公开(公告)号：NO20074431L

公开(公告)日：2007-08-31

申请号：NO20074431

申请日：2007-08-31

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO GERALD ,  BEMIS GUY W ,  FARMER LUC J ,  MESSERSMITH DAVID ,  WANG TIANSHENG ,  WANG JIAN ,  LEDEBOER MARK W ,  PIERCE ALBERT C ,  DUFFY JOHN P

IPC: C07D487/04 ,  A61K31/519 ,  A61P7/00 ,  A61P11/00 ,  A61P19/00 ,  A61P37/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AU2003297160A1

公开(公告)日：2004-07-22

申请号：AU2003297160

申请日：2003-12-17

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  MESSERSMITH DAVID ,  MOON YOUNG-CHOON ,  MULLICAN MICHAEL D ,  LEDEBOER MARK

IPC: A61K31/4745 ,  A61K31/506 ,  A61K31/519 ,  C07D413/02 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D491/02

公开(公告)号：AU2021246104A1

公开(公告)日：2022-10-20

申请号：AU2021246104

申请日：2021-04-02

Applicant: VERTEX PHARMA

Inventor： GIROUX SIMON ,  CLARK MICHAEL PHILIP ,  TANG QING ,  NUHANT PHILIPPE MARCEL ,  JONES PETER ,  MESSERSMITH DAVID ,  BANDARAGE UPUL KEERTHI ,  COTTRELL KEVIN MICHAEL ,  BRODNEY MICHAEL AARON ,  FLEMING GABRIELLE SIMONE ,  WANG JIAN ,  XU JINWANG ,  DANIEL KEVIN BRETT ,  BOYD MICHAEL JOHN ,  MORRIS MARK A ,  WAAL NATHAN D ,  COLLIER PHILIP NOEL ,  KESAVAN SARATHY ,  RONKIN STEVEN M ,  DENG HONGBO ,  BOUCHER DIANE MARIE ,  FANNING LEV T D ,  HALL AMY B ,  HURLEY DENNIS JAMES ,  JOHNSON JR MAC ARTHUR ,  MAXWELL JOHN PATRICK ,  SWETT REBECCA JANE ,  TAPLEY TIMOTHY LEWIS ,  THOMSON STEPHEN A ,  DAMAGNEZ VERONIQUE

IPC: C07D209/10 ,  A61K31/404 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/12 ,  C07D209/14 ,  C07D209/22 ,  C07D209/24 ,  C07D209/42 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

公开(公告)号：AU2010341573B2

公开(公告)日：2016-10-13

申请号：AU2010341573

申请日：2010-12-21

Applicant: VERTEX PHARMA

Inventor： ARONOV ALEX ,  COME JON H ,  DAVIES ROBERT J ,  PIERCE ALBERT C ,  WANG JIAN ,  NANTHAKUMAR SUGANTHINI ,  CAO JINGRONG ,  BANDARAGE UPUL K ,  KRUEGER ELAINE ,  TIRAN AMAUD LE ,  LIAO YUSHENG ,  MESSERSMITH DAVID ,  COLLIER PHILIP N ,  GREY RONALD ,  O'DOWD HARDWIN ,  HENDERSON JAMES A ,  GRILLOT ANNE-LAURE

IPC: C07D401/04 ,  A61K31/352 ,  A61K31/424 ,  A61K31/429 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/20 ,  C07D491/20

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CA2764989A1

公开(公告)日：2010-12-16

申请号：CA2764989

申请日：2010-06-09

Applicant: VERTEX PHARMA

Inventor： COTTRELL KEVIN MICHAEL ,  ARONOV ALEX ,  DAVIES ROBERT J ,  COME JON H ,  MESSERSMITH DAVID ,  XU JINGWANG ,  BANDARAGE UPUL K ,  CAO JINGRONG

IPC: C07D417/06 ,  A61K31/427 ,  A61P25/00

Abstract: The present invention relates to compounds useful as inhibitors of PBK, particularly of PBK?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AU2009236380A1

公开(公告)日：2009-10-22

申请号：AU2009236380

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： TIRAN ARNAUD LE ,  LEDOBOER MARK ,  WANG TIANSHANG ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  ARONOV ALEXANDER ,  MARONE VALERIE ,  MALTAIS FRANCOIS ,  CORNEBISE MARK ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CA2709710A1

公开(公告)日：2009-07-09

申请号：CA2709710

申请日：2008-12-18

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK ,  STEWART MICHELLE ,  MESSERSMITH DAVID ,  DUFFY JOHN ,  MARTINEZ-BOTELLA GABRIEL ,  COME JON ,  GAO HUAI ,  SALITURO FRANCESCO ,  MARONE VALERIE ,  PIERCE ALBERT

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.

公开(公告)号：SI1562589T1

公开(公告)日：2009-06-30

申请号：SI200331537

申请日：2003-11-17

Applicant: VERTEX PHARMA

Inventor： PIERCE ALBERT C ,  ARNOST MICHAEL ,  DAVIES ROBERT J ,  FORSTER CORNELIA J ,  GALULLO VINCENT ,  GREY RONALD ,  LEDEBOER MARK ,  TIAN SHI-KAI ,  XU JINWANG ,  BINCH HAYLEY ,  LEDFORD BRIAN ,  MESSERSMITH DAVID ,  NANTHAKUMAR SUGANTHI ,  JAYARAJ ANDREW ,  WANG JIAN

IPC: A61K31/00 ,  A61K31/4196 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D249/00 ,  C07D249/10 ,  C07D249/14 ,  C07D401/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/02 ,  C07D417/02 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/14 ,  C07D487/00 ,  C07D487/04 ,  C07D495/04 ,  C07D498/00 ,  C07D513/00

公开(公告)号：DE60326646D1

公开(公告)日：2009-04-23

申请号：DE60326646

申请日：2003-12-17

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK ,  DAVIES ROBERT J ,  MESSERSMITH DAVID ,  MOON YOUNG-CHOON ,  MULLICAN MICHAEL D

IPC: C07D413/14 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/519 ,  C07D413/02 ,  C07D413/04 ,  C07D417/14 ,  C07D491/02

公开(公告)号：DE60325761D1

公开(公告)日：2009-02-26

申请号：DE60325761

申请日：2003-11-17

Applicant: VERTEX PHARMA

Inventor： PIERCE ALBERT C ,  ARNOST MICHAEL ,  DAVIES ROBERT J ,  FORSTER CORNELIA J ,  GALULLO VINCENT ,  GREY RONALD ,  LEDEBOER MARK ,  TIAN SHI-KAI ,  XU JINWANG ,  BINCH HAYLEY ,  LEDFORD BRIAN ,  MESSERSMITH DAVID ,  NANTHAKUMAR SUGANTHI ,  JAYARAJ ANDREW ,  WANG JIAN

IPC: A61K31/41 ,  A61K31/4196 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  C07D249/10 ,  C07D249/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/02 ,  C07D417/02 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/14 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.