公开(公告)号：DK1339695T3

公开(公告)日：2006-07-31

申请号：DK01273519

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  LI TOMGMEI ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  TONG YUNSONG ,  WANG GARY T ,  WANG XILU ,  WANG WEIBO ,  HASVOLD LISA A ,  LI QUN ,  LIN NAN-HORNG ,  SHAM HING L ,  SULLIVAN GERARD M ,  WANG LE

IPC: C07D233/64 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：BR0112028A

公开(公告)日：2004-02-17

申请号：BR0112028

申请日：2001-11-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY STEPHEN L II ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：NO20032471A

公开(公告)日：2003-07-25

申请号：NO20032471

申请日：2003-05-30

Applicant: ABBOTT LAB

Inventor： CLAIBORNE AKIYO K ,  GWALTNEY II STEPHEN L ,  HASVOLD LISA A ,  LI QUN ,  LI TOMGMEI ,  LIN NAN-HORNG ,  MANTEI ROBERT A ,  ROCKWAY TODD W ,  SHAM HING L ,  SULLIVAN GERARD M ,  TONG YUNSONG ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WANG WEIBO

IPC: A61K31/4164 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：CZ467099A3

公开(公告)日：2000-08-16

申请号：CZ467099

申请日：1998-07-24

Applicant: ABBOTT LAB

Inventor： GEYER ANDREW G ,  MCCLELLAN WILLIAM J ,  ROCKWAY TODD W ,  STEWART KENT D ,  WEITZBERG MOSHE ,  WENDT MICHAEL D

IPC: A61K31/47 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  C07C251/00 ,  C07D471/00

公开(公告)号：SK174899A3

公开(公告)日：2000-06-12

申请号：SK174899

申请日：1998-07-24

Applicant: ABBOTT LAB

Inventor： GEYER ANDREW G ,  MCCLELLAN WILLIAM J ,  ROCKWAY TODD W ,  STEWART KENT D ,  WEITZBERG MOSHE ,  WENDT MICHAEL D

IPC: C07D295/08 ,  A61K31/155 ,  A61K31/341 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/443 ,  A61K31/47 ,  A61K31/472 ,  A61K31/505 ,  A61K31/5375 ,  A61P15/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C257/18 ,  C07C259/18 ,  C07C271/22 ,  C07C271/30 ,  C07C271/66 ,  C07C275/40 ,  C07C275/42 ,  C07C275/64 ,  C07C311/13 ,  C07C311/15 ,  C07C311/16 ,  C07C311/47 ,  C07C323/56 ,  C07C323/62 ,  C07D207/08 ,  C07D207/337 ,  C07D209/08 ,  C07D213/56 ,  C07D213/58 ,  C07D213/74 ,  C07D213/75 ,  C07D215/38 ,  C07D217/02 ,  C07D231/12 ,  C07D231/40 ,  C07D231/56 ,  C07D237/20 ,  C07D239/28 ,  C07D239/34 ,  C07D239/42 ,  C07D239/54 ,  C07D239/545 ,  C07D241/18 ,  C07D241/20 ,  C07D261/08 ,  C07D261/14 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D277/34 ,  C07D277/42 ,  C07D277/44 ,  C07D295/092 ,  C07D303/46 ,  C07D307/16 ,  C07D307/18 ,  C07D307/54 ,  C07D307/64 ,  C07D317/58 ,  C07D317/66 ,  C07D317/68 ,  C07D333/24 ,  C07D405/12 ,  C07D521/00 ,  C07C249/00 ,  A61K31/136

Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.

公开(公告)号：AU5722796A

公开(公告)日：1996-11-21

申请号：AU5722796

申请日：1996-05-02

Applicant: ABBOTT LAB

Inventor： ARENDSEN DAVID L ,  ROSENBERG SAUL H ,  ROCKWAY TODD W ,  STEIN HERMAN H ,  FUNG ANTHONY K L

IPC: C07C69/74 ,  C07C233/19 ,  C07C233/58 ,  C07C233/60 ,  C07C233/62 ,  C07C233/63 ,  C07C235/06 ,  C07C235/36 ,  C07C235/40 ,  C07C235/80 ,  C07C235/82 ,  C07C237/22 ,  C07C237/24 ,  C07C245/12 ,  C07C251/42 ,  C07C259/06 ,  C07C259/08 ,  C07C275/26 ,  C07C311/07 ,  C07C323/40 ,  C07C327/46 ,  C07D207/32 ,  C07D207/335 ,  C07D213/20 ,  C07D257/04 ,  C07D257/06 ,  C07D271/10 ,  C07D271/113 ,  C07D277/34 ,  C07D307/52 ,  C07D307/58 ,  C07D309/32 ,  C07D317/64 ,  C07D333/20 ,  A61K31/16 ,  A61K31/41

公开(公告)号：AU5673196A

公开(公告)日：1996-11-21

申请号：AU5673196

申请日：1996-05-02

Applicant: ABBOTT LAB

Inventor： BAKER WILLIAM R ,  ROSENBERG SAUL H ,  FUNG K L ANTHONY ,  ROCKWAY TODD W ,  FAKHOURY STEPHEN A ,  GARVEY DAVID S ,  DONNER B GREGORY ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN N ,  SHEN WANG ,  STOUT DAVID M ,  SULLIVAN GERARD M

IPC: C07C65/24 ,  C07C65/28 ,  C07C65/40 ,  C07C69/94 ,  C07C229/38 ,  C07C233/22 ,  C07C233/65 ,  C07C233/69 ,  C07C233/73 ,  C07C233/87 ,  C07C235/16 ,  C07C235/34 ,  C07C235/42 ,  C07C235/48 ,  C07C235/60 ,  C07C235/84 ,  C07C237/08 ,  C07C237/20 ,  C07C237/32 ,  C07C251/48 ,  C07C255/57 ,  C07C259/10 ,  C07C271/48 ,  C07C275/42 ,  C07C311/08 ,  C07C311/29 ,  C07C311/51 ,  C07C323/59 ,  C07C327/48 ,  C07C333/04 ,  C07D209/16 ,  C07D213/40 ,  C07D231/12 ,  C07D271/10 ,  C07D271/113 ,  C07D307/88 ,  C07D307/89 ,  C07D309/32 ,  C07D311/68 ,  C07D319/06 ,  C07D333/20 ,  C07C235/38 ,  C07D257/04 ,  C07C335/22 ,  C07C233/12

Abstract: The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.

公开(公告)号：CA2218597A1

公开(公告)日：1996-10-24

申请号：CA2218597

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  FUND K L ANTHONY ,  AUGERI DAVID J ,  BAKER WILLIAM R ,  SULLIVAN GERARD M ,  ROSENBERG SAUL H ,  O'CONNOR STEPHEN J ,  FAKHOURY STEPHEN A ,  PRASAD RAJNANDAN N ,  STOUT DAVID M ,  SHEN WANG ,  ROCKWAY TODD W ,  MCCLELLAN WILLIAM J ,  GARVEY DAVIS S ,  ARENDSEN DAVID L

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K38/04 ,  C07D215/14 ,  A61K31/16 ,  A61K31/19 ,  C07D333/24 ,  C07D263/32 ,  A61K31/33 ,  C07C323/40 ,  C07C317/44 ,  C07C311/45 ,  C07D307/54 ,  C07D213/56 ,  C07C233/57 ,  C07D317/60 ,  C07D333/60

Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：NZ233795A

公开(公告)日：1992-07-28

申请号：NZ23379590

申请日：1990-05-24

Applicant: ABBOTT LAB

Inventor： LUCAS SCOTT D ,  ROCKWAY TODD W ,  DAVIDSEN STEVEN K ,  THOMAS A MITCHELL ,  VON GELDERN THOMAS W

IPC: A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07K7/08 ,  C07K14/575 ,  C07K14/58 ,  C07K7/06 ,  A61K37/02 ,  A61K37/24

Abstract: The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.

公开(公告)号：CA2699981C

公开(公告)日：2017-08-22

申请号：CA2699981

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： WAGNER ROLF ,  TUFANO MICHAEL D ,  STEWART KENT D ,  ROCKWAY TODD W ,  RANDOLPH JOHN T ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  MARING CLARENCE J ,  LONGENECKER KENTON L ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  HUTCHINSON DOUGLAS K ,  HUANG PEGGY P ,  FLENTGE CHARLES A ,  DONNER PAMELA L ,  DEGOEY DAVID A ,  BETEBENNER DAVID A ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  SARRIS KATHY ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)-yl)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.