US10023952B2
A coated cutting tool and a hard and wear resistant coating for a body include at least one metal based nitride layer. The layer is (ZrxCrl-x-y-zAlyMez)Na with 0.55
US10023948B2
Endodontic instruments for use in performing root canal therapy on a tooth are disclosed. In one form, the instruments include an elongate shank having a cutting edge extending from a distal end of the shank along an axial length of the shank. The shank comprises a titanium alloy, and the shank is prepared by heat-treating the shank at a temperature above 25° C. in an atmosphere consisting essentially of a gas unreactive with the shank. In another form, the endodontic instruments have an elongate shank having a cutting edge extending from a distal end of the shank along an axial length of the shank. The shank consists essentially of a titanium alloy selected from alpha-titanium alloys, beta-titanium alloys, and alpha-beta-titanium alloys. The instruments solve the problems encountered when cleaning and enlarging a curved root canal.
US10023942B2
A titanium alloy, components formed thereof, and methods of use are provided. Embodiments of the alloy may be useful in the energy extraction environment. Components formed of the alloy may include subsea or land-based components associated with oil and gas production and drilling.
US10023933B2
A galvannealed steel sheet having a galvanized layer on a surface thereof is provided, having a composition which contains C: 0.10% to 0.35%, Si: 0.3% to 3.0%, Mn: 0.5% to 3.0%, P: 0.001% to 0.10%, Al: 0.01% to 3.00%, and S: 0.200% or less on a mass basis, the remainder being Fe and incidental impurities. The steel sheet has a SiC/SiO2 ratio of more than 0.20, the SiC/SiO2 ratio being a ratio of SiC amount to SiO2 amount at a depth of 1 μm or less in the steel sheet from an interface between the steel sheet and the galvanized layer, and Fe in the galvanized layer constitutes 8% to 13% by mass.
US10023930B2
A method of manufacturing a high strength stainless steel tube or pipe includes using an online heat treatment equipment line for a seamless steel tube or pipe in which a heating furnace for quenching, equipment for quenching, and a tempering furnace are used in the lower process of a rolling line, arranging cooling facilities capable of cooling a heat treated steel tube or pipe to a temperature of 20° C. or lower between the equipment for quenching and the tempering furnace, and cooling the heat treated steel tube or pipe to a temperature of 20° C. or lower before a tempering treatment is performed.
US10023927B2
A hardening tool is disclosed for producing hardened profiled shaped articles from a sheet steel material, which hardening tool has at least two tool parts which are movable relative to one another and between which a heated sheet steel material which has been preformed into a profiled shaped article and is optionally finally formed and is cooled in a hardening process, wherein the hardening tool has a mold core which, during the hardening process, is arranged in a recess of the profiled shaped article, and wherein the mold core has at least one outlet opening for the pressurization of cooling medium from a cooling medium duct on the profiled shaped article.
US10023921B2
The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize TC1507 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
US10023916B2
Compositions and methods for determining circulating biomolecules before, during, and/or after treatment of a patient with an anti-cancer or anti-tumor drug (or putative drug) are described. Methods of treatments based on the compositions and methods described herein are also provided. Noninvasive methods and kits are provided for assessing the efficacy of an anti-cancer therapy for killing or damaging cancer cells. Embodiments are used to determine the cancer-killing efficacy of an anti-cancer drug in a patient, to optimize the selection of an anti-cancer drug for treatment of a patient, to adjust the dosage of an anti-cancer drug for treatment of a particular cancer in a patient and for identifying useful anti-cancer therapeutics for any one particular type of cancer.
US10023909B2
The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.
US10023908B2
A method is described for detecting a target nucleic acid, in which the target nucleic acid is amplified in the presence of a proofreading DNA polymerase and an allele-specific reactive primer (ASRP) including (i) a nucleotide sequence complementary to the target nucleic acid and (ii) modified nucleotide(s) located in a region from a nucleotide located right before a non-complementary nucleotide on the 5′-side of the non-complementary nucleotide, so that an amplification product of the target nucleic acid is produced when the ASRP is complementary to the target nucleic acid, and so that when the ASRP is not complementary to the target nucleic acid, an amplification product of the target nucleic acid will not be produced. The detection method has a very high specificity of amplification, and is useful for applications such as detecting mutations, detecting methylation of CpG after bisulfite treatment, and detecting target DNA from a DNA library.
US10023907B2
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular marker.
US10023906B2
Provided in the present invention are a method for constructing a nucleic acid single-stranded cyclic library and reagent kit thereof. The method comprises the steps of using a transposase embedding complex to randomly break nucleic acids and connect a first linker; connecting a second linker at a gap; performing a first PCR reaction, wherein the 5′ end of one of the primers has a first affinity tag, resulting in a product with two ends connected to different linker sequences; binding the product to a solid vector having a second affinity tag; degenerating and separating single strands having no affinity tag; and cyclizing the single strands.
US10023897B2
A biosensor chip is placed in a biosensor device and is rotated while a biochemical analysis specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which the specimen is poured. The holding chamber holds the poured specimen inside the main body. The dispensing chamber is connected to the holding chamber via a first channel and dispenses the specimen. The quantification chambers are connected to the dispensing chamber, hold a specific amount of the dispensed specimen, and are disposed at positions located away from a rotational center of a rotary motion according to a distance from the first channel. The measurement chambers are connected to the quantification chambers via a second channel and react the specimen with a biochemical analysis reagent.
US10023880B2
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
US10023879B2
The invention provides compositions and methods for reprogramming minimal volumes of mononuclear cells. In particular aspects, the invention provides methods and compositions for reprogramming minimal volumes of umbilical cord blood obtained from cord blood segments from cryopreserved cord blood segments.
US10023876B2
Engineered pesticidal polypeptides that are highly active against a wide range of pests and methods of making such polypeptides are disclosed. The nucleotide sequences encoding the pesticidal polypeptide can be used to transform various prokaryotic and eukaryotic organisms, which organisms can be used to produce the pesticidal polypeptides. The recombinant organisms and/or the polypeptides produced by the recombinant organisms can be used to control pests in various environments.
US10023875B2
The present invention relates to a method of increasing resistance against fungal pathogens of the order Pucciniales, preferably the family Phacopsoraceae, in plants and/or plant cells. This is achieved by increasing the expression of an HCP5 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. Furthermore, the invention relates to transgenic plants, plant parts, and/or plant cells having an increased resistance against fungal pathogens, in particular, pathogens of the order Pucciniales, preferably the family Phacopsoraceae, and to recombinant expression vectors comprising a sequence that is identical or homologous to a sequence encoding an HCP5 protein.
US10023873B2
The present invention provides transgenic plants having increased tolerance to cold and altered flowering characteristics. Also provided are methods and compositions for producing said transgenic plants.
US10023868B2
The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
US10023865B2
The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation.
US10023862B2
The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.
US10023860B2
[Object] To provide a method of purifying nucleic acids where the operation is simple and the nucleic acids can be extracted in a short time with high efficiency.[Solving Means] A method of purifying nucleic acids including the step of adsorbing substances in a sample containing nucleic acids with an ion exchange resin 10 including a positive ion exchange resin and a negative ion exchange resin. As the positive ion exchange resin, a first positive ion exchange resin and a second positive ion exchange resin having an exclusion limit molecular weight lower than that of the first positive ion exchange resin may be used.
US10023858B2
A method for elevating a TRAIL-R1 expression in cancer cells to induce apoptosis. The method comprises the steps of receiving electrical energy having a specific voltage, frequency and power from an electrosurgical generator, up-converting the voltage and down-converting the frequency with a high voltage transformer having a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, applying said converted electrical energy to an electrode in an electrosurgical hand piece, flowing an inert gas through said electrosurgical hand piece to produce a cold plasma at a distal end of said electrosurgical hand piece; and applying said cold plasma to cancer cells for 1 to 3 minutes. The inert gas may comprise, for example, helium or argon. In a preferred embodiment the cold plasma is applied to cancer cells for about 2 minutes.
US10023855B2
A fusion protein including N-terminal domain of a fusion partner at N-terminal and C-terminal domain of RET protein at C-terminal, a fusion gene encoding the fusion protein, and a use of the fusion protein or the fusion gene as a diagnosing marker for a cancer, are provided.
US10023851B2
The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having one or more modifications as compared to a parent lipolytic enzyme having at least one improved property. In addition, the present invention provides compositions comprising a lipolytic enzyme variant of the invention. The present invention also provides methods of cleaning using compositions comprising a lipolytic enzyme variant of the invention.
US10023845B2
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
US10023844B2
The present invention aims at establishing a novel means for purifying norovirus VLPs. There is provided a purification method of norovirus virus-like particles, comprising: contacting solution containing norovirus virus-like particles with support for hydroxyapatite chromatography, binding the virus-like particles to the support, subsequently washing the support with buffer, and then eluting the virus-like particles from the support with buffer containing phosphate, wherein the phosphate concentration of the buffer used for elution is less than 10 mM.
US10023841B2
Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.
US10023839B2
A composition for inducing an immune response in a mammal, comprises lymphoid cells in which expression of tumor antigens has been chemically induced. The tumor antigens are induced in proliferating normal lymphoid cells, especially during the log phase of proliferation. The proliferation of the normal lymphoid cells is stimulated by normal mature dendritic cells. Most conveniently, the lymphoid cells are lymphocytes, especially peripheral blood lymphocytes. The tumor antigens are typically cancer/testis antigens, which may be chemically induced by DNA demethylation. Cancer/testis antigens are expressed in a wide range of tumors, so the composition is able to raise an immune response that is effective against a wide range of tumors, despite the fact that it is derived from normal cells. The composition may be used for preparation of an anti-tumor vaccine for prophylactic or therapeutic use. The composition may also be used for ex vivo activation of cytotoxic T lymphocytes, followed by expansion of the cytotoxic T lymphocyte population by normal dendritic cells, for cancer treatment by adoptive T cell immunotherapy.
US10023836B2
In order to provide a culture medium eliminating variation by lot of component concentrations, the present invention provides a culture medium, and preferably a chemical-synthetic culture medium, imparting a proliferation ability to yeast that is equivalent to or greater than that of a YPD culture medium. A culture medium is provided which includes sugars as a carbon source capable of being assimilated by yeast; amino acids as a nitrogen source; vitamins; inositol; zinc ion (Zn2+); potassium ion (K+), and magnesium ion (Mg2+), and in which inositol concentration is between 50 and 10,000 mg/L.
US10023830B2
Systems and methods are disclosed for continuously optimizing the profile of an aqueous culture comprising microorganisms. The systems and methods comprise a controlled environment comprising a housing enclosing a lighting device and controlled temperature environment, and sensor modules for measuring culture and environment parameters. The sensor modules may be in communication with an automated computer control system to continuously optimize the microorganism culture profile.
US10023820B2
A device includes a gasifier to produce a gaseous compound from a biomass. The gasifier includes inlets for the biomass and for an oxidizing agent and an outlet for the gaseous compound including carbon monoxide. A first methanation unit to methanate the carbon monoxide to produce a substitute natural gas exiting the gasifier. The first methanation unit includes at least one inlet for water and an inlet for the gaseous compound coming from the gasifier. A second methanation unit to methanate the carbon dioxide to produce the substitute natural gas. The second methanation unit includes at least one inlet for water and one inlet for the carbon dioxide from the first methanation unit. A dihydrogen producing unit to produce dihydrogen from water and electric current. The dihydrogen producing unit includes an electrical power supply, an inlet for water and an outlet for dihydrogen supplying the second methanation unit.
US10023819B2
The invention relates to quaternary ammonium amide and/or ester salts and their use as additives, including their use in fuels, such as diesel fuel. The invention particularly relates to the use of quaternary ammonium amide and/or ester salts as detergents in diesel fuels.
US10023817B2
The present invention relates to a gasification process for efficiently co-producing synthesis gas and high-grade coal from water-containing coal, and to an integrated drying and gasification system for realizing the same.
US10023807B2
A method for treatment of a carbonaceous feedstock such as coal or biomass. The method comprises adsorbing an oxidizing agent selected from an oxygen-containing gas, hydrogen peroxide, ozone and oxidizing acids from a liquid phase of an aqueous mixture comprising water and the carbonaceous feedstock onto the carbonaceous feedstock to produce an aqueous mixture with the liquid phase having a reduced content of the oxidizing agent and the carbonaceous feedstock having oxidizing agent adsorbed on a surface thereof, and heating this aqueous mixture to a temperature and for a sufficient time to partially oxidize and solubilize at least a portion of the carbonaceous feedstock. The reaction products may be chemically or physically separated, recycled to the heating step and/or subjected to microbial digestion in order to generate one or more desirable products from the carbonaceous feedstock. The solid portion of the reaction products may be further processed to be used in the paper industry.
US10023804B2
A system and method of converting tires or other solid carbon based material is disclosed, including providing a chamber, feeding the solid carbon based material into the chamber, rotating the chamber, heating and reducing the material in the chamber, collecting solid residue from the chamber, collecting vapor from the chamber, and converting vapor collected from the chamber to a liquid. In an embodiment, the material includes a whole tire. The tire is heated in the chamber causing the tire to collapse and liquefy, exposing the metal in the tire which aids in grinding the carbon material in the tire as it tumbles, collecting solid residue, for example tire carbons, and collecting vapor, for example vaporized oil, and benzene and methane gas from the chamber and converting the oil. The chamber may be heated to a temperature from about 350° F. to about 1100° F. using gases reclaimed from the material.
US10023803B2
Solid fuel in the form of particles is supplied to a pyrolyzer, and pyrolysis conditions are maintained in the pyrolyzer for separating condensable gaseous substances from the fuel. Heat required by the pyrolysis conditions is supplied at least partly with solid fluidized bed material which passes through the pyrolyzer simultaneously as it is fluidized by fluidizing gas in the pyrolyzer. Condensable gaseous substances separated from the fuel are conveyed from the pyrolyzer to a condenser, in which they are separated as so-called pyrolysis oil in liquid form, and solid fluidized bed material taken from the pyrolyzer and containing combustible pyrolysis residue originating from the fuel is circulated through a gasifier, in which product gas, which is burnt in a boiler or a kiln, is formed from the pyrolysis residue.
US10023802B2
An alignment film material and a method of producing an alignment film are described. The alignment film material has polyimide and crosslinked polymer. The crosslinked polymer is formed from a first component through a crosslinking reaction. A crosslink density of the alignment film can be enhanced without additionally adding a catalyst, so as to increase a hardness of the alignment film.
US10023789B2
Methods of introducing into a subterranean formation a series of treatment fluids comprising one of micro-proppant particulates, micro-degradable particulates, branch-proppant particulates, branch-degradable particulates, main-proppant particulates, and main-degradable particulates and placing the particulates into portions of microfracture(s), branch fracture(s), and main fracture(s) to increase fracture complexity of a fracture network in the subterranean formation.
US10023778B2
A system and method for treatment of biomass products or residues to obtain valuable adhesives and composite materials is described herein. Some embodiments do not require purification of a biomass product or residue to produce an adhesive. Some embodiments comprise a treatment of post extraction algae residue configured to produce an adhesive. Use of post extraction algae residue adds value to alternative energy produced by extracting oil from algae.
US10023774B2
Disclosed herein is an adhesive composition for clutch disc application comprising of an epoxy resin of bisphenol A and epichlorohydrin, partially hydrogenated carboxylated nitrile butadiene rubber (HX-NBR) in solid form as a toughening agent in the ratio 80:20, and optionally with additives to obtain improved lap shear strength and cushioning properties.
US10023765B2
A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.
US10023755B2
In accordance with some embodiments, compositions and methods for forming solvent-based and water-based carbon nanotubes inks with removable additives are provided. In some embodiments, an ink composition is provided that includes a plurality of carbon nanotubes, a solvent, and a triazole-based removable additive, where the plurality of carbon nanotubes are dispersed within the solvent and wherein the triazole-based removable additive stabilizes the plurality of carbon nanotubes that are dispersed in the solvent.
US10023751B2
Polyurethane-based and epoxy-based coating compositions are described that provide coatings and adhesives that are clear, amphiphobic and durable. Both water and hexadecane readily slide off these surfaces without leaving a residue. Coatings with thicknesses ranging from about 10 nm to about 10 μm exhibited excellent transmittance properties. Such films exhibited durability against abrasion, ink-resistance, anti-graffiti, anti-fingerprint, and strong adhesion to glass surfaces. The coatings are applicable to electronic devices, fabrics, glass, etc. to prepare optically clear, stain-resistant, and smudge-resistant surfaces.
US10023741B2
A silicone composition that contains (A) an organopolysiloxane having at least two aliphatic unsaturated hydrocarbon groups per molecule, (B) a filler containing an aluminum powder and a zinc oxide powder, (C) an organohydrogenpolysiloxane having two or more silicon-bonded hydrogen atoms per molecule, and (D) a platinum group metal catalyst, in which a cured product of the silicone composition exhibits a ratio of a storage elastic modulus after 3,600 seconds from the start of measurement to a storage elastic modulus after 7,200 seconds from the start of measurement of 0.7 or less, the storage elastic modulus G′ being measured by constructing a program for holding a sample at 150° C. for 7,200 seconds after the sample is heated from 25° C. to 125° C. at a temperature increase rate of 10° C./min, from 125° C. to 145° C. at a temperature increase rate of 2° C./min, and from 145° C. to 150° C. at a temperature increase rate of 0.5° C./min.
US10023738B2
The invention provides a bioabsorbable blend of (i) a polymer component comprising polylactic acid (PLA), polyglycolic acid (PGA), a copolymer of PLA and PGA, or any combination thereof and (ii) thermoplastic polyurethane (TPU) tailored to a medical application, and a process for making the same. In some embodiments, the TPU comprises units derived from a diol chain extender, a diisocyanate, and a polyol formulated to provide a set biodegradation rate in combination with at least one physical property. The blend of the invention provides useful materials for medical applications that have the individual benefits of polylactic acid and TPU while moderating each material's typical limitations.
US10023732B2
Provided are: a rigid IPVC pipe resin composition, which exhibits excellent strength and hydrostatic pressure resistance, including a PVC resin having a K-value from 72 to 84; and a rigid IPVC pipe, which exhibits excellent strength and hydrostatic pressure resistance, manufactured by extrusion of the resin composition.
US10023724B2
A nanocomposite is provided including spherical pyrogenic silica nanoparticles dispersed in a curable resin or a curing agent. The nanocomposite contains less than 2% by weight solvent and less than 0.5% by weight dispersant based on the nanoparticle weight. A composite is also provided including from about 4 to 70 weight percent of spherical pyrogenic silica nanoparticles dispersed in a cured resin, and a filler embedded in the cured resin. Optionally, the composite further contains a curing agent. Further, a method of preparing a nanoparticle-containing curable resin system is provided including mixing from 10 to 70 weight percent of aggregated spherical pyrogenic silica nanoparticles with a curable resin to form a mixture. The mixture contains less than 2% by weight solvent and less than 0.5% by weight dispersant based on the nanoparticle weight. The method also includes milling the mixture in an immersion mill containing milling media to form a milled resin system including silica nanoparticles dispersed in the curable resin.
US10023719B2
A method of forming a polyolefin-filler hybrid comprising combining vinyl/vinylidene-terminated polyolefin (VTP) and halosilane to form a silane functionalized polyolefin, followed by combining the silane functionalized polyolefin with a hydroxyl-containing filler, and/or combining the silane functionalized polyolefin with water and combining with hydroxyl-containing filler; to form a polyolefin-filler hybrid.
US10023717B2
A method of forming a salt-containing carbon-metal particle, the method including forming an aqueous mixture of acidic carbon black and one or more metals and applying energy to the aqueous mixture, whereby applying energy to the aqueous mixture results in the metal chemisorbing to the acidic carbon black. The aqueous mixture may be prepared by preparing an aqueous dispersion of the acidic carbon black and adding metal particles in a zero oxidation state to the aqueous dispersion of the acidic carbon black; or dissolving a metal in a zero oxidation state in an acidic aqueous solution, preparing an aqueous dispersion of the acidic carbon black, and adding the aqueous dispersion of the acidic carbon black to the acidic aqueous solution of the dissolved metal. The acidic carbon black may be oxidized carbon black, and the metal may be zinc, aluminum, gold, iron, lead, silver, copper, or combinations thereof.
US10023713B2
The invention provides a hollow nano-particle comprising a crosslinked shell and a void core; and a preparation method thereof. The hollow nano-particle may be used in rubber composition, tire product, and pharmaceutical delivery system etc.
US10023710B2
A formulation includes a polymeric material, a nucleating agent, a blowing, and a surface active agent. The formulation can be used to form a container.
US10023709B2
The present invention relates to a multiporous hollow-fiber membrane containing a thermoplastic resin, in which an aspect ratio of outer surface pores is 10 or more, an aspect ratio of inner surface pores is 1 to 5, and a thickness of a polymer backbone forming the outer surface pores is 1 μm to 20 μm.
US10023696B2
Medium and high molecular weight long chain aliphatic nylons and methods of making the same. A method of making medium and high molecular weight nylons is described, which not only produces consistent products, but products with enhanced properties such as impact resistance and chemical resistance.
US10023694B2
A resin according to the present invention is prepared by reacting a reaction product, which is obtained by Michael addition reaction between the following component (A) and the following component (B) and a subsequent amide group formation reaction, with the following component (C): (A) an aliphatic diamine having 2 to 8 carbon atoms or a diamine having a C6-8 aromatic ring; (B) an unsaturated carboxylic acid represented by formula (2) and/or a derivative thereof, provided that the following component (C) is excluded: [in formula (2), R1 and R2 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an aralkyl group having 1 to 8 carbon atoms or an aryl group]; and (C) a (meth)acrylic acid-type compound having at least one glycidyl or isocyanate group.
US10023692B2
A method for the preparation of a poly(ether ether ketone) (PEEK) includes: preparing the PEEK by aromatic nucleophilic substitution in the presence of: a) particulate sodium carbonate (Na2CO3), wherein said particulate sodium carbonate has a particle size distribution as follows: D90≥45 μm and D90≤250 μm and D99.5≤710 μm, wherein said particle size distribution is measured by mechanical sieving in accordance with ASTM E 359-00 (reapproved 2005), wherein said measurement is based on the mechanical separation of various fractions on a series of superimposed sieves which are superimposed by descending order of opening mesh of 1000 μm, 500 μm, 250 μm, 180 μm, 125 μm, 90 μm, 63 μm, and 45 μm; and b) potassium carbonate (K2CO3) in an amount ranging from 0.001 to about 0.05 mol K/mol Na.
US10023690B2
The present invention is directed to a process for preparing hyperbranched phosphoric acid esters as well as a hyper-branched phosphoric acid ester, its use for dispersing solid substances and in the production of water- and/or solvent-based coatings and paints, printing inks and/or plastics such as unsaturated polyesters, PVC or plastisols and a pigment dispersion comprising the at least one hyperbranched phosphoric acid ester or salt thereof and its use as a component in paints or lacquers.
US10023689B2
Biodegradable polyesters are made by synthesizing copolymers derived from biodegradable hydroxyacid monomers as well as from hydroxyacid monomers containing a functional group such as an azide group, a halogen group, a thioacetate group, and the like. Preferably, the functionalized biodegradable polyester copolymers are derived from a functionalized hydroxyacid such as a homolog of lactic acid and/or glycolic acid with the copolyester thus containing functional groups on the backbone thereof. These biodegradable polyesters can be utilized wherever biodegradable polyesters are currently used, and also serve as a polymer to which various medical and drug delivery systems can be attached.
US10023687B2
The invention relates to curable epoxy resin systems comprising polyethylene tetraamine and a tin catalyst as hardening agents, and optionally comprising 1,4-diaza[2.2.2]bicyclo octane. The invention also relates to articles made therefrom, including composites such as carbon fiber reinforced composites. The curable epoxy resins have rapid demold times and/or high glass temperature.
US10023683B2
The present invention provides a reactive catalyst composition for making a water blown flexible polyurethane foam. The catalyst composition comprises one or more tertiary amine catalysts in combination with (1) 2-methyl-1,3-propanediol or (2) a blend of 2-methyl-1,3-propanediol and a C7+ alkanol. The use of such catalyst composition improves the physical properties of the polyurethane foam.
US10023674B2
A monomer having a substituent group capable of polarity switch under the action of acid is provided. A useful polymer is obtained by polymerizing the monomer. A resist composition comprising the polymer has improved development properties and is processed to form a negative pattern having high resolution and etch resistance which is insoluble in alkaline developer.
US10023661B2
Disclosed are a modified conjugated diene-based polymer, a method of preparing the same, and a rubber composition including the same.
US10023659B2
The present invention relates to a process for the production of heparin derivatives having an average molecular weight of from about 4.6 to about 6.9 kDa and an anti-factor Xa activity of less than about 10 IU/mg, comprising the steps of oxidation of unfractionated heparin, depolymerisation and reduction of resulting terminal groups.
US10023657B2
Some aspects of this invention are based on the recognition that reversible protein multimers in which monomeric proteins are conjugated to a carrier molecule via chelation complex bonds are stable under physiological conditions and can be dissociated in a controlled manner under physiological, nontoxic conditions. Accordingly, such protein multimers are useful for a variety of in vitro, ex vivo, and in vivo application for research, diagnostics, and therapy. Some aspect of this invention provide reversible MHC protein multimers, and methods of using such multimers in the detection and/or isolation of specific T-cells or T-cell populations. Because reversible MHC multimers can efficiently be dissociated, the time of MHC binding to T-cell receptors, and, thus, T-cell receptor-mediated T-cell activation can be minimized. The use of reversible MHC multimers as provided herein, accordingly, allows for the detection and isolation of bona fide antigen-specific CD8+ T cells without inducing activation dependent cell death, including rare, therapeutically valuable T-cells expressing T-cell receptors binding tumor antigens with high affinity. Methods for the production and use of reversible multimers are also provided.
US10023655B1
We provide new monoclonal antibody inhibitors of coagulases for treatment of S. aureus. The monoclonal antibodies are useful in targeting the SC N-terminus and inhibiting SC-ProT activation. The monoclonal antibodies are able to bind to and interfere with, modulate, and/or inhibit the binding interactions between the staphylocoagulase protein and its ligand protein prothrombin in blood and tissues. The antibodies are effective in inhibiting the activation of prothrombin.
US10023648B2
In a first aspect, the present invention relates to genetically modified T-cells having a chimeric antigen receptor (CAR) in a method for adoptive cell therapy for treating TOSO+ cancer, like B-cell leukemia/lymphoma, in a subject in need thereof. In particular, the present invention relates to a genetically engineered T-cell containing and expressing a specific chimeric antigen receptor being toxic to TOSO+ cancer cells while being less toxic or non-toxic to TOSO+ non-cancer cells, in particular, being non-toxic to normal B cells and its precursors. In a further aspect, the present invention relates to a specific chimeric antigen receptor and the nucleic acid molecule encoding the same as well as vectors and cells containing the same.
US10023640B2
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
US10023634B2
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
US10023633B2
The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
US10023627B2
The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR) and/or a placental growth factor (PIGF). The fusion protein of the present invention comprises (a) a Fc domain of IgG1, wherein two heavy chains are linked by disulfide bond, and (b) four immunoglobulin domain2s of the VEGFR1, wherein two immunoglobulin domain2s are sequentially fused to each heavy chain of the Fc domain of (a). The present fusion protein has excellent activities of inhibiting cell migration and cell invasion, and has highly enhanced growth inhibition effects to various carcinomas and fibroblasts. Therefore, The fusion protein of the present invention can be used in the preparation of an agent for treating cancers or ocular diseases.
US10023625B2
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.
US10023622B2
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or antigens in methods and pharmaceutical preparations for the treatment of Alzheimer's disease and other conditions related to protein misfolding. The invention further provides transgenic animals expressing modified amyloid precursor proteins or amyloid beta peptides.
US10023612B2
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynecological condition in which an activity of AR and/or ER is a contributory factor in a subject. Preferably, the molecule comprises or consists of the structure: Bj[(Pro)n-Xr-His-Pro-His-Ala-Arg-lle-Lys]m-Rp, or Bj[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n] is the retro-inverso peptide of [(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys].
US10023605B2
Compositions, methods, and systems are provided for nucleotide analogs comprising protein shields for improving enzyme photostability in single molecule real time sequencing. Nucleotide analogs of the invention have a protein shield between the dye moieties and nucleotide moieties of the analog. The nucleotide analogs have two avidin proteins connected by a central dye component, and each avidin protein is further connected to a nucleotide component. The protein can prevent the direct interaction of the dye moiety with the enzyme carrying out nucleotide synthesis preventing photodamage to the enzyme. The nucleotide analogs of the invention can have multiple dyes and multiple nucleotide moieties.
US10023587B2
This invention provides compounds having the structure which may be used for the treatment of tumors.
US10023586B2
A method for acid-catalyzed acylation of an isohexide is described. The method involves a reaction of an isohexide and an excess of carboxylic acid in the presence of a Lewis acid or a Brnsted acid catalyst. One or more Lewis acid or Brnsted acid can facilitate conversion of isohexides to their corresponding mono and diesters with a pronounced greater regio-selectivity of exo-OH over endo-OH of the isohexide in the product. Particular catalytic acid species include zirconium chloride (ZrCl4) and phosphonic acid (H3PO3), which manifest a ratio of exo:endo regioselectivity of about 5.0≠3:1 and about 4.00.3:1, respectively.
US10023585B2
The invention covers new bicyclic bridged [1,3]oksazepine derivatives of the general formula (I) and (II): which exhibit enhanced photochromic properties as compared with known spiropyrans and can be used as molecular photoswitches. The method of production of new compounds and intermediates for preparation thereof are disclosed.
US10023581B2
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
US10023573B2
A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC1-6 alkyl; C represents a benzyl group; Rc represents a C1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.
US10023569B2
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
US10023562B2
Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.
US10023554B2
The invention provides a novel α-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament.The salt is represented by the general formula (I): (wherein R is a hydrogen atom or a methoxy group; X is a halogen atom; A is selected from the group consisting of: M is an alkali metal or an alkaline earth metal; and n is 1 when M is an alkali metal and is 2 when M is an alkaline earth metal).
US10023551B2
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
US10023544B2
A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
US10023542B2
The present invention relates to the technical field of ibrutinib, particularly to the technical field of ibrutinib intermediate compounds and preparation methods thereof. The intermediate compounds are represented by formula A, wherein, the dotted line represents a double bond or a single bond between carbon and oxygen.
US10023540B2
To provide a hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition including the hydrogen barrier agent; a hydrogen barrier film including the hydrogen barrier agent; a method for producing a hydrogen barrier film, which uses the hydrogen barrier film forming composition; and an electronic element provided with the hydrogen barrier film. A compound having a specific structure including an imidazolyl group is used as the hydrogen barrier agent. Furthermore, the hydrogen barrier film forming composition is prepared by blending the above-mentioned hydrogen barrier agent into the base material component. In addition, the hydrogen barrier film is formed using the hydrogen barrier film forming composition.
US10023534B2
Disclosed are compounds of Formula (I): or a salt thereof, wherein Q is: or; and X, R1a, R1b, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
US10023532B2
An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.
US10023531B2
The present invention relates to a process for preparing alkanesulfonic acids from dialkyl disulfides with nitric acid and oxygen.
US10023525B2
The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis apparatus.
US10023523B2
Processes for continuous preparation of bioproducts are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of an acidic heterogeneous catalyst and separating the fatty acid alkyl esters from the reaction products.
US10023520B2
A process for continuously preparing the tert-butyl ester of an aliphatic C1-C4 carboxylic acid comprises: a) the reaction of an aliphatic C1-C4 carboxylic acid with isobutene in the presence of an acidic catalyst to give an esterification mixture (G1); b) the partial evaporation of the esterification mixture (G1), giving a liquid first high boiler phase (SPh1) comprising the acidic catalyst, and a first vapor (B1) comprising tert-butyl ester; c) the fractional condensation of the first vapor (B1) by partially condensing the first vapor (B1) at a first pressure and a first temperature and obtaining a first condensate (K1), partially condensing the uncondensed second vapor (B2) at a second pressure and a second temperature and obtaining a second condensate (K2), the first temperature being 0 to 45° C. below the condensation temperature of the tert-butyl ester at the first pressure and the second temperature being 45 to 80° C. below the condensation temperature of the tert-butyl ester at the second pressure, with the proviso that the second temperature is at least 5° C. below the first temperature; and d) the combination of the first condensate (K1) and the second condensate (K2) and the feeding to a combined workup, and recycling of the third vapor (B3) not condensed at the second temperature into step a). The process allows the preparation of the tert-butyl ester of an aliphatic C1-C4 carboxylic acid by reaction of the carboxylic acid with isobutene, with isolation of unconverted isobutene from the esterification mixture in an energetically favorable manner and with an improved degree of removal.
US10023510B2
This invention provides a method for producing 2,3,3,3-tetrafluoropropene or 2-chloro-1,1,1,2-tetrafluoropropane, which is a precursor of 2,3,3,3-tetrafluoropropene, in two or three reaction steps, using at least one chlorine-containing compound selected from the group consisting of 1,1,1,2,3-pentachloropropane, 2,3-dichloro-1,1,1-trifluoropropane, and 1,1,2,3-tetrachloropropene as a starting material, the reaction products of at least two of the steps being supplied to the same distillation apparatus to subject the products to a separation operation simultaneously. With this method, 2,3,3,3-tetrafluoropropene or 2-chloro-1,1,1,2-tetrafluoropropane, which is a precursor of 2,3,3,3-tetrafluoropropene, can be efficiently produced with reduced energy and equipment costs in an economically advantageous manner.
US10023508B2
A process utilizing an ionic liquid is described. The process includes contacting a hydrocarbon feed with an ionic liquid component, the ionic liquid component comprising a mixture of a first ionic liquid and a viscosity modifier, wherein a viscosity of the ionic liquid component is at least about 10% less than a viscosity of the first ionic liquid.
US10023495B2
The glass containers described herein have at least two performance attributes selected from resistance to delamination, improved strength, and increased damage resistance. In one embodiment, a glass container may include a body having an inner surface, an outer surface and a wall thickness extending between the outer surface and the inner surface. A compressively stressed layer may extend from the outer surface of the body into the wall thickness. The compressively stressed layer may have a surface compressive stress greater than or equal to 150 MPa. A lubricous coating may be positioned around at least a portion of the outer surface of the body. The outer surface of the body with the lubricous coating may have a coefficient of friction less than or equal to 0.7.
US10023493B2
A colored lacquered substrate made of glass or glass-ceramic includes a mineral coating based on alkaline silicate, which achieves the required performance in terms of color and of change in color during tempering, and in terms of adhesion and of mechanical strength at low temperatures without requiring a high-temperature baking step.
US10023481B2
Methods and systems for preventing biofouling of membranes utilized in water treatment processes (i.e., water treatment membranes) are described. Methods include X-ray excitation of luminescent materials capable of emitting in the violet to UV range (e.g., from about 180 nm to about 440 nm). X-rays are directed at water treatment modules to contact the luminescent materials within the modules and excite internal violet/UV to prevent biofouling of membranes. The methods can be utilized in conjunction with existing processing equipment and can prevent biofouling of water treatment membranes in high volume treatment processes in an environmentally friendly fashion.
US10023477B2
A treatment solution supply method of supplying a treatment solution to a substrate, the method includes the steps of: applying a DC voltage to the treatment solution; detecting a potential difference between two points in the treatment solution in a state where the DC voltage is applied to the treatment solution; and increasing the DC voltage when the detected potential difference is less than a predetermined reference value.
US10023470B2
A controlled preparation of octachlorotrisilane and higher polychlorosilane such as DCTS and DCPS from monomeric chlorosilane, proceeds by exposing the chlorosilane to a nonthermal plasma and recycling chlorosilane that has not been converted to octachlorotrisilane into the plasma.
US10023462B2
Disclosed are Niobium Nitride film forming compositions, methods of synthesizing the same, and methods of forming Niobium Nitride films on one or more substrates via vapor deposition processes using the Niobium Nitride film forming precursors.
US10023459B2
A method and apparatus are provided to prevent or reduce stiction of a MEMS device. The MEMS device may include a protrusion extending from a surface of the MEMS device. During manufacture, the protrusion may be connected across an opening in the MEMS device to a sidewall of the substrate. Before manufacture of the MEMS device is completed, at least a portion of the protrusion connecting the MEMS device to the substrate may be removed. During operation, the protrusion may provide stiction prevention or reduction for the surface from which the first protrusion may extend. A plurality of protrusions may be formed along a plurality of surfaces for the MEMS device to prevent or reduce stiction along the corresponding surfaces. Protrusions may also be formed on devices surrounding or encapsulating the MEMS device to prevent or reduce stiction of the MEMS device to the surrounding or encapsulating devices.
US10023453B2
The present invention relates to a method for filling a fluid into a container without using measuring means and to a filling apparatus therefor which comprises an attachment having a predetermined volume VA, said attachment comprising a valve attachment which has a gas valve and a liquid valve with a valve seat in a housing. Said valve seat surrounds a displacement element that can be moved along the longitudinal axis relative to the housing, and forms an annular gap. According to said method, the attachment is tightly placed onto a container (1) while the displacement element is inserted into the container (1). When the liquid valve (5) is opened, the filling fluid flows into the nominal volume VN of the container (1), and said nominal volume is flooded with the filling fluid; the liquid valve is then closed. The displacement element is withdrawn from the container (1) and the flooded remaining volumes top up the contents in the container (1), the volumina VVA and VFV equaling the volume VRohr of a portion of the displacement element in the flooded portion so that identical containers (1) are filled with identical fill levels.
US10023445B2
The present invention relates to a rope grab arrangement comprising a rope grab for advancing a rope, the rope grab arrangement being configured to provide an increased friction between the rope grab and the rope for allowing use of multitude of different types of ropes. The invention also relates to a portable power driven arrangement comprising such a rope grab arrangement.
US10023443B2
The invention relates to a tower crane comprising a tower of at least one tower element, in particular a lattice piece, and a structural guying device having at least one guying rod for the horizontal anchorage of the tower at a structure. In accordance with the invention, the tower has a vertically adjustable guide frame, wherein at least one positioning rope is adjustably fastened to the guide frame. The invention furthermore relates to a method of mounting a wind turbine rotor blade.
US10023439B2
An escalator system includes a pit having an access cover plate, a detector indicating when the access cover plate is open and when it is closed, and a user interface which is located in said pit and which in an active state provides the escalator system with control signals controlling the operation of the escalator and which in a passive state does not affect the operation of the escalator. In order to improve the safety of the escalator system the escalator system is configured to stop movement of the escalator if the detector indicates that the access cover plate is closed while the user interface is in the active state.
US10023436B2
A drive unit for an elevator installation having a first traveling body and a second traveling body, which traveling bodies are supported by a support device, drives the support device and thus the two traveling bodies. The two traveling bodies each have at least one first support roller by which the support device supports the traveling bodies, at least partially. The drive unit includes at least one first and one second roller arranged on a common axis of rotation of the drive unit, wherein at least one of the first or second rollers is a drive unit roller for driving the support device. On the way from the first traveling body to the second traveling body, the support device is guided over the first drive unit roller and over the second drive unit roller. The guidance is hereby such that the circumferential speeds of the two drive unit rollers vary.
US10023406B2
A wheel assembly and a bin sweep system. The system may include a sweep auger for moving granules, and a wheel assembly including a rim and a tire disposed on the rim, the rim defining an interior radially inward of an inner circumference of the rim, and a cycloidal drive disposed in the interior of the rim. The cycloidal drive may include an input shaft, a drive gear having first gearing features and being eccentrically mounted on the input shaft, a stationary drive plate, and second gearing features coupled to the rim, the first gearing features engaging the second gearing features to drive the rim and wheel at a reduced speed relative to the input shaft.
US10023392B2
A belt driven linear actuator includes: a base, a linearly movable unit, a belt driven unit, a first cover, a second cover, a drive source, and a slide block. With the first and second covers removably disposed on the base, the first and second covers can be located at different positions to define different gaps in different directions, so as to allow the slide block to be assembled in different directions, and reduce the restriction on the assembling direction of the drive source. Besides, the width of the base is equal to the height of the base, and the height of the cover portion is equal to the height and the width of the base, which allows the base to be assembled in the same position while in different directions.
US10023382B2
A lock for the hook of a roll-off container box comprises a rail member with two substantially parallel brackets, each bracket having a plurality of apertures for receiving at least one padlock, said brackets terminating at one end in a carrying handle and at the opposite end with a connector pin for engaging with the container box hook. The lock further comprises a box-like outer cover for the rail member, that outer cover having a front wall, a rear wall, a top surface and spaced apart sidewalls. Each sidewall has a track that commences at its bottom edge, and extends parallel to that bottom edge before branching off into an upper and lower pathway for the rail member's connector pin to slide along.
US10023375B2
An outsert for affixing to a product package includes a base layer, a top layer, and a printed document. The base layer includes a perforated region arranged to be aligned with a tear tape on an outer wrapping of the package. The top layer is arranged on the base layer and has one or more edge regions adhered to the base layer. The printed document is enclosed in an inner volume established between the base layer and top layer. A laminate layer can be disposed in the inner volume between the top layer and the printed document to increase the rigidity of the outsert.
US10023373B2
A collating strip for holding plugs prior to insertion of the plugs into a hole such as a screw hole or nail hole after the screw or nail has been driven. The collating strip comprises an elongated strip having a plurality of perforations spaced along its length; and a plug positioned in each of the perforations, each plug having an insertion end and an external end, the insertion ends projecting from said strip. The strips may be in sheet form of a plurality of strips side by side with an individual strip being separable from the remaining strips of the sheet.
US10023372B2
A carton for holding a plurality of containers. The carton comprises a plurality of panels extending at least partially around an interior of the carton and a dispenser comprising a dispenser panel. The dispenser panel is at least partially defined by a tear line extending in at least one panel of the plurality of panels. The dispenser panel can be at least partially removable from the carton to create a dispenser opening. The carton also can comprise a handle for grasping and carrying the carton. The handle comprises a handle feature extending in at least the dispenser panel, and at least a portion of the handle can be removable from the carton with the dispenser panel.
US10023368B2
A plastic tube head for a product having a liquid to pasty consistency, comprising: a neck; a shoulder; and an insert forming a barrier having an outer edge which is covered in a continuous manner by an outer support made of plastic material forming the tube head, and an inner hole defining an inner edge. The tube head is characterized in that the inner edge of the insert is covered in a discontinuous manner by the plastic material forming the tube head, such that a portion of the face of the insert which is oriented towards the internal volume inside the tube and adjacent to the inner edge is covered by an inner support.
US10023365B2
Drink bottles, or drink containers with cap assemblies that include a drink spout. In some embodiments, the drink spout is pivotally coupled to a base of the cap assembly. In some embodiments, the drink spouts include mouthpieces, including self-sealing and/or bite-actuated mouthpieces. In some embodiments, the cap assembly includes a handle, which may include at least one guard for the drink spout and/or mouthpiece. In some embodiments, the drink containers include a manual on/off valve. In some embodiments, the dispensing spout includes a mount for the mouthpiece and/or cooperates with the cap to provide a manual on/off valve to selectively restrict flow of drink fluid from the drink container regardless of the drink spout's and/or mouthpiece's configuration. In some embodiments, the drink containers include a drink tube extending from external of the drink containers and/or an air return system.
US10023350B2
A carton for holding at least one article. The carton has a front panel and a back panel that at least partially form an interior of the carton. A first end flap is foldably connected to one of the front panel and the back panel and a second end flap is foldably connected to one of the front panel and the back panel. Locking features are for releasably securing the end flaps in a closed configuration with the first end flap and the second end flap in face-to-face contact. The locking features comprise a male locking feature foldably connected to at least one of the first end flap and the second end flap, and a female locking feature adjacent at least one of the first end flap and the second end flap.
US10023339B2
Methods and machines are provided for forming a five-sided carton of packages of smoking articles. A piece of film material is applied to a plurality of packages of smoking articles such that five sides of the plurality of packages are at least partially covered by the film material, but the sixth side remains uncovered. The film material is applied such that the group of packages is sufficiently tightly bound so that none of the packages may slip free from the carton. The sixth side of the plurality of packages in the carton remains exposed so that tax stamps may be easily applied. The film of material may be applied so that a gap is formed relative to the sixth side.
US10023328B2
A space vehicle engine (10) comprising a chemical thruster having a nozzle (30) for ejecting combustion gas, together with a Hall effect thruster. The engine is arranged in such a manner that the nozzle serves as the ejection channel for particles ejected by the Hall effect thruster when it is in operation. The engine can deliver high thrust with low specific impulse or relatively low thrust with large specific impulse.
US10023327B2
Reaction wheel assemblies having relatively compact and lightweight form factors (referred to as “small scale” RWAs) are disclosed. Such small scale RWAs are well-suited for deployment onboard relatively small satellites, but are not restricted to usage within any particular device or platform. In one embodiment, the small scale RWA includes a primary support platform to which a rotor is coupled for rotation about a spin axis. An axially-expanded face-to-face (DF) duplex bearing pair is disposed between the rotor shaft and the support platform. The DF duplex bearing pair includes first and second rolling element bearings positioned around an intermediate portion of the rotor shaft. The first and second rolling element bearings have first and second bearing load lines, respectively, which are spaced by a tailored bearing load line separation (SLL).
US10023318B2
A motorized aircraft is controlled by a drive control means that rotationally drives a propulsion system propeller. The propulsion system propeller is driven by a plurality of electric motors. A comparison detection unit compares estimated propeller torque and estimated motor torque with each other and detects an abnormal state of an electric motor on the basis of the fact that a difference between the propeller torque and a multiple of the motor torque is above a predetermined value.
US10023311B2
A system and method for painting a structure. The system comprises: a computer vision processing system configured to obtain images of a target structure and generate first instructions signals for real time communication to an unmanned aerial vehicle (UAV) having a paint fluid dispensing system provided thereon; a control device at the UAV responsive to received the first instruction signals for controlling real time navigating of the UAV to a location at the target structure; and the computer vision processing system configured to generate second instruction signals for real time communication to the UAV, wherein the control device at the UAV is configured to automatically actuate the paint fluid dispensing system to apply a paint fluid at the location on the target structure in response, the received second instruction signals configuring the UAV to render a desired visual image on the target structure.
US10023308B1
A tethering system for a remote-controlled device includes a tether line having a first end adapted to be connected to a ground support and a second end adapted to be connected to the remote-controlled device. The system further includes an anchor-point disposed between the first and second ends of the tether line, the anchor point having an eyelet for securing the tether line and allowing the tether line to slide through the eyelet during use. The anchor-point and eyelet enable the tether line to flex or bend and the remote-controlled device to maneuver one or more of over or around the target area without interfering with any nearby obstructions.
US10023301B2
A system including a load factor control module for calculating a deflection order on manual actuation of a control column by a pilot of the aircraft and transmitting that deflection order to at least one elevator of the aircraft, a longitudinal attitude control module for maintaining the longitudinal attitude of the aircraft at a target attitude in the event of absence of manual actuation of the control column by the pilot during a flight, and a transition management module for determining and storing a present longitudinal attitude value of the aircraft at a recording moment and transmitting that longitudinal attitude value to the longitudinal attitude control module for the longitudinal attitude control module to use the longitudinal attitude value as the target attitude.
US10023297B1
Techniques for using an unmanned aerial vehicle (UAV) to deliver a payload while reducing and/or altering sound generated by the UAV during delivery may be provided. For example, during delivery, the UAV may be instructed to utilize one or more sets of propellers of different sizes to reduce and/or alter the sound generated by and/or around the UAV. Intrinsic and extrinsic information associated with the UAV may be utilized to dynamically adjust the particular sets of propellers of a certain and different size to utilize during different portions of a flight path while delivering the payload.
US10023294B2
According to one embodiment, an empennage attachment system features an aft attachment mechanism and a forward attachment system. The aft attachment mechanism is configured to be coupled to a tail section of a body of an aircraft and to an empennage proximate to an aft spar of the empennage. The aft attachment mechanism defines a pitch axis such that the aft attachment mechanism allows the empennage to rotate about the pitch axis. The forward attachment system is configured to be coupled to the tail section of the body and to the empennage proximate to a forward spar of the empennage. The forward attachment system is configured to restrict rotation of the empennage about the pitch axis to an allowable range of motion.
US10023293B2
A panel assembly comprising: a panel (11); a stiffener (12) having a foot (12a), an upstanding web (12b) and a run-out region at one end; and a fitting (13), wherein the stiffener foot is bonded to the panel, and wherein the fitting is attached to the stiffener web and to the panel outboard of the end of the stiffener foot. The outboard end of the web may overhang an outboard end of the foot in the run-out region, of the stiffener.
US10023286B2
Systems and methods are provided for insulation and moisture drainage. One exemplary embodiment is an apparatus comprising a bay blanket configured to insulate an aircraft. The bay blanket includes insulation, and a first waterproof lip that protrudes from the insulation in an outboard direction towards a frame of the aircraft and extends along a length of a leftward side of the bay blanket. The bay blanket also includes a second waterproof lip that protrudes from the insulation in an outboard direction towards the frame of the aircraft along a length of a rightward side of the bay blanket.
US10023281B2
The problem of penetrating through nets and other objects is solved by cutting the object using various cutter systems, which include, for example a track and a moving carriage containing a cutter, a stationary carriage with a fixed or rotating arm, and/or abrasive cutters. The object is cut by a severing, slicing, or wearing action caused by a moveable blade or abrasive surface. An underwater vehicle incorporating an embodiment of the cutter system can cut a sufficiently large opening in the object to allow the vehicle to pass through.
US10023276B1
A canoe outrigger with built-in, covered, storage capacity. Unlike a typical pontoon type outrigger, this device is a miniature canoe form that has an open interior. The top of the outrigger has three doors allowing for storage and access within the form that holds many supplies, such as camping and fishing gear, food, water and other items. The outrigger is connected to a canoe, or other small boat, by a pair of telescoping arms. Each arm has clamps that secure the arms the gunwales of the vessel. The other end of each arm is bolted into position on the outrigger. In this way, the outrigger is securely attached for use.
US10023274B1
A water pad assembly adapted to floatingly support a human in open water, including: a water pad member and a plurality of grommets and/or cup holders.
US10023271B2
A rapid water ambulance for transport of patients, comprising a sick bay solidly constrained to a structure of the water ambulance and support apparatus (10) for a stretcher, the support apparatus (10) comprises: a support column (20), a carriage (30) slidable along the column (20) in the direction of the axis (A) thereof, a support plane (11) for a stretcher, borne projectingly by the carriage (30) and solidly constrained thereto, a damped suspension device (33), constrained to the carriage (30) and to the column (20), which supports the support plane (11) at an operating height, wherein the axis (A) of the support column (20) is inclined with respect to the perpendicular direction to a floor (P) plane of the sick bay and lies in a vertical plane parallel to the motion direction of the water ambulance.
US10023258B2
Systems, methods and apparatus are provided through which in some implementations a motorized tricycle includes a lean mechanism and an active system that is operably coupled to the lean mechanism that receives an signal indicative of an interaction with human, that is operable to detect a lean of the body of the human and that is operable to receive a sensed movement on the seat via multisensory devices, and to generate and send a signal to the lean mechanism from the signal, the lean and the sensed movement.
US10023256B2
Disclosed is a streamlined storage system for use with a motorcycle or other similar vehicle seat that does not detract from the riding experience, that is easy and convenient for the rider to access while riding, and that does not substantially increase the overall cost of the vehicle.
US10023252B1
In one embodiment, an intermodal container comprises a metal box, and left and right wheel assemblies. The box includes a front wall, a rear door opposite the front wall along a longitudinal direction, first and second sidewalls that oppose one another along a lateral direction, a top wall, a bottom wall that opposes the top wall along a vertical direction, and a structural frame. The left and right wheel assemblies are spaced from one another along the lateral direction. Each one of the wheel assemblies includes an axle and at least one tire mounted on the axle. The wheel assemblies are movable between an extended position in which the tires extend below the first and second sidewalls in the vertical direction so as to be engageable with a ground surface, and a retracted position in which the first and second sidewalls extend below the tires along the vertical direction.
US10023249B2
A drag reducing apparatus is provided for use with vehicles having surfaces that are not streamlined. The apparatus includes an exterior cover that forms a drag reducing shape when the apparatus is fully extended. The apparatus can be retracted to a space saving configuration. A scissors linkage extends and retracts the apparatus. The scissors linkage can be motorized, and the motor can extend the scissors linkage by turning in a first direction and can retract the apparatus by turning in a second direction. The scissors linkage can hold the exterior cover taut when the apparatus is fully extended. The scissors linkage can support the exterior cover at intermediate locations when the apparatus is not fully extended. The apparatus can include support linkages and intermediate moveable members that support the exterior cover and define the drag reducing shape.
US10023248B1
The sliding tailgate is adapted for use with an automobile. The automobile is further defined with a working space. The working space is an interior space within which the load carried by the automobile is stored. The sliding tailgate is an apparatus upon which the tailgate of the automobile is attached such that: 1) the tailgate can be opened and closed to provide access into the working space of the automobile; and, 2) the tailgate can be retracted to a location underneath the working space to provide less restricted access to the working space of the automobile. The sliding tailgate comprises a storage slot, a mounting structure, a track system, and a locking system. The track system is contained within the storage slot. The mounting structure attaches the tailgate to the track system. The locking system locks the tailgate in the extended position.
US10023245B2
A motor vehicle body includes a rear wheel housing with a wheel well that accommodates a rear wheel and a wall section upwardly projecting form the wheel well. A C-pillar inner wall is fastened to the wall section along a first fastening zone and overlaps an opening formed in the wall section between the first fastening zone and wheel well. A weld joins the C-pillar inner wall and a C-pillar outer wall together at the level of the opening.
US10023240B2
A motor vehicle body includes a side member and with an at least two-shell wheelhouse supported against the latter. An upper wheelhouse shell and a lower wheelhouse shell at least regionally overlap each other and are joined together. Each wheelhouse shell exhibits a passage opening for arranging a strut mount toward the top in the vehicle vertical direction.
US10023238B2
A front pillar lower outer includes a bent portion, and a first region and a second region, and is a skeletal component for automobile that is assumed to receive a collision load along the extending direction of the first region. The outer is constituted by attaching a first member that is arranged on a first region side, and a second member that is arranged on a second region side. An attachment line of the both members is arranged in a predetermined zone between a first boundary and a second boundary. The plate thickness of the first member is larger than the plate thickness of the second member.
US10023228B2
A steering device is provided which allows the vehicle to move laterally and turn with a small radius, without using a complicated mechanism, and capable of stably controlling the steering angle during such modes. The steering device includes a pair of rack bars connected, respectively, to front right and front left vehicle wheels or rear right and rear left vehicle wheels, synchronizing gears disposed between the pair of rack bars, a synchronizing gear box retaining the synchronizing gears, a rack case fixed to the frame of the vehicle, and a fixing mechanism for fixing the synchronizing gear box to the rack case.
US10023220B1
A cart ski system for urging a cart along a granular support surface includes a cart that may be rolled along a support surface. The cart has a set of rear wheels and a set of front wheels. A pair of skis is provided and each of the wheels is positioned in a corresponding one of the skis. Each of the skis slides along the support surface when the support surface is comprised of a granular material thereby enhancing urging the cart along the granular material.
US10023219B2
The snow surface skimmer is provided with: a skimmer body; a steering handle, which extends upward at a slant from the skimmer body; a seat installed on a region of the skimmer body that is behind the steering handle; and a skimming board. The skimming board is detachably attached to the bottom surface of the skimmer body by a skimmer attachment mechanism so that the attachment position in the front-back direction is adjustable. A skimming board suited to the skimming person's body type, build, etc. can be attached to the skimmer body at the appropriate position in the front-back direction.
US10023217B2
An infant stroller apparatus includes a front leg frame having a first side segment, a handle frame having a second side segment pivotally coupled with the first side segment via a first pivot connection, a rear leg frame having a third and a fourth side segment pivotally coupled with each other via a second pivot connection, the third side segment being further pivotally coupled with the first side segment via a third pivot connection, and the fourth side segment being further pivotally coupled with the second side segment via a fourth pivot connection, a seat portion pivotally coupled with the first side segment via a fifth pivot connection, and a support frame portion respectively coupled with the seat portion and the fourth side segment.
US10023213B1
A disc golf transport system to allow the movement of disc golf paraphernalia about a course utilizing existing or specialized backpacks. The system uses a three wheeled manual pull cart that has a five point adjustable suspension system incorporating two adjustable, lockable upper arms with peg horns extending therefrom; two pivotable lower arms with length and angle adjustable means for attachment; and a central attachment member. All of the five attachment points allow an attached packpack to be drawn taut from five different points so as to secure, and position the bag in the cart for both easy content access and maximum transit stability.
US10023191B2
A method controls a power train of a vehicle immobilized in a parking position, the vehicle being provided with a parking brake device for immobilizing the vehicle and at least one electric motor. The method includes detecting the slope direction and/or slope data when the parking brake device is in an actuated position, detecting that the parking brake device has switched from the actuated position to a released position, and applying a motor torque setpoint to the electric motor in accordance with the detected slope direction and/or slope data.
US10023189B2
Provided is a device for preventing sudden unintended acceleration. The device includes a driving information collector, a vehicle characteristic storage, a controller configured to determine whether the vehicle is in a sudden unintended acceleration state, and a switch configured to block input power of the electronic throttle motor of vehicle on the basis of the determination of sudden unintended acceleration by the controller.
US10023185B2
A fuel pump system of a hybrid vehicle is provided. The fuel pump system prevents a fuel pump from continuing to operate when fuel is exhausted, whereby the fuel pump may be damaged. The pressure of fuel is measured in response to exhaustion of fuel, and when the pressure of fuel is low, fuel is circulated within the fuel pump instead of being supplied to the engine side, thereby preventing the fuel pump from being stuck due to frictional heat.
US10023182B1
A transmission control device is provided for a hybrid vehicle that ensures gear shift responsiveness corresponding to a driver's request while achieving excellent gear shifting quality when shifting gears under normal conditions. The transmission control device includes a transmission controller that carries out a shift control for switching between gear shift patterns that are established by the multistage gear transmission by a movement of the engagement clutches based on a gear shift request. The transmission controller selects from among a plurality of gear shift patterns that can be established gear shift patterns in which one engagement clutch is present in a power transmission path leading from the power sources to a drive wheel, and designates the selected gear shift patterns as a normal-use gear shift pattern group, which is used for shift control under normal conditions.
US10023179B2
A hybrid vehicle includes powertrain components such as an engine, an automatic transmission, and a traction motor selectively coupled to the engine via a clutch and to the transmission. At least one controller is programmed to control these powertrain components. The vehicle is driven over a drive cycle that includes multiple engine starts and transmission gear shifts. An amount of fuel consumption used during these engine starts and transmissions gear shifts is stored on an on-board storage device. Subsequently, the engine is inhibited from starting and the transmission is inhibited from shifting gears based on the amount of fuel consumption associated with the engine starts and transmission gear shifts performed during the drive cycle as recalled from the storage device.
US10023169B2
An air dryer for a locomotive air supply system that includes a controller programmed to initiate a sleep mode that inhibits the air dryer and de-energizes all valves. The controller determines when it is appropriate to enter into sleep mode based on various conditions of the locomotive air supply system. More specifically, the controller is programmed to calculate whether the air dryer should be placed into sleep mode based on operational characteristics of the locomotive air supply system that are indicative that the system has been idled. The initiation of an air dryer sleep mode by the controller prevents undesirable venting of air from the air supply system and unnecessary usage of locomotive battery power.
US10023156B2
Washing facility for two- or three- wheeled vehicle where the vehicle is conveyed longitudinally by mechanical means opposite washing devices, where the facility comprises a lower longitudinal guiding device in order to guide a wheel of the vehicle on the floor along the longitudinal displacement thereof and an upper guiding device made firmly connected to the handlebars of the vehicle in order to keep the vehicle in vertical position.
US10023135B2
A fastening device is provided for securing a plurality of elongated vehicle components to a first side of a vehicle structural member. The fastening device includes a first elongated strap member configured to form a loop around a first bundle of the elongated vehicle components, and a head member configured to be positioned on a second side of the vehicle structural member opposite the first side. The head member is provided with a through hole configuration for receipt of two portions of the first elongated strap member forming the loop and configured to allow tying of the first elongated strap member from the second side of the vehicle structural member. Moreover, the fastening device includes a second elongated strap member configured to form a loop around a second bundle of the elongated vehicle components. The head member through hole configuration is configured for receipt of two portions of the second elongated strap member forming the loop. In addition, the head member is configured to allow tying of the second elongated strap member from the second side of the vehicle structural member.
US10023133B2
An ON/OFF switch arrangement is for a display screen pivotably mounted within a motor vehicle. The arrangement includes a mounting bracket retaining the display screen and pivotably attached to the motor vehicle such that the mounting bracket may be pivoted about an axis. A switch assembly includes a rotor attached to the mounting bracket. A contactor is attached to the rotor. A base is attached to the motor vehicle such that the rotor and the contactor rotate about the axis relative to the base when the mounting bracket is pivoted. The base has two spaced apart electrical contacts. The contactor electrically interconnects the two contacts within a first range of rotational positions of the rotor, and the contactor does not interconnect the two contacts within a second range of rotational positions of the rotor.
US10023128B2
A container has a housing and a lid. The housing has a hollow interior adapted to receive a securement strap having a crank. At least one sidewall of the container has a hole therethrough. The hole is shaped and disposed to allow the crank to pass there-through to the exterior of the housing when the securement strap is received into the hollow interior, such that the crank may be used as a handle for carrying the combination.
US10023127B2
A vehicle interior component is disclosed. The vehicle interior component is an overhead console assembly for a vehicle interior. The overhead console may comprise a bezel/base and a storage member coupled to the bezel. The storage member is configured to move between a retracted/closed position and an extended/open position. The bezel provides a resilient member to aid/facilitate installation/attachment of the storage member to the bezel.
US10023121B1
Methods and systems are provided for controlling camera images of vehicle cameras. In one example, a camera, a radio system, a processor, and a display are disposed onboard a vehicle. The camera is configured to generate camera images. The radio system is configured to process the camera images. The processor is configured to at least facilitate determining whether a radio system of the vehicle is functioning properly; processing the camera images through the radio system prior to displaying the camera images within the vehicle, if the radio system is functioning properly; and providing instructions for displaying the camera images within the vehicle without processing the camera images through the radio system, if the radio system is not functioning properly. The display is configured to display the camera images in accordance with the instructions provided by the processor.
US10023099B2
A shipping apparatus utilizes logistic bars attached laterally across a carrier shipping enclosure such as truck trailer or shipping container. The logistic bars can engage tracks attached to lateral sidewalls of the carrier shipping enclosure. One or more equipment racks are positioned behind one of the lateral logistic bars. Another logistic bar is placed behind the one or more equipment racks. Each of the equipment racks are secured in place by clamping devices positioned along a respective lateral logistic bar to be proximate to a respective corner of the equipment rack. Longitudinal logistic bars are engaged to a pair of the clamping devices that are on opposing lateral sides of the equipment rack. The shipping apparatus provides a rigid structure that is appropriately positioned without damaging components within the equipment rack and preventing swaying during transport of the equipment rack.
US10023093B2
Utilities (e.g., apparatuses, systems, methods, etc.) for use in loading power equipment such as log splitting apparatuses onto cargo trailers or the like in manners that increase the number of assembled log splitting apparatuses that can be loaded onto the cargo trailers (or otherwise result in more efficient loading of assembled log splitting apparatuses onto the cargo trailers) while facilitating assembled presentation of the log splitting apparatuses after unloading from the cargo trailer.
US10023077B1
A track assembly includes a first pair of tracks, a first lockset that may be configured to selectively restrict movement of the first pair of tracks, a second pair of tracks, a second lockset that may be configured to selectively restrict movement of the second pair of tracks, and a cross member that may be connected between the first pair of tracks and the second pair of tracks. The cross member may be configured to actuate the first lockset and the second lockset. The cross member may include a first section and a second section. The first section and the second section may be configured to rotate relative to each other.
US10023073B2
A driving system for electric vehicles. The driving system may have two or more electric motors, each with voltage inputs, which are connected to the axles and tires of the vehicle. A variable input control may provide a signal that indicates its current operation position to a vehicle control unit. The vehicle control unit takes the information from the variable input control and determines how much power to send to each of the electric motors' voltage inputs.
US10023062B2
A device includes a processor configured to execute one or more instructions stored in a memory to receive an electrical vehicle (EV) location profile having information regarding movement of an EV between a first and a second charging location of an electrical network. The processor is also configured to apply an EV mobility model to the EV location profile to determine an optimized schedule for the EV to charge or discharge a storage cell of the EV at the first or second charging locations during a scheduling period. The EV mobility model comprises constraints that describe interactions of the EV with the electrical network.
US10023059B2
The present disclosure relates to automobiles and, more specifically, teaches methods and systems that may be used for wirelessly charging batteries used in vehicles. In one embodiment, a method for detecting a relative position between a vehicle-side receiving charging coil and a fixed transmission charging coil, may include: generating an alternating magnetic orientation field using one of the coils; detecting the orientation field using at least one coil provided for inductive excitation, wherein the orientation field is detected in a frequency-selective manner by the at least one coil; and ascertaining the relative position using an orientation receiving signal induced by the orientation field in the at least one coil.
US10023056B2
The present disclosure relates to devices, systems, and methods for jump starting an electric vehicle. In some embodiments, an electric vehicle includes battery charging circuitry electrically connected to a high voltage storage system and a low voltage storage system mounted in the vehicle. The high voltage storage system may be configured to drive a motor for propelling the vehicle. The low voltage storage system may be configured to drive a contactor electrically connected between the high voltage storage system and a drive train of the vehicle. In some implementations, the vehicle may include an electrical connection that is easily accessible and configured to supply power from an external power source to the low voltage system. The electrical connection may be integrated into a standard trailer wiring system.
US10023038B2
An energy absorbing and distributing side impact system for a vehicle includes: first and second side sills, each of the first and second sills comprising multiple longitudinal channels, at least an upper longitudinal channel positioned above a vehicle floor panel and at least a lower longitudinal channel positioned below the vehicle floor panel; a battery enclosure mounted between front and rear suspensions of the vehicle, the battery enclosure having a first side member attached to the first side sill, and a second side member attached to the second side sill; cross-members integrated into the battery enclosure; and one or more bolts each extending though a respective opening in one of the cross-members and extending to an opposite side of the vehicle floor panel from the cross-member.
US10023035B2
A tonneau cover system for a pickup truck cargo box comprising a tonneau cover sized and shaped for covering the cargo box. A side rail comprises a first clamping surface adapted to engage the first side of the downward flange. A rod has a rod axis and is mounted on the side rail. A clamp body is mounted on the rod and includes a clamp arm having a second clamping surface adapted to engage the second side of the side rail. A cam is included with one of the side rail and the clamp body. A cam follower engages with the cam. The cam follower is included with the other one of the side rail and the clamp body. Movement of the clamp body along the axis of the rod advances the cam follower along the cam to thereby move the first clamping surface toward the second clamping surface.
US10023034B2
Rigid panel sections can include a rigid panel, a first frame member, a second frame member and a coupling mechanism. The rigid panel can have a first face, a second face opposite the first face, and an edge therebetween. The first face can having a first margin adjacent the edge and the second face can have a second margin adjacent the edge. The first frame member can be disposed along at least a portion of the edge and can have a first flange overlying the first margin. A second frame member, distinct from the first frame member, can be disposed along at least a portion of the edge and can have a second flange overlying the second margin. The coupling mechanism connecting the second frame member and the first frame member together can be positioned outboard of the edge. Methods of assembling the rigid panel sections are also provided.
US10023030B2
A structure of a vehicle side door includes: an inner panel including a first protrusion and a second protrusion alternately provided in a vehicle front-rear direction at an upper end of the inner pane, the first protrusion protruding to the inner side, the second protrusion protruding to an outer side; an inner reinforcement that has a flange and is provided along the vehicle front-rear direction, the flange including a joint and a cutout alternately provided in the vehicle front-rear direction, the joint being joined to a surface of the first protrusion on the outer side, the cutout exposing the second protrusion from the flange to the outer side; and a weatherstrip provided along the vehicle front-rear direction, the weatherstrip including a pinching part that contacts a surface of the first protrusion on the inner side and a surface of the second protrusion on the outer side.
US10023026B2
A slider window assembly for a vehicle includes at least one fixed window panel and a frame portion attached at the at least one fixed window panel. A movable window panel is movable along upper and lower rails of the frame portion and movable between a closed position and an opened position. At least one of the upper and lower rails includes a recess for receiving adhesive therein and a tapered end region at an end of the recess. The tapered end region includes at least one notch or groove through a wall that at least partially circumscribes the recess, with the notch or groove configured to allow excess adhesive to escape during the adhesive bonding of the at least one of the upper and lower rails to the at least one fixed window panel. The tapered end region has an outer tapered surface opposite the recess.
US10023025B2
A heat management system for an internal combustion engine has an engine cooling circuit, a main cooling circuit that has a main cooler, a heating circuit that has a heating heat exchanger, a coolant pump that moves coolant through the circuits and a rotary slide valve that has at least one switched and at least one non-switched inlet, such that the heating return flow leads into a switchable inlet of the rotary slide valve.
US10023021B2
An air vent with an adjustment insert for adjusting an air stream flowing out through the air vent, can be adjusted by rotating the adjustment insert. A first light guide and a second light guide are provided, with the first light guide being firmly attached to a housing of the air vent and the second light guide being firmly attached to the adjustment insert. The first light guide and the second light guide are rotatable with respect to each other, and the second light guide can be illuminated by the first light guide. A backlightable portion of the adjustment insert can be illuminated by the second light guide.
US10023007B2
The present disclosure relates to caster wheels having a skirt, specifically a skirt which fits over one side of the wheel only, and thus does not interfere with the actuation of a caster wheel locking mechanism.
US10022997B2
In accordance with one embodiment, a decoloring apparatus comprises a processor, a decoloring section, a shift roller, a paper discharge section and a paper discharge roller. The processor determines whether or not to execute either a decoloring job or a non-decoloring job. The decoloring section decolors an image on paper formed with decolorable coloring agent. The shift roller moves paper for decoloring job or paper for non-decoloring job in a direction orthogonal to a paper discharge direction of the paper on a same plane for a given distance to sort it. The paper discharge section stacks discharged papers. The paper discharge roller discharges the paper sorted by the shift roller to the paper discharge section.
US10022996B2
The invention is directed to an infrared sensitive color-forming composition containing a compound having an infrared absorbing skeleton and a thermochromic skeleton in a molecule thereof wherein the infrared absorbing skeleton and the thermochromic skeleton are connected with a covalent bond or an ionic bond and a binder; an infrared curable color-forming composition wherein the infrared sensitive color-forming composition further contains a radical initiator and a polymerizable compound; a lithographic printing plate precursor having an image-recording layer containing the infrared curable color-forming composition on a support; a plate making method including imagewise exposing the lithographic printing plate precursor and conducting on-press development processing by supplying printing ink and dampening water on a printing machine to remove a non-image area; a compound represented by the formula (7) as defined herein; and a compound represented by the formula (8) as defined herein.
US10022992B2
A tape cartridge detachably mounted in a tape printing apparatus, which has a printing head portion, a drive shaft, and a base convex portion that includes a pedestal erectly disposed on a mounting base and a convex portion erectly disposed on and integrally formed with the pedestal, includes a tape roll and a core shaft that has an outer circumferential face that rotatably supports the tape roll and an inner circumferential face formed into a stepped cylindrical shape formed by a concave portion and a depressed portion which has a diameter larger than that of the concave portion. A spring is installed into the concave portion. When the tape cartridge is mounted in the tape printing apparatus, the convex portion is inserted into the concave portion and presses the spring to release an inverse rotation prevention of the tape roll, and the depressed portion receives the pedestal.
US10022983B2
An image processor, a printing apparatus, and an image processing method are provided that can reduce, when a plurality of types of inks are used to print an image, the color unevenness that is caused by the variation of ejecting characteristics among a pluralities of nozzles. To realize this, for a color formed by overlapping at least two colors of inks, parameters are prepared that are determined so as to reduce the color difference in the printing medium due to the variation of the ejecting characteristic among the respective pluralities of nozzles. During printing, the parameters are used to correct the first color signal owned by the individual pixels to the second color signal.
US10022980B2
A discharge port array unit including discharge ports having a small discharge port diameter is not arranged in a position adjacent to a discharge port array unit generating a strong airflow, and a discharge port array unit including discharge port array having not a small discharge port diameter is arranged in the position adjacent to the discharge port array unit generating a strong airflow.
US10022976B2
Controlling an ink flow to a print head includes using a diaphragm positioned within a pathway to obstruct the ink flow.
US10022970B2
A liquid ejecting apparatus includes a liquid ejecting section and a protective member. The liquid ejecting section has an aperture surface having ejection outlets that eject liquid droplets. The protective member has passage openings through which the liquid droplets pass. The protective member is disposed between a medium and the aperture surface when the liquid ejecting section ejects liquid droplets onto the medium.
US10022952B1
A print system and a method for curing marking material on an object using a mask screen are disclosed. For example, the print system includes a plurality of printheads, a curing light source, a movable member to hold an object, a mask screen and a controller to control movement of the movable member to move the object past the array of printheads, to operate the plurality of printheads to eject the marking material onto the object as the object passes the two-dimensional array of printheads, to control movement of the movable member to catch the mask screen and to operate the curing light source to cure the marking material, wherein the amount of energy that is applied to the object is controlled by the mask screen.
US10022951B2
A system and method are provided for depositing a uniform layer of a dampening solution using a vapor deposition/condensation process or technique on a reimageable surface in an image forming device using a proposed variable data digital lithographic image forming architecture that transfers ink at an efficiency rate in excess of 95 percent. A reimageable surface is configured of a low surface energy surface component that directly accepts a vaporized dampening solution having a lower surface energy than the surface energy of the reimageable surface. A uniformity in the layer of condensed dampening solution on the reimageable surface is a product of the relative difference in the low surface energy of the reimageable surface and the lower surface energy of the dampening solution.
US10022947B2
There is provided a laminated structure manufacturing method including bonding a graphene film of one layer or a plurality of layers formed on a first substrate to a second substrate with an adhesive resin layer, removing the first substrate, and forming a transparent layer on the graphene film.
US10022941B2
A heat-sealable polymer-based multilayer film having a low sealing initiation temperature, good haze, and low gloss for packaging applications. The film comprises a seal interlayer formed from a blend having a propylene-butene copolymer and a skin layer applied over the seal interlayer, with the seal interlayer being between the skin layer and the core layer.
US10022923B2
The present disclosure relates to a method of repairing a damaged portion of a perforated skin of a panel using a doubler made of composite material which is designed to be applied to the damaged portion of the perforated skin. The method includes at least one step in which a sealing film is applied to the damaged portion of the perforated skin in order to temporarily seal the perforations in the skin, and a step in which the doubler is produced over the previously deposited sealing film.
US10022922B2
A patch may be used to rework a composite structure in the field. The patch is bonded to the structure by a layer of adhesive and includes perforations that allow the escape of air from the adhesive as the patch is compressed against the structure. A spacer may be introduced between the patch and the structure to control the thickness of the adhesive layer.
US10022912B2
Methods for manufacturing structures are provided. The methods include manufacturing a shell structure by additive manufacturing methods and sectioning panels with predetermined shapes from the shell structure. The panels are subsequently coupled to shell structure. Devices for performing various steps of the methods are also provided.
US10022909B2
In accordance with embodiments of the present disclosure, a method for forming a structural member may include providing a sheet of structural material and compression molding an in-mold decoration film to a side of the sheet of structural material.In accordance with these and other embodiments of the present disclosure, a method for forming a structural member may include providing a sheet of structural material and adhesively bonding a chassis attachment frame to the sheet of structural material, the chassis attachment frame having one or more attachment features for mechanically coupling the structural member to other one or more other components.In accordance with these and other embodiments of the present disclosure, a method for forming a structural member may include providing a sheet of structural material and molding a chassis attachment frame comprising sheet molding compound to the structural material.
US10022904B2
In at least some implementations, a blow molding apparatus provides that portions of the parison are engaged by one or more clamping devices disposed on or adjacent to the blow mold parts, and that the blow mold is opened whereby the parison is torn apart between the clamping devices, into two or more pieces of the parison. In other implementations, the clamping devices may be moved relative to the blow mold to tear the parison, or the parison may be torn by a combined movement of the blow mold parts and clamping devices.
US10022895B2
A machine that removes the bead wires from tires for the purpose of reclaiming the wire and recycling of the tire. The bead of the tire is placed over a drive wheel and tension rollers, the tension rollers move away from the drive wheel which stretches the bead against the drive wheel. The drive wheel is driven by a drive system and causes the bead to rotate. As the bead rotates a blade contacts the inner periphery of the bead and severs the rubber and reinforcement material. Directly following the blade are two plates that are spaced apart approximately equal to the diameter of the bead wire. The plates push the rubber and reinforcement material off of the bead wire as the bead rotates.
US10022889B2
A feedstock material for use as a support material in an additive manufacturing system includes a pre-ceramic material in powder form. The preceramic material comprises calcium carbonate, sodium carbonate, sodium aluminate or combinations thereof. The feedstock material includes a thermoplastic binder having the pre-ceramic material dispersed therein, wherein the pre-ceramic material and the thermoplastic binder are in a filament form. The filament is configured to be melted and extruded to form a support structure for a ceramifable article in a layer by layer manner, wherein the pre-ceramic material is at least about 50% of the feedstock material.
US10022883B2
A system and process for cutting and slitting media into individualized signage members without leaving material cut from said media attached to said media includes pre-die cut openings or cut outs placed in the media based upon adhesive and liner layout of the media and cutter slitter blades used in order to create a consistent break point for slit waste.
US10022881B2
A bypass pruning tool with a manual dial adjustment for varying the degree of blade and handle opening. A rotary drum dial uses a nautilus cam with a shaft cam-follower to provide adjustment of the blade and handle openings in a continuous range. A blade locking mechanism provides position closure of the blades.
US10022875B1
A handheld magnetic tool includes a body having a top arm and a bottom arm connected via a spring, the spring allows the top arm and the bottom arm to open and close; a magnet holder secured to a first end of the top arm; a first magnet secured to the magnet holder; a plate secured to a first end of the bottom arm to close against the first magnet; the first magnet attracts metal items to be secured to a bottom surface of the plate; and opening the top arm from the bottom arm separates the first magnet from the plate, thereby allowing the metal items to release from the plate.
US10022864B2
In order to stabilize control of a driving section, a robot control apparatus includes a control section that acquires a driving position of the driving section that drives a robot and an operation force that is a force operating on the robot, and performs first control of the driving section based on the driving position and second control of the driving section based on the operation force; and a changing section that changes a size of servo stiffness of the robot that is realized by the control of the control section.
US10022863B2
A device for supporting a luggage item including a vertical base member, an arm, and carrying-element having a support surface. A guide guides vertical movement of the arm along a length of the base member, a driver drives vertical arm movement, a sensor determines force acting on the carrying element, a position sensor determines a vertical position and speed of the arm, and a controller controls the driver and sets a support force based on the determined vertical speed position of the arm.
US10022857B2
A hand tool frame has a track base, at least one positioning mount, and an engaging structure. The track base has a bottom panel, a slide rail, and a connecting track. The at least one positioning mount is slidably mounted on the track base, and each has a sliding seat and an extending element. The sliding seat is slidably mounted in the slide rail and abuts the bottom panel. The extending element is formed on the sliding seat and extends out of the slide rail. The engaging structure is formed between the bottom panel of the track base and the at least one positioning mount to enable the at least one positioning mount to position securely on the track base without sliding relative to the track base, and has at least one first engaging segment and a second engaging segment.
US10022847B2
An apparatus includes a body, a sleeve, a magnetic member and an engaging member. The body includes a function end and a first groove with first and second end faces. The sleeve includes a first room and a reception area defined therein. A second groove is defined in the outside of the sleeve and located corresponding to the first groove. The second groove includes holes defined radially therethrough which communicates with the reception area. The magnetic member is receive in the first room. The engaging member is engaged with the second groove and has first portions inserted through the holes in the second groove. The second engaging portion is connected to the first engaging portions and protrudes beyond the reception area so as to be engaged with the first groove of the body and movable between the first and second end faces of the first groove.
US10022843B2
Embodiments of the invention relate to methods of forming polycrystalline diamond compacts (“PDCs”), wherein the PDC includes a polycrystalline diamond (“PCD”) table in which at least one Group VIII metal is at least partially alloyed with phosphorus and/or at least one other alloying element to improve the thermal stability of the PCD table. The disclosed PDCs may be used in a variety of applications, such as rotary drill bits, machining equipment, and other articles and apparatuses.
US10022842B2
A method and systems for controlling optical transmissivity of a polish pad material are provided. The method and systems may include adjusting control parameters to determine the optical transmissivity of a polish pad material. The control parameters may also include pre-processing controls, casting controls, and/or curing controls. Methods and systems also provided for assembling a polish pad that controls the optical transmissivity of the polish pad. Additionally, a polish pad with a controlled optical transmissivity is provided.
US10022839B2
First, it is determined in a determination step by a determination unit whether there is a nitrided layer on a surface of a water-cooled hole of a mold, by using an eddy current sensor. Next, in a shot step, when it is determined in the determination step that there is no nitrided layer, the surface of the water-cooled hole of the mold is shot-peened under a shot condition set according to a base material of the mold, and when it is determined in the determination step that there is the nitrided layer, the surface of the water-cooled hole of the mold is shot-peened under a shot condition which maintains a state where there is the nitrided layer.
US10022837B2
A carrier head for a chemical mechanical polisher includes a base, a substrate mounting surface, an annular inner ring and an outer ring. The inner ring has a lower surface configured to contact an upper surface of a substrate positioned on the substrate mounting surface, an outer surface, and an inwardly facing surface extending downwardly from the lower surface and is configured to circumferentially surround the edge of the substrate, the inner ring vertically movable relative to the substrate mounting surface. The outer ring has an inner surface circumferentially surrounding the inner ring, an outer surface, and a lower surface to contact the polishing pad, and the outer ring is vertically movable relative to and independently of the substrate mounting surface and the inner ring.
US10022832B2
A system, method and computer-readable medium for fine-tuning speed selection for reducing machine chatter. The system includes circuitry configured to determine a predetermined speed of the machine. The circuitry identifies a stability lobe based on the predetermined speed of the machine and selects a first set of fine-tuning speeds from a range of machine speeds corresponding to the determined stability lobe. Further, the circuitry causes the machine to operate at one or more of the first set of fine-tuning speeds.
US10022827B2
The method for initially setting a position of an origin of an actuator includes a first step of setting a distal end posture being a posture of a distal end side link hub relative to a proximal end side link hub of a link actuator to a specified posture; a second step of applying a preload, which is a force that causes the distal end posture to be changed, to the link actuator having the distal end posture being the specified posture; and a third step of storing an amount of operation of each actuator in a state where the preload is applied to the link actuator, wherein the stored amount of operation is set as the position of the origin of the actuator.
US10022826B2
A method for forming a hard disk drive base plate with an extended height is described. The method may include forming an initial hard disk drive base plate, forming a filler shim, and forming a shroud. The method may also include joining the initial hard disk drive base plate, the filler shim, and the shroud to extend a height of walls of the formed initial hard disk drive base plate, and to form the hard disk drive base plate with the extended height.
US10022819B2
Safety confinement equipment for laser radiation includes a safety confinement enclosure having two laterally opposite openings through which at least one metal strip can pass, the enclosure including first and second jaw devices for clamping the strip disposed on a path of travel of the strip between the two openings, the jaws being transversely disposed at least over the width of the strip. A cutting or welding equipment head emits a beam of laser radiation to be confined, in which the beam can be moved transversely between a pair of jaws disposed opposite each other on one side of a surface of the strip. In the position in which the jaws clamp the strip, the engagement of the jaws on the surfaces of the strip induces the formation of a physical screen against the laser radiation, which prevents the radiation from passing through the two openings of the chamber.
US10022813B2
A system for controlling a weld-current in an arc welding apparatus for short arc welding comprising a current regulator included in a voltage feedback loop from a power supply to a welding electrode and a ramp generator arranged to provide current ramps during a short circuit phase at said welding electrode.
US10022811B2
A dust collection system designed for a table saw is disclosed. The dust collection system includes a dust shroud and dust shield to channel dust generated by a blade as it cuts wood or other material. The dust shroud includes fins and walls to “peel” dust and air off a spinning blade and direct the dust and air downward. The dust shroud encloses the lower front portion of a blade.
US10022810B2
A cutting tool of an aspect is provided with a holder and a cutting insert attached to an insert pocket of the holder. The cutting insert includes a front end surface, a rear end surface, a front side surface, a rear side surface, an outer side surface, and an inner side surface. The cutting edge is disposed along a ridge line at an intersection between the front side surface and the front end surface, and a ridge line at an intersection between the front side surface and the outer side surface. The insert pocket includes a restraining surface that is in contact with the rear side surface, in a front end view, the restraining surface includes a projecting portion having a curved line shape projecting toward the front in the rotational direction, and the rear side surface includes a recessed portion that is in contact with the projecting portion.
US10022806B2
Damping elements for tool chucking systems for damping vibrations and shocks that occur during machining in the case of force-fitting clamping of tools in a tool receptacle or on the tool itself. At least one damping element consisting of a shape memory alloy having a mechanical effect is provided in a tool chucking system or on the tool itself, such that the damping element provided in the chucked state in the force flow of the chucked elements is present in a reversible and hysteresis-dependent state by way of a mechanical force action and the associated crystalline conversion via the pretensioning of said damping element and leads to dissipation of mechanical energy. The mechanical energy to be damped is a cyclical vibration or represents a non-cyclical overload which is transmitted in the form of shocks.
US10022804B2
A clamping device of a tool holding plate is provided for an automatic lathe, by means of which a tool holder can be detachably fastened in a receiving slot in the tool holding plate so as to be secured in place and rotationally fixed, wherein the clamping device can be detachably fastened to the tool holding plate by fastening means. Cooling of tools during operation is provided by a coolant jet introduced into the direct vicinity of the tool by means of a coolant channel arranged in or on the clamping device, running at least partially across the clamping device from an inlet, via an intermediate channel to an outlet.
US10022802B2
The invention relates to an interchangeable cutting insert (10) having a shank (12), which transitions into a cutting head (14), which has a chipping surface (32), which, when viewed from above, is a segment of a circle with a height greater than the radius of the chipping surface (32), wherein the chord of the segment of a circle constitutes the transition to the shank (12), wherein a cutting edge (30) is formed on the outer edge of the chipping surface and multiple chip-breaking structures (36, 38) are provided on the chipping surface (32), the chip-breaking structures having depressions (36) in the chipping surface (32), between which projections (38) are arranged, which protrude beyond the chipping surface (32).
US10022801B1
A bracing device for bracing pipe on a pipe machining apparatus may include a mounting portion configured to mount on a support arm of the pipe machining apparatus and may have a continuous loop to capture a portion of the support arm. The mounting portion may be pivotable and slidable on the support arm. The device may include a support portion configured to engage a pipe and having an abutment surface for abutting against the exterior of the pipe. The support portion may have an open configuration to permit the abutment surface to be moved into contact with a pipe in the pipe machining apparatus when the mounting portion is mounted on the support arm. The device may also include a spacing portion extending between the mounting and support portions to maintain the support portion at a fixed distance from the mounting portion.
US10022800B2
A turning device has two turning stations, each with a rotatable work piece spindle to hold a lens blank and each with a turning tool for the machining of a lens blank. A fabrication mechanism for the manufacturing of eyeglass lenses from lens blanks includes a milling device and the turning device, wherein the milling device has at least one milling station with a work piece holder to hold a lens blank and a milling tool for the machining of the lens blank. A loading device is configured to remove lens blanks from the milling device and load them into the turning device. A method for operating such a fabrication mechanism includes simultaneous machining of a third lens blank with the milling tool and a first and a second lens blank with the turning tools.
US10022791B2
Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
US10022790B2
A method of forming an airfoil (12), including: abutting end faces (72) of cantilevered film hole protrusions (64) extending from a ceramic core (50) against an inner surface (80) of a wax die (68) to hold the ceramic core in a fixed positional relationship with the wax die; casting an airfoil including a superalloy around the ceramic core; and machining film cooling holes (34) in the airfoil after the casting step to form an pattern of film cooling holes comprising the film cooling holes formed by the machining step and the cast film cooling holes (102) formed by the film hole protrusions during the casting step.
US10022789B2
A system for forming a soft magnetic bulk material of a predetermined shape from a magnetic material and a source of insulating material. The systems has a heating device; a deposition device; a support configured to support the soft magnetic bulk material of the predetermined shape; and a mask configured as a negative of at least a portion of the predetermined shape. The heating device heats the magnetic material to form particles having a softened state and wherein the deposition device deposits successive layers of particles of the magnetic material in the softened state on the support with the mask located between the deposition device and the support. The mask is indexed to a position relative to the support upon deposition of the successive layers. The mask selectively blocks the successive layers of particles of the magnetic material in the softened state from being deposited on the support forming the soft magnetic bulk material of a predetermined shape on the support.
US10022788B2
A method is described for producing an engine component, more particularly a piston for an internal combustion engine, in which an aluminium alloy is cast using the gravity die casting method and wherein the aluminium alloy comprises the following alloy elements: 9 to ≤10.5% by weight silicon, >2.0 to <3.5% by weight nickel, >3.7 to 5.2% by weight copper, <1% by weight cobalt, 0.5 to 1.5% by weight magnesium, 0.1 to 0.7% by weight iron, 0.1 to 0.4% by weight manganese, >0.1 to <0.2% by weight zirconium, >0.1 to <0.2% by weight vanadium, 0.05 to <0.2% by weight titanium, 0.004 to 0.008% by weight phosphorus, wherein said aluminium alloy further comprises aluminium and unavoidable impurities. The invention further describes an engine component, in particular a piston for an internal combustion engine, wherein the engine component consists, at least partially, of an aluminium alloy, and the use of an aluminium alloy to produce an engine component, more particularly a piston of an internal combination engine.
US10022785B2
A method of controlling the amount of hydrogen in steel for consistent heat transfer in continuous casting by adding a hydrocarbon to the molten metal. A heat of molten steel is formed in a ladle metallurgy furnace adapted for use in continuous casting. Then, a hydrocarbon is added to the molten metal in the ladle metallurgy furnace in an amount sufficient to increase hydrogen levels in the molten steel for casting. And finally, the molten steel with a desired level of hydrogen is delivered to a caster to continuously cast a steel product.
US10022784B2
For continuously casting an ingot of titanium or titanium alloy, molten titanium or titanium alloy is poured into a top opening of a bottomless mold with a circular cross-sectional shape, the solidified molten metal in the mold is pulled downward from the mold, a plurality of plasma torches disposed on an upper side of molten metal in the mold such that their centers are located directly vertically above the molten metal in the mold, are operated to generate plasma arcs that heat the molten metal in the mold, and the plasma torches are moved in a horizontal direction above a melt surface of the molten metal in the mold, along a trajectory located directly vertically above the molten metal in the mold, while keeping a mutual distance between the respective plasma torches such that the plasma torches do not interfere with each other.
US10022783B2
A feeder system for metal casting comprising a feeder sleeve mounted on a tubular body. The tubular body has a first end and an opposite second end and a compressible portion therebetween so that upon application of a force in use, the distance between the first and second ends is reduced. The feeder sleeve has a longitudinal axis and comprises a continuous sidewall extending generally around the longitudinal axis that defines a cavity for receiving liquid metal during casting, the sidewall having a base adjacent the second end of the tubular body. The tubular body defines an open bore therethrough for connecting the cavity to the casting. The feeder sleeve has at least one cut-out that extends into the sidewall from the base and the second end of the tubular body projects into the cut-out to a fixed depth. The cut-out can be a groove which is separate from the cavity. The invention also resides in a feeder sleeve for use in the system and a process employing the feeder system.
US10022771B2
A method of notching lamina workpieces with a notching press system. The method includes moving a ram and an upper tooling section to an open position and inserting a lamina workpiece onto an indexing spindle, and then moving the ram and the upper tooling section to a closed position, producing a cut opening in the lamina workpiece between a punch and a first die opening. The press ram and the upper tooling section are then moved back to the open position and the index motor is rotated to position the cut opening of the workpiece over a second die opening. The torque applied to the index motor is then reduced, and the press ram and the upper tooling section are moved to an intermediate position so that the piloting device cooperates with the cut opening of the workpiece for angular positioning of the workpiece.
US10022769B2
A method for producing a shaped part from an aluminum sheet that includes an aluminum alloy, in particular an aluminum alloy of the 5000 series. The method includes introducing at least one aluminum sheet in a forming tool and cold-forming the aluminum sheet in the forming tool, and heating the cold-formed aluminum sheet at least once at least in some regions and at least once further metal forming the aluminum sheet. In order to create advantageous conditions for the method, it is proposed for the heated aluminum sheet to be subjected to the further metal forming step even before a temperature has been reached which the aluminum sheet has during the cold forming thereof.
US10022764B2
In a press forming step of obtaining, from a blank of high-tensile strength steel sheet of 390 MPa or more, a press-formed product with a shape of cross section having a groove bottom part, ridge line parts, and vertical wall parts. An outward flange including parts along the ridge line parts is formed at an end part in a longitudinal direction. Forming parts to the ridge line parts is started by creating a region positioned at an end portion, in a longitudinal direction, of a part to be formed to the groove bottom part of the blank, which is separated from a punch top part. At that time or thereafter, the region is made to approach the punch top part. When forming the ridge line parts, forming of the parts of the outward flange are conducted, the parts are formed from the start to the middle of the press forming, to reduce or prevent an occurrence of stretch flange fracture and a generation of wrinkling
US10022754B2
A filling machine and a method for intermediate cleaning of a filling machine, where the filling machine comprises a hopper for filling in a pasty substance, a conveying mechanism for conveying the pasty substance in the direction toward an outlet opening. The filling machine comprises at least one spraying device above or within the hopper for distributing the cleaning medium onto the hopper inner wall.
US10022741B2
An apparatus includes a selectively actuated fluid system having a plurality of selected fluid reservoirs, for example replaceable cartridge-type fluid reservoirs. A first subset of the reservoirs can be selectively actuated to dispense an individual fluid from the selected reservoir. A second subset of the reservoirs can be simultaneously actuated to dispense two or more fluids in mixed form.
US10022728B2
The present invention provides devices and methods to separate and concentrate target species. In some embodiments, a punctuated continuous microchannel or parallel processing (array-based) separations are provided, the microchannel having a plurality of sequential, constrictive insulating features to form a plurality of reservoirs including a first, second and third reservoir, and a plurality of constricted passageways including a first constricted passageway that connects the first reservoir to the second reservoir and a second constricted passageway that connects the second reservoir to the third reservoir. A voltage is applied to the microchannel to create different electrical fields and/or different dielectrophoresis (DEP) gradients at each of the plurality of constricted passageways in order to separate species that have differing ratios of electrokinetic mobility to dielectrophoretic mobility.
US10022727B2
A discharge electrode with equal or better performance to conventional discharge electrodes, but at significantly lower cost uses carbon fiber composite tapes suspended around support rings attached to a support at the top and a bias at the bottom. The tape is in a loop and extends around the support rings, causing the rings to be pulled apart in tension by the bias to keep the tape taut. The tape, and preferably the top ring, and alternatively the lower ring, are conductively connected to a power supply.
US10022724B2
Impact shredder hammers having first and second major surfaces on opposing sides, and a circumferential edge. A mounting portion includes a mounting hole that extends from the first major surface to the second major surface, and is configured to receive a hammer mounting pin for mounting in a reducing system. A distal portion includes a primary impact face to initially impact materials to be reduced and a wear edge to subsequently compress, crumble, and/or shear the material against a wall of the equipment. The hammer is provided with a plurality of alternating protrusions and recesses in the distal portion.
US10022712B2
The precursor of a hydroprocessing catalyst is made by impregnating a metal oxide component comprising at least one metal from Group 6 of the Periodic Table and at least one metal from Groups 8-10 of the Periodic Table with an amide formed from a first organic compound containing at least one amine group, and a second organic compound containing at least one carboxylic acid group. Following impregnation heat treatment follows to form in situ generated unsaturation additional to that in the two organic compounds. The catalyst precursor is sulfided to form an active, sulfide hydroprocessing catalyst.
US10022710B2
An alkylation catalyst having a zeolite catalyst component and a binder component providing mechanical support for the zeolite catalyst component is disclosed. The binder component is an ion-modified binder that can include metal ions selected from the group consisting of Co, Mn, Ti, Zr, V, Nb, K, Cs, Ga, B, P, Rb, Ag, Na, Cu, Mg, Fe, Mo, Ce, and combinations thereof. The metal ions reduce the number of acid sites on the zeolite catalyst component. The metal ions can range from 0.1 to 50 wt % based on the total weight of the ion-modified binder. Optionally, the ion-modified binder is present in amounts ranging from 1 to 80 wt % based on the total weight of the catalyst.
US10022706B1
A composite material type oxygen transport membrane and its preparation method are disclosed. The composite material that is an ionic-electronic mixed conducting material having high ionic conductivity is stirred into slurry and formed into a thin strip-shaped green tape substrate through tape casting to obtain a predetermined half-finished substrate, and then sintered to form the half-finished substrate into a conductive function type oxygen ion conducting substrate, followed by choosing small particle shaped highly catalyzed ionic-electronic mixed conducting material to be evenly adhered to at least one side surface of the conductive function type oxygen ion conducting substrate to form a reductive function type oxygen ion conducting layer. The reductive function type oxygen ion conducting layer and the conductive function type oxygen ion conducting substrate are then bonded to produce a composite material type oxygen transport membrane element.
US10022692B2
A Fischer-Tropsch catalyst activation system including separation apparatus configured for separating a product gas comprising primarily hydrogen from a gas stream comprising hydrogen, an activation reactor fluidly connected with the separation apparatus via an activation gas inlet line whereby the product gas may be introduced into the activation reactor, and a circulation loop fluidly connecting a gas outlet of the activation reactor with the activation gas inlet line or with another gas inlet of the activation reactor and fluidly connecting the activation reactor with one or more apparatus configured for removal of H2O. A method of activating a Fischer-Tropsch catalyst is also provided.
US10022691B2
A wetting agent according to Formula (I): wherein R1 is selected from a branched alkyl group or linear alkyl group or a cycloaliphatic group or an aromatic group, each having 6 to 15 carbon atoms; R2 is selected from hydrogen, methyl, or ethyl; R3 is selected from hydrogen, methyl, or ethyl; R4 is selected from hydrogen, methyl, or ethyl; R5 is selected from methyl or ethyl; x ranges from 0 to 5; y ranges from 0 to 10; z ranges from 1 to 10; with the proviso that when x ranges from 1 to 5, R2 is different from R3; and with the proviso that when x=0, R3 is different from R4. The wetting agent also imparts anti-foam properties to aqueous solutions while reducing surface tension.
US10022690B2
A method and apparatus for mixing at least two fluids is provided. The method involves using means for providing a spiral stream of a first fluid and a second fluid is injected directly inside the first fluid to achieve effective mixing.
US10022685B2
Inside a driven cylindrical housing 23 that is a cylindrical rotation member 13, a liquid to be mixed 4 is caused to become an inner circulation current f by extruded plate portions 24A-24D. Discharge ports 22A-22D formed in the cylindrical housing 21 discharge a portion of the inner circulation current f outward as outer discharge current d1-d4 by centrifugal force. At the same time, the outer portion of the liquid to be mixed 4 is sucked into suction ports 23, 30 as suction current e1-e3, h1-h4, thus mixing the liquid to be mixed 4 in the mixing tank 3.
US10022679B2
The present invention relates to polymer compositions and their manufacture. Specifically, the invention relates to multiblock polymers and copolymers, their fabrication, modification and/or functionalization and use as membranes or films.
US10022665B2
The present embodiments provide an acidic gas recovery apparatus or method capable of efficiently reducing emission of amine to the environment. In the embodiment, an acidic gas recovery apparatus 10A comprises: an acidic gas-absorber 11a; a regeneration tower 12; a gas-cleaner 11b; a cleaning liquid drawing-out line L23; an absorbing liquid drawing-out line L21; and an acidic component-remover 13A. The cleaning water 27c from the cleaning liquid drawing-out line L23 and a purified lean solution 23C from the absorbing liquid drawing-out line L21 are supplied to the acidic component-remover 13A. The acidic component-remover 13A comprises a cathode 53, an anode 54, an absorbing liquid-purification compartment 57 for removing acidic components from the objective lean solution 23B, and cleaning liquid compartments 58-1 and 58-2. The cleaning water 27 is supplied to the cleaning liquid compartments.
US10022664B2
Disclosed is a canister for a vehicle having an auxiliary canister, which includes: a main canister that has an inlet and an outlet formed therein, an evaporation gas being introduced into the main canister through the inlet from a fuel tank and the evaporation gas introduced through the inlet being discharged through the outlet to the intake side of an engine when the engine is driven, and has a trapping member therein; and an auxiliary canister that is installed to communicate with the main canister to allow external air to be introduced into the main canister or to allow the evaporation gas to flow when the engine is turned off, and has a second trapping member therein, wherein the auxiliary canister includes the second trapping member therein, which has a plurality of pores in the form of a honeycomb.
US10022663B2
An air separation system includes an air separation module configured to receive feed air and separate the feed air into nitrogen-enriched air and oxygen-enriched air, a nitrogen-enriched air line for transporting the nitrogen-enriched air from the air separation module to a fuel tank for inerting, an oxygen sensing line connected to the nitrogen-enriched air line, a gas adsorption filter located in the oxygen sensing line, and an oxygen sensor downstream of the gas adsorption filter in the oxygen sensing line.
US10022660B2
A filter system for filtering intake air of a gas turbine is presented. The filter system includes a first filter arrangement. The filter system further includes a second filter arrangement located downstream from the first filter arrangement and having a collection efficiency higher than a collection efficiency the first filter arrangement. Furthermore, the filter system includes a guard filter arrangement located between the first filter arrangement and the second filter arrangement, where a collection efficiency of the guard filter arrangement is lower than the collection efficiency of the first filter arrangement.
US10022652B2
A solution treatment apparatus connected to a supply nozzle that supplies a treatment solution to a substrate, includes: a supply pipeline connecting a treatment solution storage container and the supply nozzle; a filter apparatus provided in the supply pipeline; a pump on a secondary side of the filter apparatus; a circulation pipeline connecting a discharge side of the pump and an intake side of the filter apparatus; a supply control valve provided in the supply pipeline on a secondary side of the pump; a circulation control valve provided in the circulation pipeline; and a control unit, wherein the control unit opens the circulation control valve and drives the pump when supply of the treatment solution from the supply nozzle to the substrate is stopped by closing the supply control valve, to thereby circulate the treatment solution between the supply pipeline having the filter apparatus and the circulation pipeline.
US10022649B2
A system for recovering water from air includes a base plate having an upper surface having a substantially non-reflective surface to absorb heat energy from the sun. A column is positioned on the base plate and has at least one wall through which heat energy from the sun may pass to the base plate to heat the base plate, and the base plate heats air in the column. An upper thermally conductive plate is secured at an angle between horizontal and vertical within an upper end of the column. A lower plate is secured within the column parallel to and spaced beneath the upper plate to define a flow channel between the upper plate and the lower plate. A thermoelectric cooler is connectable to a power source for cooling the upper plate. An accumulator is positioned for collecting and accumulating water that condenses on and flows through the flow channel.
US10022647B1
The present invention comprises an evaporation system for wastewater wherein the staging tank is utilized to pretreat the wastewater to strip hydrocarbons from the staging tank before sending to the evaporator by sparging the wastewater in staging tank with air from the blower and or hot gases from the combustion utilized in the evaporation system.
US10022636B2
A flight simulator, motion simulator or orientation simulator for the spatial movement of at least one person, and in particular for the simulation of acceleration sequences, has a holding device for holding a person in a region of the center. The holding device is mounted on a carriage via a movement device. The carriage can be displaced, in particular linearly, along a horizontally oriented main carrier. The main carrier is rotationally driven about a vertically oriented major axis of rotation and the center is displaceable between a first outer maximum position and a second outer maximum position by moving the carriage along a trajectory on the main carrier. A normal distance between the first outer maximum position of the center and the major axis of rotation is greater than the normal distance between the second outer maximum position of the center and the major axis of rotation.
US10022631B2
An avatar or avatar environment to visualize data may be provided within a social networking system or service, for example as part of the Internet, and/or within a desktop widget, panel, gadget, or the like. The avatar may further evolve or alter its appearance, animation, or other visual or audio characteristics in response to the data or other input such as athletic activity performed by a corresponding user. In particular, the avatar of an embodiment may respond to and provide visualization of athletic or sport performance data.
US10022630B2
Systems and methods are provided for playing a video game in which a user is associated with a particular gaming level in a plurality of gaming levels and is subjected to one or more challenges. The user responds to the challenges. The user is provided with a first mechanism for acquiring a first subpart, from among a plurality of subparts, at a time when the user has collected none of the subparts. The subparts collectively define a virtual composite item that has functional value within the game and the subparts do not have functionality within the game until the user has collected the entire plurality of subparts. Subsequently, the user is provided with a second mechanism for acquiring a second subpart from among the plurality of subparts. Use of a virtual composite item is enabled when the user has collected all the subparts of the composite item.
US10022626B2
First placement information for placing a first virtual object based on a first reference is transmitted, and the first virtual object is displayed in a first captured image based on the first reference and the first placement information. On the other hand, the transmitted first placement information is acquired, and the first virtual object is displayed in a second captured image based on a second reference and the first placement information.
US10022625B2
Methods and systems for adjusting a weight of a peripheral device while presenting content to a head mounted display are disclosed. One method includes processing instructions for rendering a virtual reality scene in the head mounted display. The virtual reality scene includes a virtual object. The method also includes receiving pairing of the peripheral device for use with the head mounted display for rendering the virtual reality scene and determining a movement of the virtual object. The method causes sending of instructions to the peripheral device for execution by a controller of the peripheral device to move a weight in the peripheral device. The weight is moved to provide a correlation to the determined movement of the virtual object.
US10022621B2
An elongated member such as a bar includes spaced-apart infrared light illumination ports at opposite ends thereof. Exemplary spacing between the two spaced-apart light ports may be 20 centimeters or more. Each light port comprises an array of plural light sources. The plural light sources in each array may be directionally aimed to as to provide different illumination directions. The plural light sources in each array may emit different colors or frequencies of light. Example applications include targeting or marking capabilities for a video game or other system handheld pointing device.
US10022618B2
A method including, manufacturing individual playing cards; shuffling, using a shuffling machine with multiple pockets, a multiple number of decks of the playing cards at random in a factory utilizing at least a first card feeding step and a second card feeding step; detecting, using an imaging device and an image processing unit, a rank and a suit of each of the cards; counting, using the image processing unit, the number of each rank and each suit; inspecting, using the image processing unit, during or after the shuffling of the decks of playing cards, but before packaging, whether or not there is an excess or deficiency in the number of the rank or the suit contained in the multiple number of decks of the playing cards; and, after the inspecting step, packaging a set of the shuffled decks of the playing cards in an individual package.
US10022617B2
A playing card shuffling device includes a visual display in information communication with the playing card shuffling device. At least one processor is programmed to provide displayable information to the visual display indicative of an amount of time remaining or time expired in a procedure performed by the playing card shuffling device.
US10022615B2
Various powered wheeled board vehicles are disclosed. In some embodiments, the vehicle includes a deck having a forward portion and a rearward portion. At least one front wheel can be connected with the deck under the forward portion. The front wheel can be configured to swivel about a first axis and rotate about a second axis. A powered wheel can be connected with the rearward portion. In some configurations, the rear wheel comprises a hub motor.
US10022611B2
A safety fence support device with flexibility may be provided. More particularly, a safety fence support device with flexibility may be provided which is simply installed on a safety fence used in various sports facilities, e.g., a baseball field, an ice hockey rink, a ski slope, etc., causes the safety fence to be tilted backward even when players playing a game or people enjoying the sports in the sports facilities collide with the safety fence at various angles, thereby preventing injury by mitigating impact applied to a human body through the safety fence, and is used in various sports facilities regardless of the kind of the safety fence by controlling the degree of flexibility for mitigating the impact in accordance with the impact strength.
US10022593B2
A basketball configured for organized, competitive play and having a total mass. The basketball includes an inflatable, generally spherical bladder, a set of winding surrounding the bladder, an elastomeric layer surrounding the set of windings and the bladder, and a plurality of cover panels positioned over the elastomeric layer. The bladder has a bladder mass that is greater than 25 percent of the total mass. The elastomeric layer and the set of windings have a collective mass that is less than 55 percent of the total mass.
US10022587B1
A walking trainer includes a linear transmission unit including two carriages, and two pedal units each including a pedal holder, which includes a bottom frame carried on one respective carriage, upright posts mounted at the bottom frame and a top block mounted on and movable up and down along the upright posts, a rotary shaft mounted in the top block in a direction perpendicular to the upright posts and a pedal mounted on the rotary shaft and biasable with the rotary shaft relative to the pedal holder. Thus, the pedals of the pedal units can be moved with the respective carriages linearly and alternatively back and forth, on the other hand, and can also be moved with the associating top blocks up and down and biased with the respective rotary shafts relative to the respective pedal holders to simulate the walking gait path.
US10022585B2
An exercise glove for strengthening the muscles of the hand, wrist, fingers and forearm through full, natural ranges of motion, while providing a tightening grip of the hand on objects.
US10022583B2
A dumbbell assembly includes a number of weight members, a handle device engageable with the weight members for anchoring a selected number of the weight members to the handle device, a base support includes a number of socket openings for accommodating the weight members, and a follower is slidably engaged in the base support, and the follower includes one or more catches for selectively engaging with the weight members that are supported on the base support and for selectively retaining the weight members to the base support. A spring biasing member is engaged with the follower for biasing the catches of the follower to engage with the weight members.
US10022579B1
A shuttle training and therapy device including in one example: a floor standing fame having a headward end and a footward end; a carriage slidably attached to the frame; a resistance system of elastic cords attached to the footward end of the frame; the elastic cords selectively attached to the carriage; and a range of motion limiting system including a control cord having a first end attached to the carriage, a second end selectively attached to the frame, and an intermediate portion attached to an elastic member attached to the carriage.
US10022572B2
A system for assembly of a lifeline of the type that uses an anchor post and retractable drum assembly to horizontally stretch the mentioned as a means to protect workers constructing buildings or other structures from falls; the anchor post is modular and can be coupled to complementary tube(s) with telescopic adjustment means; said modular anchor post being provided with (i) a structural base with a plane region and ribs welded to the side of the post so as to keep said plane slightly removed from said anchor post; a hole drilled in the ground of the building receives the tubular sector, arranged between the end and the plane region; (ii) by at least one safety guide, formed by three arched segments; (iii) by at least one transport handle in a single piece; and (iv) by at least two brackets for mounting and attaching the retractable lifeline drum assembly, optimizing the ways of holding the lifeline stretched horizontally.
US10022565B2
A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.
US10022558B1
Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula.
US10022557B2
A guide member facilitates a device swap for brachytherapy treatment. A cavity evaluation device is introduced during surgery such that a distal end of the device is disposed in a resected cavity of the patient. The cavity evaluation device includes a shaft in which is disposed an elongated guide member. In a subsequent out-patient procedure the cavity evaluation device is removed from the resected cavity. If a brachytherapy treatment is to be performed then the cavity evaluation device is removed without removing the elongated guide member such that position of a portion of the elongated guide member in the resected cavity is maintained relative to the resected cavity. An anchor member helps to maintain the position of the guide member. Introduction of a brachytherapy catheter is then facilitated by introducing the elongated guide member into an opening of the brachytherapy catheter and using the elongated guide member to guide the brachytherapy catheter to the resected cavity.
US10022552B2
Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
US10022544B2
This disclosure concerns a method for enhancing vision for a vision impaired user comprises. A processor, such as a controller of a retinal prosthesis, determines based on input image data a shape associated with an object represented by the input image data. The processor then determines for each of multiple areas of the input image data a coverage value that indicates to what extent the shape covers that area of the input image. Each of the multiple areas is associated with one of multiple imaging elements of the retinal prosthesis. The processor then determines an output value for each of the multiple imaging elements of the retinal prosthesis, such that when the output values are applied to the imaging elements to create a visual stimulus, a contrast is perceivable between a first element and a second element based on their respective coverage values.
US10022535B2
An apparatus and method for implanting and securing an implanted medical device in a recipient. The implantable medical device of the generally includes an electrode assembly that comprises an elongate carrier member having at least one stimulating electrode positioned thereon. The carrier member further has a fixation structure positioned thereon configured to interact with a portion of the rigid structure to longitudinally secure the carrier member in the recipient.
US10022529B2
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
US10022522B2
A balloon catheter includes an inner shaft with a distal variant portion and a proximal variant portion. A bulged portion is provided at the distal end of a reinforcement member, and the bulged portion is configured to move in an axial direction between the distal variant portion and the proximal variant portion. Thus, the balloon catheter may smoothly pass through a curved blood vessel with improved kink resistance of the reinforcement member.
US10022513B2
A resuscitator has a patient airway interface device, a bag, a flow passage coupled between the bag and patient airway interface device, and a sensor assembly. The patient airway interface device may be a mask or an endotracheal tube. The sensor assembly has a display, at least one sensor coupled to the flow passage and configured to provide a measurement of at least one parameter, and a processor coupled to the display and the at least one sensor. The processor is configured to receive the measurement from the sensor and provide information on the display based on the received measurement. The information may include a current breath rate, a pressure-vs-time curve, and guidance to the user to assist in achieving a target breath rate.
US10022511B2
A device for treating nasal congestion and/or relieving sinusitis symptoms in a patient comprises: a vibration generator, a fastener configured to attach the vibrator to a location adjacent to the patient's nasal cavity, nasal passageway or sinuses and a generator of a fluid stream which delivers the fluid stream to the respiratory tract of the patient. The vibration includes a motor, an eccentric member rotatable by the motor and an impact member mechanically linked to the eccentric member such that the impact member is vibratable by the eccentric member.
US10022510B2
A tape system for a dose counter for an inhaler, the tape system having a main elongate tape structure, dosing indicia located on the main elongate tape structure, tape positioning indicia located on the main elongate tape structure, a tape size marker located on the main elongate tape structure indicating a number of dosing indicia on the tape, and priming indicia located on the main elongate tape structure, the priming indicia being located between the dosing indicia and one end of the tape.
US10022508B2
A method for filling a plurality of microdepressions in a major surface of a web with finely divided powder in which the web is fed continuously to and through a powder filling stage including a driven roller. A method of manufacturing an elongate carrier with microdepressions containing finely divided powder comprising steps filling a plurality of microdepressions in a major surface of a web as described, removing from upper surface of the web excess powder not filled within the microdepressions and remaining on areas of the surface between the depressions, and optionally slitting and/or cutting the web in width and/or length.
US10022503B2
Exemplary embodiments provide a needle shield remover that reliably engages with a distal cap of an automatic injection device and with one or more needle shields coupled to a syringe of the device. When a user removes the distal cap, the needle shield remover reliably removes the needle shields (e.g., a soft needle shield and a rigid needle shield) from the syringe, thereby exposing the injection needle for performing an injection. In an exemplary assembly method, a needle shield remover is engaged to a needle shield coupled to a syringe, prior to insertion of the syringe and needle shield remover assembly into a housing of the device. This exemplary assembly method allows visual inspection, outside the housing of the device, to ensure that the needle shield remover is correctly and reliably engaged to the needle shield before the syringe and needle shield remover assembly is inserted into the housing.
US10022498B2
A system and method for monitoring and delivering medication to a patient includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule base application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.
US10022489B2
An aspiration probe tip for use in surgical procedures includes a body defining a first channel therein for aspirating material therethrough from a surgical region along a first vector. The body includes a straight portion connected to a first end and a curved portion connecting the straight portion to a second end. A fluid sleeve surrounds at least a portion of the body and defines a second channel between the fluid sleeve and the body for injecting a fluid into the surgical region along a second vector. An end of the fluid sleeve securely fits over the body to substantially seal the end of the fluid sleeve. The fluid sleeve further defines an aperture for injecting fluid along the second vector from the second channel into the surgical region.
US10022478B2
A medical device is provided including a base member and a coating layer containing an antithrombogenic material and covering a surface of the base member. The antithrombogenic material contains a copolymer having a repeating unit (A) represented by the following formula (1): wherein R11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R12 is a C1-6 alkylene group, R13 and R14 are each independently a C1-4 alkyl group, and R15 is a C1-2 alkylene group, and a repeating unit (B) represented by the following formula (2): wherein R21 is a hydrogen atom or a methyl group, R22 is a C1-6 alkylene group, and R23 is a C1-4 alkyl group. The repeating unit (A) is contained in a proportion of 1 to 7 mol % based on all the structural units of the copolymer.
US10022475B2
Systems and methods are disclosed for body augmentation by mixing hyaluronic acid (HA) with polyvinyl alcohol (PVA) to form an HA-PVA hydrogel; and exposing the HA-PVA hydrogel to one or more freeze-thaw cycles or to an amount of radiation effective to crosslink the HA to the PVA to crosslink the HA to the PVA.
US10022474B2
Bone grafts and constructs including stem cells are provided. Example bone grafts include osteogenic stem cells seeded on a scaffold of osteoconductive cortico-cancellous chips and/or osteoinductive demineralized bone. Example constructs include extracellular matrix on a synthetic scaffold, in which the ECM is secreted from MSCs seeded onto the synthetic scaffold. Also provided are methods of making the present bone grafts and scaffolds. Further provided are methods of promoting bone healing and treating wound healing, by administering the present bone grafts and constructs to a mammal in need thereof. Also provided are kits that include the present bone grafts and/or constructs, or components thereof.
US10022471B2
Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
US10022469B2
Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
US10022468B2
Improved skin-adhesive compositions for bonding a substrate, such as an absorbent article, to skin are disclosed. More particularly, the skin-adhesive composition has an improved, yet gentle, adhesion to the skin of a user, while maintaining strong, effective bonding to various inanimate, non-skin substrates. In one embodiment, the skin-adhesive composition can provide one or more skin benefit agents to the user. The skin-adhesive composition may be applied to an absorbent article, such as a panty-liner, sanitary napkin, or an incontinence article, for directly adhering the article to the skin of a user.
US10022463B2
The invention provides an apparatus and a process for continuous virus inactivation. The apparatus for continuous virus inactivation in a product stream comprises a tube or hose 1 having an inlet 4 and an outlet 5 in each case connected to a product flow line 8 for conveying the product stream, where the tube or the hose 1 is curved and/or helically coiled with a number n of windings around a coil axis h and has one or more changes in direction and/or bends 2 in the coil axis h having an angle α of from 45° to 180° to alter the direction of action of the normals of the centrifugal force and the apparatus is characterized by a Dean number>0 and a torsion parameter>0.
US10022450B2
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
US10022437B2
The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
US10022436B2
Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus replicon is coated onto or embedded into a plurality of microneedles. Also described herein are methods of preparing a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. Also disclosed herein are methods of inducing an immune response in an individual comprising contacting the individual with a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide.
US10022433B2
The present document discloses a new species of Aliivibrio, herein denoted Aliivibrio friggiae. A strain Aliivibrio friggiae, denoted Aliivibrio sp. 130206K7F2 506, has been deposited at the National Collection of Industrial and Marine Bacteria and has been assigned accession number NCIMB 42181. Further disclosed is the medical use of Aliivibrio friggiae for vaccinating fish against a new disease identified and herein denoted friggiosis.
US10022431B2
This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.
US10022428B2
The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
US10022425B2
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
US10022423B2
Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli (E. coli) and/or Shigella bacteria via proximity-dependent inhibition (PDI).
US10022421B2
Disclosed are methods of treating a chemotherapy-resistant cancer, of treating a cholangiocarcinoma, of treating a metastatic carcinoma, and of treating a transition cell urothelial carcinoma by administering a therapeutically effective amount of an endothelin B (ETB) receptor agonist and a chemotherapeutic agent to a subject afflicted with such a cancer.
US10022417B2
A peptide having 12 to 60 amino acids and including (a) a sequence of SEQUENCE ID NO: 11, or (b) a fragment of SEQUENCE ID NO: 11 that includes the sequence of SEQUENCE ID NO: 1 or 5, is described for use in improving glycemic management in a mammal. A composition, for example a food product, that includes substantially all of the peptides of SEQUENCE ID NO:'s 1 to 11, that is capable of reducing post-prandial blood glucose levels, and increasing insulin secretion in humans, is also described.
US10022413B2
In one embodiment, the present application provides an herbal supplement and method for treating bloating, constipation and/or weight gain in a human subject comprising orally administering to a subject in need thereof an effective amount of the herbal supplement comprising a red quebracho extract. In other embodiments, the supplement may additionally include a triterpenoid saponin, an anti-spasmodic agent, or both.
US10022403B2
The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase β-cell viability.
US10022394B2
The present invention relates to the use of hydroxymethyl-group-containing glycosaminoglycans, such as in particular hydroxymethyl-hyaluronic acid, for the treatment and prevention of infectious diseases or malignant or premalignant diseases, in particular of the skin or mucosa. The invention additionally provides a preparation method for glycosaminoglycans modified with hydroxymethyl groups.
US10022378B2
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like, are also disclosed. In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in further combination with at least one additional antiviral agent that works via a different mechanism than a nucleoside analog. This combination has the potential to eliminate the presence of HIV in an infected patient.
US10022374B2
Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.
US10022370B2
This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.
US10022364B2
The present invention relates to the field of molecular biology and cancer biology. Specifically, the present invention relates to methods of treating a subject with a farnesyltransferase inhibitor (FTI) that include determining whether the subject is likely to be responsive to the FTI treatment based on genotyping and expression profiling of certain immunological genes and RAS mutation status in the subject.
US10022362B2
The present invention provides a method for treating an allergy disease or disorder or symptoms related thereto, in a subject in need thereof, the method comprising: administering a therapeutically effective amount of an anti-allergy benzocycloheptathiophene derivative compound of Formula I: or a pharmaceutically acceptable salt thereof, solvate, or prodrug thereof, and a pharmaceutically acceptable carrier, vehicle or excipient.
US10022351B2
The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.
US10022348B2
The present invention relates to a topical solution comprising a retinoid or its pharmaceutically acceptable salts thereof and process of preparing it.
US10022347B2
Compositions including an odd chain fatty acid, and salts and derivatives thereof, and methods for metabolic syndrome treatment and prophylaxis are provided, including compositions and methods for treating diabetes, obesity, hyperferritinemia, elevated insulin, glucose intolerance, dyslipidemia and related conditions. Methods for the diagnosis and monitoring of metabolic syndrome are also provided.
US10022344B2
Described herein are oral pharmaceutical compositions comprising liquid dosage forms of sodium naproxen in soft gel capsules. In one embodiment, the pharmaceutical composition comprises sodium naproxen, 0.2-1.0 mole equivalents of a de-ionizing agent per mole of naproxen, polyethylene glycol, and one or more solubilizers such as propylene glycol, polyvinyl pyrrolidone or a combination thereof.
US10022338B2
This disclosure describes compounds that affect the olfactory responses of the honey bee mite (Varroa destructor) and methods of use thereof. The compounds do not kill Varroa destructor, and are therefore unlikely to generate Varroa destructor resistance, compared to an acaricide. The compounds can work in conjunction with other mite control approaches, such as a bottom board excluder and sticky board control devices, and can enhance the performance of other forms of mite control while decreasing disadvantages associated therewith.
US10022333B2
A computer-implemented method for image-guided delivery of a nanoparticle mixture to a target tumor located in a region of interest includes selecting a non-hypoxic delivery location within the region of interest for delivery of a non-bacteria-associated nanoparticle component included in the nanoparticle mixture and selecting a hypoxic delivery location within the region of interest for delivery of a bacteria-associated nanoparticle component included in the nanoparticle mixture. An image-guided delivery and monitoring process may then be performed. During this process intra-operative images of the region of interest are continually acquired and used to guide placement of a device into the non-hypoxic delivery location, monitor delivery of the non-bacteria-associated nanoparticle component included in the nanoparticle mixture at the non-hypoxic delivery location, guide placement of the device into the hypoxic delivery location, and monitor delivery of the bacteria-associated nanoparticle component included in the nanoparticle mixture at the hypoxic delivery location.
US10022330B2
The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release formulations of the drug, and the duration of effect falls rapidly at the end of the dosing interval.
US10022329B2
An edible energy tablet containing at least 80 weight % carbohydrates for consumption during exercise, is fabricated by a process including providing tablet material free of hydrophobic and/or PEG lubricants and free of CO2 sources. The tablet material includes a sucrose and dextrose mixture of 77-95 wt. %, maltodextrin of 2-13 wt. %, an edible soluble oil of 0.2-2.0 wt. %, and an edible acid of 1-4 wt. %. The tablet material is introduced to a tablet press that alternately moves first and second punches towards and away from one another to compress the tablet material to form and release a tablet. A punch cleaner engaged with the first and second punches removes tablet material from the punches after tablet release. The tablet has a diameter of 1.2 to 3.8 cm, a thickness of 0.6 cm to 2.3 cm, and a resistance to breakage forces of 8.5 to 30 kilopounds.
US10022325B2
The present invention provides compositions and methods for the treatment of cancer are provided.
US10022319B2
An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.
US10022318B2
This invention provides an effervescent solid form that dissolves in cold water quickly enough to not disappoint consumers yet not so quickly that the visual interest generated during the effervescent reaction is lost. This performance is achieved by forming effervescent particles that are dense enough to retard dissolution and small enough to not take too long to dissolve. The aim of this invention is to provide a beverage in solid effervescent form that takes between about 30 and about 120 seconds to dissolve in warm water. The granules may carry functional additives such as flavors, vitamins, minerals, sweeteners, colors and drugs. The granules may also be compounded of materials intended to provide relief from skin or topical discomfort, as in the form of a wash or bath additive. The granules may also be formulated to provide cleaning agents, such as ceramic cleaners and denture cleaners.
US10022312B2
The disclosure relates to a method for gradually coloring hair comprising the steps of: a) applying an air oxidation haircolor composition to hair; b) removing the air oxidation haircolor composition from the hair directly after application; and c) repeating a set comprising the steps a) and b) in multiple spaced intervals. The air oxidation haircolor composition can include: 1) at least one primary oxidation dye intermediate; 2) at least one aromatic triol; and 3) water.
US10022311B1
The disclosure comprises a process that pertains to the chemical reaction of hair when exposed to a series of chemical compositions. Utilization of named ingredients in specified order manipulates the pH value and driving agents; the nature of the process is an improvement of delivery methods for hair strengthening and smoothing treatments.
US10022310B2
An antimicrobial mixture comprising or consisting of: one or more compounds of the formula (I) their salts or solvates, wherein R1 and R2 in each case independently of one another are chosen from the group consisting of: H, OH, F, Cl, Br and I, and wherein X in each case denotes: (CH2)m where m=1, 2 or 3 or OCH2n where n=1, 2 or 3 or O—CH2—CH(R3) where R3=CH3 or CH2OH or (CH2—OpCH2 where p=1 or 2, wherein in the compound(s) of the formula I a primary alcohol function CH2OH is optionally replaced by a radical which is chosen from the group consisting of CH2OR4, COOH and COOR4 and/or a secondary alcohol function CHOH is optionally replaced by the radical CHOR4, wherein each R4 denotes an aliphatic or aromatic radical, independently of the meaning of further radicals, and one, two or more compounds chosen from the group consisting of the tropolones of the formula (II) wherein the substituents R5, R6, R7, R8, R9 independently of one another have the following meaning: H; linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; OH; OR10, wherein R10 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; COOH; COOR11, wherein R11 is a linear or branched, saturated or unsaturated, aliphatic hydrocarbon radical having up to 30 C atoms; NO2, NH2, F, Cl, Br, I.
US10022307B2
A hardenable two part acrylic composition is described for the treatment of human or animal bone is described. The composition comprises a storage stable liquid first part and a storage stable liquid second part which react with each other upon mixing to form a cement which hardens. The composition further comprises an acrylic monomer component and an initiator component in an amount effective to polymerize the monomer component. The monomer component and the initiator component are generally located in separate parts of the two part composition so that the monomer component is storage stable. The liquid first part comprises emulsion polymerized acrylic polymer particles in a liquid carrier. A method of producing a hardenable two part acrylic composition is also described. The composition is particularly useful in a syringe or caulking gun having at least two barrels.
US10022306B2
Presently described are dental compositions comprising one or more fatty mono(meth)acrylates, methods of use, dental articles, and methods of making dental compositions. It has been found that a relatively low concentration of a fatty mono(meth)acrylate can improve the handling characteristics of a dental composition by reducing the tendency of the composition to stick to a dental instrument and/or by reducing the tendency of a dental composition to string when being manipulated by a dental instrument. In one embodiment, a hardenable dental composition is described comprising a polymerizable resin composition comprising at least one multifunctional ethylenically unsaturated monomer; 0.2 to 10 wt-% of one or more fatty mono(meth)acrylate monomers; and at least 50 wt-% of inorganic oxide filler.
US10022305B2
Methods and systems are described for monitoring medication use with a home automation system. An example medication monitoring system includes a medication storage device, a proximity device, and a dispenser module. The medication storage device is configured to hold a plurality of medications. The proximity device is configured to detect an activity of a user relative to the medication storage device. The dispense module is configured to detect a pattern of the activity based on data received from the proximity device, and generate a notice. The notice may be generated if the pattern is broken. The notice may include a summary report on usage of the medication storage device. The notice may include an alarm if the medication storage device is, for example, tampered with or moved.
US10022304B2
A medication dispenser having a housing adapted to securely retain patient medication until such a time as a controller enables a patient interface to permit a patient to access medication stored and distributed by the dispensing assembly.
US10022296B2
The present invention provides a fluid injection system (11) which transitions between a maintenance mode wherein an outlet (15) is closed and no fluid is discharged through the outlet, and an operation mode, wherein the outlet is open and fluid is discharged through the outlet. The fluid injection system injects a first fluid transported in a first pipeline (21) with a second fluid, wherein there is a temperature differential between the first fluid and the second fluid. The fluid injection system comprises a holding tank (49) for storing the second fluid, a cooling means (35) to cool the second fluid, and a pump (39) for delivering the second fluid into the first pipeline. The second fluid mixes with the first fluid in the first pipeline to provide a combined third fluid having a temperature within a predetermined temperature range, wherein the third fluid is maintained within the predetermined temperature range when the fluid injection system is in either mode such that the temperature of the third fluid made available to an outlet is within the predetermined temperature range.
US10022292B2
Embodiments of the present invention provide a massager device, system, and method. A massager is configured to communicate (directly or indirectly) a user feedback message to a target in response to a determination that an event has occurred. The massager may be a sexual aid. User feedback messages may be generated based on various pre-sets and/or user selections established to determine a message medium type, content for inclusion in the user feedback message, the target, the event, and other customizations. The content of the user feedback messages may be generated according to a content selection method, such as random, user-customized, pre-sets, categorical, or based on usage parameters, such as biometric, massager settings, and temporal data.
US10022291B2
A sensory lounging chair system and method of use. The system generally includes a frame, a pump, air tubes connecting the pump to a pair of inflatable air tubes, pressure release valves, piping and hardware, a pressure sensor, and a fabric cover. In a preferred embodiment, the pump and pressure sensor are powered by a power supply connected to a terminal board, which in turn is connected to the pump and the pressure sensor. The fabric cover provides a comfortable barrier between the occupant and the air tubes, which initially are usually deflated or less than fully inflated. As the pressure in the air tubes increase, deep touch pressure is applied to the occupant's body in the places where the air tubes are in contact with the occupant. Deep touch pressure is thus applied to the occupant via contact with the tubes through the fabric cover.
US10022282B2
A gown dispenser system has a plurality of gowns, each having a back region, the gowns folded and stacked back region facing up, such that, pulling on the back region of a gown on top of the stack removes that gown from the stack and exposes the back region of the next gown in the stack, an enclosure containing the stack of gowns, the enclosure having an opening exposing the back region of the gown at the top of the stack, enabling a user to grasp the exposed back region and pull the topmost gown from the enclosure, exposing the next gown in the stack, and an interface mechanism attached to the enclosure, enabling the enclosure to be suspended on a substantially vertical surface, with the opening facing outward from the substantially vertical surface. Gowns are drawn from the enclosure one-at-a-time, at need.
US10022277B2
A moisture management apparatus monitors an area for moisture events and wirelessly transmits moisture-related information to one or more notification devices. An embodiment of the moisture management apparatus includes a substrate and one or more sensors supported by the substrate. The sensor(s) emit wireless signals indicative of the moisture-related information. A sensor event communication system forwards the sensor signals to another device, such as a notification device. The sensor event communication system may monitor other types of patient events. Portions of the moisture management apparatus and/or the moisture event communication system may be embodied in a patient support apparatus, such as a bed.
US10022272B1
A safety system includes safety glasses and an apparatus. The safety glasses include an electronic system having a sensor configured to detect when the safety glasses are worn by a user and a wireless communication device. The apparatus includes a body housing an electrical isolation device and a wireless communication device. The body includes a first end defining a female electrical socket, a second end defining a male electrical plug and a fastening device coupled to the body and configured to move from an open position to a closed position in which an electrical cord that is electrically coupled to the body at one of the first end or the second end is also physically secured to the body by the fastening device. The electrical isolation device is configured to prevent current flow in the line conductor included in the body when the safety glasses are not being worn by the user.
US10022266B2
Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, including a dispensing accessory with a first valve made of an elastomer material that allows the substance to pass through when the dispensing accessory is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory is relaxed, characterized in that the first valve is covered by a layer of Parylene.
US10022261B1
A male external incontinence device comprising a drainage tube assembly having a proximal chamber in fluid communication with a drainage tube, the proximal chamber comprising an atmospheric equilibrium valve assembly. The atmospheric equilibrium valve assembly has an airway conduit with a upper portion in fluid communication with the proximal chamber, and a lower portion having an air inlet chamber. A one-way air valve disposed in the airway conduit above the air inlet chamber, the one-way air valve comprising a first pair of opposing walls disposed at a first set of opposing angles such that the first pair of opposing walls abut each other at an apex, the apex having a self-sealing slit.
US10022247B2
An automatic machine for processing a tooth by a graft material includes: a body including a power supply supplying power to a controller, which controls the amount of supply solution and operation of a suction pump and a vibrator, and having a receiving space; a receiving container disposed in the receiving space, having a space for keeping a tooth bone graft material, and including a net and a cover having a handle; a cylinder having a space for keeping the receiving container, and inlets and outlets for supplying and discharging the supply solution; a vibrator fastened to the cylinder and generating vibration of 1 to 100,000 VPM; a supplying container supplying the supply solution to the cylinder; and a suction pump discharging solution in the cylinder to a discharging container.
US10022246B2
An interlaminar fixation device (“ILFD”) and related tools for implanting and extracting the ILFD in surgical procedures to provide support for patients having degenerative spinal conditions. The ILFD comprises an implant body, a pair of fixation pin assemblies, and a locking plug. The body may be a boxlike structure made of a material such as polyetheretherketone (PEEK) or other material with similar beneficial properties. An implant-sizing tool is provided for determining the appropriately sized ILFD. An implant-grasper tool is provided for grasping the ILFD for insertion and positioning of the ILFD. A bone-punch tool is provided for creating openings aligned for insertion of fixation pins. A pin-inserter tool is provided for urging fixation pins into position. A locking-plug inserter tool is provided for inserting the locking plug into the body of the ILFD. A locking-plug extractor tool is provided for removing the locking plug.
US10022242B2
An expandable interbody fusion device includes superior and inferior endplates that are configured to receive a sequentially inserted stack of expansion members or wafers in interlocking engagement. The expansion members are formed to each have a generally U-shaped rearward facing opening. The superior and inferior endplates have openings through their outer surfaces in at least partial alignment and communication with the rearward facing openings of the expansion members. The inferior endplate has a fully bounded cavity for telescoping receipt of the superior endplate. The inferior endplate also has a fully bounded channel extending through the rear endwall thereof in direct communication with the rearward facing opening of at least one expansion member for the receipt of bone graft material into the device to promote fusion between opposing vertebral bodies of the spine.
US10022236B2
An internal joint cavity expander includes femur-side magnets, tibia-side magnets, and magnetic shield-members. Each femur-side magnet has a plate curved into an arc and fixed to a femur. Each tibia-side magnet has length smaller than the femur-side magnet length and having a plate curved into arc concentric with the femur-side magnet arc. Each tibia-side magnet is fixed to a tibia. The pole on the convex surface of each femur-side magnet is same as the pole on the concave surface corresponding tibia-side magnet. The convex surface of each femur-side magnet faces the concave surface of corresponding tibia-side magnet. Each magnetic shield-member covers the surface of corresponding femur-side magnet and tibia-side magnet facing the skin throughout range in which the femur-side magnet moves relative to the tibia-side magnet. Each magnetic shield-member prevents magnetism of corresponding magnets and from leaking outside without hindering the femur-side magnet movement relative to the tibia-side magnet.
US10022235B2
A modular articulated spacer system provides for screw-based assembly of an articular spacer intended to replace an artificial joint temporarily, whereby the articulated spacer system comprises at least two modules connectable by means of a screw connection, whereby a first module of the articular spacer system comprises a surface for formation of a sliding surface of the joint of the articular spacer and a second module of the articular spacer system comprises a stem for connection to a bone. The modules are connectable by means of the screw connection comprising at last one screw-locking device for each screw connection, whereby the screw-locking device is connected to one of the modules or is provided in the form of the same part as one of the modules. A method builds-up an articular spacer using said articulated spacer system, in which the articular spacer is screwed together using at least two modules, whereby the modules are screwed together appropriately such that the screw-locking devices prevent the modules from detaching or being unscrewed.
US10022234B2
An instrument for assembling an implant on a neck. The implant and neck being coupled via a taper having a taper axis. The instrument includes a frame having a distal portion and a proximal portion, the distal portion of the frame including a retaining member adapted to engage a portion of the neck. The retaining member includes a pair of moveable arms extending from the distal portion of the frame, the pair of moveable arms adapted to engage a pair of recesses on opposing sides of the neck. The instrument also includes a force applier retained in the proximal portion of the frame. The force applier includes a screw having a screw axis that is coaxial with the taper axis, wherein the screw is adapted to engage the implant. As the screw is turned, the force applier applies a force on the implant while the neck is held in place by the frame, thereby causing the tapers of the implant and neck to engage.
US10022227B2
An implant includes a microstructured hyperhydrophilic surface with protrusions and depressions in which a spacing between the protrusions as a statistical mean is in a range of 1 to 100 μm and a profile height of the protrusions and depressions as a statistical mean is in the range of 1 to 80 μm.