US11254998B2
An object of the present invention is to provide a method for separating Dy and Tb from an alloy containing Dy and Tb as constitutional metals without using a solvent extraction method. The method of the present invention as a means for resolution is characterized by comprising vaporizing Dy by subjecting the alloy to a heat treatment in an atmosphere of a pressure Pt(Pa) that, when a Dy—Tb composition in the alloy is DyxTby (atomic composition ratio) and a heat treatment temperature is t, satisfies formula 1: PtTb
US11254993B2
For the purpose of providing a method of die cast product of spheroidal graphite cast iron and a die cast product of spheroidal graphite cast iron having the number of spherical graphites of 3000/mm2 or more in an as cast state, there is disclosed a method of die cast product of ultrafine spheroidal graphite cast iron, including the steps of: a melting step of heating and melting raw materials made of cast iron to obtain source melting metal; a spheroidizing treatment step in which a spheroidizing treatment is performed; an inoculation step of inoculating; and a casting step of casting in a die mold. The amount of nitrogen is adjusted so that the amount of nitrogen generated in the time of melting becomes 0.9 ppm (mass) or less.
US11254991B2
A leather finishing composition includes water, a polymeric component, and a non-ionic surfactant component covalently bonded to the polymeric component. Advantageously, the leather finishing composition is substantially free of ionic groups. A method for applying the leather finishing composition to a leather substrate is provided.
US11254990B2
The present invention relates to a composition comprising an aqueous dispersion of submicron-sized polymer particles and micron-sized polymer beads, wherein the polymer particles or beads or both are functionalized with phosphorus acid groups. The composition of the present invention is useful for providing a matte finish on substrates, such as leather, textiles, wallboard, decorative coatings, concrete, and wood, with improved stain resistance. The present invention also relates to a leather substrate coated with a clear matte finish comprising an acrylic or styrene-acrylic polymer film and micron-sized polymer beads, wherein the film or the beads or both are functionalized with a phosphorus acid monomer.
US11254989B2
The present disclosure provides methods and compositions of modified oligonucleotide primer and probe combinations, structurally modified with locked nucleic acids, quenchers, and dyes, effective to detect tumor-derived Human Papilloma Virus (HPV) and tumor-derived Epstein-Barr virus (EBV) and, especially, to distinguish viral DNA derived from tumors from viral DNA derived from infectious viral particles.
US11254987B2
This invention provides methods for the treatment of cancer in subjects having medium or low methylation level in the PD-L1 promoter region. Also provided are related kits and articles of manufacture.
US11254984B2
Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHD1, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1.
US11254981B2
Compositions, systems, and methods for detecting events are provided. A composition can include a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and a permanent tether including head and tail regions and an elongated body disposed there between. The head region can be anchored to or adjacent to the first or second side of the nanopore. The elongated body including a reporter region can be movable within the aperture responsive to a first event occurring adjacent to the first side of the nanopore. For example, the reporter region is translationally movable toward the first side responsive to the first event, then toward the second side, then toward the first side responsive to a second event. The first event can include adding a first nucleotide to a polynucleotide. The second event can include adding a second nucleotide to the polynucleotide.
US11254970B2
This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided.
US11254962B2
The present invention provides a method for preparing salidroside. The present invention uses β-glucoside and CoFe2O4 particles to form a cross-linked aggregate capable of effectively catalyzing the reaction of β-D-glucose and tyrosol, thereby increasing the yield of the salidroside. The steps of the preparation method of the present invention are simple and short, and the method is easy to operate and readily applicable to industrial production.
US11254960B2
Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases, ligases, and primers.
US11254951B2
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-UTR) element comprising a nucleic acid sequence which is derived from the 3′-UTR of a ribosomal protein gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′-UTR element comprising a nucleic acid sequence which is derived from the 3′-UTR of a ribosomal protein gene for enhancing, stabilizing and/or prolonging protein expression from a nucleic acid sequence comprising such 3′-UTR element.
US11254939B2
The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency).
US11254932B2
Methods of generating conditionally active biologic proteins, in particular therapeutic or diagnostic proteins, which are more active at an aberrant condition than at a normal physiological condition. The methods include discovery methods using libraries of proteins and assays employing physiological concentrations of components of bodily fluids. The conditionally active biologic proteins may be further evolved, conjugated to other molecules, masked, reduced in activity by attaching a cleavable moiety. Criteria for selecting starting proteins for the discovery methods, as well as formats of the proteins are also disclosed.
US11254920B2
The present invention relates to a factor VII composition having a substantially homogeneous isoelectric point and to a method for formulating such a composition. The present invention also relates to the therapeutic use of a factor VII composition having a substantially homogeneous isoelectric point.
US11254919B2
Provided herein is a method for producing a protein hydrolysate using a polypeptide having endopeptidase activity and a polypeptide having carboxypeptidase activity and the use of these enzymes for hydrolysing a protein substrate. Also provided are polypeptides having carboxypeptidase activity and polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US11254895B2
The present disclosure provides for improved oilseed extraction methods using sequential extractions with polar solvents and non-polar solvents or extractions with an azeotrope of a polar solvent and a non-polar solvent to produce oilseed meal concentrates having increased protein content and reduced soluble carbohydrate and anti-nutritional compound content.
US11254892B2
The present invention relates to a grease composition containing a base oil (A), a thickener (B), and an additive (C) composed of at least two selected from a sarcosine derivative (C1), an amine compound (C2), and an amide compound (C3), wherein the content of the component (C) is 0.1 to 10.0% by mass on a basis of the total amount of the grease composition.
US11254889B2
Provided is a mineral base oil that conforms to viscosity grades VG22 to VG100 as defined in ISO 3448 and exhibits a distillation curve with a temperature gradient Δ|DT| of distillation temperature between two points of 2.0 vol % and 5.0 vol % of distillation amount being 6.8° C./vol % or less. A vacuum pump oil containing the mineral base oil is excellent in vacuum characteristics and can conform to viscosity grades VG22 to VG100 as defined in ISO 3448.
US11254887B1
An oxidation-reduction desulfurization system includes a reactor vessel with sour gas inlet at the bottom and a gas outlet at the top. A primary stage phase separator includes a vertically-oriented pipe with an inlet located inside the reactor vessel. The ratio of the reactor vessel diameter to the pipe inlet diameter is in a range of 2:1 to 5:1. Surface foam and non-gaseous multi-phase mixture including emulsion flow into a partially gas-filled upper section of the vertically-oriented pipe and freefall to a lower level, thereby facilitating mechanical breaking of the foam and the emulsion. A secondary stage phase separator connected to the gas outlet separates non-gaseous surge from sweet gas. Valves and a controller automatically maintain target levels of the non-gaseous multi-phase mixture and non-gaseous surge.
US11254880B2
The present invention relates to the use of adsorbents comprising zinc oxide nanowires decorated with catalytically active metal particles for the removal of sulfur from hydrocarbon feedstocks, including the desulfurization of diesel fuels and the deep desulfurization of natural gas, and to the use of decorated zinc oxide nanowire adsorbents for the hydrogenation of naphthalene selectively to tetralin in the presence of sulfur compounds. The adsorbent comprises nickel metal particles or nickel-zinc alloy particles deposited on zinc oxide nanowires.
US11254867B1
Scintillator materials, as well as related systems, and methods of detection using the same, are described herein. The scintillator material composition may comprise a Tl-based scintillator material. For example, the composition may comprise a thallium-based halide. Such materials have been shown to have particularly attractive scintillation properties and may be used in a variety of applications for detection radiation.
US11254861B2
A system for slowly releasing an oil-soluble well treatment agent into a well or a subterranean formation includes a composite of the oil-soluble well treatment agent associated with a second component. The amount of the oil-soluble well treatment agent in the composite is from 20 to 35 weight percent and the average particle size of the oil-soluble well treatment agent in the composite is less than or equal to 1 micrometer. The composite may further contain a water-soluble well treatment agent.
US11254860B2
A method may comprise: introducing a treatment fluid into a wellbore penetrating a subterranean formation wherein the treatment fluid comprises a base fluid; a carbonate compound, wherein the carbonate compound at least partially plugs a zone in the subterranean formation; and an acid; and diverting at least a portion of the treatment fluid and/or a subsequently introduced fluid away from the zone.
US11254859B2
An injection method for a solid retarded acid includes mixing a solid acidic substance with a natural polymer, extruding through an extruder to produce particles; putting the produced particles in a coating pan, and sprinkling zinc acetate powder; turning on the coating pan to rotate while irradiating with an infrared lamp; spraying a glycolic acid aqueous solution with a spray gun, and continuing to rotate to obtain the solid retarded acid; injecting non-reactive liquid and the solid retarded acid into the a sand mixing truck; after the mixture is uniformly mixed in the sand mixing truck, injecting the mixture into a formation by a fracturing truck; conveying the solid retarded acid to a designated location, then stopping a pump, removing pipelines, and opening the well for gushing. The method is good in drag reduction, easy for flowback, thereby reducing the construction cost and facilitating environmental protection, and has broad application.
US11254849B2
A method for producing a polyorganosiloxane resin composition including: (a) mixing a thermally-conductive filler having a particle size distribution having a single peak, with a surface treatment agent containing a siloxane to form a mixture, and (b) mixing the mixture from step (a) with a polysiloxane resin.
US11254845B2
Provided is an adhesive composition including lysine, itaconic acid, and water, wherein the lysine and the itaconic acid are present in the form of an aqueous solution of a salt such that precipitates are not formed in the aqueous solution. In addition, provided is a method of preparing an adhesive composition including mixing lysine, itaconic acid, and water to thereby form a mixture of the lysine, the citric acid, and the water, and stirring the mixture at a temperature of 80° C. or less, wherein amounts of the lysine, the itaconic acid, and the water are adjusted such that precipitates of the lysine and the itaconic acid do not form in the adhesive composition.
US11254840B2
A polishing slurry including a hydrophilic nanocarbon particle having a nitrogen-containing functional group, and a weight ratio of a nitrogen element relative to a carbon element of the hydrophilic nanocarbon particle, the weight ratio expressed as N/C×100% is greater than or equal to about 5 wt %, and a method of manufacturing a semiconductor device using the polishing slurry.
US11254837B2
A coating composition includes a coating resin, a triazine ultraviolet light absorber of Formula (I), and a hindered light amine stabilizer, where Formula (I) has the structure:
US11254834B2
This application relates to coating and inks compositions comprising starch derivatives, their uses and substrates comprising such compositions.
US11254833B2
A coating composition includes, in relation to 100% of the weight thereof: between 10 and 90 wt. % of at least one film-forming polymer selected from cellulosic polymers or derivatives of cellulosic polymers, derivatives of vinyl alcohol, derivatives of vinyl pyrrolidones, polymers of a natural origin, acrylic or methacrylic derivatives, derivatives of glycol or propylene glycol or combinations of the two substances or the copolymers of vinyl alcohol and polyethylene glycol (PEG); between 1 and 50 wt. % of at least one food colouring agent; and between 0 and 50 wt. % of at least one auxiliary coating agent selected from white opacifiers, diluents, surfactants, plasticizers, and anti-foaming agents.
US11254827B2
The present invention provides a silver coating composition that develops excellent conductivity (low resistance value) by low-temperature and short-time calcining and that has excellent printability. A silver particle coating composition including: silver nano-particles whose surfaces are coated with a protective agent including an aliphatic hydrocarbon amine; and a dispersion solvent, wherein the dispersion solvent includes a solvent selected from the group consisting of a glycol ether-based solvent and a glycol ester-based solvent. The silver particle coating composition is suitable for various printing methods such as intaglio offset printing and screen printing.
US11254821B2
A silicone oil-treated fumed silica and a method of producing the silicone oil-treated fumed silica are provided. The silicone oil-treated fumed silica, which has the following physical properties: A) the silicone oil-treated fumed silica has a degree of hydrophobicity of 68 vol % or more; B) the silicone oil-treated fumed silica has a silicone oil fixation rate of from 60 mass % to 95 mass %; and C) a composition obtained by adding 6 parts by mass of the silicone oil-treated fumed silica to 100 parts by mass of an amine composition containing trimethylolpropane polyoxypropylene triamine and 1,3-bis(aminomethyl)cyclohexane at a mass ratio of 95:5 has a viscosity of 4,000 mPa·s or more after the composition is left to stand at 25° C. for 1 hour.
US11254816B2
The invention pertains to composition of fluoroplastic and poly(aryletherketone), to method of making the same, and to shaped products therefrom, including notably wire sheaths, which combine advantageous performances of both ingredients, which can be easily manufactured through conventional equipment's, and which notably deliver room temperature toughness, in combination with notably chemical resistance and dielectric properties of fluoroplastics and with mechanical performances of poly(aryl ether ketone)s.
US11254814B2
The present invention is to provide a resin composition capable of producing a molded product sufficiently excellent in hydrolysis resistance and mold release characteristics and having an excellent balance between heat resistance and fluidity, even if a heat stabilizer and a mold release agent are contained.
The present invention relates to a resin composition, comprising: (A) a polyarylate resin; (B) a melt-polymerized polycarbonate resin; (C) a specific phosphite compound; and (D) a dipentaerythritol fatty acid ester, a mass ratio (A/B) of the (A) polyarylate resin and the (B) melt-polymerized polycarbonate resin being from 2/98 to 98/2, and the resin composition having a Vicat softening point of 140° C. or higher.
US11254805B2
Described herein is flooring formed of an eco-friendly material, where the flooring has excellent heat resistance, durability, abrasion resistance and dimensional stability, and is formed of a non-PVC material and thus is recyclable via an extrusion processing at the time of disposal after use. Specifically, eco-friendly flooring is described in which a coating layer, an overlayer having ionomers, a printing layer, at least one middle layer, and at least one underlayer are laminated in order, where the overlayer of the flooring has ionomers, at least one of the middle layer and the underlayer has a thermoplastic polyolefin-based resin, a styrene-based resin, oil, and a filler, the thermoplastic polyolefin-based resin is contained in an amount of 50 to 150 parts by weight with respect to 100 parts by weight of the styrene-based resin, and the styrene-based resin may contain 25 to 45% styrene.
US11254802B2
The present invention provides a diarylamine-based compound represented by General Formula (1): (where A1 and A2 each independently represent a C6 to C18 arylene group which may have a substituent, and A3 and A4 each independently represent an organic group having a cyclic imide structure which may have a substituent).
US11254801B2
The present invention relates to a modified polymerization initiator for a conjugated diene-based polymer, and a modified conjugated diene-based polymer including a functional group derived from the modified polymerization initiator.
US11254797B2
The invention relates to a PET regranulate which, after modification of a granulated PET recyclate, has an intrinsic viscosity of at least 0.95 dl/g measured according to ASTM D 4603, preferably greater than 1.0 dl/g and particularly preferably between 1.1 dl/g and 1.7 dl/g and is suitable for the production of extrusion blow-molded containers.
US11254795B2
A process for producing a melamine-formaldehyde foam by heating and foaming an aqueous mixture M using microwave radiation, said mixture M comprising at least one melamine-formal-dehyde precondensate, at least one curative, at least one surfactant, at least one blowing agent and at least one linear polymer with a number average molecular weight Mn in the range from 500 to 10,000 g/mol and at least two functional groups selected from OH, NH2 or COOH as well as a melamine-formaldehyde foam obtainable by this process and its use.
US11254792B2
A method for at least partial deacetylation of a biopolymer comprising acetyl groups, including: a1) providing a biopolymer including acetyl groups; a2) reacting the biopolymer including acetyl groups with hydroxylamine (NH2OH) or a salt thereof at a temperature of 100° C. or less for 2-200 hours to form an at least partially deacetylated biopolymer; and a3) recovering the at least partially deacetylated biopolymer.
US11254790B2
The present invention discloses a silicone rubber and a method for preparing it, and a phenolic modified silicone rubber resin and a method for preparing it. The structural formula of the silicone rubber is shown as follows: Wherein x=70-80, y=10-20. The structural formula of the phenolic-modified silicone rubber resin is shown as follows: wherein n, x, y are degrees of polymerization, n=10-20, x=70-80, y=10-20. A method for preparing the phenolic-modified silicone rubber resin orderly comprises: adding 90-110 parts by mass of brominated phenolic resin and 180-220 parts of organic solvent into 100 parts by mass of silicone rubber, reacting at 70-80° C. for 24-48 h until the solution is clear and transparent; adding 9-11 parts by mass of capping agent, reacting for another 4-5 h to obtain a reaction liquid containing phenolic-modified silicone rubber resin. The phenolic-modified silicone rubber resin prepared in the present invention can solve the problem of easy pulverization in the ablation process of conventional silicone rubber and meanwhile has high mechanical properties.
US11254784B2
A method for deblocking a blocked isocyanate is described herein. The method includes contacting a blocked isocyanate and a halide ion source under conditions effective to provide a deblocked isocyanate. A method of making a polyurethane is also disclosed. The method of making a polyurethane includes combining a blocked isocyanate, a polyol, and a halide ion source in the presence of solvent and under conditions effective to provide the polyurethane.
US11254777B2
Described herein are nitrogen-containing multi-block copolymers, as well as methods for making such multi-block copolymers, and articles comprising such multi-block copolymers. The nitrogen-containing multi-block copolymers contains at least one A block comprising polyisoprene; and at least one B block comprising amino-functionalized polybutadiene, the amino-functionalized polybutadiene comprising nitrogen-containing pendant groups.
US11254762B2
A multiple-component composition that can be used for producing a corrosion inhibiting (meth)acrylic hydrogel. The multiple-component composition including at least one water soluble (meth)acrylic compound, at least one free radical initiator, at least one benzoate, and optionally at least one catalyst for free radical formation. A method for producing a hydrogel, to a hydrogel obtainable by the method, to a (meth)acrylic injection material, and to a method for sealing cracks, voids, flaws and cavities in building structures.
US11254759B2
The present invention relates to a transition metal compound for an olefin polymerization catalyst, the transition metal compound being represented by chemical formula 1. The description of chemical formula 1 is as defined in the specification.
US11254751B2
Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
US11254747B2
The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through nonpeptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody like functionality to engineered into the molecule.
US11254742B2
A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to Ror2 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to Ror2 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide are also provided.
US11254729B2
IL-7Rα ligands and compounds comprising IL-7Rα ligands are disclosed. The IL-7Rα binding compounds include fusion proteins comprising the IL-7Rα ligands and can act as IL-7R agonists.
US11254728B2
Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-It-CSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.
US11254724B2
The present invention relates to a novel peptide of a glucagon derivative and a composition for preventing or treating obesity comprising the peptide as an active ingredient. The glucagon derivative according to the present invention shows a more excellent activating effect with regard to both glucagon-like peptide-1 receptors and glucagon receptors compared to native glucagon, and thus can be widely used as an effective agent for treating obesity.
US11254723B2
Provided are a mutated nucleic acid molecule of a recombinant human-basic fibroblast growth factor (rh-bFGF), a pharmaceutical composition of the rh-bFGF, and a use thereof.
US11254716B2
A polypeptide having a sequence at least 60% identical to SEQ ID NO: 1 (WFEWPYWEMNVPDVWN) is provided. The polypeptide includes no more than 100 total amino acid residues.
US11254714B2
The present invention relates to a method for inhibiting, improving, or preventing aging, comprising administering to a subject in need thereof a composition comprising a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, which is pneumococcal surface protein A (PsaA) of Streptococcus pneumonia. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
US11254698B2
The inventive concept relates to a cobalt precursor, a method for manufacturing a cobalt-containing layer using the same, and a method for manufacturing a semiconductor device using the same. More particularly, the cobalt precursor of the inventive concept includes at least one compound selected from the group consisting of a compound of Formula 1 and a compound of Formula 2.
US11254693B2
The invention relates to benzothiazole-containing silanes of the formula I which are prepared by reacting benzothiazole-containing silanes of the formula II with a compound of formula III R2—H (III). The benzothiazole-containing silanes of the formula I can be used in rubber mixtures.
US11254689B2
The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
US11254684B2
The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of N-((1S,3S)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide. The present invention also relates to salt forms and pharmaceutical compositions comprising the crystalline form, and to methods for use of the compound prepared from a crystalline form in the treatment of various diseases.
US11254683B2
The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.
US11254674B2
The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
US11254663B2
Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
US11254661B2
The present invention covers quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
US11254656B2
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1 or a salt thereof, wherein q, r, s, Q, R1, R2′, R2″, R3 and R4 are as defined herein.
US11254655B2
The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
US11254648B2
A process for preparing glycerol carbonate methacrylate, wherein glycidyl methacrylate is reacted with carbon dioxide in the presence of a catalyst and a solvent,
wherein the catalyst is potassium iodide, the solvent is acetonitrile, one or more monoalcohols, or any desired mixture of acetonitrile and one or more monoalcohols, and the reaction of glycidyl methacrylate with carbon dioxide is carried out at a pressure from 0.5 to 5 bar.
US11254645B2
The present disclosure relates to a method for preparing tolimidone on large scale with maintaining high purity and uniform particle size distribution, and more specifically, a method suitable for preparing tolimidone on industrially large scale by using tetrabutyl ammonium bromide catalyst and recrystallization in ethanol, which can prepare highly pure tolimidone in a time shorter than prior arts while maintaining water content and particle size distribution constantly.
US11254638B2
A compound of the formula (III): wherein R21 is a hydrogen atom or an alkyl group; R22 is a hydrogen atom or an alkyl group; and R23 is a divalent organic group.
US11254636B2
Purification methods and systems for working up a crude vinyl acetate stream containing vinyl acetate monomer, acetic acid, water, ethyl acetate, and other impurities. Crude vinyl acetate streams are purified with an azeotropic distillation tower using a side draw to remove ethyl acetate and water, and a bottom stream to remove acetic acid from the crude vinyl acetate. The methods and systems move the side draw to a location on the azeotropic distillation tower that maintains a constant water concentration in the bottom product of about 4 to about 15 wt. % and forms a vapor side product. A second distillation tower is used to further purify the vapor side product to obtain water, VAM, ethyl acetate and AA. The system provides easier disposal of ethyl acetate, and cleaner water that can be recycled in the reactor or purification sections of a VAM plant and full recovery of AA.
US11254622B2
A combined organomineral NPK—Si-humate fertilizer having at least one particulate mineral NPK fertilizer is provided, which has at least one nutrient compound of nitrogen, phosphorous or potassium; and a particulate humic substance based silicon fertilizer, having chelates of monosilicic acid-humate compounds. The application also relates to a method of production of the combined organomineral NPK—Si-humate fertilizer.
US11254614B2
Disclosed are a lightweight conductive mortar material, a preparation method therefor and use thereof. The lightweight conductive mortar material includes the following components in parts by weight: 100 parts of cement, 25 parts to 60 parts of a conductive porous lightweight aggregate loaded with a modified agar gel, and 30 parts to 45 parts of water.
US11254608B2
An article includes a substrate that is transparent, the substrate being covered on at least one of its faces, totally or partly, with a protective layer based on zirconium and aluminum mixed oxide.
US11254601B2
Compounds, compositions, articles, devices, and methods for the manufacture of light guide plates and back light units including such light guide plates made from glass. In some embodiments, light guide plates (LGPs) are provided that have similar or superior optical properties to light guide plates made from PMMA and that have exceptional mechanical properties such as rigidity, CTE and dimensional stability in high moisture conditions as compared to PMMA light guide plates.
US11254586B1
A method for making a customized beverages in a beverage maker is provided using a filtered water system for processing pressurized potable water. The filter system is monitored to allow for certification of a filter system performance for a claimed contaminant reduction up through 320 gallons of use while providing NSF/ANSI Standard 42 or NSF/ANSI Standard 53 health claims when operated at a flow rate of at least 0.50 gallons per minute (gpm).
US11254585B2
A novel process for treating pickling acid residue and recovering sulfates and nickel therefrom has been developed. By lowering the pH of a magnesium compound slurry to 4-5.5 with sulfuric acid containing pickling acid residue in the presence of ammonium sulfate, both magnesium sulfate and nickel sulfate are solubilized. Magnesium sulfate and nickel sulfate solution is separated from the solids by filtration and an iron hydroxide and chromium hydroxide residue is obtained as a precipitate. Magnesium sulfate and nickel sulfate are then separated from the solution.
US11254574B2
A graphene material prepared using waste tires and a preparation method thereof. Waste tires are crushed to 30-200 meshes to obtain tire powders. The tire powders are mixed with KOH or an aqueous solution of KOH to obtain a homogeneous mixture. The mixture is dried at 50-90° C. for 12-48 hours, heated and calcinated in a tube furnace under a protective gas for 1-48 hour to obtain a black lump. The black lump is washed with distilled water, dilute hydrochloric acid or dilute sulfuric acid for at least 3 times, and then washed with deionized water for at least 3 times to obtain a black powder. The black powder is dried to obtain the graphene material. The graphene material has a three-dimensional structure composed of oligolayer graphene intertwined and connected with each other, has a high crystallinity, is not easily agglomerated, and thus can maintain nano-effect of the graphene material.
US11254571B1
A method for purifying a boron nitride nanotube feedstock is disclosed, including an initial step of mixing a boron nitride nanotube (BNNT) feedstock with a solvent to form an initial mixture. This BNNT feedstock is made up of hexagonal boron nitride (h-BN) particles and less than about 50 weight percent BNNTs on a dry basis. This initial mixture is then sonicated within a treatment vessel using an ultrasonic probe. At least a portion of the initial mixture is filtered out of the treatment vessel and across a nanoporous membrane at the same as the sonication. In this manner, the method provides a filtrate which is enriched in h-BN particles relative to the initial mixture and a retentate which is enriched in BNNTs relative to the initial mixture.
US11254560B2
The present disclosure relates to an integrated circuit comprising a transconductance amplifier which is connectable to a microelectromechanical systems (MEMS) transducer. The transconductance amplifier comprises a first input coupled to a first current conveyor and a second input coupled to a second current conveyor for converting a single-ended or differential transducer signal voltage into an intermediate signal current representative of the transducer signal voltage through a shared reference resistor. The transconductance amplifier further comprises first and second output circuits coupled to the shared reference resistor and being configured to convert the intermediate current signal into a corresponding differential output current signal through first and second output terminals for driving a load.
US11254559B2
This invention describes the structure and function of an integrated multi-sensing system. Integrated systems described herein may be configured to form a microphone, pressure sensor, gas sensor, multi-axis gyroscope or accelerometer. The sensor uses a variety of different Field Effect Transistor technologies (horizontal, vertical, Si nanowire, CNT, SiC and III-V semiconductors) in conjunction with MEMS based structures such as cantilevers, membranes and proof masses integrated into silicon substrates. It also describes a configurable method for tuning the integrated system to specific resonance frequency using electronic design.
US11254558B2
A micro-electrical-mechanical system (MEMS) assembly includes a micro-electrical-mechanical system (MEMS) actuator configured to be coupled, on a lower surface, to a printed circuit board, an image sensor assembly coupled to an upper surface of the micro-electrical-mechanical system (MEMS) actuator, and a holder assembly coupled to and positioned with respect to the micro-electrical-mechanical system (MEMS) actuator.
US11254552B2
A lift arm of a floor jack is composed of a number of components made from metal bar stock. The lift arm is adapted to transfer power and motion from a power unit to a saddle, which is adapted to be placed at a lift point of the vehicle, thereby applying pressure to the lift point and raising the vehicle.
US11254546B2
A motorized container carrier can be configured to travel along a suspended railway. The motorized container carrier can include at least one motorized trolley configured to move the motorized container carrier along the suspended railway. The motorized container carrier can include a plurality of end beams with container engagement devices configured to interact with containers of various lengths. In some embodiments, the container engagement devices are twist locks. The motorized container carrier can include a system of bumpers and/or guide wheels.
US11254545B2
A method predicts whether an approaching passenger intends to travel on a passenger moving system having at least one movable pallet. The method includes positioning at least one monitoring device in the vicinity of the passenger moving system such that it monitors a detection area wherein the detection area includes at least a first detection area. The monitoring system then detects the presence of a passenger in the at least first detection area and monitors a trajectory of the passenger. A response is triggered at a control unit of the passenger moving system when the monitored trajectory of the passenger provides a predicted trajectory that reaches the entrance to the passenger moving system.
US11254537B2
Provided is a printing apparatus comprising: a discharging unit configured to convey and discharge print media; a tray configured to receive print media discharged in a first direction from the discharging unit; and a drive unit configured to move the tray in a second direction perpendicular to the first direction. In discharging print media, the tray is moved in the second direction to thereby receive the discharged print media at a plurality of different positions on the tray. The tray is movable to a take-out position being a position closer in the second direction to a take-out side where print media are taken out than any of the positions at which the tray receives the print media discharged from the discharging unit.
US11254533B2
A device for winding up a film at a packaging machine, the device including a reception mandrel drivable for rotation about a rotation axis and a reception sleeve for the film for being pushed onto the reception mandrel. The reception sleeve may be formed by segments arranged next to each other along a circumference or perimeter of the reception sleeve, wherein neighboring or adjacent segments may be pivotably connected to each other. The reception mandrel may be formed as rigid body having engagement structures that are configured to cooperate with shape features of an inner circumference or perimeter of the reception sleeve, when the reception sleeve has been pushed onto the reception mandrel, so that a rotation of the reception mandrel about the rotation axis causes the reception sleeve to rotate with the reception mandrel.
US11254524B2
Systems and methods for processing debris from job sites are disclosed. Carts for receiving the debris are also disclosed. Each cart has a base, a plurality of wheels extending downwardly from the base relative to a vertical axis, and a plurality of walls extending upwardly from the base. The walls and the base of each cart cooperate to define a debris-receiving space. The carts can be engaged by a lifting apparatus that rotates along an arcuate path to position the carts in an unloading position.
US11254520B2
A conveying system for pneumatically conveying plastic granulate comprises a feed location, at which the plastic granulate is fed into a conveying line by pressurized conveying gas, a target location, in conveying connection with the feed location, for moisture contained in the conveying gas, and a condensation tempering unit, which is arranged along a section or sections of the conveying line, for making the conveying line such temperature to at least partial condensation of moisture contained in the conveying gas to form a sliding film on an internal wall of the conveying line.
US11254514B2
A feeding assembly and a method of feeding components comprising a track along which components can be moved, said track comprising a sloped surface and a ledge, wherein said sloped surface slopes in a direction perpendicular to the direction which the components move along the track so that the components maintain a tilted orientation as they move along the track, a pickup platform comprising a pocket which can receive components from said track, and a pivot on which the pickup platform can be selectively rotated between a first position and second position. In the first position, the pocket is aligned with the track and the pocket is parallel with the sloped surface of the track, so that a component can move from the track into the pocket of the pickup platform. In the second position the pocket is in a horizontal orientation.
US11254512B2
A machine includes a frame having a first frame member selectively coupled to a second frame member. The machine also includes an alignment and connection assembly including a protrusion coupled to the first frame member. The protrusion is receivable within the second frame member to align the first frame member with the second frame member. The alignment and connection assembly also includes a fastener coupled to the protrusion. The fastener is operable to secure the first frame member relative to the second frame member.
US11254509B2
A drive wheel for driving a feed chain for dry-feeding livestock includes a base wheel having an axial passage for receiving a drive shaft and a gear rim having a toothed external circumferential face, wherein the external circumferential face has a multiplicity of tooth elements. Each tooth element has two tooth tips and one chain clearance disposed between the two tooth tips. At least the gear rim composed of an elastic material.
US11254506B1
Within a sortation center, robotic drives may coordinate to sort packages. In some instances, first robotic drives on a third floor may deposit packages into first chutes that transfer the packages to a second floor. Awaiting second robotic drives on the second floor may receive the packages and may deposit the packages into second chutes that transfer the packages to a first floor. At the first floor, the packages may arrive into a container associated with shipping the packages. Depositing the packages in the first chutes may align the packages with a respective container on the first floor in a first direction and depositing the packages in the second chutes may align the packages with their respective container on the second floor in a second direction.
US11254500B2
A refuse vehicle includes a chassis, tractive elements, a lift apparatus, and a reach assembly. The tractive elements couple with the chassis and support the refuse vehicle. The lift apparatus includes a track and a grabber assembly. The track includes a straight portion and a curved portion. The grabber assembly releasably grasps a refuse container and ascends or descends the track to lift and empty refuse into a body of the refuse vehicle. The reach assembly includes an outer member, a first extendable member, and a second extendable member. The first extendable member is received within an inner volume of the outer member and translates relative to the outer member. The second extendable member is received within an inner volume of the first extendable member and translates relative to the first extendable member. The lift apparatus is fixedly coupled at an outer end of the second extendable member.
US11254499B2
A refuse vehicle includes a chassis, a body assembly coupled to the chassis and defining a refuse compartment, an electric energy system, and a lift assembly. The lift assembly includes a pair of lift arms pivotally coupled to the body assembly, a pair of forks pivotally coupled to the pair of lift arms, a lift arm actuator positioned to facilitate pivoting the pair of lift arms relative to the body assembly, and a fork actuator extending between the pair of lift arms and the pair of forks. The fork actuator is positioned to facilitate pivoting the pair of forks relative to the pair of lift arms. The lift arm actuator and the fork actuator are powered by the electric energy system.
US11254497B2
A container and a method of fabrication thereof, the container comprising side walls, a front wall and a back wall, the walls extending from a base wall to a top edge of the container, and defining an inner cavity, wherein the front wall comprises an upper part and a lower part recessed inward from the upper part, the lower part comprising facing walls extending inwardly from an external surface of the upper part to a recessed wall, the facing walls and the recessed wall extending downwardly to the base wall; each one of the two facing walls supporting an engaging element, the two engaging elements facing each other; and a grab bar is secured in rotation between the two facing walls, a first end thereof engaging with a first one of the engaging elements and a second end thereof engaging with a second one of the engaging elements.
US11254496B2
A garbage-can-type dust collecto includes a housing assembly, an inner barrel body for mounting or fixing a garbage bag, and a draught fan for driving airflow movement such that dust enters the garbage bag. The inner barrel body is detachably mounted on the housing assembly, the inner barrel body is provided with an accommodating chamber, and the garbage bag arranged in the accommodating chamber divides the accommodating chamber into an upper chamber and a lower chamber. The gas extraction hole is communicated to the wind chamber and the upper chamber, the inner barrel body is provided with a gas suction port for extracting air in the lower chamber when the draught fan is in operation, and the gas suction port communicates the wind chamber to the lower chamber. The present disclosure has the beneficial effect of effectively preventing a garbage bag from blowing up.
US11254493B2
A foldable container enables the entire height of a folded state thereof to be one fifth of the entire height of the state of being folded, such that the height of an international standard container can be satisfied even though empty containers are stacked in five stages. To this end, the hexagonal foldable container can include an upper panel part and a lower panel part respectively forming the upper surface and lower surface thereof; a left panel part and a right panel part respectively forming the left surface and right surface thereof, and respectively folded; a front panel part and a rear panel part respectively forming the front surface and rear surface thereof; and a fixing bar provided at the outer surface of the rear panel part.
US11254485B2
An insulating transport/storage container for transporting/storing temperature sensitive materials, with a generally tubular wall element defining a load volume between first and second apertures at either end thereof, the tubular wall element having an axis. First and second closures operate to close first and second apertures and fastening means operable to secure said first and second closures. The tubular wall element comprises a multiple-layer winding of single-sided corrugated sheet, with the layers coupled together whereby to define a high level of thermal resistance.
US11254484B2
An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck defining an opening that provides fluid communication with the interior; a cap assembly including a funnel having a first portion and a second portion, where the second portion extends radially outward from the first portion to form a floor on an interior thereof and a shoulder on an exterior thereof, the first portion defining a first bore and the second portion defining a second bore fluidly connected to the first bore; a self serum stopper having a self sealing membrane that extends radially outward to overlie at least a portion of the floor of the funnel; and a cap having a cap wall sized to fit over the funnel and a cover portion extending radially inward from the cap wall.
US11254480B2
The present invention discloses a strap system for securing a payload. The strap system includes a first fastener having a connecting crosspiece, a reversing crosspiece, and a hanger capable of attaching to the payload, and all connected together on each side by lateral members. The strap system also includes a strap attached to the connecting crosspiece of the first fastener and capable of passing around the reversing crosspiece and tightening the strap around the payload.
US11254478B2
A sanitary cover for various items is provided. The device includes a flexible member having a base opposite an end, an upper wall, a lower wall, and a pair of sidewalls defining an interior volume. In some embodiments, the end is open, wherein alternate embodiments an opening is defined through the lower wall. A closure is disposed along the opening, wherein the closure seals the interior volume when the closure is removably secured together. A germicidal coating is disposed on an exterior surface of the flexible member.
US11254475B2
A structure of a mouth plug portion includes a nozzle and a cap, the nozzle includes a first outer protrusion and a second outer protrusion, the first outer protrusion includes a locking surface that locks the cap and a first guide surface spirally extending, the cap includes a cap body and a tamper band provided with a weak portion that can be broken by an external force received from the second outer protrusion during rotation of the cap body, the cap body includes a first inner protrusion and a second inner protrusion, an outer peripheral surface of the nozzle is provided with a second guide surface along which the first inner protrusion and the second inner protrusion can move in an axial direction.
US11254467B2
A foldable fabric lawn and indoor/outdoor caddy that opens with a flexible spring wire loaded frame when placed on the ground. Debris/material can be swept/raked into the invention via its flexible 27″ rubber sweeping edge or by other means (shovel, hands, drop-cloth). The invention can then be closed together with its two handles and locked together for transport by the user. A rear fabric handle aides in the dumping/disposal of the aforementioned debris. The invention can then be placed on the ground ready for its next use. The invention can be used for clean-up, yard/garden work, as a drop-cloth, gather trash, and construction debris.
US11254464B2
A package system is provided. The package system comprises a carton having at least a first carton panel including a first tab having a first tab edge defined by internal walls of the first panel, a second carton panel opposing the first panel, and a third carton panel between the first carton panel and the second carton panel, the carton having a carton length that is defined as a first distance parallel to the third carton panel between the first carton panel and the second carton panel; and a drawer configured to slide into and out of an interior of the carton, the drawer having at least a first drawer panel opposing the first carton panel, a second drawer panel opposing the second carton panel, and a third drawer panel opposing the third carton panel, the third drawer panel adjoined between the first drawer panel and the second drawer panel.
US11254452B2
A radiative fin for a spacecraft is disclosed having an end fitting of heat conductive material, configured to be mounted on the spacecraft, a flexible radiative laminate, connected to the end fitting at one end and having an opposite free end, at least one pyrolytic graphite sheet, and at least one heat emission layer in contact with the pyrolythic graphite sheet on at least part of the surface of the pyrolythic graphite sheet, and a flexible rod, extending from the end fitting along at least part of a side of the flexible radiative laminate and being affixed to the latter. The flexible rod is adapted to occupy a folded position and a deployed position and to exert, while in the folded position, a deployment torque adapted to bring the flexible rod back to the deployed position.
US11254448B2
A method and apparatus for servicing a shock absorber on a landing gear assembly of an aircraft in a weight-on-wheels state is disclosed. The shock absorber includes at least one chamber containing both hydraulic fluid and a gas in fluid communication with each other. The apparatus includes a source of gas and a source of hydraulic fluid. The amount of hydraulic fluid in the chamber is corrected, preferably such that the chamber is then filled with a known amount of degassed hydraulic fluid. The process may be at least semi-automatically performed, for example under the control of a control unit. By delivering a pre-set mass of gas into the chamber, there is no need to rely on a measure of gas pressure or H-dimension (h) when servicing the shock absorber, and more accurate servicing of a shock absorber may thus be provided.
US11254439B2
Fuel tank inerting systems for aircraft are provided. The systems include a fuel tank, a catalytic reactor arranged to receive a first reactant from a first reactant source and a second reactant from a second reactant source to generate an inert gas that is supplied to the fuel tank to fill an ullage space of the fuel tank, a heat exchanger arranged between the catalytic reactor and the fuel tank and configured to at least one of cool and condense an output from the catalytic reactor to separate out the inert gas, and a controller configured to perform a light-off operation of the catalytic reactor by controlling at least one light-off parameter and, after light-off occurs, adjusting the at least one light-off parameter to an operating level, wherein the at least one light-off parameter comprises a temperature of the catalytic reactor.
US11254428B2
A method for controlling an unmanned aerial vehicle (“UAV”) includes receiving locking instruction information from a user terminal for locking the UAV. The method also includes transmitting a locking command to a remote control device of the UAV based on the locking instruction information, to instruct the remote control device to lock the UAV based on the locking command.
US11254423B2
A damping landing gear assembly for a vertical takeoff and landing aircraft includes a spring housing forming a spring chamber, a spring disposed in the spring chamber and a plunger slidably coupled to the spring housing and movable between a compressed position and an extended position. The spring biases the plunger into the extended position during flight. The vertical takeoff and landing aircraft experiences a landing force during landing. The landing force compresses the plunger into the compressed position against the bias of the spring, thereby absorbing at least a portion of the landing force.
US11254418B2
A tiltrotor controls shield having a blade or wire substructure under a fragile spinner fairing improves bird strike durability. The present disclosure discloses a spinner wind fairing with a shield structure disposed thereunder for providing protection to the proprotor assembly components. The shield structure can segment a projectile, such as a bird, that penetrates the spinner fairing into a series of smaller and lower energy elements spread across a wider area, such that the rotor components can withstand the impact of the smaller elements without damage.
US11254411B2
An airfoil-shaped body having a variable outer shape, comprising: a first skin, defining a suction surface, a second skin, defining a pressure surface and connected to the first skin at least at a leading edge and/or a trailing edge of the airfoil-shaped body, at least one elongate stiffening beam, arranged inside a cavity of the airfoil-shaped body and secured to at least one of said first and second skins, the stiffening beam including at least a first and a second beam section arranged one after the other and a joining member, arranged between end portions of the beam sections and connected thereto, said joining member being adapted to allow relative movement between the beam sections by an elastic deformation; and an actuator that is operationally associated with said elongate stiffening beam, wherein, upon operating the actuator, the first beam section is moved with respect to the second beam section, or vice versa, changing the orientation of the beam sections with respect to each other, which causes a change in the variable outer shape of the airfoil-shaped body.
US11254400B2
Systems and processes for initiating a rescue, using peer-to-peer distress alert systems, are described. An exemplar process of initiating, from a distressed vessel, a recue includes: (i) generating an outgoing distress signal that includes a distress signal and distressed vessel location information; (ii) broadcasting the outgoing distress signal to one or more potential rescue vessels located away from the distressed vessel; (iii) receiving, from one or more of the potential rescue vessels, one or more outgoing rescue signals, each of which includes potential rescue vessel location information; (iv) of identifying, using the potential rescue vessel location information from one or more of the potential rescue vessels and vessel location information of the distressed vessel, one or more rescue potential rescue vessels that are suitable for rescuing the distress vessel; and (v) transmitting, from the distressed vessel, a confirmation rescue signal to each of the potential rescue vessels that are suitable for rescuing the distress vessel.
US11254397B1
A specially-equipped ship is configured for environmental cleanup to collect plastic waste floating in the ocean. A method of using the ship is described. The specially-equipped ship can retrieve floating plastic waste in the ocean, shred it, melt it, and cool it to form a solidified block that is usefully employed to form an artificial reef on the ocean floor to house aquatic biota. The ship is outfitted with a conveyor belt fixed to the ship; a furnace to make molten plastic; a davit to drop the solidified block into the ocean to form a reef on the ocean floor. Optionally the ship includes a mold to contain molten plastic; a shredder; a storage compartment to receive plastic particles from the shredder; a fish escape; a vertical wall; a boring machine; photovoltaic cells and/or windmills to produce electric energy.
US11254390B2
A hydrofoil device for a mobile offshore apparatus, in particular, a watercraft. The hydrofoil device includes at least one base body with at least one connection unit which is arranged for connecting the hydrofoil device to the mobile offshore apparatus. At least one hydrofoil is arranged on the base body. At least one flow generator is arranged to generate a flow around the hydrofoil. The hydrofoil device in its intended use is rotatable at least about a substantially vertical axis of rotation depending on at least one control data set that can be provided.
US11254380B1
A trailer includes a housing including an internal frame and an external frame. The external frame is coupled to the internal frame. In certain embodiments, the internal frame is positioned between interior panels and exterior panels of the housing. In certain embodiments, the external frame is spaced from exterior panels.
US11254375B2
A car having: a passenger compartment; a body surrounding the passenger compartment and having: a roof, a tail provided with a rear bumper, and a joining portion connecting the roof to the tail; a rear spoiler, which is arranged at the end of the joining portion in the area of the tail; and a deflector panel, which is arranged on the joining portion, is directly hit by an air flow brushing the joining portion during the travel and is mounted in a movable manner so as to move between a rest position, in which the deflector panel rests on the joining portion, and an active position, in which the deflector panel is lifted and spaced apart from the joining portion.
US11254361B2
A steer-by-wire system and method for a vehicle, including and utilizing: a steering wheel system including a steering wheel, an angle sensor or mechanism coupled or applied to the steering wheel and for determining an angular magnitude of the steering wheel and provide a corresponding control signal, and an angular rate sensor or mechanism coupled or applied to the steering wheel and for determining an angular rate of the steering wheel and provide a corresponding control signal offset; and a steering actuator system including a wheel angle actuator coupled to one or more wheels of the vehicle and for receiving the collective control signal and control signal offset and turning the wheels in response. The steering wheel system further includes an angular rate filter/tuner for receiving an angular rate input from the angular rate sensor or mechanism and deriving an angular offset output corresponding to the control signal offset.
US11254360B2
A steerable cart or trailer is towed by another vehicle. A reverse linkage made up of arms that crisscross one another extends between the tow vehicle and the steerable trailer. The linkage arms are parallel a distance from the tow vehicle before crisscrossing with one another towards the trailer. The linkage arms are rotatable at each end. This allows the arms to rotate in a manner in which the trailer will more closely follow the path of the tow vehicle, especially when the tow vehicle is in the process of turning. The trailer will follow in a manner that reduces compaction and provides a simpler overall operation of equipment.
US11254357B2
An apparatus and a method are provided for an offset tie rod joint for vehicle steering systems. The offset tie rod joint comprises a ball rotatably retained within a casing that is disposed in an opening of an offset housing. A threaded shank fixedly coupled with the offset housing is received by a steering rod. The opening is displaced from a longitudinal axis of the threaded shank by a distance that provides clearance between the offset housing and a spindle assembly during articulation of the spindle assembly during steering. A rear backstop and a front snap-ring in a groove retain the casing within the opening. A bore extending through the ball receives a bolt that fixates the ball between parallel prongs of the spindle assembly. A misalignment spacer on each side of the ball provides clearance for rotation of the ball within the offset housing.
US11254353B2
An embodiment of the present invention allows for application of an assist torque or reaction torque which causes a driver to feel less discomfort. An ECU (600) includes a control variable calculating section (611) configured to calculate a control variable for controlling a magnitude of the assist torque or reaction torque, with reference to a steering torque applied to a steering member (410); and a control variable correcting section (612) configured to correct the control variable calculated by the control variable calculating section, with reference to a roll rate of a vehicle body, a steering angle of the steering member, and a steering angle speed of the steering member.
US11254344B2
A method for introducing electric conductors into an overmolding of a steering wheel frame is provided. The electric conductors are used for heating and shielding purposes and for sensing contact on a steering wheel. In a first step, at least one cut is introduced into the overmolding using a cutting tool. In a second step, both a first layer of an electric conductor and a second layer of an electric conductor are simultaneously introduced into the cut that has been created. The first layer forms both a heating layer for heating the steering wheel and a guard layer which, together with the second layer acting as a sensor layer, allows the capacitive sensing of hand contact.
US11254343B1
A vehicle system including one or more sensors, a steering wheel including a rim and an adjusting mechanism for adjusting a coefficient of friction between a surface of the rim and a driver's hand, and a controller configured to determine whether a deviation factor between a target path and an actual path based on the one or more sensors exceeds a threshold deviation, send a first signal to the adjusting mechanism for operating to a first state in response to determining that the deviation factor exceeds the threshold deviation, the coefficient of friction being decreased when the adjusting mechanism is in the first state, and send a second signal to the adjusting mechanism for operating to a second state in response to determining that the deviation factor does not exceed the threshold deviation, the coefficient of friction being increased when the adjusting mechanism is in the second state.
US11254340B2
A cart for medical equipment includes a column supporting a platform for mounting a piece of medical equipment to the cart. A base including one or more wheels that support the column, and a handgrip at least partially encircling the platform. The handgrip includes an upper surface substantially devoid of openings and an opposite lower surface including one or more elongated accessory slots opening downwardly toward the one or more wheels. The one or more elongated accessory slots are configured to receive a portion of an accessory mount such that the accessory mount is slidingly adjustable along a length of the one or more accessory slots.
US11254333B2
An electronic control device acquires at least one of subject vehicle information, surrounding environment information, and road information, detects an abnormality that has occurred in a vehicle during an autonomous driving based on a first travel plan, identifying a cause of the abnormality based on at least one of a content of the abnormality, the subject vehicle information, the surrounding environment information, and the road information, determines a situation around the vehicle based on at least one of the subject vehicle information, the surrounding environment information, and the road information, determines a target stop position for stopping the vehicle in a stoppable location based on the cause of the abnormality and the situation around the vehicle, and changes the first travel plan to a second travel plan for stopping the vehicle to the target stop position.
US11254331B2
A method for updating an object detector of an autonomous vehicle to adapt the object detector to a driving circumstance is provided. The method includes steps of: a learning device (a) (i) inputting a training image, corresponding to a driving circumstance, into a circumstance-specific object detector to apply (i-1) convolution to the training image to generate a circumstance-specific feature map, (i-2) ROI pooling to the circumstance-specific feature map to generate a circumstance-specific pooled feature map, and (i-3) fully-connected operation to the circumstance-specific pooled feature map to generate circumstance-specific object detection information and (ii) inputting the circumstance-specific feature map into a circumstance-specific ranking network to (ii-1) apply deconvolution to the circumstance-specific feature map and generate a circumstance-specific segmentation map and (ii-2) generate a circumstance-specific rank score via a circumstance-specific discriminator; and (b) training the circumstance-specific object detector, the circumstance-specific deconvolutional layer, the circumstance-specific convolutional layer, and the circumstance-specific discriminator.
US11254327B2
Methods and apparatus to present anticipated vehicle maneuvers to a passenger are disclosed. An example method includes determining an anticipated autonomous maneuver of a vehicle based on collected information corresponding to autonomous operation of the vehicle, determining a notification type to present to a passenger device based on a device type, and presenting the anticipated autonomous maneuver to a user via the passenger device based on the notification type.
US11254324B2
A vehicle and a vehicle controlling method are provided. The vehicle includes a computing system; a vehicle controlling module coupled to the computing system; and a positioning module coupled to the computing system and the vehicle controlling module. The vehicle controlling module receives a safe stop path and a fusion coordinate from the computing system. When the vehicle controlling module determines that an abnormality occurs in the computing system, the vehicle controlling module receives a positioning coordinate from the positioning module and calculates an offset corresponding to the positioning coordinate and the fusion coordinate. The vehicle controlling module transmits a vehicle controlling command to the vehicle according to the offset and the safe stop path.
US11254321B2
A driving assist apparatus comprises a driver monitor sensor which detects a state of a driver of an own vehicle installed with the driving assist apparatus. The apparatus determines whether the driver is in a drowsy state, based on the state of the driver detected by the driver monitor sensor. The apparatus determines that a light collision occurs when a light collision determination condition that at least one collision index value representing a level of a collision of the own vehicle is larger than a light collision determination threshold at which an airbag is not developed, is satisfied. The apparatus executes a secondary collision damage mitigation control to apply a braking force to the own vehicle or limit a driving force applied to the own vehicle when determining that the driver is in the drowsy state, and the light collision occurs.
US11254315B2
A system control a vehicle using a friction function describing a friction between a type of surface of the road and a tire of the vehicle as a function of a slip of a wheel of the vehicle. The parameters of each friction function include an initial slope of the friction function defining a stiffness of the tire and one or combination of a peak friction, a shape factor and a curvature factor of the friction function. Upon estimating a slip and a stiffness of the tire, the system selects from the memory parameters of the friction function corresponding to the current stiffness of the tire, determines a control command using a value of the friction corresponding to the slip of the tire according to the friction function defined by the selected parameters, and submits the control command to an actuator of the vehicle.
US11254314B2
An apparatus for controlling a lane change of a vehicle includes: a sensor to sense an external vehicle, an input device to receive a lane change command from a driver of the vehicle, and a control circuit to be electrically connected with the sensor and the input device. The control circuit may receive the lane change command using the input device, calculate a minimum operation speed for lane change control, and determine whether to accelerate the vehicle based on a distance between a preceding vehicle which is traveling on the same lane as the vehicle and the vehicle, when a driving speed of the vehicle is lower than the minimum operation speed when receiving the lane change command.
US11254308B2
A lane departure avoidance system includes: a recognition unit that recognizes a road edge of the road, and recognizes an outer line as a dividing line drawn on a road-edge side of a lane closest to the road edge; and an assist implementation unit that provides, within an area including the lane closest to the road edge and extending to the road edge, a forbidden position over which a vehicle is forbidden from going toward the road edge, and implements traveling assistance such that the vehicle does not go over the forbidden position. The system includes a shoulder width calculation unit that calculates, as a shoulder width, a width from the outer line to the road edge. The wider the shoulder width calculated by the shoulder width calculation unit is, the closer the forbidden position is set to the road edge by the assist implementation unit.
US11254287B2
A vehicle-mounted device includes vehicle information detecting unit for detecting an on/off state of vehicle power, relay input/output unit for controlling an external relay configured to make a switch between a starting-disabled state and a starting-enabled state of a vehicle, and vehicle information-associated control unit for controlling the external relay based on a relay control command. The vehicle information-associated control unit controls the external relay based on an elapsed time since a change in the on/off state of vehicle power detected by the vehicle information detecting unit.
US11254286B2
One general aspect includes a system to restrict vehicle operations, the system including: a memory configured to include one or more executable instructions and a processor configured to execute the executable instructions, where the executable instructions enable the processor to carry out the following steps: receiving a vehicle-occupant credential; determining whether the vehicle-occupant credential triggers an operation constraint; and when the operation constraint is triggered, restricting a vehicle from operating in an autonomous driving mode.
US11254285B2
An apparatus is provided to inhibit forcible separation of a shift cable 100 coupled to a shift lever 220 by a cover member 300 combined with a shifting device 200 which includes a shift lever housing 210 and the shift lever 220, thereby preventing forcible changing of a current gear from a P-stage to a N-stage in a vehicle. Accordingly, it is possible to help prevent theft of the vehicle.
US11254282B2
A tongue mechanism for use in an occupant restraint system also having a buckle mechanism and a webbing. The tongue mechanism includes a tongue member configured to selectively engage the buckle mechanism, a body formed over a portion of the tongue member, a slider, and a biasing member configured to laterally bias the slider. The body includes a body contact surface. The slider includes a slider contact surface and is configured to travel along a track between a first free position and a second locking position. When the slider is positioned in the first free position the tongue mechanism is free to slide along the length of the webbing, and when the slider is positioned in the second locking position a portion of the webbing is clamped between the slider contact surface and the body contact surface thereby preventing the tongue mechanism from sliding along the length of the webbing.
US11254278B2
The invention relates to an airbag assembly comprising an airbag through-opening arranged over the chute channel of the airbag, which opening is closed by at least one airbag flap and an, in particular sprayed-on, covering made of plastic and secured over the airbag flap, wherein the covering has at least one target break line at the edge of the airbag flap in order to enable the unfolding of the airbag cushion, and wherein the airbag flap is connected via a joining point to a flap support wall in a moulded manner, which is in contact with the inner side of the chute channel wall in a secured manner, wherein am additional flat element is inserted (as a cover) in the chute channel between the airbag cushion and the airbag flap, which flat element at least partially overs the airbag flap and the inner side of the chute channel wall.
US11254275B2
An airbag device for a driver's seat adapted to be mounted on a boss of a steering wheel disposed at a center of a rim is disclosed. The airbag device includes an inflatable airbag folded in the form of an airbag package. The airbag includes a vehicle-side wall that includes a gas inlet port and is configured to be supported by the rim when deployed, and a driver-side wall. The airbag, before folded into the airbag package, has a flat initial folded form in which the driver-side wall lies over the vehicle-side wall. The initial folded form includes a folded-in portion in which a front edge portion of the vehicle-side wall is folded inwardly and rearwardly beneath a front edge portion of the driver-side wall, and a folded-back portion in which the front edge portion of the driver-side wall which adjoins the folded-in portion is folded towards the inlet port on the vehicle-side wall.
US11254272B2
A vehicle with a pod separable from a chassis therein, and when a collision detection system detects a collision or an imminent collision, the system will issue a signal to cause an electro-mechanical locking system to detach the pod, and further, to inflate airbags surrounding the pod.
US11254270B1
Systems and methods for using image analysis techniques to facilitate adjustments to vehicle components are disclosed. According to aspects, a computing device may access and analyze image data depicting an individual(s) within a vehicle, and in particular determine a positioning of the individual(s) within the vehicle. Based on the positioning, the computing device may determine how to adjust a vehicle component(s) to its optimal configuration, and may facilitate adjustment of the vehicle component(s) accordingly.
US11254260B2
A method for trailer lighting recognition by a control unit for trailer lighting control of a towing vehicle, in particular for trailer lighting recognition during or after the coupling of the trailer to the towing vehicle, wherein the control unit has, for each light of the trailer lighting system, a voltage supply connection that is connected by an actuator to a voltage supply of the towing vehicle in order to switch on the light of the trailer associated with the voltage supply connection.
US11254257B2
A system and method control a vehicular headlamp for preventing a shadow area between a low beam and a high beam of a headlamp using a camera unit. The method includes periodically determining whether a high beam of the vehicular headlamp is lit or illuminated. Upon determining that the high beam is illuminated, the method includes determining whether a darkness cell is formed in front image data of the vehicle, which is transmitted from a camera unit. Upon determining that the darkness cell is formed, the method includes changing a leveling motor to be directed upward by 1 step and storing a changed number of steps. Upon determining that the darkness cell is not formed, the method includes driving the leveling motor by the pre-stored number of steps.
US11254254B2
Methods and systems are provided for loading and unloading an item onto a vehicle. In one embodiment, a system includes: a loading system configured to receive a locker configured to store the item; a shuttle transfer system configured to transfer the locker to a storage position within the vehicle; and a swing arm system that couples to the loading system and the shuttle transfer system, the swing arm system configured to adjust a position of the loading system relative to the vehicle.
US11254253B1
A carrying bracket for a cup holder used in vehicles is provided, including: a base unit, a rotating unit, and a plurality of expansion units; the outer wall of the base unit being disposed with a plurality of through holes; the rotating unit being mounted on the base unit and rotatable without detachment, the rotating unit having a spiral guide groove facing the base unit; the expansion units being installed in the base unit through the through holes at corresponding positions, and the expansion unit comprising a moving part and a wall support; the wall support for installing the moving part with adjustable position to change the length of the expansion unit; each moving part having a guide block and the plurality of guide blocks all located in the spiral guide groove. When the rotating unit rotates, each moving part moves linearly and protruding outward through the through hole.
US11254235B2
Provided are a deterioration information acquisition unit that acquires deterioration information indicating a deterioration state of each of a plurality of storage batteries, a temperature condition determination unit that determines a temperature condition allowable at the start of charging or during charging for each of the plurality of storage batteries in accordance with the deterioration information acquired by the deterioration information acquisition unit, a temperature information acquisition unit that acquires temperature information indicating the temperature of each of the plurality of storage batteries, and a charge target extraction unit that extracts a storage battery to be charged from the storage batteries among the plurality of storage batteries in which the temperature indicated by the temperature information acquired by the temperature information acquisition unit satisfies the temperature condition determined by the temperature condition determination unit.
US11254229B2
A method of migrating unmanned aerial vehicle (UAV) operations between geographic survey areas, including: uploading a first plurality of flight missions into a first UAV pod; deploying the UAV pod; autonomously launching the UAV from the UAV pod a plurality of times to perform the first plurality of flight missions; providing first survey data from the UAV to the UAV pod; autonomously migrating the UAV from the first UAV pod to a second UAV pod; receiving a second plurality of flight missions in a second UAV pod; providing the UAV with one of the second plurality of flight missions from the second UAV pod; autonomously launching the UAV from the second UAV pod a plurality of times to perform the second plurality of flight missions; and providing a second survey data from the UAV to the second UAV pod; where the autonomous migrating of the UAV to accomplish the first and second survey data happens autonomously and without active human intervention.
US11254217B2
A method for manually and individually configuring a recuperation behavior of an electrically driven vehicle includes the manual setting of the recuperation behavior. The manual setting of the recuperation behavior includes both setting a recuperation intensity and setting a recuperation delay. Accordingly, it is possible to manually meter the braking torque such that both a pleasant driving sensation as well as a situation-specific energy recovery is achieved.
US11254209B2
A method for controlling vehicle systems in a vehicle includes providing a steering wheel having a plurality of sensors configured to sense contact on the steering wheel. The steering wheel has a left zone and a right zone. The method includes determining a left contact value based on one or more signals received from at least one of the plurality of sensors. The left contact value indicates contact with the steering wheel within the left zone. The method includes determining a right contact value based on the one or more signals received from the at least one of the plurality of sensors. The right contact value indicates contact with the steering wheel within the right zone. The method includes determining a driver state index based on the left contact value and the right contact value and modifying control of the vehicle systems based on the driver state index.
US11254199B2
A transmission (G) includes an input shaft (GW1), an output shaft (GW2), an electric machine (EM), a plurality of planetary gear sets (P1-P3; 2P1-2P5), and gear-implementing shift elements (S1-S6; 2S1-2S5). Via engagement of a first of the gear-implementing shift elements (S1, 2S1), which is a force-locking shift element having a variable torque transmission capacity, the input shaft (GW1) and an element (E1, 22E1) of one of the planetary gear sets (P3; 2P4) can be brought into a fixed rotational speed relationship with respect to each other. Another element (E2, 22E2a, 22E2b) of one of the planetary gear sets (P1, 2P3, 2P5) is permanently connected to a rotor (R) of the electric machine (EM). By engaging an auxiliary shift element (ZS, 2ZSa, 2ZSb), which is a form-locking shift element, the rotor (R) and the input shaft (GW1) can be brought into a fixed rotational speed relationship with respect to each other.
US11254194B2
A vehicle door structure includes an outer panel, an inner panel assembled to a vehicle width direction inner side surface of the outer panel so as to form a panel space with the outer panel, a cover assembled to the inner panel so as to close a service hole, which is a through hole formed in the inner panel in order to facilitate a work in the panel space, a control box assembled to the cover and configured to control input/output of electric power and/or control signal to/from at least one of electric components disposed on a vehicle door; and a door trim assembled to a vehicle width direction inner side surface of the inner panel so as to cover the cover and the control box.
US11254177B2
A hollow coil spring is made of a hollow wire in which a terminal sealed portion is formed on an end portion of the wire. The terminal sealed portion has a rotationally symmetric shape in which an axis passing through the center of the wire is the symmetric axis. The hollow coil spring includes an end wall portion, and an end face arc-shaped curved surface. The end wall portion includes an end face perpendicular to the axis. A distal-end-center closure portion is formed on the axis at the center of the end wall portion. A spring seat includes a base member and a sheet member. An end turn portion of the hollow coil spring is in contact with the sheet member. The end face of the end turn portion is opposed to a stopper wall of the spring seat.
US11254169B2
A tire (1) comprising a tread (8), this tread comprising at least one channel (2), at least one wear indicator (3) disposed on the bottom of the channel (2), the wear indicator comprising a contact face (7) intended to come into contact with a road surface when the tire reaches a wear limit, the channel (2) comprising a texture (4) surrounding the wear indicator (3) and contrasting with the contact face (7) of the wear indicator.
US11254168B2
The tread profile of a vehicle tire has a circumferential rib. Grooves are formed in the circumferential rib with a width, which increases along its entire extent, wherein the grooves are formed with a vertex point between a first portion and a second portion. The groove direction from the beginning to the vertex point is formed with a greater directional component in the circumferential direction than in the axial direction and between the vertex point and the entry into the circumferential groove is formed with a greater directional component in the axial direction than in the circumferential direction. The groove is formed in the first portion with a depth T1, which increases continuously from the beginning over the first portion up to reaching its maximum value T1max at the vertex point and is formed with a constant depth T2 in the second portion wherein T2≥T1max.
US11254164B2
A tire has a tread comprising a rubber composition based on at least an elastomer matrix comprising more than 50 phr and up to 100 phr of a first diene elastomer bearing at least one SiOR function, R being a hydrogen atom or a hydrocarbon radical, and optionally, 0 to less than 50 phr of a second diene elastomer which is different from the first diene elastomer; a reinforcing filler predominately comprising a reinforcing inorganic filler, wherein the content of reinforcing inorganic filler is 20 to 200 phr; and a plasticizing agent comprising 5 to 100 phr of a liquid phosphate plasticizer having a glass transition temperature of less than −80° C.
US11254161B2
A wheel includes a body (10) having a cylindrical outer circumference; a first ring member (21) provided at one side edge of the body (10) in the form of a protruding ring; a second ring member (22) provided at the other side edge of the body (10) in the form of a protruding ring; a rotation ring (30) located between the first ring member (21) and the second ring member (22) and located out of the body (10) and rotatably coupled thereto; a plurality of pivoting plates (40) coupled to the rotation ring (30) to be pivotal outward and configured to protrude out of the rotation ring (30); a connection member (50) located between the plurality of pivoting plates (40) to connect the first ring member (21) and the second ring member (22) and serve as a stopper for limiting a pivoting range of the pivoting plate (40); a first opening (31) formed at the rotation ring (30) along a rotation direction of the rotation ring (30); a second opening (11) formed at the body (10) at a position corresponding to the first opening (31); a stopper bar (60) configured to be pivotal based on a center portion (C) of the body (10) and provided through the first opening (31) and the second opening (11); and a shock absorber (70) coupled to the body (10) to absorb shock when the stopper bar (60) pivots.
US11254157B2
The present invention relates to an ink-jet printing method including the step of ejecting a water-based ink containing pigment-containing water-insoluble polymer particles and water onto a printing medium to print characters or images on the printing medium, in which the pigment is at least one pigment selected from the group consisting of C.I. Pigment Red 177, C.I. Pigment Red 254, C.I. Pigment Green 7, C.I. Pigment Green 36 and C.I. Pigment Blue 15:6; the water-insoluble polymer constituting the particles contains a constitutional unit derived from an ionic monomer, a constitutional unit derived from a hydrophobic monomer and a constitutional unit derived from a monomer capable of forming a graft chain; and the printing medium is a low-water absorbing printing medium.
US11254155B1
Craftwork tools are described. The craftworks tools may include a stamp and a jig with matching alignment patterns. Methods of using same are also described. The method may include placing the jig on a stamp platform, aligning the stamp with the jig, placing cardstock or another substrate on the jig, inking the stamp, and closing the lid of the stamp platform to mark the cardstock with the stamp. The cardstock and the jig may then be rotated clockwise or counterclockwise on the stamp platform without rotating the stamp on the lid, the stamp may be re-inked and then the lid may be closed again to mark the cardstock with the stamp. Methods of using embossing tools are also described.
US11254146B2
The present invention relates to a printing apparatus including: a conveyance roller; and a slitter unit configured to cut a printing medium, which is conveyed by the conveyance roller, wherein the slitter unit includes a cutting mechanism including an upper movable blade and a lower movable blade, each of which is in a round shape, and configured to cut the printing medium at a contact point of the upper movable blade and the lower movable blade, a driving unit configured to rotate the upper movable blade and the lower movable blade, and a control unit configured to control a driving amount of the driving unit, and wherein the control unit controls the driving amount of the driving unit such that a movement speed of the upper movable blade and the lower movable blade passing through the contact point becomes greater than a conveyance speed of the printing medium.
US11254145B2
A post-processing device includes an intermediate tray on which a medium transported in a transport direction is placed, a discharge port through which the medium post-processed on the intermediate tray is discharged, a discharge tray which is disposed in a gravity direction with respect to the discharge port and on which the medium discharged from the discharge port is placed, and an elevating mechanism which elevates the discharge tray, in which the elevating mechanism can move the discharge tray to a first normal position and a first standby position positioned in a direction opposite to the gravity direction with respect to the first normal position, and moves the discharge tray to the first normal position or the first standby position according to an amount of ink before the medium comes in contact with the discharge tray or the medium previously placed on the discharge tray.
US11254141B2
A printing system includes: a control unit; and a printing device including: a supply unit configured to be attached with a supply roll configured by an ink ribbon; a winding unit configured to be attached with a winding roll for winding the ink ribbon fed out from the supply roll; a ribbon motor configured to rotationally drive at least one of the supply unit and the winding unit; a thermal head configured to perform printing by heating the ink ribbon transported from the supply roll toward the winding roll by driving the ribbon motor; and a head drive source configured to move the thermal head. The control unit is configured to control the ribbon motor to decrease tension of the ink ribbon when the thermal head is moved in a first direction, in which the tension of the ink ribbon increases, with the head drive source.
US11254138B2
A liquid storage device includes a tank, an agitation blade, and a first tube. The tank is configured to store ink to be supplied to an inkjet head. The agitation blade is disposed inside the tank, and is configured to agitate the ink stored in the tank. The first tube is configured to supply the ink stored in the tank to the inkjet head. A lower end portion of the first tube extends in a direction different to the downward direction.
US11254134B2
A fluid supply component for a replaceable fluid supply may include a channel fluidically coupled to a pliable fluid supply bag; a ball housed within the channel; and a gasket to prevent movement of the ball into the fluid supply bag; wherein the valve prevents fluid from entering the fluid supply bag while the fluid supply bag imparts a negative fluidic pressure.
US11254133B2
A printing apparatus is provided with a print head having at least a first type nozzles and a second type nozzles positioned on a first direction side with respect to the first type of nozzles and a controller. The controller is configured to perform a first ejection control with performing a main scanning. The first ejection control includes a control of performing flushing when the print head is in a first state where the second type of nozzles are located at a position corresponding to an ink receiver and the first type of nozzles are located at a position corresponding to the medium range, and a control of causing the first type nozzles to eject the ink toward the printing medium during a period where the ink is ejected from the second type of nozzles toward the ink receiver when the print head is in the first state.
US11254131B2
A liquid discharge head includes: individual channel rows; a common channel; a supply port via which liquid is supplied to the common channel; and a discharge port via which the liquid is discharged from the common channel. Each of the individual channel rows is formed of individual channels aligned in a first direction, each of the individual channels includes a nozzle, and the individual channel rows are arranged in a second direction crossing the first direction. The common channel extends in the first direction, and extends in the second direction over an entire length of an area in which the individual channel rows are arranged. The common channel overlaps with the individual channel rows in a third direction orthogonal to both of the first and second directions, and communicates with the individual channels constructing each of the individual channel rows.
US11254124B2
A liquid ejecting device includes a plurality of liquid ejecting heads reciprocally movable in a main scanning direction and arrayed in the main scanning direction. Each of the plurality of liquid ejecting heads include a liquid ejecting portion configured to eject liquid. The plurality of liquid ejecting heads includes: a first endmost liquid ejecting head; and a second endmost liquid ejecting head. The first endmost liquid ejecting head constitutes one end in the main scanning direction of the plurality of liquid ejecting heads. The second endmost liquid ejecting head constitutes another end in the main scanning direction of the plurality of liquid ejecting heads. The liquid ejecting portion of at least one of the first endmost liquid ejecting head and the second endmost liquid ejecting head is disposed at a position deviated toward the remaining one of the first endmost liquid ejecting head and the second endmost liquid ejecting head.
US11254115B2
A build material container outlet structure (100) comprises: a connector (107) comprising an interface surface (116) and an adaptor to receive a nozzle structure (202) of an external aspiration system; and a retaining structure (128) to releasably hold the nozzle structure in an engagement position with the interface surface of the connector; wherein the retaining structure comprises one or more retaining elements (118-1, 118-2, 118-3) disposed in the connector to exert an attractive magnetic biasing force on the nozzle structure of the external aspiration system to releasably hold the nozzle structure in the engagement position with the interface surface of the connector.
US11254106B2
A machining system includes an application device that applies a photocurable resin to surfaces of a plurality of linear objects provided in a workpiece; a curing device that brings the linear objects, to which the photocurable resin has been applied by the application device, into close contact with each other in radial directions and that radiates light onto the photocurable resin, which has been applied to the linear objects brought into close contact, thus curing the photocurable resin; and a machining device that machines the workpiece, in which the plurality of linear objects have been bound together through the curing of the photocurable resin performed by the curing device.
US11254100B2
A metal-clad laminate includes an insulating layer including a cured product of a resin composition, and a metal foil disposed on a principal surface of the insulating layer. The resin composition includes a polyphenylene ether copolymer and a thermosetting curing agent, the polyphenylene ether copolymer having an intrinsic viscosity measured in methylene chloride at 25° C. of between 0.03 dl/g and 0.12 dl/g, inclusive. And the polyphenylene ether copolymer has, at a molecular terminal, a group represented by formula (1) or formula (2) at an average number of 1.5 to 3 per one molecule. Further, the metal foil has a first surface that is in contact with the insulating layer, the first surface having a 10-point average roughness (Rz) of 2.0 μm or less. And the metal foil includes a barrier layer disposed at a side of the first surface, the barrier layer containing cobalt.
US11254098B2
A composite light blocking sheet includes a first surface layer, a second surface layer, an inside substrate layer and a central axis. The first surface layer has a first opening and a first outer surface connected to the first opening. The second surface layer has a second opening and a second outer surface connected to the second opening. The inside substrate layer has a substrate opening and is disposed between the first surface layer and the second surface layer and connects the first surface layer and the second surface layer. The central axis is coaxial with the first opening, the second opening and the substrate opening. More than 95% of the first outer surface has a first gloss being GU1, more than 95% of the second outer surface has a second gloss being GU2, and the first gloss GU1 and the second gloss GU2 satisfy specific conditions.
US11254090B2
The invention provides a method for fabricating a spacer fabric composite having a pattern, fabricating machine and composite fabricated by method thereof. The method comprises a film forming step, a patterning step, a laminating step and a hole opening step.
US11254087B2
Some embodiments of present disclosure are directed to a micro-perforated glass or glass-ceramics laminate, comprising a first substrate laminated to a second substrate by a first polymer interlayer, wherein the first and the second substrates are independently selected from glass or glass-ceramics, and a plurality of micro-perforations, each of the plurality of micro-perforations extending through the first substrate, the first polymer interlayer, and the second substrate. Some embodiments are directed to methods of forming such micro-perforated glass or glass-ceramics laminates.
US11254086B2
A packaging material for packaging of light-sensitive goods, said packaging material comprising a first layer and a second layer, at least one hole penetrating said first layer and being covered by said second layer, and a light barrier, wherein said light barrier comprises a layer of ink being essentially nontransparent to light and provided on said second layer to at least partly cover said hole. The disclosure further relates to a method for providing a light barrier covering a hole in a packaging material as well as to a package for packaging of light-sensitive goods.
US11254085B2
Absorbent microstructure panels are described herein. An example filter device includes a plurality of microstructure panels each having a front surface and a back surface, and a plurality of capillary ridges protruding from the front surface. The plurality of capillary ridges are each spaced apart from one another. The plurality of microstructure panels form an absorbent microstructure array by layering the plurality of microstructure panels together such that the plurality of capillary ridges of one microstructure panel contacts the back surface of an adjacent microstructure panel to create capillary tubes that draw fluid into the absorbent microstructure array.
US11254084B2
A plurality of mass-produced identical multi-component housings for toothbrush handles, each housing having a length of about 120-200 mm, which is at least three times greater than a maximal orthogonal dimension thereof. Each housings includes at least a first component made of a first hard-plastic material, a second component made of a second hard-plastic material, and a third component made of a soft-plastic material, which are integrally joined together to form a generally tubular structure. Each housing includes a tolerance-elimination element made of the second plastic material, attached to one of first component's ends, at least partially overmolded by the soft-plastic material, and having an average length of about 3-20 mm, which average length varies among at least some of the tolerance-elimination elements by a lengthwise dimension that is at least ten times greater than the lengthwise maximal dimension variations of the length among the individual multi-component housings.
US11254080B2
Device for the manufacturing a block comprising a locking key and a folded shell that is scored and/or pre-grooved. The device includes a first device that includes at least one shaping device comprising a funnel having corner folding elements and at least a pressing element or a traction element. The at least one shaping device is configured to shape a sheet element into the folded shell so that corner edges of the sheet element are folded inwardly by the corner folding elements and sides of the sheet element assume a vertical position after the pressing or traction element applies a force to a center of the sheet element. A second device is utilized that includes at least a pressing element configured to insert the locking key into said folded shell so as to form said block.
US11254076B2
The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprising the steps of formulating a lens formulation by dissolving/blending all polymerizable components in a mixture a hydrophobic acrylic monomer as a reactive diluent and an organic solvent as a non-reactive diluent at a weight ratio of least 0.24 (reactive diluent over the sum of reactive and non-reactive solvents) per gram of the polymerizable composition and using a relatively low ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.
US11254070B2
A method for producing a high-pressure tank capable of winding a reinforcing fiber bundle around a liner without deteriorating tank performance. The method for producing a high-pressure tank by winding a resin-impregnated strip-shaped reinforcing fiber bundle around a rotating liner so as to form a fiber-reinforced resin layer on the outer surface of the liner includes while winding the strip-shaped reinforcing fiber bundle around the liner, concurrently winding another bundle of fibers narrower than the strip-shaped reinforcing fiber bundle around the liner so as to cross the strip-shaped reinforcing fiber bundle.
US11254065B2
A support device for a tubular element, includes a housing part configured to house, during use, the tubular element, and at least a mobile part for guiding and positioning the tubular element and for protecting the housing part. The mobile part is configured to assume at least a first position to access the housing part of the tubular element, in order to easily insert the tubular element into the housing part, and to assume at least a second position to retain the tubular element and to at least partly cover said housing part and the tubular element positioned therein. The mobile part includes a lever for passage from the first position to the second position and drivable by the tubular element during its insertion into the housing part.
US11254062B2
An apparatus for fabricating an elastic nonwoven material generally includes a rotary ultrasonic horn and a rotary anvil positionable in close proximity to the ultrasonic horn. The anvil has a face with a width and a circumferential axis. The face has a plurality of ridges each of which defines a plurality of interspaced lands and notches.
US11254058B2
A three-dimensional printer with improved adjustment mechanisms for calibrating the orientation of the build platform and an extrusion assembly to optimize the accuracy of models deposited on the build platform. The printer includes a frame carrying an extrusion assembly proximate the top, and a carriage within. A build platform is mounted on the top of the carriage. Carriage adjustment mechanisms are provided at at least two corners of the carriage for calibrating the orientation of the build platform with respect to the X-Y plane. An extrusion assembly adjustment mechanism is provided at at least one end of the extrusion mechanism for calibrating the orientation of the extrusion mechanism with respect to the Y-axis. A height adjustment mechanism is provided for translating the carriage within the frame along the Z-axis.
US11254054B2
Printing systems, compositions suitable for the printing system, use of the compositions, methods for additive manufacturing, and exposure systems, all allowing for improved 3D manufacturing of products, include the exposure of layers of photopolymer material by two different wavelengths coming from LEDs.
US11254053B2
A three-dimensional printing system for fabricating a three-dimensional article includes a motorized build platform, a dispensing module, a pulsed light source, an imaging module, a movement mechanism, and a controller. The imaging module receives radiation from the pulsed light source and includes a two-dimensional mirror array. The movement mechanism imparts lateral motion between the imaging module and the build platform. The controller is configured to operate the motorized build platform and the dispensing module to form a layer of build material at a build plane, operate the movement mechanism to laterally scan the imaging module over the build plane, operate the pulsed light source to generate a sequence of radiation pulses that illuminate the mirror array, and operate the mirror array to selectively image the build material.
US11254050B2
The present disclosure provides a 3D printing bottom plate system, including a printing bottom plate and a storage unit for base plates, the printing bottom plate is movable in a direction towards or away from the storage unit for base plates; in the process of the printing bottom plate moving towards the storage unit for base plates, the lowermost one of base plates stored in a stacked manner in the storage unit for base plates slides onto the printing bottom plate; and in the process of the printing bottom plate moving away from the storage unit for base plates, the base plate slid onto the printing bottom plate is driven to a preset working position by the printing bottom plate.
US11254048B2
Additive manufacturing systems and methods used for creating 3D parts from continuous-fiber reinforced composites such as, e.g., carbon-fiber or glass-fiber pre-impregnated tape are provided. The systems and methods lay tape in successive layers and cut each layer according to a 2D slice of a 3D CAD file. During the placement of each piece of tape, a laser welds the tape to other tape, eliminating the need for post-processing of each layer. By utilizing tape instead of large fiber-reinforced sheets, the systems and methods described herein reduce waste compared to known manufacturing techniques.
US11254047B2
A three-dimensional (3D) object production system and methods for 3D printing reactive components to form a thermoset product. The disclosure relates to Use of a 3D printer having a controller comprising one or more processors to print a 3D object. The disclosure also provides a 3D object production system and methods for 3D printing comprising adjusting one or more parameters of an at least one actuator to produce a 3D object based on a reaction rate between reactive components.
US11254037B2
A method of forming a cross-car beam is provided. A composite is melted to form a viscous polymer. The polymer is injected into a mold. Pressurized fluid is injected into the mold to evacuate a portion of the viscous polymer from the mold and to form a channel therethrough. The remaining viscous polymer is cooled within the mold to form a cross-car beam.
US11254029B2
A wafer dividing apparatus for dividing a wafer stuck to an adhesive tape and supported at an opening of a frame into individual chips along a scheduled division line is provided. The wafer dividing apparatus includes a cassette table movable upwardly and downwardly in a Z axis direction, a first carry-out/in unit that carries out the frame from the cassette placed on the cassette table or carry in the frame to the cassette, a first temporary receiving unit including a pair of first guide rails extending in the X axis direction and a guide rail opening/closing portion that increases the distance between the pair of first guide rails, a reversing unit including a holding portion that holds the frame and rotates by 180 degrees to reverse the front and back of the frame, and a transport unit that moves the reversed frame.
US11254027B2
The present invention is directed generally at three-dimensional printing and more particularly to using three-dimensional (3D) printing to produce concrete and concrete-like (i.e. hempcrete) structures. Recently, 3D printing has advanced to the point where it is now possible to 3D print more complex concrete structures, such as homes. Unfortunately, prior art methods of 3D printing concrete structures have numerous drawbacks. For example, many existing systems suffer from excessive mechanical complexity and/or are susceptible to jamming (e.g. caused by dirt getting into delicate mechanisms). Other problems include difficulty with field maintainability, a lack of horizontal and vertical construction scalability, excessive weight and/or difficulty in printing structures on uneven or difficult ground. Also, existing devices are difficult and time consuming to assemble and disassemble in the field, thereby increasing project costs. The present innovation successfully addresses all of these limitations.
US11254025B2
Lumber retrieval systems and methods feed a centrally located saw with a predetermined assortment of boards picked from certain stations distributed at either side of the saw. In some examples, an overhead trolley system carries individual boards in a certain sequence from chosen stations to a board-receiving apparatus. The board-receiving apparatus, in turn, feeds the boards to the saw. The saw then cuts the boards into board segments, which can be used for making prefabricated trusses and wall panels. In some examples, the trolley system has a laser-scanning feature for determining the location of the next-to-pick board while simultaneously transporting the board currently heading to the board-receiving apparatus. In some examples, the trolley system includes two board carriers each of which are dedicated or assigned to certain stations. In some examples, one carrier serves as backup for the other one when one of the carriers is broken or otherwise inactive.
US11254024B2
A method of perforating a web includes: rotating a cylinder comprising a longitudinal cylinder axis and at least one shaped anvil disposed on the cylinder; operatively engaging a support with the cylinder, wherein the support is moveable with respect to the cylinder; positioning a blade disposed on the support so as to cooperate in contacting relationship with the anvil, wherein the blade is substantially parallel to the longitudinal cylinder axis, and wherein at least one of the blade and the anvil comprise a plurality of teeth, and wherein adjacent teeth are separated by a recessed portion; and feeding a web between the cylinder and the support while the blade cooperates in contacting relationship with shaped anvil to perforate the web.
US11254022B1
Disclosed here are shaving razor systems and methods including razor cartridges with a unitary frame having a length and width, a topside and an underside, wherein the unitary frame includes angled joints or bends connecting at least three guards running lengthwise on the unitary frame, the guards separated by at least three gaps in the frame, and at least three blades, affixed to the underside of the guards of the unitary frame, wherein the at least three blades include edges, and wherein the blade edges extend into the gaps in the frame when affixed to the underside of the guards of the unitary frame.
US11254016B2
The present invention relates to a joint mechanism (100), a method for controlling the joint mechanism (100), a multi-arm device (200) including the joint mechanism (100), and a robot. The joint mechanism (100) comprises: a base (4) having a pivot shaft (41); a swinging arm (1) having a first end (11) mounted on the pivot shall (41); a first driving member (2) and a second driving member (3) mounted on the pivot shall (41) for interacting with the swinging arm (1) through magnetorheological fluid; and a first electromagnetic component (22) and a second electromagnetic component (32), configured to change phase state of the magnetorheological fluid. The first driving member (2) and the second driving member (3) can selectively drive tire swinging arm (1) to rotate along a first direction or a second direction.
US11254010B2
A machine tool is disclosed which continues monitoring even when there is an obstacle such as swarf or a cutting fluid between a machining portion to be monitored and a visual sensor. A visual sensor is attached to an in-machine robot which is movable in a machine tool. A controller operates the visual sensor while judging influences of the swarf and the cutting fluid, automatically judges an orientation experiencing less influence, and executes monitoring from an optimum direction.
US11253996B1
A method of manufacturing an electrode assembly includes positioning a layer stack comprising an electrode positioned between an electrode insulator and a support polymer in a vacuum bag, removing air from the vacuum bag thereby vacuum coupling the electrode to the electrode insulator, and removing the layer stack from the vacuum bag, where upon removal of the layer stack from the vacuum bag, the electrode remains vacuum coupled to the electrode insulator and the electrode insulator is in direct contact with the electrode, thereby forming an electrode assembly.
US11253985B2
A cup plug insertion tool comprises a cylindrical base and a cylindrical collet extending from the base and including at least two longitudinal slots that divide the collet into at least two flexible segments adapted to flex radially inward under force, an annular groove formed adjacent the base, the annular groove adapted to allow the flexible segments to flex radially inward, further wherein, the force necessary to flex the flexible segments radially inward is tunable based on a width and depth of the annular groove, a first section defining a circumferential outer diameter and a circumferential inner diameter, a second section defining a circumferential outer diameter that is larger than the circumferential outer diameter of the first section, a tip positioned at the distal end of the collet, and a chamfer formed between the outer diameter of the first section and the tip.
US11253971B1
A method of processing a superabrasive element includes providing a superabrasive element including a polycrystalline diamond table that includes a metallic material disposed in interstitial spaces defined within the polycrystalline diamond table. The polycrystalline diamond table includes a superabrasive face and a superabrasive side surface extending around an outer periphery of the superabrasive face. The method also includes leaching the metallic material from at least a volume of the polycrystalline diamond table to produce a leached volume in the polycrystalline diamond table by (1) exposing at least a portion of the polycrystalline diamond table to a processing solution, (2) exposing an electrode to the processing solution, and (3) applying a charge to the electrode such that a voltage is generated between the polycrystalline diamond table and the electrode and the voltage is applied to the processing solution.
US11253967B2
Provided is a machine tool configured for machining by removing material from an object defining a machining surface and including a removal tool of material from the object and driving means configured to be placed directly in contact with the machining surface and to move said machine tool and, thus, the removal tool, with respect to the object.
US11253966B2
A modular frame structure for a machining center which includes at least one modular unit having a first and a second individual module. Each individual module includes two mutually parallel vertical columns, each one extending parallel to a vertical direction; a pair of first horizontal cross-members, each one extending parallel to a first horizontal direction, each horizontal cross-member of the pair of first cross-members being joined to both columns.
The modular unit further includes two pairs of second horizontal cross-members, each horizontal cross-member parallel to a second horizontal direction that is perpendicular to the first horizontal direction.
US11253960B2
A nozzle with changeable press fit and a method for calibrating a nozzle is described. The nozzle may be used in a nozzle/flapper type servovalve. The method comprises the steps of providing a nozzle within a cylindrical body defining a cylindrical bore, the nozzle having a tubular shape with an outer cylindrical surface and an inner radial surface, the method further comprises the steps of positioning a first, tubular locking member within the nozzle, and axially moving the first, tubular locking member within the nozzle. The first tubular locking member is configured to cause the nozzle to become positionally fixed at a selected position within the bore in response to the first, tubular locking member being axially moved relative to the nozzle. A nozzle positioning system is also described herein.
US11253958B2
A method of manufacturing a heat exchanger array that includes stacking a plurality of heat exchanger units in an aligned configuration with respective first ports of the plurality of heat exchanger units aligned. The method can further include generating heat in the first coupling elements at the same time and at a temperature sufficient to generate a first plurality of respective couplings between adjacent sheets of adjacent heat exchanger units about adjacent first ports and without a coupling being generated between the first and second sheets of a given heat exchanger unit.
US11253948B2
The invention relates to an ultrasonic oscillating unit that comprises a cylindrical base body having a center axis and a jacket surface into which a plurality of slits are introduced that extend obliquely to the center axis in a side view of the jacket surface.
US11253943B2
Provided is a seam welding device capable of seam welding various shapes of objects to be welded. A seam welding device which performs seam welding by causing electricity to be conducted between a first electrode wheel and a second electrode wheel comprises a first motor which drives the first electrode wheel, a second motor which drives the second electrode wheel, and a first belt provided between the first electrode wheel and the first motor. If a direction joining the axes of the first electrode wheel and the second electrode wheel is defined as a vertical direction, the direction from the first electrode wheel toward the second electrode wheel is upward, and the direction from the second electrode wheel toward the first electrode wheel is downward, then the first motor is disposed further upward than a point of contact of the first electrode wheel and the second electrode wheel.
US11253937B2
The present disclosure relates to generating a modified gear flank geometry on an active surface of the workpiece by generation grinding or honing. In at least one example, the modified gear flank geometry of the workpiece may be generated on the active surface of the workpiece by variation of an engagement depth of a tool into the workpiece in dependence on an angle of rotation of the tool. Additionally, the workpiece may comprise a cylindrical spur gear, a helical gear, a spherical gear, or a conical gear. Further, in one or more examples, the modified gear flank geometry of the workpiece includes at least one of a profile waviness or a defined periodic flank waviness.
US11253934B2
A cutting tool includes: a body extending along a longitudinal axis between a leading and trailing ends, the body having a clamping region disposed at or about the trailing end and a cutting region which extends toward the clamping region from the leading end of the body; a plurality of flutes defined in the body, each extending from the leading end toward the coupling portion; a plurality of peripheral cutting edges, each extending from the leading end toward the coupling portion along a corresponding flute of the plurality of flutes; and a plurality of end cutting edges disposed at the leading end, each end cutting edge extending from at or near the longitudinal axis outward along a corresponding flute. At least one end cutting edge is defined, in-part, by a plurality of rake faces which each extend from a corresponding portion of the one cutting edge into the corresponding flute.
US11253924B2
A control device for a machine tool and a machine tool, for which settings of the number of vibrations per rotation become easy, is provided. The control device of the machine tool controls a relative rotation between a workpiece and a cutting tool and a relative reciprocal movement between the workpiece and the cutting tool in a feed direction to perform vibration cutting to the workpiece. The control device includes a control section for controlling a spindle headstock, a first tool post, and a second tool post, the workpiece W being installed on the spindle headstock, the first tool post being provided to be reciprocally movable along the feed direction with respect to the spindle headstock and installed with a first cutting tool for cutting the workpiece, and the second tool post being provided to be reciprocally movable along the feed direction with respect to the spindle headstock independently of the first tool post and installed with a second cutting tool for cutting the workpiece.
US11253916B2
A method is provided for producing a three-dimensional object that includes an external skin, a 3D mesh enclosed in the skin and having a portion that penetrates at least a part of a thickness of the skin, and an unmelted portion enclosed in the skin. The object is formed from superposed layers each including an outer edge and an inner mesh, with the superposed outer edges forming the skin, and with the superposed inner meshes forming the 3D mesh. Each superposed layer is formed by scanning a powder layer using an energy beam to form micro-connections between grains of the powder without melting the metal powder. First and second melting and solidifying steps are performed using the energy beam to form the outer edge in one of the first and second steps and the inner mesh in the other of the first and second steps.
US11253911B2
The present invention provides a curing agent for casting a water glass, including an ester and an amorphous silicon dioxide obtained by a thermal decomposition of ZrSiO4; and the curing agent for casting the water glass does not contain water. According to the present invention, the curing agent for casting the water glass has a strong adhesion-enhancing effect and a long shelf life, and is easy to use.
US11253907B2
A roll-forming manufacturing method of a roller bearing seal case includes (a) roll-forming, from a cylindrical ring, a first profiled ring having a first section extending along cylinder axis of the cylindrical ring and a second section extending from the first section inward toward the cylinder axis, (b) applying outward pressure to the first section, in direction away from the cylinder axis, to round the first section, and (c) roll-forming a second profiled ring from the first profiled ring.
US11253887B1
A caulking gun is provided, including: a gun body, including a main body, a push mechanism, a driving member movably disposed within the main body and a lever rotatably mounted to the main body to drive the driving member, the push mechanism including a restriction member swingably disposed on the main body and a push rod movably disposed on the main body and disposed through the restriction member; and an adjustment mechanism, mounted to the gun body, being movable to be located in a first position or at least two different other positions; wherein when the adjustment mechanism is located in the first position, the adjustment mechanism contacts the restriction member or the driving member; the adjustment mechanism is distanced by different distances from the restriction member or from the driving member when the adjustment mechanism is located in the at least two different other positions.
US11253885B2
A handheld misting device includes a sonic generator, a power source coupled to the sonic generator, at least one reservoir containing a first liquid, and a conduit from the at least one reservoir. The sonic generator includes a converter and an elongate horn comprising a first horn section coupled to the converter and a second horn section physically connected to and removable from the first horn section. Sonic energy delivered to the first horn section is conducted to the second horn section. The conduit transports liquid from the at least one reservoir to the second horn section to a delivery opening distal the first horn section.
US11253872B2
A dust collecting module for reducing vibration by maintaining a distance between electrodes includes an arrangement of discharge electrodes and dust collecting electrodes alternately disposed and spaced apart from each other, the discharge electrodes configured to be charged to a predetermined voltage for generating a corona discharge between the discharge electrodes and the dust collecting electrodes, at least one dust collecting electrode of the dust collecting electrodes having a first hole; a first hole jig received in the first hole and fixed to the at least one dust collecting electrode, the first hole jig having a larger thickness than the at least one dust collecting electrode; a first tie rod coupled to the discharge electrodes and configured to pass through and fix the discharge electrodes by being fitted into the first hole jig; and a second tie rod coupled to the dust collecting electrodes to fix the dust collecting electrodes.
US11253869B2
The invention relates to a magneto-centrifugal flotation cell for ore concentration which reduces water consumption. A disadvantage of conventional flotation cells is the use of a large amount of water, some flotation cells requiring at least 60% water. The present invention uses ore pulp with increased density and viscosity, owing to the application of an axial magnetic field, wherein the Lorentz force, which is the force exerted by an electromagnetic field that receives a charged particle or an electrical current, can be used. The solution is a cell which, in addition to the forces that usually act on conventional flotation cells, uses external forces which, in principle, produce synergy in the separation of ore particles that have different gravitational and magnetic properties.
US11253867B2
Dry nano-sizing equipment with fluid mobility effect dryly processes viewable fine-grained substances into a nano-sized dimension by high-pressure airflow resulted from a pressure-generating unit, as well as high-speed fluid and high mechanical momentum generated in a pressure cylinder by high-speed rotation of a booster impeller.
US11253865B2
An exemplary aspect encompasses a comminution apparatus for comminution of material to be comminuted which includes a machine frame, a driven comminution roller which is mounted on the machine frame and comminution tools. A comb including counter tools and a comb flap is pivotably mounted on the machine frame, wherein the comminution roller cooperates with the comb for comminution, wherein the comb is pivotably mounted on the comb flap in the range of its upper end, wherein at least one spring means engages the comb with its first end and wherein the comb is resiliently supported via the spring means. In accordance with one aspect the spring means is supported by its second end on the machine frame.
US11253864B2
A comminution device comprises a plurality of first cutting elements having first serrated cutting edges disposed on a first circular path; a second cutting element having a second serrated cutting edge corresponding to the first serrated cutting edges for cutting through cutting material, the second cutting element being displaceable about an axis of rotation on a second circular path concentric with the first circular path. The second serrated cutting edge comprises a plurality of jags and each jag comprises a radially inner flank and a radially outer flank, each at an angle to the axis of rotation. A drive rotationally drives the second cutting element about the axis of rotation and an adjustment mechanism by which the plurality of first cutting elements and the second cutting element are displaceable relative to each other axially in the direction of the axis of rotation, that a cutting gap between them is adjustable.
US11253858B2
A system for processing a sample includes a chamber having at least one inlet and at least one outlet, where the chamber is configured to accommodate flow of the sample from the at least one inlet toward the at least one outlet, and an imager array configured to image the flow of the sample in the chamber, where the imager array includes at least one lensless image sensor configurable opposite at least one light source.
US11253855B2
There is provided an arrangement in a capillary driven microfluidic system for dissolving a reagent in a fluid. The arrangement (200) comprises a channel (102) for receiving a fluid at a first end, a valve (105) arranged at a second end of the channel so as to control a flow of the fluid to stop as it reaches the second end of the channel, and an actuator (108) for opening the valve (105) a predetermined time after receipt of the fluid by the channel (102). The arrangement further comprises one or more structures (106) for holding a dried reagent. The one or more structures (106) each has a width (W2) which is larger than a width (W1) of the channel (102), and the one or more structures are coupled to a side wall of the channel such that the fluid is allowed to enter the one or more structures from the channel, dissolve the dried reagent held therein, and diffuse back into the channel.
US11253853B2
Fluidic devices and methods are provided.
US11253839B2
Shaped porous carbon products and processes for preparing these products are provided. The shaped porous carbon products can be used, for example, as catalyst supports and adsorbents. Catalyst compositions including these shaped porous carbon products, processes of preparing the catalyst compositions, and various processes of using the shaped porous carbon products and catalyst compositions are also provided.
US11253837B2
A composition of matter for selective binding of at least one heavy metal comprising at least one porous metal-organic framework (MOF) with unsaturated coordination sites, at least one organic ligand functionalized with at least one functional group tailored to bind to the at least one MOF, and at least one separate functional group tailored to bind to the at least one heavy metal.
US11253828B2
The invention relates to an additive manufacturing device for the layered production of three-dimensional objects from a polymerizable liquid. The device comprises a trough with a bottom for receiving the liquid, a support platform, on which the object is built up and which is height-adjustable relative to the trough, a structural element having a first and a second side, on which the liquid polymerizes on the first side to form an object layer, and a radiation source which irradiates the second side of the beam-permeable structural element. The structural element is disposed above the upper support platform.
US11253826B2
The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter di of the radially-conveying element. In one embodiment the stirrer according to the invention is a combination of one anchor stirrer with at least one inclined-blade stirrer. Furthermore the use of the stirrer according to the invention for the culture of cells in a dialysis method is described.
US11253824B1
A method for mixing and dispersing an internal phase and an external phase in a liquid compound. The method includes preparing the compound by combining the internal phase of the compound and the external phase of the compound, the external phase of the compound being a liquid, forming a film of the compound by depositing a first volume of the liquid compound on a rotating surface and collecting the film as a dispersed liquid compound on a collection surface.
US11253822B2
A system and method of injecting a gas enriched and/or emulsified first liquid into a second liquid is disclosed. The injection can cause generation of a high density of bubbles having a mean diameter of a selected size. The mean diameter of the bubbles can be selected and varied based on the characteristics of the injection system.
US11253820B2
A lithium extraction composite comprising: (i) a porous support and (ii) particles of a lithium-selective sorbent material coated on at least one surface of the support, wherein the support has a planar membrane, fiber (or rod), or tubular shape. A method for extracting and recovering a lithium salt from an aqueous solution by use of the above-described composition is also described, the method comprising (a) flowing the aqueous source solution through a first zone or over a first surface of the lithium extraction composite to result in selective lithium intercalation in the lithium-selective sorbent material in the first zone or first surface; and (b) simultaneously recovering lithium salt extracted in step (a) from said lithium-selective sorbent material by flowing an aqueous stripping solution through a second zone or over a second surface of the lithium extraction composite in which lithium ions from the first zone or first surface diffuse.
US11253818B2
A method of producing cellulase includes steps (1) to (3): (1) subjecting an aqueous solution of cellulase derived from filamentous fungi to filtration through an ultrafiltration membrane with a molecular weight cut off of 100,000 to 200,000 to obtain a filtrate and concurrently obtain a concentrated enzyme liquid as a retentate; (2) further subjecting the filtrate obtained in step (1) to filtration through a second ultrafiltration membrane with a molecular weight cut off of 5,000 to 50,000 to obtain a second concentrated enzyme liquid as a retentate; and (3) mixing the concentrated enzyme liquid obtained in steps (1) and (2) to obtain cellulase derived from filamentous fungi.
US11253801B2
The prevent invention addresses the problem of providing a filter cloth for a bag filter, which has excellent collection efficiency, has excellent collection efficiency, provides low pressure drop and is resistant to clogging, and also has excellent dust-off ability; a method for producing the same; and a bag filter. As a means for resolution, a nonwoven fabric containing an ultrafine fiber having a fiber diameter D of 200 to 2,000 nm is laminated on a base material to form a filter cloth for a bag filter.
US11253799B2
A filtration device comprising a media basket, a baseplate, and a canister. The media basket is affixed to the baseplate. The canister has a cavity therein and is detachably coupled with the baseplate to enclose the media basket. The media basket contains a porous filtration material that efficiently removes contaminants from liquid. The device is configured to establish a first siphon to convey liquid from outside the device into the canister cavity through a canister pipe when a liquid level outside the filtration device is higher than the top of the weir in the canister pipe and configured to establish a second siphon to convey liquid from canister cavity through the top of a center riser pipe and out an outlet pipe when the first siphon has been established and the liquid level outside the filtration device is higher than the top of the center riser pipe.
US11253795B2
Chromatography apparatus and methods are described, especially for expanded bed adsorption. A column tube has a process fluid input device at the bottom and a movable piston in the top. The piston is enclosed in the column by a cover plate. The piston body has an inflatable seal, and is connected by a frame to a contact ring which carries another inflatable member to contact the tube wall. Process fluid leaves the operating volume through an opening of the piston and flexible hose, through the enclosed space and out through the cover plate. The space above the piston can be pressurised to control piston movement. The contact ring maintains piston alignment. The inflatable seals are used to fix the piston in position, allow it to slide or allow washing. The piston outlet may include a vortex-inhibitor. Bed and piston levels may be monitored by ultrasound sensors.
US11253789B2
A light projection apparatus in the shape of a toy animal includes components that promote a twinkling effect on a display of light through an outer shell. The outer shell includes apertures that together form a pattern in the appearance of a constellation on a surface when light is projected outwardly from inside the apparatus. Light-emitting members are spread apart internally on a surface within the apparatus, and each member has a perforated cover positioned above it to partially block light emitted therefrom. Each cover has either a different pattern and/or a different orientation relative to the light-emitting member it covers, and each member is also configured to slowly brighten and dim, the combination of which creates the twinkling effect when light is projected out through the apertures. Each member's brightening and dimming function may be at predetermined intervals independent of other members, and may also be of a different color, to increase the effect.
US11253787B2
A server system reproduces a past gameplay based on original data in a virtual three-dimensional space and displays the scenes of the gameplay on a user terminal of a live commentary user. Along with this, the server system causes a live commentary object having not existed in the original gameplay to appear in the virtual three-dimensional space in accordance with a live commentary addition operation by the live commentary user, and adds an additional virtual camera (additional camera CM1) to the virtual three-dimensional space to modify the reproduction play of the original gameplay. The server system generates modified reproduction data capable of reproducing a modified reproduction play and manages the modified reproduction data in association with the original data.
US11253784B2
A terminal device includes a timer that can count a time in a virtual game, a memory that stores item information regarding a special item associated with player identification information identifying a player and a time limit in which the virtual game is executable, and a processor that performs processing for starting counting of an execution time of the virtual game on the basis of the timer when receiving an instruction input of start of the virtual game via the input interface, stopping the counting of the execution time when receiving an instruction input for the special item by the player via the input interface, resuming the counting of the execution time when a predetermined condition is satisfied in the virtual game, and terminating the virtual game when the execution time reaches the time limit.
US11253783B2
The invention discloses a pure end-to-end deep reinforcement learning for training car racing game AI bot that uses only the velocity information extracted from screen for both training and testing phases without using any internal state from game environment, such as the car facing angle. The learned AI bot can play better than the average performance of human players. In addition, the reward function is designed to consist only the velocity value, and use Ape-X distributed training framework combined with a variant of Deep Q Network to solve the sparse training signal problem caused by the reward function of an original design. Moreover, limit learner rate method is designed that improves the training efficiency and training performance. The AI bot trained in this way can achieve performance beyond the average human level and reach a level close to professional players.
US11253781B2
Various embodiments are directed towards employing one or more physical sensors arranged on or in proximity to a video game player to obtain biofeedback measures that are then useable to dynamically modify a state of play of a video game. The sensors may be connected or even unconnected to the game player, replace, or otherwise augment traditional physical game controllers. The sensors gather various biofeedback measures and provide such measures to a biofeedback application programming interface (API). Before and/or during video game play, the video game queries the biofeedback API to request inferences about the game player's state of arousal. The response to the query is then used to modify the state of the video game play. Where the video game is a multi-player video game, biofeedback measures from other game players may also be obtained and used to further modify the state of the video game play.
US11253780B2
Provided are a program, a control method, and an information processing apparatus which may provide an improved user interface on which a user may easily and efficiently execute various processes on a game content. The information processing apparatus may be caused to execute a game content specifying step of specifying a selected game content on the basis of first input operation data from an operation unit, a step of retrieving information from a storage unit, a step of specifying a direction from a start point to an end point of a second input operation on the basis of second input operation data from an operation unit, and an execution step of executing one process associated with the direction from the start point to the end point of the second input operation in the information from the storage unit on the selected game content.
US11253778B2
The present disclosure provides method and apparatus for providing content in an electrical game. Current interface information of the electrical game may be obtained. Content associated with the electrical game may be provided in a chat flow based on at least the current interface information.
US11253747B2
A method is provided for detecting at least one fitness related activity is provided. Data is obtained from at least one sensor of a wearable device, wherein the at least one sensor detects the data based on at least one body movement of a user wearing the wearable device. Based on the obtained data, the at least one fitness related activity is detected from a set of fitness related activities, wherein the detection is performed without pre-training by the user for the detecting.
US11253746B2
Handle grip are configured to interface to the end of a bar allowing a user to employ the bar for motion, exercise, stretching or other activity. For example, the handle grips may slip onto the bar under force. The handle grips include a grip section, configured to provide a surface the user can grab. Accordingly, the grip surface may include features that increase the effective friction coefficient. The handle grip also includes an end section configured to react both axial and lateral loads applied by the user via the grip section. The bar can be sectioned, making storage and transport easier. Accordingly, the sectioned bar can be assembly to provide the desired length of exercise bar.
US11253745B2
A chair arm exercise apparatus includes three distinct back positions with hand resistance members such as springs supported from a pair of supports spaced from the upper end of the back. The arm chair includes a base configured to rest on a horizontal floor surface, a seat, a pair of spaced apart trapezoidal shaped upright frame sides, a front upright end wall beneath and supporting a front end of the seat, a seat back pivotally supported from the frame sides behind the seat, and a seat cross member beneath the rear edge of the seat fastened to the frame sides. In a first position the back is at about 90 degrees to the seat. In a second position the back is about 80 degrees to the seat. In the third position the back is reclined.
US11253742B2
A frame lifting mechanism includes a base, a motor, a lead screw, a sliding member, a lifting member and a supporting shaft. The motor is connected to the lead screw, and the lead screw is fastened onto a transmission tube, allowing the transmission tube to move forward and backward while being driven by the lead screw. The sliding member is installed on a sliding track arranged on the base and connected to the transmission tube, allowing the sliding base to actuate with the transmission tube synchronously. A rear end of the lifting base is pivotally attached onto the base for support, and the supporting member uses its two top and bottom ends to be pivotally attached onto the lifting member and the sliding member respectively, allowing the supporting shaft to utilize the movement of the sliding member to drive the lifting member to move upward and downward.
US11253730B2
An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.
US11253724B2
The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.
US11253723B2
An osseointegrated fixture of a percutaneous osseointegrated prosthesis (POPs) anchors directly into a bone of a residual limb within an amputation stump. By anchoring directly into the bone, the POPs provides improved mobility, comfort, and function for an amputee, but an interface between an opening in the skin and the osseointegrated fixture, which allows the anchoring directly into the bone, is prone to infection by microbes. An anti-microbial device can be attached to and/or embedded within an extracorporeal portion of the osseointegrated fixture to irradiate at least a portion on the interface with at least one wavelength of light selected for its antimicrobial effects.
US11253720B2
Dermatological systems and methods for providing a therapeutic laser treatment using a handpiece delivering one or more therapeutic laser pulses to a target skin area along a first optical path, and sensing the temperature of the target skin area based on infrared energy radiating from the target skin area along a second optical path generally counterdirectional to the first office action, and sharing a common optical axis with the first optical path for at least a portion of the first and second optical paths. The handpiece may also provide contact cooling for a first skin area comprising the target skin area.
US11253707B2
Implantable medical systems enter an exposure mode of operation, either manually via a down linked programming instruction or by automatic detection by the implantable system of exposure to a magnetic disturbance. A controller then determines the appropriate exposure mode by considering various pieces of information including the device type including whether the device has defibrillation capability, pre-exposure mode of therapy including which chambers have been paced, and pre-exposure cardiac activity that is either intrinsic or paced rates. Additional considerations may include determining whether a sensed rate during the exposure mode is physiologic or artificially produced by the magnetic disturbance. When the sensed rate is physiologic, then the controller uses the sensed rate to trigger pacing and otherwise uses asynchronous pacing at a fixed rate.
US11253706B2
The present disclosure provides systems and methods for selecting contacts for use in deep brain stimulation (DBS). A computing device includes a processor and a memory device communicatively coupled to the processor. The memory device includes instructions that, when executed, cause the processor to apply a spatial filter to local field potential (LFP) recordings for a plurality of contacts of a DBS lead, calculate a power spectral density (PSD) for each contact from the filtered LFP for that contact, calculate a parametric approximation for each PSD, select at least one frequency band based on the parametric approximations, calculate a spectral coherency matrix for each of the at least one selected frequency band, and calculate an eigenvector centrality for each spectral coherency matrix to facilitate identifying a contact for stimulation.
US11253705B1
Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Improvements for the treatment of pain are disclosed.
US11253697B2
An integral closure mechanism is described to be used for implantable cuffs of tubular shapes. This mechanism relates to cuffs used to surround internal organ or tissue in animals and human for specific clinical applications or for evaluation purposes in biomedical research. The closure mechanism is designed to provide a safe and reliable way in keeping the cuff in its original dimension around biological tissue, and to assist in surgical implantation by introducing a convenient and less time-consuming method to secure the cuff at the surgical site. To eliminate distortion of the implantable cuff by having an integral closure mechanism, the underlying body tissue is better protected from damages caused by compression of the cuff and from connective tissue overgrowing at the distorted sites. Thus, therapeutic attempts by using implantable cuffs may reach their desired potential in various applications.
US11253694B2
An intracorporeal device is provided for supporting heart function of a patient. The intracorporeal device is configured to be secured across at least two anatomical walls of the heart. The intracorporeal device is configured to be secured to one or more anatomical walls by a connector. The connector is arranged to be positioned across one or more anatomical walls.
US11253689B2
A medical connector is described which is formed by a body having an inlet port, an outlet port through a male luer portion of the body, and a fluid path between the inlet port and the at least one outlet ports. A retractable post extends through the fluid path in the male luer sealing a tip of the male luer thereby closing the fluid path when the connector in not activated. There is a seal between the retractable post and the body that forms a fluid volume within a portion of the cavity. The fluid path passes through the fluid volume. When actuated, the retractable post is forced away from the tip of the male luer, thereby opening the fluid path through the medical connector and decreasing the fluid volume.
US11253688B2
A method of making and using a medical delivery device includes forming a first compartment to contain at least a portion of an activator, where forming the first compartment includes forming a first wall with a first ferrous material such that the first wall disintegrates in response to first electromagnetic radiation received by the first ferrous material. Upon contact, the activator activates one or more molecular nanomachines. The method also includes forming a second compartment adjacent to the first wall of the first compartment to contain the one or more molecular nanomachines. The second compartment includes a second wall that includes a second ferrous material. The second wall is configured to disintegrate and release one or more activated molecular nanomachines into a patient in response to second electromagnetic radiation received by the second ferrous material.
US11253682B1
The present invention discloses a urinary catheter that utilizes balloons to generate a method of urine drainage. The disclosed invention does not implement a traditional drainage port and avoids an exposed catheter tip. Rather, this invention consists of a multi-lumen shaft with a divided tip that generates a horizontal aperture for urine drainage when separated. The invention utilizes retention members that can take the form of multiple expandable balloons or a singular, expandable, central balloon. The balloon element can consists of balloons that are attached separately to each divided tip or one balloon shared with adjacent divided tips so that when the balloon element expands, a communication channel is revealed between the bladder and the central lumen of the shaft, ultimately generating a method of urine drainage.
US11253677B2
An apparatus includes a cannula assembly and a sensor assembly. The cannula assembly includes a proximal end, a distal end, and a first lumen extending from the proximal end to the distal end. The cannula is formed of a rigid material. The sensor assembly includes a sensor and a communication wire. The sensor is fixed to the cannula assembly. The communication wire is in electrical communication with the sensor. The communication wire extends along a length of the cannula assembly exterior to the first lumen.
US11253671B2
The invention relates to an inhaler component for forming a vapor/air mixture or/and condensation aerosol by evaporation of a liquid material and, if appropriate, condensation of the formed vapor, comprising: an electric heating element for evaporating a portion of the liquid material; a wick with a capillary structure, which wick forms a composite with the heating element and automatically supplies the heating element with the liquid material; a carrier plate, preferably a printed circuit board, which carries the composite and on which the heating element is electrically contacted; a capillary gap formed at least partially by the carrier plate and automatically supplying the composite with the liquid material, by means of an end portion of the wick extending into the capillary gap; a liquid container which contains the liquid material and from which the capillary gap draws the liquid material. In order to achieve a compact overall arrangement, it is proposed that the capillary gap at least partially covers the liquid container on the outside, in a view perpendicular to the carrier plate.
US11253668B2
FIGS. 1-16D & 66A-92D disclose a large variety of methods of forming the headgear for use in combination with a breathing apparatus including a unitary plastic core within textile casings. In some configurations, the plastic core material penetrates or bursts-through the textile casing of the straps. Some configurations include over moulding, alignment posts, T-joints and joint housings with injection aperture. FIGS. 17-65 & 93A-94C disclose a large variety of different headgear arrangements including top strap, front strap, rear strap and pairs of straps extending from the mask above and below the ear to meet behind the ear. FIGS. 95-121B disclose a large variety of connectors connecting the headgear assembly to the mask assembly where the headgear, mask and connector form a closed loop the connector is disengaged with the mask assembly.
US11253667B2
A cushion member (10) for a mask structured to be worn on a face of a user. The cushion member includes a cushion portion (12) having a sealing portion (13) and a body portion (14) extending from the sealing portion, the sealing portion being structured to engage the face of the user; and at least one mesh member (22) embedded in at least one of the sealing portion and the body portion.
US11253662B2
An electronic cigarette, including an atomization assembly and a battery assembly. The atomization assembly includes a mouthpiece, a first sealing ring sealing the mouthpiece, an insulating gasket, a first fixing ring fixing the insulating gasket, a mouthpiece holder, a second sealing ring sealing the mouthpiece holder, an observation tube, a cover, an e-liquid chamber, O-rings, a seal plug, a piece of cotton, a heating wire, a limit cover, an insulation ring, and a joint. The atomization assembly includes a mouthpiece, a first sealing ring sealing the mouthpiece, an insulating gasket, a first fixing ring fixing the insulating gasket, a mouthpiece holder, a second sealing ring sealing the mouthpiece holder, an observation tube, a cover, an e-liquid chamber, O-rings, a seal plug, a piece of cotton, a heating wire, a limit cover, an insulation ring, and a joint.
US11253660B2
An aerosol-generating system includes an aerosol-generating device and at least two consumables. Each consumable includes an aerosol-forming substrate. The aerosol-generating device further includes a device housing comprising at least two receiving chambers, wherein each consumable is accommodated in a separate receiving chamber of the at least two receiving chambers. The aerosol-generating device further includes at least two mouthpieces, wherein each mouthpiece of the at least two mouthpieces is aligned with a separate consumable of the at least two consumables and wherein the aerosol-generating device is configured to isolate airflows through separate, respective mouthpieces of the at least two mouthpieces.
US11253654B2
An injection device (1) for the delivery of medicament has an indicator (50) for providing an end of dose indication. The device comprises a housing (10), an extendable plunger (40), an actuation mechanism (30), a trigger arrangement (15), and an indicator (50). The extendable plunger (40) comprises a leading portion (42) and a trailing portion (48) configured to allow the plunger (40) to extend from an initial length to a maximum extended length, the plunger portions ((42),48) being slidably mounted within the housing (10). The actuation mechanism (30) is configured to move the leading portion (42) of the plunger (40) forwardly relative to a syringe (20) so as to express medicament from the syringe (20). The trigger arrangement (15) is moveable in use to release the actuation mechanism (30). The indicator (50) is responsive to the forward movement of the plunger (40) and is configured to provide an audible and/or tactile and/or visual indication of the end of dose when the plunger (40) reaches or approaches its forwardmost position.
US11253650B2
An electrical information device and a medicament delivery device are presented. The electrical information device includes at least one start of delivery sensor configured to detect a distal axial movement of a release member of the medicament delivery device. The release member is configured to be distally moved when an activator member of the medicament delivery device 1 is forced distally. The electrical information device also includes at least one information communication unit, which is configured to communicate information related to the medicament delivery. The electrical information device further includes at least one activation unit, which is configured to activate the at least one information communication unit based on a detected distal axial movement of the release member.
US11253646B2
Systems and methods are provided for injecting one or more agents into tissue within a patient's body. In one embodiment, an injection device is provided that includes an outer tubular member comprising a proximal end, a distal end sized for introduction into a patient's body, and a lumen extending between the proximal and distal ends; a relatively small cross-section needle tip extending distally beyond the distal end, and an internal pressure release member slidably disposed within the lumen between a distal position and a proximal position to prevent viscous injectate from expressing from the distal tip.
US11253634B2
This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.
US11253632B2
A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and/or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.
US11253629B2
A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).
US11253627B2
An embolic material contains at least one type of polymer and a liposoluble contrast medium. A method for producing an embolic material includes extruding a raw material that is in a molten state into a solvent, and cooling the raw material so as to solidify the raw material. The raw material contains a polymer and a liposoluble contrast medium.
US11253610B2
Anti-lymphoma plant virus particles are described. The anti-lymphoma plant virus particles include a filamentous or rod-shaped plant virus particle linked to an antimitotic agent. A therapeutically effective amount of an anti-lymphoma plant virus particle can be administered to a subject to provide a method of treating lymphoma.
US11253609B2
Methods of treating cancer are provided that include administering glycan-interacting antibodies. Included are anti-sialyl Tn antigen antibodies and related compositions and formulations suitable to achieve desirable bioactivity, bioavailability, and toxicity levels.
US11253606B2
The present invention relates to combination therapy with drugs, such as microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or PI3K inhibitors, with antibodies or immunoconjugates against HLA-DR or Trop-2. Where immunoconjugates are used, they preferably incorporate SN-38 or pro-2PDOX. The immunoconjugate may be administered at a dosage of between 1 mg/kg and 18 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg, more preferably 8 or 10 mg/kg. The combination therapy can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Preferably, the combination therapy has an additive effect on inhibiting tumor growth. Most preferably, the combination therapy has a synergistic effect on inhibiting tumor growth.
US11253603B2
Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
US11253589B2
Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.
US11253585B2
Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
US11253581B2
The present disclosure relates to a composition for preventing and treating Mycoplasma synoviae infection, the composition comprising Tuf, NOX, MS53-0285 or a combination thereof as active ingredients. The composition of the present disclosure is effective in alleviating symptoms caused by Mycoplasma synoviae infection and can be used as an effective tool in preventing or treating poultry diseases.
US11253580B2
Disclosed are compositions, methods, and kits for treating a cancer or pre-cancer. In particular, the invention generally relates to cancer vaccines as well as methods of delivering the vaccines. Combination treatments including the vaccines in combination with immunomodulatory agents are also contemplated.
US11253577B2
The present invention relates to, inter alia, safe and effective doses of a beta-lactamase for, e.g. microbiome protection.
US11253571B2
The present invention provides a prophylactic or therapeutic agent for a kidney disease, comprising Apoptosis Inhibitor of Macrophage (AIM) or a partial peptide thereof, or a nucleic acid comprising a base sequence encoding the same, or a screening method for a prophylactic or therapeutic agent for a kidney disease, comprising using an animal obtained by subjecting a non-human mammal deficient in AIM expression to unilateral ureteral obstruction or transient kidney ischemia/reperfusion and the like.
US11253570B2
The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-κB-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subject for developing a NF-κB-associated postnatal inflammatory disorder.
US11253568B2
Methods are provided for treating a subject with cancer, with a therapeutic dose of annexin V to the subject.
US11253560B2
The present disclosure relates to modified vaccinia Ankara (MVA) virus or MVAΔE3L delivered intratumorally or systemically as an anticancer immunotherapeutic agent, alone, or in combination with one or more immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to mobilizing the host's immune system to mount an immune response against the tumor.
US11253553B1
The present invention relates to a composition for improving cognitive ability, and preventing or treating dementia and a hyperactivity disorder, which includes a Galla rhois extract and fraxin as active ingredients. It was identified that the composition including the Galla rhois extract and fraxin significantly improves cognitive memory in an Alzheimer's disease model induced by Aβ (1-42) administration and an APPswe/PS1dE9 double-expressing Alzheimer's disease model, and inhibits the generation of amyloid plaques, suggesting the usefulness of the combination of the Galla rhois extract and fraxin, as a therapeutic material, against Alzheimer's disease, and showing that the combination of the Galla rhois extract and fraxin is able to be used as a therapeutic agent for ADHD.
US11253546B2
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
US11253542B2
Methods of treating viral infections. At least one example embodiment is a method including: measuring a core temperature of a human patient; testing the human for the presence of a virus that causes disease; responsive to the human having both fever and presence of the virus, submerging at least a trunk and legs of the human in water comprising a surfactant, the human at least partially submerged in the water for a treatment period of at least three hours; and controlling a temperature of the water during the treatment period.
US11253532B2
An object of the present invention is to provide a composition for stimulating an increase in an androgen. The composition for stimulating an increase in an androgen contains compound K. The composition for stimulating an increase in an androgen contains a fermentation product and/or enzymatically degraded product of ginseng as an active ingredient.
US11253526B2
Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.
US11253523B2
The present invention relates to oral sustained release formulations of tofacitinib and pharmaceutical acceptable salts thereof. The formulations described herein have desirable pharmacokinetic characteristics.
US11253517B2
Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.
US11253513B2
Described herein is a method of administering injectable cetirizine or levocetirizine including intravenously injecting a mammal in need thereof with a therapeutically effective amount of an injectable cetirizine or levocetirizine composition, wherein the mammal receives a maximum daily dose of the cetirizine or levocetirizine that is no more than 15 times a maximum recommended daily clinical dose for the mammal.
US11253512B2
A opioid taper regimen, and its method of manufacture, for use in a method of opioid reduction leading to abstinence. Said regimen is administered within the range of 2 to 4 years, or more. The regimen comprises novel approaches to common problems encountered during tapers of low dose opioid addiction. The reduction regimen is generally linear; reduces the dosage level once per week; doses every six hours; reduces doses by steps in the range of about 0.001 to 0.0500 mg; has, near the end, ten weeks of doses of about 0.0025 mg buprenorphine q.i.d.; followed by four or more weeks of placebos. Instructions for manufacture of doses that differ by 0.0025 mg and 0.0050 mg buprenorphine are specified.
US11253507B2
Methods of preventing or delaying onset of myopia in pre-myopic patients and also methods of reducing or preventing progression of myopia in patients having low myopia through the use of compositions comprising less than 0.025% of atropine are disclosed.
US11253506B2
The present invention includes compounds, compositions and methods for treating and/or preventing chlorine inhalation toxicity and/or injury in a subject subjected to chlorine inhalation.
US11253496B2
Provided herein are nutritional, or therapeutic, compositions and methods of use in primarily treating kidney patients suffering from low serum albumin. The compositions are divided into four formulations, comprising: 1) the magnesium salt and/or the calcium salt of the alpha keto acids of: α-leucine, α-valine, α-isoleucine, α-phenylalanine, α-hydroxy methionine; and/or α-tryptophan, and/or α-tyrosine; 2) L-lysine monoacetate, L-threonine; and/or 3) histidine, tryptophan, and tyrosine, as amino acids or base acids. The specific formulation administered depends in part upon which stage 2-5 of renal disease the patient has. The invention further comprises methods of treatment of disorders associated with low serum albumin using the composition as an over-the-counter pill. The patient's serum albumin is tested on a periodic basis and the selected composition and dose are adjusted accordingly. And the invention comprises method of making α-leucine, α-valine, α-isoleucine, a-tyrosine and α-tryptophan in a multi-step process.
US11253494B2
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant administration of an MCT inhibitor, such as diclofenac, valproate, or ibuprofen, will affect GHB administration. For example, it has been discovered that diclofenac lowers the effect of GHB in the body, thereby potentially causing an unsafe condition. Furthermore, it has been discovered that valproate increases the effect of GHB on the body, thereby potentially causing an unsafe condition.
US11253487B2
The present invention provides a method for safe and efficacious administration of esketamine.
US11253483B2
A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.
US11253482B2
The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
US11253481B1
Provided are a self-nanoemulsifying 3D printer ink composition and a method of using such composition to manufacture a 3D-printed tablet having compartmentalized active pharmaceutical ingredients. In particular, the 3D-printed tablet composition includes glimepiride and/or rosuvastatin in a curcuma oil based self-nanoemulsifying drug delivery system (SNEDDS).
US11253480B2
A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent is a histone deactylase inhibitor.
US11253477B2
A process for obtaining compositions constituted by propolis nanoparticles is disclosed. The nanoparticles are optionally associated to a substance of interest such as active ingredients, and, optionally, substances of secondary effect such as synergists and adjuvants. The process includes preparing a fraction A, which consists of propolis extract dissolved in an organic solvent, to which stabilizer and/or emulsifier may be added, and, optionally, substances of interest and/or of secondary effect; ii) preparing a fraction B, aqueous phase, constituted by: (ii.1) water; or (ii.2) an aqueous solution or dispersion, to which stabilizer and/or emulsifier may be added; (iii) dropping the fraction A onto the fraction B or vice versa; iv) homogenizing the mixture by stirring and spontaneous formation of nanoparticles with average size from 1 to 1000 nm in a dispersion; and v) optionally (v-1) removing organic solvent and/or (v-2) drying the nanodispersion.
US11253475B2
Dental treatments and methods, including treating gum disease, using peroxide gel and a viscous antibacterial agent including tetracycline to chemically debride and curettage a treatment area. Treatments and methods include non-surgically scaling and root plaining the treatment area with dental tools such as periodontal scalers and/or curettes during the active period of the chemical debridement. The working surfaces of dental tools can be sharpened for optimal root and tooth surfacing during treatment. Treatment can include instructions for co-therapy by or on behalf of treatment subjects between visits and for maintenance care.
US11253474B1
Disclosed herein is a liquid pharmaceutical formulation substantially free of water, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. Also disclosed herein is a liquid pharmaceutical formulation substantially free of water and ethanol, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin.
US11253473B2
The present invention relates to a method of producing a tableted chewing gum composition for oral administration of cannabinoids, the method comprises the steps of: i) feeding a gum composition comprising water-insoluble gum base into an extruder from one or more feeding inlets, optionally including additional ingredients, ii) pressurizing the gum composition in the extruder while controlling temperature and pressure of the gum composition, optionally including further ingredients from one or more feeding inlets, iii) extruding the gum composition through a die means, iv) cutting the extruded gum composition in a liquid filled chamber, thereby obtaining a first population of particles comprising water-insoluble gum base, v) including the first population of particles with a second population of particles comprising water-soluble chewing gum ingredients and one or more cannabinoids, the second population of particles being free of water-insoluble gum base, thereby obtaining a chewing gum composition and vi) tableting the chewing gum composition in a tablet pressing apparatus, thereby obtaining a tableted chewing gum composition.
US11253471B2
A rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 contains Pulsatilla chinensis (Bge.) Regel saponin B4 and a pharmaceutically acceptable substrate. The drug preparation is a rectal gel or a rectal suppository. Compared with oral administration, the rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 has a lower effective dose, and has a better medicinal effect at the same dose.
US11253470B2
An object of the present invention is to provide a composition for external use having excellent percutaneous absorption properties. A composition for external use comprising a water-soluble fraction dispersed in an oily phase, wherein the water-soluble fraction contains a surfactant and a solution in which a water-soluble substance is dissolved in water, and the content of the water in the water-soluble fraction is 0.1 to 2.5% by weight based on the composition for external use.
US11253459B2
The present invention relates to a composition for dyeing keratin fibers, comprising at least (i) one or more copolymers derived from the polymerization of at least one crotonic acid monomer or crotonic acid derivative and of at least two different vinyl ester monomers, (ii) one or more thickening polymers bearing (meth)acrylic acid unit(s), and (iii) one or more pigments. The invention also relates to a dyeing process in which said composition is applied to keratin fibers, the operation optionally being followed by drying. The composition makes it possible to obtain temporary dyeing having the advantage of forming a transfer-resistant deposit, leaving the treated fibers individualized, with an improved cosmetic feel.
US11253446B2
Disclosed herein are oral care compositions comprising: a) one or more pyrophosphate compounds, wherein the total concentration of pyrophosphate compounds in the composition is 0.5 wt % to 1.5 wt %, based on the weight of the oral care composition; b) one or more thickening gums, wherein the total concentration of thickening gums in the composition is 1.25 wt % to 1.6 wt %, based on the weight of the oral care composition; and c) a metal ion source.
US11253440B2
A moldable gel cleanser comprising a carrageenan, a source of potassium and a glycol is disclosed.
US11253437B2
Oxidation dyeing process using a substrate bearing at least one oxidation dye, several preservatives and an oxidizing aqueous composition The present invention relates to a process for the oxidation dyeing of keratin fibres, in particular human keratin fibres such as the hair, comprising a step of application, to said keratin fibres, i) of a substrate comprising on its surface one or more oxidation dyes, one or more thiolated reducing agents and one or more organic reducing agents of reductone type, and a step of application, to said keratin fibres, ii) of an oxidizing aqueous composition comprising one or more oxidizing agents. The present invention also relates to a process for preparing said substrate. The invention also relates to an element in sheet form, pretreated by a composition comprising one or more oxidation dyes, one or more thiolated reducing agents, and one or more organic reducing agents of reductone type.
US11253432B1
To address the widespread problem of half of all patients failing to take prescribed medications as directed by their physicians, the present inventor devised, among other things, one or more medication reminders. For example, one embodiment, particularly suitable for only two- or three-a-day prescriptions, comprises a repositionable indicator mechanism that attaches via a self-adhesive microsuction backing to the top or other surface of a plastic prescription medication bottle. The indicator, which can take the form of a slider that moves between two or three indicator positions, in some cases using a detent locking mechanism, to simultaneously indicate the prescribed dosage frequency, last dosage taken, and remaining dosages for a day.
US11253431B2
A vial cap is configured to releasably contain a portion of a material, for example a powdered medication, for dispensing into a container. Via operation of a depressable plunger, the material is released into the container for rehydrating and mixing with a liquid, and thereafter may be extracted, such as via a needle. In this manner, a rehydrated medication may be provided in a predetermined amount and at a desired time.