMSON STEPHEN ,  XU JINWANG ,  COTTRELL KEVIN MICHAEL

IPC: A61P1/16 ,  A61P11/00 ,  C07D231/56 ,  C07D487/04 ,  C07D498/18 ,  C07D513/04

Abstract: PIRROLES TRICCICLICOS CONDENSADOS COMO MODULADORES DE ANTITRIPSINA ALFA-1