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公开(公告)号：SK8232003A3
公开(公告)日：2004-01-08
申请号：SK8232003
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEI ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：CZ20031804A3
公开(公告)日：2003-11-12
申请号：CZ20031804
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： CLAIBORNE AKIYO K , GWALTNEY STEPHEN L II , HASVOLD LISA A , LI QUN , LI TOMGMEI , LIN NAN-HORNG , MANTEL ROBERT A , ROCKWAY TODD W , SHAM HING L , SULLIVAN GERARD M , TONG YUNSONG , WANG GARY T , WANG LE , WANG XILU , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：BR0010555A
公开(公告)日：2003-09-23
申请号：BR0010555
申请日：2000-10-10
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , TU NOAH P , WAGENAAR FRANK L , WANG SHELDON , WIEDEMAN PAUL E , XU YIBO , YEUNG MING C , BAYRAKDARIAN MALKEN , LUO XUEHONG
IPC: C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
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公开(公告)号：CA2430619A1
公开(公告)日：2002-09-26
申请号：CA2430619
申请日：2001-11-30
Applicant: ABBOTT LAB
Inventor： LI QUN , SULLIVAN GERARD M , HASVOLD LISA A , GWALTNEY STEPHEN L II , CLAIBORNE AKIYO K , WANG XILU , WANG LE , WANG GARY T , LI TOMGMEI , LIN NAN-HORNG , SHAM HING L , TONG YUNSONG , ROCKWAY TODD W , MANTEI ROBERT A , WANG WEIBO
IPC: A61K31/4164 , A61K31/4178 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/64 , C07D277/20 , C07D277/30 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Substituted imidazoles and thiazoles having formula (I), are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase- inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
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公开(公告)号：ZA200005238B
公开(公告)日：2001-12-04
申请号：ZA200005238
申请日：2000-09-28
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , C07D , A61K
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Patent Agency Ranking
公开(公告)号：UY26684A1
公开(公告)日：2001-11-30
申请号：UY26684
申请日：2001-04-25
Applicant: ABBOTT LAB
Inventor： WANG WEI-BO , II STEPHEN L GWALTNEY , LI QUIN , CONNOR STEPHEN J O , WANG GARY T , CURTIN MICHAEL L , HASVOLD LISA A , LIN NAN-HORNG , SHAM HING L , WANG XILU , FAKHOURY STEPHEN A , HUTCHINS CHARLES W , JENNINGS LISSA TAKA , SULLIVAN GERARD M
Abstract: Compuestos de la fórmula (I) o una sal del mismo aceptable para el uso farmacéutico que inhiben la farnesiltransferasa. Métodos para preparar los compuestos, composiciones de uso farmacéutico que contienen los compuestos, y métodos de tratamiento que usan los compuestos.
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97.发明专利
公开(公告)号：AU7608100A
公开(公告)日：2001-04-30
申请号：AU7608100
申请日：2000-09-22
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , STEWART KENT D , WANG GARY T , WANG JIANCHIO , MADIGAN DAROLD L
IPC: A61K31/16 , A61K31/19 , C07C233/52 , C07C247/12 , C07D303/38
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公开(公告)号：TR200003065T2
公开(公告)日：2001-02-21
申请号：TR200003065
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLAIM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40
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99.发明专利
公开(公告)号：BR112012012918A2
公开(公告)日：2015-09-08
申请号：BR112012012918
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： KUNZER AARON , SOUERS ANDREW J , PETROS ANDREW M , PARK CHANG H , PARK CHEOL-MIN , WANG GARY T , DOHERTY GEORGE A , SULLIVAN GERARD M , DING HONG , HEXAMER LAURA , WANG LE , HASVOLD LISA , WENDT MICHAEL D , BRUNCKO MILAN , MANTEI ROBERT A , ELMORE STEVEN W , HANSEN TODD M , MCCLELLAN WILLIAM J , SONG XIAOHONG , WANG XILU , DAÍ YUJIA , TAO ZHI-FU
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: agente indutor de apoptose para o tratamento de câncer e de doenças imunes e autoimunes. a presente invenção descreve compostos que inibem a atividade de proteínas anti-apoptóticas da família bcl-2, além de composições contendo os compostos e métodos para tratar doenças que cursam com a expressão da proteína antiapoptótica bcl-2.
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公开(公告)号：PE13852012A1
公开(公告)日：2012-11-09
申请号：PE0007592012
申请日：2010-06-01
Applicant: ABBOTT LAB
Inventor： BRUNCKO MILAN , DING HONG , DOHERTY GEORGE A , ELMORE STEVEN W , HASVOLD LISA , HEXAMER LAURA , KUNZER AARON , MANTEI ROBERT A , MCCLELLAN WILLIAM J , PARK CHEOLMIN , PETROS ANDREW M , SONG XIAOHONG , SOUERS ANDRES J , SULLIVAN GERAR M , TAO ZHI-FU , WANG GARY T , WANG LE , WENDT MICHAEL D , HANSEN TODD M , PARK CHANG H , WANG XILU
IPC: A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: SE REFIERE A COMPUESTOS DERIVADOS DE SULFONAMIDA DE FORMULA (I) DONDE A2, B1, D1 Y E1 SON CADA UNO R1, OR1, SR1, S(O)R1, ENTRE OTROS, DONDE R1 ES R2, R3, R4 O R5, EN DONDE R2 ES FENILO OPCIONALMENTE FUSIONADO CON ARENO, HETEROARENO, ENTRE OTROS; R3 ES HETEROARILO OPCIONALMENTE FUSIONADO CON BENCENO, HETEROARENO, ENTRE OTROS; R4 ES CICLOALQUILO, CICLOALQUENILO, HETEROCICLOALQUILO, ENTRE OTROS; R5 ES ALQUILO, ALQUENILO O ALQUINILO; Y1 ES H, CN, NO2, F, CF3, OCF3, ENTRE OTROS; Z1 ES R26 O R27, EN DONDE R26 ES FENILO OPCIONALMENTE FUSIONADO CON ARENO O HETEROARENO; R27 ES HETEROARENO OPCIONALMENTE FUSIONADO CON ARENO O HETEROARENO. SON COMPUESTOS PREFERIDOS: 4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-N-((3-NITRO-4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)-2-FENOXIBENZAMIDA; 4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-2-FENOXI-N-((4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)BENZAMIDA; 2-(BENCILOXI)-4-(4-((4'-CLORO-1,1'-BIFENIL-2-IL)METIL)PIPERAZIN-1-IL)-N-((3-NITRO-4-((TETRAHIDRO-2H-PIRAN-4-ILMETIL)AMINO)FENIL)SULFONIL)BENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LAS PROTEINAS ANTI-APOPTOTICAS Bcl-2 SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE VEJIGA, LEUCEMIA LINFOCITICA CRONICA, MELANOMA
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