公开(公告)号：UY31881A

公开(公告)日：2010-01-29

申请号：UY31881

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： ERICSSON ANNA M ,  DAVID CALDERWOOD ,  WISHART NEIL ,  STEWART KENT D ,  ARGIRIADI MARIA A ,  FIAMENGO BRYAN R ,  FRANK CRISTINE E ,  MICHAEL FRIEDMAN ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  VOSS JEFFREY W ,  WALLACE GRIERE A ,  LU WANG ,  WOLLER KEVIN R

IPC: A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  C07D209/00 ,  C07D233/00 ,  C07D235/00 ,  C07D241/00 ,  C07D249/00 ,  C07D401/00

Abstract: Un compuesto de la fórmula (I) sales, prodrogas, metabolitos biológicamente activos, estereoisómeros e isómeros farmacéuticamente aceptables del mismo, en donde las variables se definieron en la presente. Los compuestos de la invención son de utilidad para el tratamiento de condiciones inmunológicas y oncológicas.

公开(公告)号：CA2727032A1

公开(公告)日：2009-12-17

申请号：CA2727032

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： WISHART NEIL ,  ARGIRIADI MARIA A ,  CALDERWOOD DAVID J ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  FRANK KRISTINE E ,  FRIEDMAN MICHAEL ,  GEORGE DAWN M ,  GOEDKEN ERIC R ,  JOSEPHSOHN NATHAN S ,  LI BIQIN C ,  MORYTKO MICHAEL J ,  STEWART KENT D ,  VOSS JEFFREY W ,  WALLACE GRIER A ,  WANG LU ,  WOLLER KEVIN R

IPC: C07D487/14 ,  A61K31/438 ,  A61K31/4985 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：AU2009257602A1

公开(公告)日：2009-12-17

申请号：AU2009257602

申请日：2009-06-09

Applicant: ABBOTT LAB

Inventor： CALDERWOOD DAVID J ,  WISHART NEIL ,  WOLLER KEVIN R ,  JOSEPHSOHN NATHAN S ,  ERICSSON ANNA M ,  FIAMENGO BRYAN A ,  ARGIRIADI MARIA A ,  WANG LU ,  GEORGE DAWN M ,  FRIEDMAN MICHAEL ,  STEWART KENT D ,  VOSS JEFFREY W ,  GOEDKEN ERIC R ,  MORYTKO MICHAEL J ,  LI BIQIN C ,  FRANK KRISTINE E ,  WALLACE GRIER A

IPC: A01N43/42

Abstract: The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：AU2008302448A1

公开(公告)日：2009-03-26

申请号：AU2008302448

申请日：2008-09-17

Applicant: ABBOTT LAB

Inventor： HAIGHT ANTHONY R ,  RANDOLPH JOHN T ,  LONGENECKER KENTON L ,  FRANCZYK THADDEUS S II ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  STEWART KENT D ,  TUFANO MICHAEL D ,  LIU YAYA ,  WAGNER ROLF ,  SARRIS KATHY ,  LIU DACHUN ,  BARNES DAVID M ,  ROCKWAY TODD W ,  FLENTGE CHARLES A ,  KATI WARREN M ,  KOTECKI BRIAN J ,  ZHANG GEOFF G Z ,  CHEN SHUANG ,  GAO YI ,  HENRY RODGER F ,  HUANG PEGGY P ,  PRATT JOHN K ,  DONNER PAMELA L ,  MARING CLARENCE J ,  HUTCHINSON DOUGLAS K ,  KRUEGER ALLAN C ,  LOU XIAOCHUN ,  MOTTER CHRISTOPHER E ,  HENGEVELD JOHN E

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia , inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; and (e) use of such compounds, salts, and compositions.

公开(公告)号：DE60315336T2

公开(公告)日：2008-05-08

申请号：DE60315336

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  MICHMERHUIZEN MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/00 ,  A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：NZ538567A

公开(公告)日：2007-04-27

申请号：NZ53856703

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: A61P37/02 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  A61K31/401 ,  A61K31/506 ,  A61K31/4439

Abstract: Compounds of formula (I), pharmaceutically acceptable salts and prodrugs thereof which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases are disclosed, wherein X, R, R1, R2 and R3 have the definitions given in the description.

公开(公告)号：CA2617495A1

公开(公告)日：2007-03-08

申请号：CA2617495

申请日：2006-08-25

Applicant: ABBOTT LAB

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LONGENECKER KENTON L ,  STEWART KENT D ,  LI XIAOFENG ,  YONG HONG ,  BACKES BRADLEY J ,  MULHERN MATHEW M ,  BASHA FATIMA ,  JUDD ANDREW S

IPC: C07C211/40 ,  A61K31/137 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II, as well as hyperglycemia, metabolic syndrome, hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：CA2768674A1

公开(公告)日：2004-04-01

申请号：CA2768674

申请日：2003-09-15

Applicant: ABBOTT LAB

Inventor： MADAR DAVID ,  PEI ZHONGHUA ,  PIREH DAISY ,  DJURIC STEVAN W ,  WIEDEMAN PAUL E ,  YONG HONG ,  FEENSTRA MELISSA J ,  KOPECKA HANA ,  LI XIAOFENG ,  LONGENECKER KENTON ,  SHAM HING L ,  STEWART KENT D ,  SZCZEPANKIEWICZ BRUCE G

IPC: C07D207/16 ,  A61K31/40 ,  A61P3/00 ,  A61P37/02 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.

公开(公告)号：CA2427312A1

公开(公告)日：2002-05-02

申请号：CA2427312

申请日：2001-10-26

Applicant: ABBOTT LAB

Inventor： HUTH JEFFREY R ,  NG IOK C ,  HARLAN JOHN E ,  KEMPF DALE J ,  STOLL VINCENT S ,  BETZ STEPHEN F ,  HARRIS KEVIN S ,  STEWART KENT D ,  STEFFY KEVIN R

IPC: G01N33/566 ,  C07K14/16 ,  C07K16/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C40B30/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  C12N15/11

Abstract: The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV-1) gp41 protein and to methods of use thereof. F or example, the proteins may be utilized in the screening of anti-HIV compounds .

公开(公告)号：SK15092000A3

公开(公告)日：2001-05-10

申请号：SK15092000

申请日：1999-04-12

Applicant: ABBOTT LAB

Inventor： MARING CLARENCE J ,  GU YU GUI ,  CHEN HUI-JU ,  CHEN YUANWEI ,  DEGOEY DAVID A ,  FLOSI WILLIAM J ,  GIRANDA VICENT L ,  GRAMPOVNIK DAVID J ,  KATI WARREN M ,  KEMPF DALE J ,  KLEIN LARRY L ,  KRUEGER ALLAN C ,  LIN ZHEN ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  MUCHMORE STEVEN W ,  SHAM HING L ,  STEWART KENT D ,  STOLL VINCENT S ,  SUN MINGHUA ,  WANG GARY T ,  WANG SHELDON ,  XU YIBO ,  YEUNG MING C ,  ZHAO CHEN ,  KENNEDY APRIL

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61K31/5377 ,  A61P31/16 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D207/325 ,  C07D207/327 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D521/00 ,  C07F9/572 ,  A61K31/40 ,  C07D407/04