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公开(公告)号：AU784291B2
公开(公告)日：2006-03-02
申请号：AU5739300
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , CHANG SOU-JEN , CONDON STEPHEN , DEMATTEI JOHN J , KING STEVEN A , KOLACZKOWSKI LAWRENCE , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R , PLATA DANIEL J , STONER ERIC J , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
IPC: C07D215/14 , C07C33/03 , C07C43/303 , C07C47/22 , C07C57/04 , C07C68/06 , C07C69/96 , C07C269/06 , C07C271/12 , C07D215/18 , C07D401/12 , C07H17/08
Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)
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公开(公告)号：AU2005275387A1
公开(公告)日：2006-02-23
申请号：AU2005275387
申请日：2005-07-08
Applicant: ABBOTT LAB
Inventor： KOTECKI BRIAN J , JI JIANGUO , LI WENKE , HANNICK STEVEN M , ZHANG GEOFF G , WAYNE GREG S , ROBBINS TIMOTHY A , BUCKLEY MICHAEL J , WANG WEILI W , WITTENBERGER STEVEN J , HENRY RODGER F , MARCI BRYAN S , TOWNE TIMOTHY B
IPC: C07D487/04 , A61K31/4439
Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.
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公开(公告)号：DK1272500T3
公开(公告)日：2005-09-05
申请号：DK00942860
申请日：2000-06-15
Applicant: ABBOTT LAB
Inventor： KU YI-YIN , COOPER ARTHUR J , HAIGHT ANTHONY R , RASMUSSEN MICHAEL , TIEN JIEN-HEH J , STONER ERIC J , PETERSON MATTHEW J , CINK RUSSELL D , DESHPANDE MAHENDRA N , GRIEME TIM , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RILEY DAVID , WITTENBERGER STEVEN J
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公开(公告)号：CA2553724A1
公开(公告)日：2005-08-18
申请号：CA2553724
申请日：2005-02-03
Applicant: ABBOTT LAB
Inventor： ARNOLD LEE D , TIAN ZHENGPING , FIX-STENZEL SHANNON R , YANG BRYANT , ERICSSON ANNA , STEINMAN DOUGLAS H , HOLMS JAMES H , WITTENBERGER STEVEN J , FRIEDMAN MICHAEL , WISHART NEIL , MICHAELIDES MICHAEL R , QIAN XIAO-DONG
IPC: C07D487/04 , A61K31/519
Abstract: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
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15.发明专利
公开(公告)号：AU781355B2
公开(公告)日：2005-05-19
申请号：AU2984101
申请日：2001-03-23
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/40 , C07D207/16 , C07D401/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
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Patent Agency Ranking
公开(公告)号：HK1053659A1
公开(公告)日：2003-10-31
申请号：HK03104301
申请日：2003-06-16
Applicant: ABBOTT LAB
Inventor： STONER ERIC J , PETERSON MATTHEW J , KU YI-YIN , CINK RUSSELL D , COOPER ARTHUR J , DESHPANDE MAHENDRA N , GRIEME TIM , HAIGHT ANTHONY R , HILL DAVID R , HSU MARGARET CHI-PING , KING STEVEN A , LEANNA MARVIN R , LEE ELAINE C , MCLAUGHLIN MAUREEN A , MORTON HOWARD E , NAPIER JAMES J , PLATA DANIEL J , RAJE PRASAD S , RASMUSSEN MICHAEL , RILEY DAVID , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4''-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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公开(公告)号：AU2001298065A1
公开(公告)日：2003-09-02
申请号：AU2001298065
申请日：2001-12-26
Applicant: ABBOTT LAB
Inventor： CHANG SOU-JENG , FERNANDO DILINIE P , HILL DAVID R , WITTENBERGER STEVEN J , GUPTA ASHOK
IPC: C07C315/04 , C07C317/22 , C07D317/18 , C07D317/28
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公开(公告)号：HK1047089A1
公开(公告)日：2003-02-07
申请号：HK02107126
申请日：2002-09-26
Applicant: ABBOTT LAB
Inventor： ALLEN MICHAEL S , PREMCHANDRAN RAMIYA H , CHANG SOU-JEN , CONDON STEPHEN , DEMATTEI JOHN J , KING STEVEN A , KOLACZKOWSKI LAWRENCE , MANNA SUKUMAR , NICHOLS PAUL J , PATEL HEMANT H , PATEL SUBHASH R , PLATA DANIEL J , STONER ERIC J , TIEN JIEN-HEH J , WITTENBERGER STEVEN J
IPC: C07C20060101 , C07C68/06 , C07D20060101 , C07D215/14 , C07D215/18 , C07D401/12 , C07H17/08
Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)
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公开(公告)号：NO20024678D0
公开(公告)日：2002-09-30
申请号：NO20024678
申请日：2002-09-30
Applicant: ABBOTT LAB
Inventor： HILL DAVID R , HSIAO CHI-NUNG , KURUKULA-SURIYA RAVI , WITTENBERGER STEVEN J
IPC: C07D233/74 , C07C239/10 , C07C259/06 , C07D277/34 , C07D317/28 , C07C
Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.
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20.发明专利
公开(公告)号：NZ502395A
公开(公告)日：2002-08-28
申请号：NZ50239598
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： KING STEVEN A , WITTENBERGER STEVEN J , WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
Abstract: [2S,3R,4S]-2-(2,2-Dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-1 -(N,N-di-(n-butyl)-aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid and [2S,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[(N-butyl-N- (4-dimethylaminobutyl)-amino)carbonylmethyl]-pyrrolidine-3-carboxylic acid, a pharmaceutically acceptable salt thereof and the pharmaceutical composition thereof are useful for antagonizing the endothelin activity.
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