-
公开(公告)号：AU2003282800A1
公开(公告)日：2004-04-08
申请号：AU2003282800
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： SZCZEPANKIEWICZ BRUCE G , MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , FEENSTRA MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D
IPC: A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12 , C07D207/00
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
-
公开(公告)号：PL343678A1
公开(公告)日：2001-08-27
申请号：PL34367899
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
-
公开(公告)号：BG104962A
公开(公告)日：2001-07-31
申请号：BG10496200
申请日：2000-11-17
Applicant: ABBOTT LAB
Inventor： MARING CLARENCE J , GU YU-GUI , CHEN HUI-JU , CHEN YCANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GIRANDA VINCENT L , GRAMPOVNIK DAVID J , KATI WARREN M , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , LIN ZHEN , MADIGAN DAROLD L , MCDANIEL KEITH F , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , STOLL VINCENT S , SUN MINGHUA , WANG GARY T , WANG SHELDON , XU YIBO , YEUNG MING C , ZHAO CHEN , KENNEDY APRIL
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminodase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. 56 claims
-
公开(公告)号：CZ467099A3
公开(公告)日：2000-08-16
申请号：CZ467099
申请日：1998-07-24
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: A61K31/47 , A61P19/02 , A61P29/00 , A61P35/00 , C07C251/00 , C07D471/00
-
公开(公告)号：SK174899A3
公开(公告)日：2000-06-12
申请号：SK174899
申请日：1998-07-24
Applicant: ABBOTT LAB
Inventor： GEYER ANDREW G , MCCLELLAN WILLIAM J , ROCKWAY TODD W , STEWART KENT D , WEITZBERG MOSHE , WENDT MICHAEL D
IPC: C07D295/08 , A61K31/155 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/5375 , A61P15/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07C259/18 , C07C271/22 , C07C271/30 , C07C271/66 , C07C275/40 , C07C275/42 , C07C275/64 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/47 , C07C323/56 , C07C323/62 , C07D207/08 , C07D207/337 , C07D209/08 , C07D213/56 , C07D213/58 , C07D213/74 , C07D213/75 , C07D215/38 , C07D217/02 , C07D231/12 , C07D231/40 , C07D231/56 , C07D237/20 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/54 , C07D239/545 , C07D241/18 , C07D241/20 , C07D261/08 , C07D261/14 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/42 , C07D277/44 , C07D295/092 , C07D303/46 , C07D307/16 , C07D307/18 , C07D307/54 , C07D307/64 , C07D317/58 , C07D317/66 , C07D317/68 , C07D333/24 , C07D405/12 , C07D521/00 , C07C249/00 , A61K31/136
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
-
Patent Agency Ranking
公开(公告)号：CA2329422A1
公开(公告)日：1999-10-28
申请号：CA2329422
申请日：1999-04-12
Applicant: ABBOTT LAB
Inventor： MADIGAN DAROLD L , LIN ZHEN , KRUEGER ALLAN C , MARING CLARENCE J , DEGOEY DAVID A , XU YIBO , YEUNG MING C , FLOSI WILLIAM J , ZHAO CHEN , KENNEDY APRIL , MUCHMORE STEVEN W , STEWART KENT D , KEMPF DALE J , SHAM HING L , GRAMPOVNIK DAVID J , STOLL VINCENT S , KATI WARREN M , WANG GARY T , GU YU-GUI , SUN MINGHUA , WANG SHELDON , MCDANIEL KEITH F , GIRANDA VINCENT L , KLEIN LARRY L , CHEN YUANWEI , CHEN HUI-JU
IPC: A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/5377 , A61P31/16 , A61P43/00 , C07D207/16 , C07D207/32 , C07D207/325 , C07D207/327 , C07D401/12 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/572 , A61K31/40 , C07D407/04
Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
-
公开(公告)号：CA2238977A1
公开(公告)日：1997-06-19
申请号：CA2238977
申请日：1996-12-06
Applicant: ABBOTT LAB
Inventor： SHAM HING LEUNG , STEWART KENT D , KEMPF DALE J
IPC: C07D253/06 , A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/505 , A61K31/513 , A61P31/00 , A61P31/18 , C07D207/26 , C07D207/27 , C07D207/40 , C07D207/404 , C07D207/408 , C07D233/32 , C07D233/36 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D263/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , A61K31/53
Abstract: Inhibitors of HIV protease are provided. When bound to HIV protease, the inhibitors are characterized by a unique three-dimensional conformation and orientation relative to the S1, S1', S2, S2', S3, and S3' subsites of the protease. Pharmaceutical compositions containing the inhibitors and methods of treating HIV infection are also provided.
-
公开(公告)号：ZA201204224B
公开(公告)日：2015-12-23
申请号：ZA201204224
申请日：2012-06-08
Applicant: ABBOTT LAB
Inventor： LOU XIAOCHUN , ZHANG GEOFF G Z , KOTECKI BRIAN J , HANGEVELD JOHN E , GAO YI , CHEN SHUANG , BETEBENNER DAVID A , DONNER PAMELA L , HUANG PEGGY P , KATI WARREN M , LIU YAYA , MARING CLARENCE J , PRATT JOHN K , ROCKWAY TODD W , TUFANO MICHAEL D , LIU DACHUN , SARRIS KATHY , HENRY RODGER F , HAIGHT ANTHONY R , FRANCZYK II THADDEUS S , BARNES DAVID M , DEGOEY DAVID A , FLENTGE CHARLES A , HUTCHINSON DOUGLAS K , KRUEGER ALLAN C , LONGENECKER KENTON L , MOTTER CHRISTOPHER E , RANDOLPH JOHN T , STEWART KENT D , WAGNER ROLF
Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; and (e) use of such compounds, salts, and compositions.
-
公开(公告)号：BR112012013349A2
公开(公告)日：2015-09-15
申请号：BR112012013349
申请日：2010-12-01
Applicant: ABBOTT LAB
Inventor： ERICSSON ANNA M , LI BIQIN C , FIAMENGO BRYAN A , CALDERWOOD DAVID J , GEORGE DAWN M , GOEDKEN ERIC R , WALLACE GRIER A , VOSS JEFFREY W , STEWART KENT D , WOLLER KEVIN R , FRANK KRISTINE E , WANG LU , ARGIRIADI MARIA A , FRIEDMAN MICHAEL , MORYTKO MICHAEL J , JOSEPHSOHN NATHAN S , WISHART NEIL
IPC: A01N43/58
Abstract: novos compostos tricíclicos. a invenção fornece compostos da fórmula (i) e fórmula (ii) sais automáticamente aceitáveis, pró-fármacos, metabólitos biologicamente ativos, estereoisômeros e isômeros dos mesmos, em que as variáveis são definidas neste relatório. os compostos da invenção são úteis para tratar condições imunológicas e oncológicas.
-
公开(公告)号：CY1110361T1
公开(公告)日：2015-04-29
申请号：CY071101364
申请日：2007-10-23
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: ΗπαρούσαεφεύρεσησχετίζεταιμεενώσειςτουτύπουΙ οιοποίεςαναστέλλουντηνδιπεπτιδυλικήπεπτιδάση IV (DPP-IV) καιείναιχρήσιμεςγιατηνπρόληψηή τηναγωγήτουδιαβήτη, ειδικάτουδιαβήτητύπουΙΙ, όπωςεπίσηςτηςυπεργλυκαιμίας, τουΣυνδρόμουΧ, τηςυπερινσουλιναιμίας, τηςπαχυσαρκίας, τηςαθηροσκλήρωσης, καιδιαφόρωνανοσορρυθμιστικώννόσων. Ήφαρμακευτικώςαποδεκτάάλαταή προφάρμακααυτών, όπουτα X, R, R1, R2 και R3 έχουντουςορισμούςπουδίνονταιστηνπεριγραφή.
-
-
-
-
-
-
-
-
-
Search Results
151
records
(took 0.022 seconds)
