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    보폭 추정 장치, 및 그 방법
    33.
    发明公开
    보폭 추정 장치, 및 그 방법 无效
    步长度的估计装置及其方法

    公开(公告)号：KR1020130012714A

    公开(公告)日：2013-02-05

    申请号：KR1020110074039

    申请日：2011-07-26

    Applicant: 한국과학기술연구원

    Inventor： 이택진 ,  이석 ,  우덕하 ,  전영민 ,  김재헌 ,  이혁재 ,  이정호 ,  신범주 ,  김은경 ,  변영태 ,  이성춘 ,  김선호

    IPC: G01C22/00 ,  G01C21/00 ,  G01B21/06

    CPC classification number: G01C22/006 ,  A61B5/112 ,  A63B2220/22 ,  G01C21/00 ,  G01S19/13

    Abstract: PURPOSE: A stride estimating device and a method thereof are provided to easily estimate different strides by using various sensors, thereby enabling to estimate travelling time and to grasp a travelling path. CONSTITUTION: A stride estimating device comprises a vibration detecting sensor(130), a rotation detecting sensor(140), a database unit(180), a travelling distance measuring unit(160), a step number calculation module, a stride estimation module(170), and a control unit(150). The vibration detecting sensor detects vibration information based on a walk of a user. The rotation detecting sensor detects rotation information based on the walk of the user. The database unit stores geographic information. The travelling distance measuring unit measures a travelling distance of the user by using the geographic information and the rotation information. The step number calculation module calculates the number of the steps of the user. The stride estimation module estimates stride of the user by using the calculated the number of the steps and the measured travelling distance. [Reference numerals] (100) User terminal; (120) Communication unit; (130) Vibration detecting sensor; (140) Rotation detecting sensor; (150) Control unit; (160) Travelling distance measuring unit; (170) Stride estimation module; (180) Database unit; (184) Map information database

    Abstract translation: 目的：提供一种步幅估计装置及其方法，通过使用各种传感器容易地估计不同的步幅，从而能够估计行驶时间并且抓住行驶路径。 构成：步幅估计装置包括振动检测传感器（130），旋转检测传感器（140），数据库单元（180），行进距离测量单元（160），步数计算模块，步幅估计模块 170）和控制单元（150）。 振动检测传感器基于用户的行走来检测振动信息。 旋转检测传感器基于用户的行走来检测旋转信息。 数据库单元存储地理信息。 行驶距离测量单元通过使用地理信息和旋转信息来测量用户的行驶距离。 步数计算模块计算用户的步数。 步幅估计模块通过使用计算出的步数和测量的行驶距离来估计用户的步幅。 （附图标记）（100）用户终端; （120）通讯单元; （130）振动检测传感器; （140）旋转检测传感器; （150）控制单元; （160）行驶距离测量单元; （170）步幅估计模块; （180）数据库单元; （184）地图信息数据库

    디페닐 유도체를 포함하는 항균제
    34.
    发明公开
    디페닐 유도체를 포함하는 항균제 失效
    含有二苯甲基衍生物的抗菌剂

    公开(公告)号：KR1020120079616A

    公开(公告)日：2012-07-13

    申请号：KR1020110000897

    申请日：2011-01-05

    Applicant: 한국과학기술연구원

    Inventor： 배애님 ,  김은경 ,  금교창 ,  서선희 ,  홍승곤 ,  무하마드무다사

    IPC: A61K31/435 ,  A61K31/4418 ,  A61P31/04 ,  A61P31/00

    CPC classification number: A61K31/167 ,  A61K31/12 ,  A61K31/137 ,  A61K31/235 ,  A61K31/24 ,  A61K31/4035 ,  A61K31/4409 ,  Y10S514/924

    Abstract: PURPOSE: An antibacterial agent containing novel diphenyl derivative or pharmaceutically acceptable salt thereof is provided to suppress bacterial fatty acid biosynthesis. CONSTITUTION: An antibacerial agent against mycobacteria contains a compound of chemical formula I or pharmaceutically acceptable salt thereof as an active ingredient. The mycobacteria are Mycobacterium tuberculosis. A composition for preventing or treating mycobacterium infections contains the compound or salt as an active ingredient. The mycobacterium infections are tuberculosis. The composition is manufactured in the form of a pharmaceutical composition administered to mammals and birds.

    Abstract translation: 目的：提供含有新二苯衍生物或其药学上可接受的盐的抗菌剂以抑制细菌脂肪酸生物合成。 构成：抗分枝杆菌的抗菌剂含有化学式I的化合物或其药学上可接受的盐作为活性成分。 分枝杆菌是结核分枝杆菌。 用于预防或治疗分枝杆菌感染的组合物含有化合物或盐作为活性成分。 分枝杆菌感染是结核病。 该组合物以施用于哺乳动物和鸟类的药物组合物的形式制造。

    형광편광도를 이용한 파네소이드 Ｘ 수용체-리간드복합체의 상호작용 분석방법 및 결합 저해물질 검색방법
    37.
    发明授权
    형광편광도를 이용한 파네소이드 Ｘ 수용체-리간드복합체의 상호작용 분석방법 및 결합 저해물질 검색방법 失效
    用于分析法呢型X受体 - 配体复合物相互作用的荧光偏振方法和用于筛选针对法呢型X受体 - 配体复合物结合的抑制剂

    公开(公告)号：KR100784859B1

    公开(公告)日：2007-12-14

    申请号：KR1020050003829

    申请日：2005-01-14

    Applicant: 한국과학기술연구원

    Inventor： 양은경 ,  김은경 ,  한기철

    IPC: G01N33/533

    Abstract: 본 발명은 형광편광도를 이용한 파네소이드 X 수용체-리간드 복합체의 상호작용 분석방법 및 결합저해물질 검색방법에 관한 것으로서, 구체적으로 형광편광도를 이용한 파네소이드 X 수용체 (FXR)와 형광표지된 리간드간의 상호작용 분석방법 및 형광표지된 리간드와 파네소이드 X 수용체를 포함한 시료에 결합저해 후보물질을 가하고, 형광편광도를 측정하여 파네소이드 X 수용체에 대한 리간드와 결합저해 후보물질의 경쟁적 결합여부를 확인함으로써 파네소이드 X 수용체와 리간드 복합체의 결합 저해물질 검색방법에 관한 것이다. 본 발명의 상호작용 분석방법 및 결합 저해물질 검색방법은 웰 플레이트를 이용한 초고속 검색에 효과적으로 적용될 수 있어서 고지혈증 치료제 개발에 매우 유용하다.
    파네소이드 X 수용체, 형광편광도, 리간드

    변형된 ＡＭＰ-활성화 단백질 키나아제, 그의 제조 방법 및그의 용도
    38.
    发明授权
    변형된 ＡＭＰ-활성화 단백질 키나아제, 그의 제조 방법 및그의 용도 失效
    된된AMP-활성화단백질키나아제，그의제조방법및그의용도

    公开(公告)号：KR100732604B1

    公开(公告)日：2007-06-27

    申请号：KR1020060013726

    申请日：2006-02-13

    Applicant: 한국과학기술연구원

    Inventor： 김은경 ,  양은경 ,  황광연 ,  이원호 ,  한기철

    IPC: C12N15/54 ,  C12N9/12

    Abstract: A modified 5-AMP(adenine monophosphate)-activated protein kinase(AMPK), a method for preparing the same protein kinase, and use thereof are provided to confer the water-soluble and crystalline structure which is more easily analyzed in the three-dimensional structure analysis on the protein kinase, so that the modified protein kinase acts as a target protein of obesity treatment. The method for preparing the modified water-soluble and crystalline 5-AMP-activated protein kinase comprises the steps of: (i) preparing water-soluble modified AMPK protein wherein a preserved protein kinase active domain of AMPK alpha subunit having the amino acid sequence of SEQ ID NO:1 is contained, and one polypeptide molecule selected from 1-12 amino acid sequences from the N-terminal region is deleted, one polypeptide molecule selected from 250-280 amino acid sequences from the C-terminal region is deleted, or both the polypeptide molecules are deleted; and (ii) crystallizing the modified AMPK protein by performing a hanging-drop vapour diffusion method using water tank solution containing a precipitating agent selected from ammonium sulfate and MES(Methyl ester sulfonate) at 16-26 deg.C and pH 6.0-6.5.

    Abstract translation: 提供了修饰的5-AMP（腺嘌呤单磷酸）激活的蛋白激酶（AMPK），制备相同蛋白激酶的方法及其用途，以赋予在三维中更容易分析的水溶性和晶体结构 对蛋白激酶进行结构分析，使修饰的蛋白激酶作为肥胖治疗的靶蛋白。 制备修饰的水溶性和结晶5-AMP活化蛋白激酶的方法包括以下步骤：（i）制备水溶性修饰的AMPK蛋白，其中AMPKα亚基的保守蛋白激酶活性结构域具有氨基酸序列 含有SEQ ID NO：1，并且选自N末端区域的1-12个氨基酸序列中的一个多肽分子缺失，选自C末端区域的250-280个氨基酸序列中的一个多肽分子缺失，或者 多肽分子都被删除; （ii）通过使用含有选自硫酸铵和MES（甲基酯磺酸盐）的沉淀剂的水罐溶液在16-26℃和pH 6.0-6.5下进行悬滴蒸气扩散方法使修饰的AMPK蛋白质结晶。

    필로폰과 대마초의 동시감식용 면역검출지
    39.
    发明公开
    필로폰과 대마초의 동시감식용 면역검출지 无效
    同时检测PHILOPON和CANNABIS的免疫纸

    公开(公告)号：KR1020030008748A

    公开(公告)日：2003-01-29

    申请号：KR1020010043630

    申请日：2001-07-20

    Applicant: 한국과학기술연구원

    Inventor： 최명자 ,  김은경 ,  최정은 ,  이정란

    IPC: G01N33/543

    Abstract: PURPOSE: Provided are an mmunostrip paper for the simultaneous detection of philopon and cannabis without involving additional reagents. CONSTITUTION: The mmunostrip paper for the simultaneous detection of philopon and cannabis comprises the parts of: (i) a sample membrane(1) coated with protein and sugar; (ii) a glass fiber membrane(2) positioned under the sample membrane(1) and containing a drug antibody-colored minute particle complex; (iii) a polyester supporting nitrocellulose membrane(3) connected vertically to the glass fiber membrane(2), and containing a test resulting line as a drug-protein complex and a test controlling line as a second antibodies of the drugs in different sites; (iv) a reaction solution absorbing membrane(4) connected vertically to the polyester supporting nitrocellulose membrane(3); and supporting bars positioned under each membrane, wherein the sugar is dextran; the protein is bovine serum albumin; the colored minute particle is colloidal; and the supporting bar is made of polyester resin.

    Abstract translation: 目的：提供用于同时检测philopon和大麻而不涉及额外试剂的mmunostrip纸。 构成：用于同时检测philopon和大麻的mmunostrip纸包括以下部分：（i）涂有蛋白质和糖的样品膜（1）; （ii）位于样品膜（1）下方并含有药物抗体着色的微粒子复合体的玻璃纤维膜（2） （iii）垂直于玻璃纤维膜（2）连接的聚酯支撑硝酸纤维素膜（3），并且包含作为药物 - 蛋​​白质复合物的测试结果线和作为不同部位药物的第二抗体的测试控制线; （iv）垂直于聚酯支撑硝酸纤维素膜（3）连接的反应溶液吸收膜（4）; 和位于每个膜下方的支撑杆，其中所述糖是葡聚糖; 蛋白质是牛血清白蛋白; 有色微粒是胶体的; 支撑杆由聚酯树脂制成。

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