US08207391B2
An adsorbent for radioelement-containing waste composed of the following spherical layered double hydroxide (A) or spherical metal hydroxide (B) is provided. (A) is a nonstoichiometric compound represented by general formula (a) or (b): [M2+1-xM3+x(OH)2]x+[An−x/n·mH2O]x− . . . (a), [Al2Li(OH)6]x+[An−x/n·mH2O]x− . . . (b) wherein 0.1≦x≦0.4, 0
US08207389B2
We provide a process for making a base oil, comprising: oligomerizing an olefin feed comprising propylene and propane with an ionic liquid catalyst at a temperature from 0° C. to 150° C. to make a base oil having: i. from 45 to 70 wt % hydrocarbons boiling at 482° C. (900° F.) or higher, ii. a viscosity index from 25 to 90, and iii. a cloud point less than −25° C.
US08207385B2
A process is disclosed for fluid catalytic cracking of oxygenated hydrocarbon compounds such as glycerol and bio-oil.In the process the oxygenated hydrocarbon compounds are contacted with a fluid cracking catalyst material for a period of less than 3 seconds.In a preferred process a crude-oil derived material, such as VGO, is also contacted with the catalyst.
US08207384B2
The invention provides a process for preparing 1234yf, comprising: (i) contacting 243db with hydrogen fluoride HF in gas phase in the presence of a fluorination catalyst under conditions sufficient to produce a reaction mixture; (ii) separating the reaction mixture into a first stream comprising HCl, 1234yf and a second stream comprising HF, 1233xf and 245cb; (iii) recycling at least a part of the second stream at least in part back to step (i). The invention also provides a process for preparing 1234yf, comprising: (i) contacting 243db with hydrogen fluoride HF in gas phase in the presence of a fluorination catalyst under conditions sufficient to produce a reaction mixture; (ii) separating the reaction mixture into HCl and a stream containing the fluorinated products; (iii) separating said stream containing the fluorinated products into a first stream comprising 1234yf and a second stream comprising HF, 1233xf and 245cb; (iv) recycling at least a part of the second stream at least in part back to step (i).
US08207380B2
An alkylated hydroxyaromatic compound prepared by reacting at least one hydroxyaromatic compound with a branched olefinic oligomer having from about 20 to about 80 carbon atoms in the presence of a acid catalyst. The alkylated hydroxyaromatic compound has been determined to be substantially free of endocrine disruptive chemicals when the effects were quantified on pubertal development and thyroid function in the intact juvenile female rat.
US08207374B2
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.
US08207373B2
HPV inhibitors with formula (I) where G1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, R1 and R2 each represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, R3 represents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts.
US08207364B2
The present invention provides a process for the preparation of a complex of formula (A) or (B): wherein, M is a platinum group metal atom; each X is an anionic monodentate ligand; is a bidentate phosphine ligand; and R1 and R2 are independently selected from the group consisting of straight-chain C1-10 alkyl, branched-chain C3-10 alkyl, C3-10 cycloalkyl and optionally substituted aryl; comprising the steps of: (a) preparing by reacting the lithium salt of R1R2PH with a dihaloalkane in a solvent comprising an alkyl ether and, optionally, an alkane, provided the alkyl ether is not diethyl ether; (b) reacting with a platinum group metal precursor compound to form the complex of formula (A) or formula (B).
US08207357B2
An antitumor agent which is not easily excreted from tumor cells and is suitable for a topical treatment. Specifically disclosed is a rotaxane compound with contains a compound represented by chemical formula 1 as the base structure. (In chemical formula 1, m≧2, n≧3, and X represents an anionic molecule or an anionic atom.
US08207356B2
A method for the preparation of a duloxetine hydrochloride salt from a duloxetine base, comprising the steps of: reacting duloxetine base with concentrated hydrochloric acid in ethylmethylketone; and crystallizing duloxetine hydrochloride salt from said concentrated hydrochloric acid in ethylmethylketone.
US08207354B2
A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) where R is methyl or ethyl, from crude reaction mixtures of alkyl 4,4-difluoroacetoacetates (I) by a) reacting where M is a sodium or potassium ion, and without additional solvent to form an enolate (V) b) releasing the corresponding alkyl 4,4-difluoroacetoacetate (I) from the enolate (V) by means of acid, c) removing the salt formed from cation M and acid anion as a solid and d) converting (I), without isolation from the crude reaction mixture, to the alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrate (VI), and the use of (VI) for preparing 1-methyl-3-difluoromethyl-pyrazol-3-ylcarboxyates VII
US08207350B2
The present invention relates to compounds of formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
US08207340B2
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
US08207337B2
[Problem]To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active.[Means for Solving Problems]The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R1 represents alkyl, alkenyl, etc.; R2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m+ represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).
US08207334B2
The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compound of Formula I is also provided.
US08207333B2
A new process for preparing pure amorphous rosuvastatin calcium, substantially free of impurities, is disclosed. A process comprising hydrolysing a C1 to C5 alkyl ester of rosuvastatin, preferably methyl rosuvastatin or tert-butyl rosuvastatin, with a base, e.g. sodium hydroxide, in the presence of an aprotic solvent, preferably tetrahydrofuran and N,N-dimethyl acetamide, or in the presence of a mixture of an aprotic solvent and water, to obtain a solution of rosuvastatin salt, which may be converted to another rosuvastatin salt using another cation, e.g. with calcium cation to obtain rosuvastatin calcium. Rosuvastatin amine salts may be obtained as well.In another preferred aspect of the invention rosuvastatin free acid may be converted to various rosuvastatin salts, e.g. to rosuvastatin calcium, rosuvastatin sodium or various rosuvastatin amine salts, including rosuvastatin solvates, e.g. rosuvastatin calcium hydrate.Rosuvastatin calcium is useful in the treatment of hyperlipidemia, hypercholesterolemia and atherosclerosis.
US08207325B2
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US08207319B2
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 59 to 61 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium.
US08207316B1
The present invention relates to a group of noel viral RNA regulatory genes, here identified as “viral genomic address messenger genes”or “VGAM genes”, and as “Viral genomic record”or “VGR genes”. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a pervasive viral attack mechanism. VGR genes encode an “operon”-like cluster of VGAM genes. VGAM and viral VGR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.
US08207308B2
The present invention is related to complementarity determining region (cdr)-grafted humanized r24 antibodies that bind to the gd3 ganglioside antigen. The humanized antibodies disclosed herein have characteristics that are comparable or superior to the murine r24 antibody, and the humanized antibodies are useful in treating cancer (e.g. Melanoma).
US08207300B2
The invention relates to CTSP polypeptides and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof in methods and compositions for the diagnosis, prognosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of a novel cancer/testis (CT) antigen, CTSP-1.
US08207297B2
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
US08207296B2
The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or prevention of intraocular hypertension. The invention thus relates to the use of pharmaceutical compositions comprising antisecretory factors in the treatment and/or prevention of intraocular hypertension, which is preferably characterized by hampered outflow of body fluid resulting in elevated pressure in the eye. The invention provides for a novel approach for treating and/or preventing such a condition turning the intraocular pressure to an acceptable level, optionally 21 mm Hg, or less.
US08207279B2
Disclosed is a method for producing a norbornene monomer composition, a norbornene polymer produced using the norbornene monomer composition, an optical film including the norbornene polymer, and a method for producing the norbornene polymer. The method includes reacting a reaction solution that contains cyclopentadiene, dicyclopentadiene, or a mixture of cyclopentadiene and dicyclopentadiene, an acetate compound, and a solvent so that a content of an exo isomer is 50 mol % or more. Variables such as a reaction temperature, a reaction time, a molar ratio between reactants, and addition of a solvent are controlled so that the exo isomer is contained in content of 50 mol % or more. Accordingly, it is possible to industrially produce an acetate norbornene addition polymer by using the acetate norbornene monomer composition containing the exo isomer in content of 50 mol % or more.
US08207275B2
A functionalized polymer defined by the formula π-R1-α, where π is a polymer chain, R1 is a bond or a divalent organic group, and α is a sulfur-containing heterocycle.
US08207272B2
Heterophasic polypropylene composition comprising:—a polypropylene matrix (M) and—an elastomeric copolymer (E) being dispersed in the matrix (M), wherein the elastomeric copolymer (E) comprises units derived from—propylene and—ethylene and/or C4 to C20 α-olefin, and wherein further,—the intrinsic viscosity of the xylene cold soluble fraction (XCS) of the heterophasic polypropylene composition is above 2.1 dl/g measured according to ISO 1628-1 (at 135° C. in decaline) and/or—Mz/Mw of the xylene cold soluble fraction (XCS) of the heterophasic polypropylene composition is more than 2.6, preferably 2.7, wherein the Mz is the z-average molecular weight measured according to ISO 16014-4:2003 and Mw is the weight average molecular weight measured according to ISO 16014-4:2003.
US08207269B2
A terpolymer containing: a) from 90% to 50% by weight; preferably from 90% to 70% by weight of ethylene derived units; b) from 5% to 40% by weight; preferably from 5% to 20% by weight of derived units of alpha olefin of formula CH2═CHA wherein A is a C1-C20 alkyl radical; c) from 2% to 30% by weight, preferably from 5% to 20% by weight of cycloolefins derived units. Said terpolymer being characterized by the following features i) distribution of molecular weight Mw/Mn lower than 3.5; preferably lower than 3; more preferably lower than 2.7 ii) solubility in xylene at 25° C. higher than 99%.
US08207268B2
A thixotropic agent comprising a first polyurea reaction product of a first polyisocyanate with a first amine and a second polyurea reaction product of a second polyisocyanate with a second amine different from the first polyurea reaction product precipitated in the presence of the colloidal particles of the first reaction product.
US08207261B2
Disclosed herein is a type of two-shot molded article, comprising a metallizable composition and a less-metallizable composition, that can be partially coated with metal, as well as methods of making the articles.
US08207258B2
Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use.
US08207255B2
A polyethylene composition comprising 0.01% to 1% by weight of at least one platelet-shaped nano boehmite nucleator, wherein the platelet-shaped nano boehmite nucleator comprises at least 70% by weight of Al2O3 and has a crystallite size of at least 5 nm, and the polyethylene composition comprises a density greater than 0.94 g/cm3, a melt index (MI2) ranging from equal to or greater than 0.3 g/10 min. up to equal to or less than 3 g/10 min., and a peak crystallization temperature (Tc) value determined according to ASTM D 3418, with an annealing temperature of 160° C. and a cooling rate of 10° C./min., that corresponds to formula (I): Tc≦(A*density)−73.5° C. (I) where A is 200 cm3-° C./g, Tc is in units of ° C., and density is in units of g/cm3.
US08207253B2
Novel ester compositions are prepared by reacting 1) at least one diol, glycol or oligomeric glycol with 2) a mixture of at least one aromatic monocarboxylic acid and at least one aliphatic monocarboxylic acid containing from 2 to 4 carbon atoms. The compositions are effective plasticizers for a variety of polymers, particularly those employed in water-borne adhesives. The freezing point of the present ester mixtures and their efficacy as plasticizers and other types of additives and/or modifiers for a variety of polymer compositions can be varied by adjusting the relative concentrations of the aromatic and aliphatic acids used to prepare the ester composition.
US08207249B2
A modified sulfur binder capable of implementing a physical property of being re-melted at a temperature less than 100° C., by mixing sulfur with a heterocyclicamine or alkylamine-based modifier and a dicyclopentadiene-based modifier, and a fabrication method thereof. A hydraulic modified sulfur material composition capable of being mixed with water by adding a surfactant to the modified sulfur binder, and obtained by mixing aggregate and a hydraulic material to the modified sulfur binder, and a fabrication method thereof. A hydraulic modified sulfur material obtained by molding the hydraulic modified sulfur material composition, and a fabrication method thereof. A combustible modified sulfur material composition obtained by adding aggregate to the modified sulfur binder, and by selectively adding a filler to the modified sulfur binder, and a fabrication method thereof. A combustible modified sulfur material obtained by molding the combustible modified sulfur material composition, and a fabrication method thereof.
US08207245B2
The present invention relates to silicon-containing biostable gels and processes for their preparation. The gels possess properties which make them useful in the manufacture and repair of biomaterials and medical devices, articles or implants, in particular the manufacture of soft tissue implants such as breast implants and the repair of orthopaedic joints such as spinal discs.
US08207240B2
A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
US08207234B1
The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.
US08207230B2
The present invention relates generally to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of inhibitors of endocannabinoid membrane transport and combinations thereof.
US08207227B2
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above. The invention also provides a hydrate of a disodium salt of a delivery agent of the formula above. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
US08207216B2
Compounds of formula: and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3. Pharmaceutically compositions and medicaments containing a compound of the invention are provided. The invention provides methods of treatment of protein kinase-related disease, disorders or conditions. The invention provides methods of treatment of GSK-3-related diseases, disorders or conditions. More specifically, methods of treatment of bipolar disorder, including mania, schizophrenia, stroke, epilepsy, motor neuron disease, cranial or spinal trauma, neurodegenerative disorders, including multiple sclerosis (MS), Alzheimer's disease, Fragile X syndrome, autism, Huntington's disease, Parkinson's disease, amylotrophic lateral sclerosis (ALS), AIDS-associated dementia, diabetes, particularly type II diabetes, cardiomycete hypertrophy, reperfusion/ischemia, cancer, particularly colorectal cancer, pancreatic cancer, allergies and/or asthma and hair loss or baldness.
US08207213B2
A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
US08207211B2
The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
US08207203B2
This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.
US08207199B2
A compound which is useful as an active ingredient of a pharmaceutical composition for treating neuropathic pain is provided. The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that an azole compound substituted with an N-(pyridine-3-yl)oxycarbonyl-piperidin-4-yl group and a phenyl group or a pharmaceutically acceptable salt thereof has an excellent FAAH inhibitory activity, thereby completing the present invention. The compound of the present invention is confirmed to have an excellent FAAH inhibitory activity and an antiallodynic effect in rat models with neuropathic pain, and thus is useful as an agent for preventing and/or an agent for treating neuropathic pain.
US08207176B2
The present invention is directed to novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds, compositions, and use in therapy as CSBP/RK/p38 kinase inhibitors of Formulas (V) and (Va) wherein inter alia, G5 and G6 are nitrogen and CH, provided that only one of G5 or G6 is nitrogen and the other is CH; R1 is C(Z)N(R10′)(CR10R20)vRb, C(Z)O(CR10R20)vRb, N(R10′)C(Z)(CR10R20)vRb, N(R10′)C(Z)N(R10′)(CR10R20)vRb, or N(R10′)OC(Z)(CR10R20)vRb; R1′ is independently selected at each occurrence from halogen, C1-4 alkyl, halo-substituted-C1-4 alkyl, cyano, nitro, (CR10R20)v′NRdRd′, (CR10R20)v′C(O)R12, SR5, S(O)R5, S(O)2R5, or (CR10R20)v′OR13; Rb is hydrogen, C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-10 alkyl, aryl, arylC1-10alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or heterocyclylC1-10 alkyl moiety, which moieties, excluding hydrogen, may all be optionally substituted; X is R2, OR2′, S(O)mR2′, (CH2)n′N(R10′)S(O)mR2′, (CH2)n′N(R10′)C(O)R2′, (CH2)n′NR4R14, (CH2)n′N(R2′)(R2″), or N(R10′)RhNH—C(═N—CN)NRqRq′; and R3 is a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-10 alkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic or a heterocyclylC1-10 alkyl moiety, and wherein each of these moieties may be optionally substituted.
US08207158B2
The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
US08207157B2
A method for repelling arthropods involving treating an object or area with an arthropod repelling effective amount of at least one compound having the formula wherein X is O, S, NH, N-NH2, N-CH3 or CH2, R′ is H or alkyl, R″ is alkyl, n is 0, 1, 2, 3 or 4, and mixtures thereof, optionally including a carrier material or carrier. The compound is preferably selected from homopiperazine, 1-methylhomopiperazine, 1-methylpyrrolidine, (R)-(−)-2-methylpiperazine, (S)-(+)-2-methylpiperazine, 2-methylpiperazine, 1-methylpiperazine, pyrrolidine, 1-methylpiperidine, piperidine, 1-ethylpiperazine, 1-methylimidazolidine, 1-methylthiomorpholine, 1,4-dimethylpiperazine, homopiperidine, imidazolidine, 4-methylpiperidine, thiomorpholine, 1-amino-4-methylpiperazine, 4-methylmorpholine, azocane, 2,6-dimethylpiperazine, 2,5-dimethylpiperazine, piperazine, 1-methlyhomopiperidine, or mixtures thereof.
US08207156B2
The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
US08207150B2
The 17β-cyano-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, in which R is hydrogen or C1-C4-alkyl, R4 is hydrogen or halogen, furthermore either: R6a, R6b together form methylene or 1,2-ethanediyl or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising hydrogen, C1-C4-alkyl, C2-C3-alkenyl and cyclopropyl, or: R6a is hydrogen and R6b and R7 together form methylene or are omitted with formation of a double bond between C6 and C7, R9, R10 are hydrogen or are omitted with formation of a double bond between C9 and C10, R15, R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrogen, C1-C4-alkyl and allyl, where at least one of the substituents R4, R6a, R6b, R7, R15, R16 and R17 is unequal to hydrogen or R6b and R7 are omitted with formation of a double bond between C6 and C7, and moreover comprise their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts.
US08207146B2
The present invention relates to substituted phenothiazines with a double bond and physiologically acceptable salts thereof, and their use as a medicament.
US08207145B2
The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in women.
US08207142B2
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
US08207140B2
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
US08207137B2
A method of inhibiting angiogenesis or invasion or formation of metastases in a mammal including administering a therapeutically effective amount of an active agent selected from the group consisting of a protein substance including all or part of a disintegrin domain of an adamalysin or a derivative thereof, a nucleic acid molecule including a polynucleotide sequence coding all or part of the disintegrin domain of an adamalysin or a derivative thereof to the mammal.
US08207135B2
Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+ T cell response, a CD8+ T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.
US08207133B1
The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein said RS1 fragment is characterized in comprising at least 3 consecutive amino acid residues as comprised in the amino acid sequence S-D-S-D-R-I-E-P (Serine-Aspartic acid-Serine-Aspartic acid-Arginine-Isoleucine-Glutamic acid-Proline) (SEQ ID NO: 9) or derivatives thereof. Furthermore, the present invention relates to a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, said method comprising administering to a patient in need of such amelioration, prevention and/or treatment a pharmaceutically active amount of said regulatory protein RS1 fragment as defined herein or a nucleic acid molecule encoding said regulatory protein RS1 fragment. Moreover, the present invention relates to the use of said regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of food, feed and/or food supplements.
US08207121B2
A method of sensitizing a mammal, especially a human, to another anticancer therapy by administering a sensitizing effective amount of a GST-activated anticancer compound. A method of ameliorating a side effect of another anticancer therapy in a mammal, especially a human, by administering an ameliorating effective amount of a GST-activated anticancer compound. Pharmaceutical compositions for the methods. The GST-activated anticancer compound is preferably a compound of U.S. Pat. No. 5,556,942, and more preferably canfosfamide, especially as the hydrochloride salt.
US08207116B2
The present invention relates to uses and methods of parathyroid hormone (PTH), preferably PTH (1-34), and/or parathyroid hormone-related peptide (PTHrP), preferably PTHrP (1-34), for recruiting stem cells into tissue suffering from ischemia, wherein said stem cells are preferably capable of repairing and/or regenerating said tissue suffering from ischemia. Accordingly, the uses and methods of the present invention are preferably suitable for the prevention and/or treatment of ischemia. Moreover, the present invention relates to a composition comprising parathyroid hormone (PTH), preferably PTH (1-34), and/or parathyroid hormone-related peptide (PTHrP), preferably PTHrP (1-34), and/or G-CSF or a G-CSF fragment for use as a pharmaceutical composition. In a particular aspect, a DPP IV antagonist is applied in the uses, methods and/or compositions of the present invention.
US08207090B2
A process for the anti-germination and/or biocide treatment of bulbs or tubers by separate application of 3-chlorophenylisopropylcarbamate (CIPC) and a component selected from the group consisting of clove oil and eugenol, in this order or vice versa. The process may be used for the treatment of potato tubers.
US08207082B2
This invention relates to a method for making shaped bodies having a silica content of at least 85 wt %, to shaped bodies made by such method, to catalyst compositions comprising shaped bodies made by such methods and to catalytic conversion processes using catalyst compositions comprising shaped bodies made by such methods. The method of making the shaped bodies comprises the steps of a) forming shaped bodies from a mixture obtained from at least one amorphous silica powder, at least one silica sol having a pH below 7, and at least one polymeric organic extrusion aid, optionally supplemental liquid medium and optionally crystallites of a zeolite or zeolite-type material; b) drying the shaped bodies obtained in step a); and c) heating the shaped bodies to a temperature ranging from about 500° C. to about 800° C.
US08207073B2
A highly water pressure-resistant polyester nonwoven fabric having a water pressure resistance of 2 kPA or more and composed of a laminated nonwoven fabric structure that is integrated by thermocompressive bonding an extremely fine fiber nonwoven fabric layer in which a polyester material is mixed with 1% or more of a polyolefin material and which has a fiber diameter of 5 μm or less, and a polyester filamentary fiber nonwoven fabric layer having a fiber diameter of 7 μm or more. The polyester nonwoven fabric is a nonwoven fabric material appropriate to moisture-permeable waterproof sheets used for building materials and shoe materials and, moreover, to fields requiring filtering properties, for example, various packaging materials such as dry packaging materials used as packaging materials and sterilization packaging materials also required to have radiation resistance and peel strength.
US08207072B2
An adhesive resin composition excellent in adhesiveness and heat resistance thereof, film-forming properties, and film quality and a laminate having an adhesive resin layer made of this adhesive resin composition are provided.The Composition is an adhesive resin composition comprising 10-99.5% by weight resin ingredient (A), 0.5-30% by weight another resin ingredient (unsaturated-carboxylic-acid-modified polypropylene), and 0-89.5% by weight still another resin ingredient (olefin resin).Resin ingredient (A): a product of successive propylene polymerization comprising 10-60% by weight (propylene homopolymer) component and 40-90% by weight (propylene/ethylene copolymer) component. The contents of room-temperature-xylene solubles derived from (a2), room-temperature-xylene insolubles derived from (a2), and room-temperature-xylene solubles derived from the same are 1-20% by weight, lower than 20% by weight, and 10-60% by weight, respectively, based on resin ingredient (A). The room-temperature-xylene solubles derived from (a2) have a content of α-olefins excluding propylene of 20% by weight or higher.
US08207071B2
The present invention teaches a vehicular upholstery PPT-fiber fabric that is formed from a double woven fabric in which a face weaving textile design has a number of intersections, called warp up intersections where a warp yarn passes over a weft yarn, and these are more than the number of intersections, called weft up intersection, where a weft yarn passes over a warp yarn. The warp yarn is formed by twisting an intermingled yarn composed of a PPT-multi-filament yarn and a high heat shrinkable PET-multifilament yarn whose shrinkage percentage in boiling water is more than 15%. An intermingle ratio of the PPT-multifilament yarn of the warp yarn is more than the intermingle ratio of the PET-multifilament yarn of the warp yarn. In the warp yarn, the PET-multifilament yarn is shrunk by heating, so that the substantial length of the PET-multifilament yarn becomes shorter than the substantial length of the PPT-multifilament yarn. The weft yarn is composed of PPT-multifilament yarn.
US08207070B2
Polyolefin woven and nonwoven fibers, filaments and fabrics made therefrom which comprise a melt blend which comprises (a) a polyolefin; and (b) at least one compound of the formula (I) R1—(hydrophilic oligomer) (I) wherein R1 is a straight or branched chain alkyl of 22 to 40 carbon atoms and the hydrophilic oligomer is a homo- or co-oligomer consisting of monomer units derived from monomers selected from the group consisting of ethylene oxide, propylene oxide, ethylene glycol, propylene glycol, epichlorhydrin, acrylic acid, methacrylic acid, ethylene imine, caprolactone, vinyl alcohol and vinyl acetate; and wherein the hydrophilic oligomer consists of between 2 and 10 monomer units, exhibit excellent durable wettability. The fabrics are useful in disposable diapers, training pants, feminine napkins, tampons, incontinence care products, wet and dry wipes, wound dressings, surgical capes, filter medial, battery separators and the like.
US08207069B2
An integrated processing tool is described comprising a full-wafer processing module and a combinatorial processing module. Chemicals for use in the combinatorial processing module are fed from a delivery system including a set of first manifolds. An output of each first manifold is coupled to at least one mixing vessel. An output of each mixing vessel feeds more than one of a set of second manifolds. An output of each set of second manifolds feeds one of multiple site-isolated reactors of the combinatorial processing module.
US08207066B2
The invention provides a dry etching method capable of obtaining a good profile with little side etch without receiving the restriction of a micro loading effect. A dry etching method for etching a sample having formed on the surface thereof a pattern with an isolated portion and a dense portion using plasma comprises a first etching step using an etching gas containing a CF-based gas and a nitrogen gas in which an etching rate of a dense portion of the pattern is greater than the etching rate of the isolated portion of the mask pattern, and a second etching step in which the etching rate of the isolated portion of the pattern is greater than the etching rate of the dense portion of the pattern.
US08207063B2
The present invention relates to a process of making a zinc-oxide-based thin film semiconductor, for use in a transistor, comprising thin film deposition onto a substrate comprising providing a plurality of gaseous materials comprising at least first, second, and third gaseous materials, wherein the first gaseous material is a zinc-containing volatile material and the second gaseous material is reactive therewith such that when one of the first or second gaseous materials are on the surface of the substrate the other of the first or second gaseous materials will react to deposit a layer of material on the substrate and wherein the third gaseous material is inert with respect to reacting with the first or second gaseous materials.
US08207061B2
Provided is a semiconductor device which has excellent adhesiveness to a copper film and a base film thereof and has a small resistance between wirings. The semiconductor device includes a porous insulating layer (SIOC film 11) which absorbed water from the atmosphere, and a substrate (wafer W) having a trench 100 formed on such insulating film is placed in a processing chamber. The substrate is coated with a first base film (Ti film 13) made of a valve metal. The surface of the first film brought into contact with the insulating film is oxidized by the water discharged from the insulating layer, and a passivation film 13a is formed. The surface of the first base film is coated with a second base film made of nitride or carbide of the valve metal, and a copper film 15 is formed on the surface of the second base film by CVD by using a copper organic compound as a material.
US08207058B1
A system and method are provided for fabricating a low electric resistance ohmic contact, or interface, between a Carbon Nanotube (CNT) and a desired node on a substrate. In one embodiment, the CNT is a Multiwalled, or Multiwall, Carbon Nanotube (MWCNT), and the interface provides a low electric resistance ohmic contact between all conduction shells, or at least a majority of conduction shells, of the MWCNT and the desired node on the substrate. In one embodiment, a Focused Electron Beam Chemical Vapor Deposition (FEB-CVD) process is used to deposit an interface material near an exposed end of the MWCNT in such a manner that surface diffusion of precursor molecules used in the FEB-CVD process induces lateral spread of the deposited interface material into the exposed end of the MWCNT, thereby providing a contact to all conduction shells, or at least a majority of the conduction shells, of the MWCNT.
US08207044B2
Methods of fabricating an oxide layer on a semiconductor substrate are provided herein. The oxide layer may be formed over an entire structure disposed on the substrate, or selectively formed on a non-metal containing layer with little or no oxidation of an exposed metal-containing layer. The methods disclosed herein may be performed in a variety of process chambers, including but not limited to decoupled plasma oxidation chambers, rapid and/or remote plasma oxidation chambers, and/or plasma immersion ion implantation chambers. In some embodiments, a method may include providing a substrate comprising a metal-containing layer and non-metal containing layer; and forming an oxide layer on an exposed surface of the non-metal containing layer by exposing the substrate to a plasma formed from a process gas comprising a hydrogen-containing gas, an oxygen-containing gas, and at least one of a supplemental oxygen-containing gas or a nitrogen-containing gas.
US08207043B2
A method for making a semiconductor MOS device is provided. A gate structure is formed on a substrate. A source and a drain are formed in the substrate on both sides of the gate structure. The substrate is then subjected to a pre-amorphization implant (PAI) process. A transitional stress layer is then formed on the substrate. Thereafter, a laser anneal with a first temperature is performed. After the laser anneal, a rapid thermal process is performed with a second temperature that is lower than the first temperature. Subsequently, the transitional stress layer is removed.
US08207041B2
Some embodiments include methods in which a pair of spaced-apart adjacent features is formed over a substrate. The features have silicon dioxide surfaces. Silicon nitride is deposited between the features. A first region of the silicon nitride is protected with a mask while a second region is not. The second region is removed to form an opening between the features. Some embodiments include semiconductor constructions that contain a pair of spaced-apart adjacent features. The features are lines extending along a first direction, and are spaced from one another by a trench. Alternating plugs and intervening materials are within the trench, with the plugs and intervening materials alternating along the first direction. The intervening materials consist of silicon nitride, and the plugs have lateral peripheries that directly contact silicon dioxide of the features, and that directly contact silicon nitride of the intervening regions.
US08207026B2
To provide a method for manufacturing a thin film transistor and a display device using a small number of masks, a thin film transistor is manufactured in such a manner that a first conductive film, an insulating film, a semiconductor film, an impurity semiconductor film, and a second conductive film are stacked; then, a resist mask is formed thereover; first etching is performed to form a thin-film stack body; second etching in which the first conductive film is side-etched is performed by dry-etching to form a gate electrode layer; and a source electrode, a drain electrode, and the like are formed. Before the dry etching, it is preferred that at least a side surface of the etched semiconductor film be oxidized.
US08207024B2
At least two TFTs which are connected with a light emitting element are provided, crystallinities of semiconductor regions composing active layers of the respective TFTs are made different from each other. As the semiconductor region, a region obtained by crystallizing an amorphous semiconductor film by laser annealing is applied. In order to change the crystallinity, a method of changing a scan direction of a continuous oscillating laser beam so that crystal growth directions are made different from each other is applied. Alternatively, a method of changing a channel length direction of TFT between the respective semiconductor regions without changing the scan direction of the continuous oscillating laser beam so that a crystal growth direction and a current flowing direction are different from each other is applied.
US08207023B2
Methods for selectively depositing an epitaxial layer are provided herein. In some embodiments, providing a substrate having a monocrystalline first surface and a non-monocrystalline second surface; exposing the substrate to a deposition gas to deposit a layer on the first and second surfaces, the layer comprising a first portion deposited on the first surfaces and a second portion deposited on the second surfaces; and exposing the substrate to an etching gas comprising a first gas comprising hydrogen and a halogen and a second gas comprising at least one of a Group III, IV, or V element to selectively etch the first portion of the layer at a slower rate than the second portion of the layer. In some embodiments, the etching gas comprises hydrogen chloride (HCl) and germane (GeH4).
US08207018B2
A semiconductor package is disclosed. One embodiment provides a semiconductor package singulated from a wafer includes a chip defining an active surface, a back side opposite the active surface, and peripheral sides extending between the active surface and the back side; a contact pad disposed on the active surface; and a metallization layer extending from the contact pad onto a portion of the peripheral sides of the chip.
US08207016B2
The invention includes semiconductor packages having grooves within a semiconductor die backside; and includes semiconductor packages utilizing carbon nanostructures (such as, for example, carbon nanotubes) as thermally conductive interface materials. The invention also includes methods of cooling a semiconductor die in which coolant is forced through grooves in a backside of the die, and includes methods of making semiconductor packages.
US08207015B2
A method of manufacture of an integrated circuit packaging system includes: applying a conductive material on a support structure; providing a bottom integrated circuit package having a bottom lead extended therefrom; attaching the bottom lead to the conductive material; stacking a top integrated circuit package over the bottom integrated circuit package, the top integrated circuit package having a top lead extending therefrom and the top lead over the bottom lead; attaching a conductive paste at an end portion of the top lead; and forming a stacking joint by flowing the conductive paste and the conductive material, the stacking joint below the top lead as well as below and above the bottom lead.
US08207012B2
A system and method of forming a thin film solar cell with a metallic foil substrate are provided. After forming a semiconductor absorber film over the front surface of the metallic foil substrate a back surface of the metallic foil substrate is treated using a material removal process to form a treated back surface in a process chamber. In one embodiment, the material removal process is performed while depositing a transparent conductive layer over the semiconductor absorber film in the process chamber.
US08207009B2
Methods for laser scribing a film stack including a plurality of thin film layers on a substrate are provided. A pulse of a laser beam is applied to the film stack, where the laser beam has a power that varies as a function of time during the pulse according to a predetermined power cycle. For example, the pulse can have a pulse lasting about 0.1 nanoseconds to about 500 nanoseconds. This pulse of the laser beam can be repeated across the film stack to form a scribe line through at least one of the thin film layers on the substrate. Such methods are particularly useful in laser scribing a cadmium telluride thin-film based photovoltaic device.
US08206999B2
In a chip-type LED according to an embodiment of the present invention, a first recess hole for mounting an LED chip and a second recess hole for connecting a fine metal wire are formed in an insulating substrate, a metal sheet serving as a first wiring pattern is formed at a portion that includes the first recess hole, a metal sheet serving as a second wiring pattern is formed at a portion that includes the second recess hole, an LED chip is mounted on the metal sheet within the first recess hole, the LED chip is electrically connected to the metal sheet within the second recess hole via a fine metal wire, the LED chip including the first recess hole and the fine metal wire including the second recess hole are encapsulated in a first transparent resin that contains a fluorescent material, a surface of the insulating substrate including the first transparent resin is encapsulated in a second transparent resin.
US08206998B2
A method for manufacturing a substrate for a liquid discharge head provided with a silicon substrate and a supply port, including: providing the silicon substrate having an insulating layer on a first surface and an etching mask layer having a plurality of apertures on a second surface which is a rear surface of the first surface, wherein the insulating layer is provided in a region ranging from a position opposing the apertures to a position opposing a portion between the adjacent apertures of the mask layer; and forming holes by etching a silicon part of the silicon substrate so that an etched region reaches a portion of the insulating layer opposing the apertures, wherein the silicon wall provided between the adjacent holes is etched so that the portion in the first surface side thereof can be thinner than the portion in the second surface side thereof.
US08206997B2
A probe having a sufficient height is manufactured by selectively depositing, over the main surface of a wafer, a copper film in a region in which a metal film is to be formed and a region which will be outside an adhesion ring when a probe card is fabricated; forming the metal film, polyimide film, interconnect, another polyimide film, another interconnect and a further polyimide film; and then removing the wafer and copper film. According to the present invention, when probe testing is performed using a prober (thin film probe) having the probe formed in the above-described manner while utilizing the manufacturing technology of semiconductor integrated circuit devices, it is possible to prevent breakage of the prober and a wafer to be tested.
US08206996B2
A method for providing a process indicator for an etching chamber is provided. A wafer with a blanket etch layer is provided into the etching chamber. A blanket etch is performed on the blanket etch layer. A blanket deposition layer is deposited over the blanket etch layer after performing the blanket etch has been completed. A thickness of the blanket etch layer and a thickness of the blanket deposition layer is measured. The measured thicknesses are used to determine a process indicator.
US08206995B2
A method for manufacturing a resistive switching memory device comprises providing a substrate comprising an electrical contact, providing on the substrate a dielectric layer comprising a trench exposing the electrical contact, and providing in the trench at least the bottom electrode and the resistive switching element of the resistive memory device. The method may furthermore comprise providing a top electrode at least on or in the trench, in contact with the resistive switching element. The present invention also provides corresponding resistive switching memory devices.
US08206990B2
The present invention is related to a method for isolating a target nucleic acid from a sample comprising said target nucleic acid, comprising the steps of mixing a sample containing said target nucleic acid with a binding solution and a nucleic acid binding matrix, binding at least part of said target nucleic acid to said nucleic acid binding matrix, wherein said nucleic acid binding matrix is treated simultaneously or has been previously treated with at least one compound comprising a metal substance selected from the group consisting of metals of the main groups 13 to 16, semimetals and transition metals for reducing non-target nucleic acid contaminations or wherein said nucleic acid binding matrix is modified with hydrophobic groups. Furthermore, respective kits and reagents are provided with the teaching of the present invention.
US08206989B2
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
US08206973B2
An automated biological growth and dispensing system utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient.
US08206972B2
A biologically pure culture of a yeast of the species Pichia anomala (WRL-076). The yeast is identified as NRRL Y-30842 and is applied to a site containing a deleterious microorganism. Further disclosed is a growth medium for increasing the viablility of yeast organisms.
US08206960B1
The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.
US08206959B2
The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively separated from the modified protein after use.
US08206954B2
An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and inherently has a native activity of a glucose dehydrogenase that uses pyrroloquinoline quinone as a coenzyme, but has been modified so that the activity of the glucose dehydrogenase is reduced, in a medium, and collecting the L-amino acid from the medium.
US08206941B2
The present invention relates to a method of determining kinase or phosphatase activity based on a three parts system. The method comprises contacting a binding partner which can bind phosphorylated peptides, a detection molecule and a substrate peptide. Determination of activities is achieved by measuring energy transfer between an energy donor and an energy acceptor that are present on the detection molecule and the substrate molecule.
US08206940B2
Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying FcyR receptors, and kits for this assay. An ultrasensitive cell based immunocytotoxicity assay for detecting less then 1 pg/ml of C. difficile toxins in clinical samples. A TcdA-specific monoclonal antibody, AIH3, was found to significantly enhance the cytotoxicity of TcdA to macrophages and monocytes. The AIH3-dependent enhancement of glucosyltransferase activity, cytoskeleton disruption, and TNF-a production induced by TcdA was demonstrated also in RAW 264.7 cells. Methods for high level recombinant expression of C. difficile toxins in Bacillus cells, and vectors for expression, strains of Bacillus carrying the vectors are provided.
US08206938B2
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
US08206930B2
Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of Borrelia afzelii, are useful as forward and reverse primers for a polymerase chain reaction using nucleic acids from a biological sample as templates, and as probes for detecting any resultant amplicon. Detection of an amplicon indicates the sample contains Borrelia afzelii. Real-time PCR and detection using florescence resonance energy transfer is disclosed.
US08206927B2
The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment.
US08206925B2
There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
US08206914B2
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
US08206912B2
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof.
US08206908B2
The invention provides a combination of target genes that are useful as genetic markers for the strain-specific detection of Ehrlichia ruminantium. The invention also provides diagnostic methods using said combination of markers.
US08206907B2
This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.
US08206905B2
The objects of the present invention are to provide a new technology platform for quantitation number of copies of nucleic acid molecules of interest by lumonogenic (i.e., enzymatic luminescence) detection. The detection approach of the method of present invention is essentially employing time-resolved approach, e.g., based on detection transient parameters of luminescent signal. The various disclosed embodiments allow DNA and RNA quantification in a broad dynamic range; can be used for detection of DNA, as well as long (mRNA) and short (microRNA) RNA targets. The present invention provides methods, instruments, and kits for fast and highly sensitive identification and measurements of nucleic acids in various life science and biomedical applications.
US08206904B2
The present invention relates to compositions and methods for the detection and characterization of small nucleic acid molecules (e.g., RNA (e.g., small RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs)) and other short nucleic acid molecules). More particularly, the present invention relates to methods for the detection and quantification of RNA expression. The present invention further provides for the detection of miRNA and siRNA variants.
US08206903B2
The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
US08206902B2
A primer set that allows a target nucleic acid to be amplified specifically and efficiently. The primer set of the present invention includes at least two primers that allow a target nucleic acid sequence to be amplified. A first primer included in the primer set contains, in its 3′ end portion, a sequence (Ac′) that hybridizes to a sequence (A) located in the 3′ end portion of the target nucleic acid sequence. The first primer also contains, on the 5′ side of the sequence (Ac′), a sequence (B′) that hybridizes to a complementary sequence (Bc) to a sequence (B) that is present on the 5′ side with respect to the sequence (A) in the target nucleic acid sequence. A second primer included in the primer set contains, in its 3′ end portion, a sequence (Cc′) that hybridizes to a sequence (C) located in the 3′ end portion of a complementary sequence to the target nucleic acid sequence. The second primer also contains, on the 5′ side of the sequence (Cc′), a folded sequence (D-Dc′) that contains, on the same strand, two nucleic acid sequences that hybridize to each other.
US08206901B2
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
US08206897B2
The disclosure relates to methods for identifying a subject having elevated CD200 levels and/or comprising cells overexpressing CD200, the method comprising the step of assaying a biological fluid from the subject to determine a level of soluble CD200, wherein a level above control indicates the subject has elevated CD200 levels. Diagnostic methods, methods of monitoring prognosis and methods of medical treatment relating to CD200 associated medical conditions are also provided. The disclosure also provides assays and kits useful in the diagnosis of a medical condition associated with elevated CD200 and/or comprising cells overexpressing CD200.
US08206895B2
According to an aspect of the present invention, there is provided a method for forming a pattern including: applying a photosensitive resin onto a film on a wafer substrate; partly exposing the photosensitive resin to light and developing the photosensitive resin to form a first pattern having an opening portion; applying a photo-curable material onto the film exposed by the opening portion of the first pattern; bringing one face of an optically-transmissive template having a second pattern formed on the one face into contact with the photo-curable material, the second pattern including projections and reentrants; irradiating the photo-curable material with light; and separating the template from the photo-curable material.
US08206891B2
A positive resist composition including: a base component (A) which includes a polymeric compound (A1) containing a structural unit (a0) represented by the general formula (a0-1) and a structural unit (a1) derived from an acrylate ester having an acid dissociable, dissolution inhibiting group; and an acid generator component (B) which includes an acid generator (B1) containing an anion moiety represented by the general formula (I): (in the formula (a0-1), R1 represents a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms or a halogenated lower alkyl group of 1 to 5 carbon atoms; R2 represents a bivalent linking group; and R3 represents a cyclic group containing —SO2— within the ring skeleton. In the formula (I), X represents a cyclic group of 3 to 30 carbon atoms, Q1 represents a bivalent linking group containing an oxygen atom; Y1 represents an alkylene group of 1 to 4 carbon atoms or a fluorinated alkylene group of 1 to 4 carbon atoms).
US08206890B2
A resist composition including: a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid; and an acid-generator component (B) which generates acid upon exposure, wherein said acid-generator component (B) comprises an acid generator (B1) including a compound represented by general formula (b1-11) shown below: wherein R7″ to R9″ each independently represent an aryl group or an alkyl group, wherein two of R7″ to R9″ may be bonded to each other to form a ring with the sulfur atom, and at least one of R7″ to R9″ represents a substituted aryl group having a group represented by general formula (I) shown below as a substituent; X− represents an anion; and Rf represents a fluorinated alkyl group.
US08206887B2
A positive resist composition includes a base material component (A) which exhibits increased alkali solubility under an action of an acid, and an acid generator component (B) which generates an acid upon exposure, wherein the base material component (A) contains a compound (A1) in which phenolic hydroxyl groups in a polyhydric phenol compound (a) containing two or more phenolic hydroxyl groups and having a molecular weight of 300 to 2,500 are protected with acid dissociable, dissolution inhibiting groups, and the compound (A1) exhibits a standard deviation (sn) of the number of protective groups per molecule of less than 1, or exhibits a standard deviation (sp) of a protection ratio (mol %) per molecule of less than 16.7.
US08206885B2
A toner prepared by pulverization methods, including a binder resin; and a colorant, wherein the binder resin is prepared by melting and kneading a polyester resin having an unsaturated bond with a crosslinking reaction initiator diluted with a release agent, and the colorant is a press cake pigment after washed.
US08206879B2
To provide an image forming method for obtaining excellent image quality under high humidity. The image forming method including charging a surface of a latent electrostatic image bearing member, exposing the charged surface of the latent electrostatic image bearing member so as to form a latent electrostatic image, developing the latent electrostatic image using a developer so as to form a toner image, and transferring the toner image from the latent electrostatic image bearing member to a transfer medium, wherein in the developing step, a toner is used that has an interparticle adhesion force of 500 nN to 1,200 nN when pressed at 500 nN and a volume average particle diameter of 4 μm to 8 μm, and in the transferring step, the transfer pressure applied to the transfer medium is 20 N/m to 60 N/m, and wherein a tandem image forming apparatus is used in the image forming method.
US08206877B2
A membrane electrode assembly includes an ion conducting membrane; an anode catalyst layer arranged on one side of the ion conducting membrane; a cathode catalyst layer arranged on the other side of the ion conducting membrane; an anode diffusion layer arranged on an outer side of the anode catalyst layer; and a cathode diffusion layer arranged on an outer side of the cathode catalyst layer. Only in the anode catalyst layer, the density of a first catalyst layer portion located close to the anode diffusion layer is smaller than the density of a second catalyst layer portion located close to the ion conducting membrane.
US08206874B2
This disclosure provides polymer electrolytes, polymer electrolyte membranes (PEM's) and membrane electrode assemblies (MEA's) such as may be useful in fuel cells which contain or comprise polyoxometalates (POM's) or heteropolyacids (HPA's). In some embodiments the polyoxometalate, it's counterions or both may comprise Mn and/or Ce. In some embodiments the polymer electrolyte is fluorinated. In some embodiments the polymer electrolyte comprises a second acidic functional group other than a polyoxometalate. In another aspect, the present disclosure provides methods of making polymer electrolytes including methods which comprising a step of copolymerizing monomers comprising a covalently bound polyoxometalates and methods which comprise a step of covalently attaching a polyoxometalate to the polymer.
US08206871B2
A fuel cell assembly is disclosed, the fuel cell assembly including a pair of terminal plates, one terminal plate disposed at each end of the fuel cell assembly, a fuel cell disposed between a pair of end fuel cells and the terminal plates, and a thermally insulating, electrically conductive layer formed between the fuel cell and one of the terminal plates adapted to mitigate thermal losses from the end plate, and fluid condensation and ice formation in an end fuel cell. The end fuel cells of the fuel cell assembly have a membrane and/or a cathode having a thickness greater than an average thickness of a membrane and/or a cathode disposed in the fuel cell that may be used in conjunction with, or instead of, the insulating layer to further mitigate thermal losses from the end plate, and fluid condensation and ice formation in the end fuel cells.
US08206870B2
A membrane electrode assembly comprising two electrode separated by a polymer electrolyte membrane wherein the surfaces of the membrane are in contact with the electrodes so that the first electrode partially or totally covers the front of the membrane and the second electrode partially or totally covers the back of the membrane; two gasket layers wherein the first gasket layer partially covers the front of the membrane and/or the first electrode and the second gasket layer partially covers the back of the membrane and/or the second electrode the assembly also comprises a second gasket material on the front of the first gasket layer and on the back of the second gasket layer; each of the gasket layers comprises at least one recess; the second gasket material on the front of the first gasket layer is in contact with the second gasket material on the back of the second gasket layer.
US08206863B2
A fuel cell system having a fuel cell, coolant circulating means which circulates cooling water into the fuel cell, temperature sensors which detect a cooling water outlet temperature and a cooling water inlet temperature, and temperature adjusting means which adjusts a temperature of the fuel cell by controlling a flow rate of the coolant on the basis of the cooling water outlet temperature, is characterized by including abnormality determining means which determines whether or not abnormality occurs in the temperature sensor, and coolant temperature estimating means which, when the abnormality determining means determines that abnormality occurs in the temperature sensor, estimates the cooling water outlet temperature on the basis of physical information relating to operating states of the fuel cell.
US08206858B2
A fuel cell system and a starting method therefor are capable of setting a start-up mode which is appropriate to energy stored in a secondary battery so as to eliminate problems in starting the fuel cell system. The fuel cell system includes a fuel cell, a secondary battery which is electrically connected with the fuel cell, a secondary-battery charge-amount detection unit which detects an amount of charge in the secondary battery, and a memory which stores at least one threshold value for determining the start-up mode of the fuel cell system. Stored electric energy which corresponds to the amount of charge in the secondary battery is calculated, and a start-up mode of the fuel cell system is determined based on the electric energy stored in the secondary battery and the threshold value stored in the memory.
US08206854B2
A composition comprising: hydrogen; and an oxygenate odorant; wherein the oxygenate odorant has a vapor pressure of about 0.002 psi. or greater at 25° C. and having a smell detectable at less than 1 ppm by a human nose; wherein the oxygenate odorant includes one or more carbonyl groups; and wherein the oxygenate odorant consists only of carbon, hydrogen and oxygen. The oxygenate odorants may be cyclic or acyclic.
US08206849B2
An integral cap assembly comprising a top cap mounted as a base plate to an opening of a battery can and a cap subassembly including a protective circuit module and the like integrally mounted on the top cap, a method for manufacturing a secondary battery comprising the same, and a secondary battery manufactured thereby are disclosed. The cap assembly is provided as an integral member comprising the top cap acting as the base plate, and the cap subassembly having the protective circuit module provided thereon, thereby simplifying a manufacturing process of the battery while minimizing frequency of defective products. Additionally, the integral cap assembly is manufactured through insert injection molding, thereby providing notable advantages over the conventional technology.
US08206837B2
According to one aspect, an interventional medical device includes a first wire disposed at a distal end and made of an alloy containing Ti and a transition metal other than Ti and Cr, and a second wire disposed at a proximal end of the first wire and made of an alloy containing Cr and a transition metal other than Cr and Ti. The device may include the first wire and the second wire being brazed to each other by a brazing material. The brazing material contains a metal whose ionization tendency is more basic than Ti and Cr. The brazing material is preferably an Ag—Mg alloy or an Ni—Mg alloy, and preferably has a composition near the eutectic point.
US08206822B2
A method of reshaping an article comprising a polyelectrolyte complex, the polyelectrolyte complex comprising an intermolecular blend of a predominantly positively-charged polyelectrolyte and a predominantly negatively charged polyelectrolyte by controlling the salt doping level.
US08206815B2
Disclosed is a metal-based carbon fiber composite material exhibiting an improved thermal expansion coefficient, improved thermal conductivity, and is smaller in weight, and a method for producing the same. The composite material includes a metal and a carbon fiber including a micron carbon fiber and a nanofiber; the composite material having a first surface; the micron-size carbon fiber being oriented in one direction parallel to the first surface and being continuous from end to end; at least 80% of the nanofiber being oriented at an angle within 30° with respect to the first surface; and the nano-size carbon fiber being oriented randomly in a plane parallel to the first surface. In the composite material, a surface region may include a smaller amount of micron carbon fiber than other regions, or include no micron carbon fiber; the nanofiber may have an orientation parallel to the surface of the composite material.
US08206813B2
Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
US08206812B2
The present invention relates to a coated cutting tool for metal machining with a from about 2.0 to about 20 μm thick PVD coating, having both the wear resistance of a coating of homogeneous layers and the toughness of a multilayer coating, comprising a first (Mec1,Mec2)(C,N,O) layer where Mec1 is one or more of the elements in the transition metal group IV-VI, Al and Si and Mec2 is one of the elements in the transition metal group IV-VI from about 1.0 to about 4.5 μm thick, a second (Med1,Med2)(C,N) layer where Med1 is one or more of the elements in the transition metal group IV-VI, Al and Si and Med2 is one of the elements in the transition metal group IV-VI and Y, from about 0.5 to about 4.5 μm thick, and in between the first and the second layer, an (Mee1, Mee2)(C,N,O) layer where Mee1 is one or more of the elements in the transition metal group IV-VI, Al and Si and Mee2 is one of the elements in the transition metal group IV-VI and Y, from about 0.1 to about 1.0 μm thick, where the thickness of the in between layer is less than about 0.5 times the thickness of thinnest of the first and the second layer and the layers in between has a composition differing from the first and the second layer, and a method of making thereof.
US08206811B2
A material of cured film, a thermosetting film and a display device are provided. The thermosetting composition includes a solvent and at least one siloxane polymer selected from the group consisting of siloxane polymer (A) obtained by hydrolyzing or condensing a silane mixture containing a monofunctional silane represented by formula (1) and a trifunctional silane represented by formula (2), and siloxane polymer (B) obtained by hydrolyzing or condensing a silane mixture containing a bifunctional silane represented by formula (3) and a tetrafunctional silane represented by formula (4). R independently represents hydrogen, an alkyl group having 1 to 10 carbons whose arbitrary hydrogen can be replaced by a halogen, an aryl group having 6 to 10 carbons whose arbitrary hydrogen can be replaced by a halogen, or an alkenyl group having 2 to 10 carbons whose arbitrary hydrogen can be replaced by a halogen. R′ independently represents a hydrolyzable group.
US08206809B2
A matte seal includes a seal body that extends along and about a width-wise axis. The seal body has a first surface and an opposite parallel second surface and an outer peripheral surface extending to and between the first and second surfaces. The seal body has an inner through hole surface defining a through hole extending along and about the width-wise axis and between and through the first and second surfaces. The seal body has at least one recess formed into the first surface. The at least one recess is disposed apart from and between the inner through hole surface and the outer peripheral surface. The at least one recess extends parallel to the width-wise axis and partially into the seal body.
US08206804B2
Phase change memory materials and more particularly GeAs telluride materials useful for phase change memory applications, for example, optical and electronic data storage are described.
US08206803B2
Provided is an information storage medium using nanocrystal particles, a method of manufacturing the information storage medium, and an information storage apparatus including the information storage medium. The information storage medium includes a conductive layer, a first insulating layer formed on the conductive layer, a nanocrystal layer that is formed on the first insulating layer and includes conductive nanocrystal particles that can trap charges, and a second insulating layer formed on the nanocrystal layer.
US08206790B2
A polyurea-based curable coating for use with sports equipment, such as golf balls, golf shoes, golf clubs, footballs, billiard balls, baseballs, and the like, of which the coating may be cured over time, with heat, or a combination thereof, providing enhanced adhesion to equipment surfaces, improved abrasion resistance, and increased water resistance.
US08206773B2
Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.
US08206770B2
A frozen composition is provided which includes hydrophobin. Also provided is the use of hydrophobin in inhibiting ice crystal growth and/or modifying ice crystal habit in frozen food products.
US08206769B2
A large scale processing method for separating banana pulp from its peel is shown. In this method bananas are separated into two parts (generally in a transverse direction), each part having a tip end and a cut end. A compression force is applied to those banana parts such that the force increases from the tip end to the cut end. A device which implements that process, including a cutting device, a means for feeding bananas into the cutting device, and two processing conveyor devices (to apply the compression force to the banana parts), is also shown.
US08206766B2
A method for using a bamboo leaf extract as an acrylamide inhibitor for heat processing food, includes adding to the bamboo leaf extract at least one selected from a group consisting of ginkgo extract, tea extract, rosemary extract, apple polyphenol extract, haw extract, onion extract, licorice extract, root of kudzuvine extract, grape seed extract and leech extract; and preparing a composition, in which the bamboo leaf extract takes up 34-95% of the total weight of the composition. The bamboo leaf extract used as the acrylamide inhibitor in food systems has an inhibiting rate to acrylamide formation of up to 15-98%.
US08206761B2
A multipurpose cleaning composition. The composition is a mixture of therapeutic grade essential oils, distilled white vinegar, and purified water that disinfects, degreases, and deodorizes, and also provides bioseptic and therapeutic benefits. Also provided is a method of disinfecting a surface by shaking a spray bottle having the composition, spraying the composition on the surface to be disinfected, allowing the composition to remain in contact with the surface for an amount of time sufficient to disinfect the surface, and removing the composition by wiping with a cloth. Essential oils may include, but are not limited to, therapeutic grade essential oils of eucalyptus, lemon, lavender, and grapefruit.
US08206760B2
Disclosed is a composition for the inhibition of transplant rejection and the treatment of skin diseases, comprising a cordyceps mycellia extract as an active ingredient. The cordyceps mycellia extract significantly suppresses the production of antibodies to transplants without side effects, such as weight change. Based on natural material, the composition is non-toxic and harmless to the human body and thus can be used as an immunosuppressant for organ transplantation. Also, it stops oozing from sores and is useful in the treatment of skin diseases, including atopy, allergic reactions, decubitus ulcers, pemphigus and smallpox.
US08206759B2
Combinations of vasoprotective agents useful for the treatment of reducing blood cholesterol and triglyceride levels induced by an excess of plasma lipids. The agents include polycosanols, tocotriends and/or lycopene, procyanidole oligomers and vegetable oil rich in insaturated fatty acids.
US08206747B2
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
US08206744B2
The invention concerns novel materials based on biodegradable branched polyaminoacids particularly useful for transporting active principle(s). The invention also concerns novel pharmaceutical, cosmetic, dietetic or phytosanitary compositions based on polyaminoacids. The invention aims at providing a novel polymeric material, capable of being used for transporting active principle(s) and enabling all the required relevant specifications to be optimally satisfied: biocompatibility, biodegradability, easy ability to be combined with a large number of active principles or to solubilize same, and to release the active principles in vivo. This is achieved by the present invention which firstly concerns branched polyaminoacids comprising aspartic acid units and or glutamic acid units, and which bear hydrophobic groups including 8 to 30 carbon atoms. The branched polyaminoacids are amphiphilic and are capable of being easily and economically transformed into particles for transporting active principles, the particles being themselves capable of forming stable aqueous colloidal suspensions.
US08206725B2
The present invention relates to an immunogenic agent comprising a low dose of an antigenic component from one or more pathogens and an agent capable of increasing an amount of IL-12 in animal, and use thereof for reducing infection or improving recovery from an infection from the pathogen. The immunogenic agent preferably comprises CpG nucleic acid, IL-12 protein and/or IL-12 nucleic acid. The pathogen is preferably an intracellular pathogen comprising one or more species and strains, such as Plasmodium spp. The invention also relates to a pharmaceutical composition comprising the immunogenic agent. The pharmaceutical composition is preferably an immunotherapeutic composition. The immunotherapeutic composition, is preferably a vaccine capable of providing protection against or treating Plasmodium spp infection, the causative agent of malaria in humans.
US08206700B2
The disclosure provides an antigenic composition useful for immunization against tularemia. The disclosure provides a method for producing a vaccine for preventing tularemia in humans and animals, a new vaccine against tularemia in humans and animals, and a new approach to producing vaccines against tularemia.
US08206699B2
One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types. This further aspect of the present invention involves removing neurons and neuronal progenitor cells from the mixed population to produce a treated mixed population. Oligodendrocyte progenitor cells are then separated from the treated mixed population to form an enriched population of oligodendrocyte progenitor cells.
US08206694B2
A hair conditioning composition comprising a cationic surfactant, triglyceride oil, and an anti dandruff agent.
US08206692B2
The present invention relates to a method for screening compounds having the ability to prevent, treat or reduce malodor development on body surfaces. In particular, the method allows to efficiently screen for compound having the ability of preventing sweat malodor development caused by volatile sulfur compounds (VSCs). The present invention is based on the finding of the direct precursor of naturally VSCs, which is present in human sweat and which will be metabolized by Staphylococci to VSCs.
US08206689B2
The invention provides an oral preparation or a chewing gum comprising an organic acid and/or inorganic acid and a fluoride ion supplying compound, wherein a light scattering layer is formed inside enamel of the teeth when the oral preparation or the chewing gum is applied to teeth. An internal tooth colored layer in the enamel is masked by the light scattering layer, and a white appearance is imparted to the teeth.
US08206682B2
A method for recovering catalytic elements from a fuel cell membrane electrode assembly is provided. The method includes converting the membrane electrode assembly into a particulate material, wetting the particulate material, forming a slurry comprising the wetted particulate material and an acid leachate adapted to dissolve at least one of the catalytic elements into a soluble catalytic element salt, separating the slurry into a depleted particulate material and a supernatant containing the catalytic element salt, and washing the depleted particulate material to remove any catalytic element salt retained within pores in the depleted particulate material.
US08206680B2
Calco-magnesian aqueous suspension having particles of solid matter with, before being put into suspension, a specific surface area, calculated according to the BET method, which is less than or equal to 10 m2/g, and its method of preparation. Such an aqueous suspension of calco-magnesian solid matter can achieve a very low viscosity, making it possible to greatly increase the solid matter concentration of the suspension, or again to reduce the size of the particles in suspension, thus obtaining a concentrated and reactive milk of lime.
US08206676B2
The method described herein provides a method for preparing a chlorinated silane at least one end product comprising SiH3Cl, SiH2Cl2, and combinations thereof in molar yields of 50% or greater with respect to silane in the feed stream. The method described herein therefore provides an end product comprising the one or more chlorinated silanes by contacting reaction mixture comprising silane and hydrogen chloride with a catalyst at a temperature and time sufficient to provide the end product.
US08206674B2
Boron nitride nanotubes are prepared by a process which includes: (a) creating a source of boron vapor; (b) mixing the boron vapor with nitrogen gas so that a mixture of boron vapor and nitrogen gas is present at a nucleation site, which is a surface, the nitrogen gas being provided at a pressure elevated above atmospheric, e.g., from greater than about 2 atmospheres up to about 250 atmospheres; and (c) harvesting boron nitride nanotubes, which are formed at the nucleation site.
US08206672B2
Disclosed herein are processes for making a plurality of substantially phase-pure metal oxide particles, the particles comprising a garnet structure, the process comprising: subjecting a dispersion of precursors to a solvothermal treatment to form a garnet intermediate and applying a flow-based thermochemical process to said garnet intermediate.
US08206664B2
Microfluidic devices are prepared by providing a substrate material having a solid adhesive thin sheet, printing solid ink on the substrate using a conventional printer, selectively etching the substrate using a wax masking layer to obtain a desired pattern, removing the masking layer from the substrate, aligning and bonding together the pattern of the substrate to a pattern of a second substrate to form a layer of substrates, and curing the layer of substrates to result in a three-dimensional microfluidic device.
US08206661B2
An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip.
US08206659B2
Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, the device can control evaporation of different solutions comprising solvents of dissimilar volatilities simultaneously. In another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the pressure at an inlet port and an exhaust port of the device. In yet another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the size of a disk flow control orifice positioned between the wells and a vapor removal outlet of the device. In still another embodiment, control over the flow of solvent vapor out of the device is provided by the opening and closing of the vapor removal outlet of the device. In yet a further embodiment, the rate of evaporation of solvent is controlled by controlling the temperature of the solution. The flow rate control mechanisms can be used alone or in any combination to control evaporation of one or more solvents from solutions.
US08206657B2
An enclosure includes at least one packed bed and a mixture supply line for delivering at the bottom of the enclosure a mixture of a liquid with a gas. The enclosure includes a system for separating the liquid phase and the gas phase of the mixture, the system being arranged between the bed and the mixture supply line, and this system including a housing having a flow passage for the degassed liquid and discharge passages for the disengaged gas.
US08206655B2
An apparatus for burning sulfur to produce sulfur dioxide, which sulfur dioxide is associated with a multi-channel gas valve associated with other gas sources to selectively be blended each into water by a combination mixer/aerator to aerate water in one monde, admix sulfur dioxide with water to form sulfurous acid in another mode, and stir and mix water without gases in a third mode.
US08206642B2
A pivoting, liquid cooled slag door for metallurgical furnaces is disclosed. The slag door can pivot from the top using one or more robust mechanisms that enable the door to be moved into and stopped in any position between a closed position and an open position. The slag door can also incorporate wing walls disposed in close proximity to the sides of the slag door. The wing walls can minimize air infiltration into the furnace when the slag door is in an open position. The slag door can be disposed in close proximity to the hearth of the furnace to eliminate problems associate with conventional slag door tunnels. The slag door can be fitted with a furnace apparatus such as a burner or a lance and can be used to provide access to the interior of the furnace and to control the flow of material out of the furnace.
US08206640B2
A process and apparatus for collecting continuous fibers or filaments as a uniform batt comprises a filament emitter in the form of a spinning die, a venturi, a diffuser, and a fiber collection bed. The filaments move downward after being created by the emitter, and exhaust ports create in the diffuser an airflow having a direction against the flow of the filaments so that the filaments are decelerated before contacting the fiber collection bed.
US08206638B2
Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source.
US08206635B2
Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.
US08206613B2
Disclosed is a phosphor composite material which can be fired at low temperatures and enables to obtain a phosphor composite member which is excellent in weather resistance and reduced in deterioration after long use. Also disclosed is a phosphor composite member obtained by firing such a phosphor composite material. Specifically disclosed is a phosphor composite material composed of a glass powder and a phosphor powder, which is characterized in that the glass powder is composed of SnO—P2O5—B2O3 glass.
US08206607B2
A method for cooling an internal combustion engine using a reduced toxicity, ethylene glycol and water based heat transfer fluid is provided. A heat transfer fluid is formulated comprising water and a glycol component consisting of ethylene glycol and either propylene glycol or glycerol. Propylene glycol may be provided in an amount between 5% to less than 30% of the total weight of the glycol component. Glycerol may be provided in an amount between 5% to 20% of the total weight of the glycol component. The glycol component is less toxic than 10,000 mg/kg on an acute LD50(rat) oral toxicity basis. The water comprises between 40% and 70% by weight of the total weight of the heat transfer fluid. The cooling system of the internal combustion engine is substantially filled with the heat transfer fluid such that the heat transfer fluid absorbs heat that is produced by the internal combustion engine and releases the absorbed heat to the atmosphere.
US08206606B2
An oxide magnetic material includes a ferrite with a hexagonal structure as its main phase. Metallic elements included in the oxide magnetic material are represented by the formula: Ca1-x-x′LaxSrx′Fe2n-yCoy, where atomic ratios x, x′ and y and a molar ratio n satisfy 0.4≦x≦0.6, 0.01≦x′≦0.3, 0.2≦y≦0.45 and 5.2≦n≦5.8, respectively.
US08206602B2
According to one embodiment, there is provided a method of manufacturing a magnetic recording medium, including forming a first hard mask including carbon as a main component, a second hard mask including a main component other than carbon and a resist on a magnetic recording layer, contacting a stamper to the resist to transfer patterns of protrusions and recesses to the resist, removing residues in the recesses of the patterned resist, etching the second hard mask, etching the first hard mask, patterning the magnetic recording layer, and removing the first hard mask, the method further including, between etching the first hard mask and removing the first hard mask, removing the second hard mask remaining on the protrusions of the first hard mask, and removing a contaminating layer on a surface of the first hard mask by a mixed gas of oxygen-based gas and a fluorine compound.
US08206599B2
Exemplary systems and methods relating to washboxes are described.
US08206598B2
An adapter for the purging of lines is described that comprises a plate and an attachment mechanism. The plate includes a first side and an opposed second side that are connected by at least one edge. The plate has a first interface defined on the second side that is adapted to connect to a portion of a cap of a filter assembly in a close fitting relation. The first interface is also adapted to define an interior space between the portion of the cap and the plate. The interior space is in fluid communication with a first line that is connected to the filter assembly. The attachment mechanism secures the plate and the portion of the cap in the close fitting relation. The plate includes a second interface that is adapted to connect to an external source of pressure. The second interface is in fluid communication with the interior space.
US08206592B2
The invention relates to systems and methods of treating water by directing the water to a first reverse osmosis (RO) membrane; separating the water using the first RO membrane; adding a chelating agent to first permeate and/or raising the pH of the first permeate to between about 5.5 and 7.5 before a second RO membrane; and separating the first permeate into a second permeate and a second concentrate using the second RO membrane, thereby separating constituents from the water.
US08206585B2
An automatic oil-water separation and recovery device, which comprises a cylindrical tank, on the top of which exists an oil collector. The tank has an inflow pipe that links to a pre-separation regulating water distributor therein. The said water distributor is in the shape of an obconic bell mouth. At the lower part of the tank stands an outflow collector on which a bar-shaped oil-water separation unit is secured. The said outflow collector has an outlet. The said oil-water separation unit is made from stainless steel or plastic antipriming pipe firstly wrapped with unwoven cloth, and then taped with wires and outside the wires further wrapped with nonwoven cloth. All the cloth and wires are made of the same highly hydrophilic, oil-resistant material. The automatic oil-water separation and recovery devices described in this invention can be assembled together for separating and recovering ship-generated oily water. The assembled system works very well even though the oil content in the oily water fluctuates significantly. The average oil content in the treated water is about or lower than 5.0 m/L.
US08206575B2
A process for upgrading a hydrocarbon feedstock by hydroprocessing using multi-metallic catalysts is disclosed. In one aspect, the invention relates to hydroprocessing of a hydrocarbon feedstock using a catalyst derived from a catalyst precursor of the formula Av[(MP)(OH)x(L)ny]z(MVIBO4), wherein A comprises an alkali metal cation, an ammonium, an organic ammonium or a phosphonium cation, MP is selected from Group VIII, Group IIB, Group IIA, Group IVA and combinations thereof, L is an organic, oxygen-containing ligand, MVIB is at least one of Group VIB metals, and the atomic ratio of MVIII:MVIB is between 100:1 and 1:100.
US08206571B2
The present invention claims a method for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. The present invention also provides for an apparatus for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. Kit claims for formation of [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species are also provided.
US08206560B2
Disclosed is an aluminum electrolytic cell having profiled cathode carbon blocks structures, comprising a cell case, a refractory material installed on the bottom, an anodes and a cathode. The cathode carbon blocks include a profiled structure having projections on the top surface of the carbon blocks, that is, a plurality of projections are formed on a surface of the cathode carbon blocks. The aluminum electrolytic cell having the cathode structure according to the present invention can reduce the velocity of the flow and the fluctuation of the level of the cathodal molten aluminum within the electrolytic cell, so as to increase the stability of the surface of molten aluminum, reduce the molten lose of the aluminum, increase the current efficiency, reduce the inter electrode distance, and reduce the energy consumption of the production of aluminum by electrolysis. With the above configuration, compounds or precipitates of viscous cryolite molten alumina can be formed on the lower portion between walls protruding on the upper surface of the cathode, which can prohibit the molten aluminum from flowing into the cell bottom through the cracks and apertures on cathodes, so that the life of the electrolytic cell can be extended.
US08206556B2
A blade for creping a paper web from a dryer surface is provided, said blade having a sliding surface facing the dryer surface during use of the blade, a web impact surface upon which the paper web impacts during creping, and a working apex formed between the sliding surface and the web impact surface, wherein the working apex is located no more than 30 percent of the total blade thickness away from a neutral fiber of the blade. Preferably, the working apex of the inventive creping blade is located at or close to the neutral fiber of the blade. A method for manufacturing the blade is also disclosed.
US08206546B2
A heat shield having a honeycomb core. The honeycomb core has a plurality of intersecting wall portions forming a plurality of cells. A strain compliant material is applied to the wall portions of the honeycomb core prior to filling of the cells with an ablative material. An ablative material at least substantially fills the cells of the honeycomb core.
US08206536B2
A method of stacking a flexible substrate is provided. The method includes the steps of: preparing a carrier substrate; stacking an adhesive layer on the carrier substrate; and stacking a flexible substrate having at least one image display device on the adhesive layer using a laminating or pressing method. Thus, the flexible substrate is easily fabricated without modification of conventional mass-production equipment for fabricating a display, and thereby a lightweight, thin, and compact flexible display can be realized.
US08206528B2
A method of applying a film to an endless moving handrail comprises the steps of adhering a first film layer, having sufficient resilience to accommodate strains occurring on the surfaces of the endless moving handrail and including a barrier coating on at least one of top and bottom surfaces of the first layer, to a top surface of an endless moving handrail, and adhering a substantially transparent film layer over the first film layer.
US08206523B1
A process of manufacturing a multi-shade design on an at least semi-transparent substrate having a first surface and a second surface. The process comprising a template preparation step of preparing a template, the template being visible through the substrate, applying a first design film to a surface of the substrate, carving at least a portion of the first design film, applying a second design film over the first surface, and carving at least a portion of the second design film. An alternative process of manufacturing a multi-color design comprising the template preparation step, applying a first design film, of a first color, to the first surface, carving the first region, applying a second design film, of a second color, to the first surface, and carving the second region from the second design film.
US08206521B2
According to one embodiment, a high-strength stabilizer steel for vehicles having excellent corrosion resistance and low-temperature toughness, containing 0.07 to 0.20% C, more than 0.6% and 1.5% or less Si, 1 to 3% Mn, 0.1 to 1.0% Cr, 0.005 to 0.080% sAl, 0.005 to 0.060% Ti, 0.005 to 0.060% Nb, 0.070% or less Ti+Nb, 150 ppm or less N, 0.035% or less P, 0.035% or less S, 0.01 to 1.00% Cu, 0.01 to 1.00% Ni, the remainder being Fe, and unavoidable impurities, wherein a structure before molding a stabilizer is any one of a bainite, a martensite, and a mixed structure of bainite/martensite and an original austenitic crystal grain size number after a heat treatment of the stabilizer is Gh 9 or more.
US08206516B2
In a method for producing an R—Fe—B based rare-earth sintered magnet according to the present invention, first, provided is an R—Fe—B based rare-earth sintered magnet body including, as a main phase, crystal grains of an R2Fe14B type compound that includes a light rare-earth element RL, which is at least one of Nd and Pr, as a major rare-earth element R. Thereafter, the sintered magnet body is heated while a heavy rare-earth element RH, which is at least one element selected from the group consisting of Dy, Ho and Tb, is supplied to the surface of the sintered magnet body, thereby diffusing the heavy rare-earth element RH into the rare-earth sintered magnet body.
US08206515B2
A lead-free, cream solder composition that is printable includes a SnZn alloy which is lead-free and which is a powder; a solder flux including an epoxy resin; microcapsules that are organic carboxylic acid particles encapsulated with a resin selected from a group consisting of epoxy, polyimide, polycarbonate, polyamide, polyester, polyurea, polyolefin, and polysulfone resins; and a solvent which is a glycol. The presence of the organic carboxylic acid encapsulated with a resin as microcapsules suppresses reactivity of zinc in the SnZn alloy with the organic carboxylic acid Alternately, the solder flux may include the epoxy resin; an organic carboxylic acid; and the solvent; and microcapsules that are particles of a SnZn alloy encapsulated with the described resin. The presence of the SnZn alloy encapsulated with a resin as microcapsules suppresses reactivity of zinc in the SnZn alloy with the organic carboxylic acid so that viscosity and solderability are stabilized.
US08206514B2
A cleaning device for a medical implement is disclosed. The cleaning device includes a cap having an opening to an inner cavity, the opening being adapted to receive a site of the medical implement. The cleaning device further includes a compressible cleaning material that contains a cleaning agent prior to receipt of the site of the medical implement, i.e. the cleaning material is pre-loaded with the cleaning agent. The compressible cleaning material is at least partially secured in the inner cavity and adapted to swab and clean the site with the cleaning agent.
US08206511B2
A method of cleaning an uncoated surface includes providing a composition having a pH of between about 7 and about 11 and applying the composition to the uncoated surface. The composition includes a fatty acid salt constituting between about 5% and about 40% by weight of the composition, a gloss-enhancing agent constituting between about 0.1% and 20% by weight of the composition, an anti-slip agent constituting between about 0.5% and about 10% by weight of the composition, and water constituting between about 20% and about 94.6% by weight of the composition. The composition can be applied at least three times a week.
US08206505B2
The inventive method for forming nano-dimensional clusters consists in introducing a solution containing a cluster-forming material into nano-pores of natural or artificial origin contained in a substrate material and in subsequently exposing said solution to a laser radiation pulse in such a way that a low-temperature plasma producing a gaseous medium in the domain of the existence thereof, wherein a cluster material is returned to a pure material by the crystallization thereof on a liquid substrate while the plasma is cooling, occurs, thereby forming mono-crystal quantum dots spliced with the substrate material. Said method makes it possible to form two- or three-dimensional cluster lattices and clusters spliced with each other from different materials. The invention also makes it possible to produce wires from different materials in the substrate nano-cavities and the quantum dots from the solution micro-drops distributed through an organic material applied to a glass.
US08206503B2
A method for making a sludge aggregate concrete includes the steps of collecting and dehydrating sludge, sintering the sludge at a temperature of about 800˜900° C., grinding and sieving the sludge through a screen to obtain sludge ash, forming the sludge ash into an artificial sludge aggregate by mixing the sludge ash with an inorganic binder and water followed by granularizing, and mixing the artificial sludge aggregate with an inorganic binder and water to form the sludge aggregate concrete product.
US08206491B2
An apparatus is provided for implementing water separation in the vacuum system of a paper machine. The apparatus includes a guiding baffle structure connected to an inlet pipe and a water trap vessel, and a droplet separation cell mounted at the mouth of an outlet pipe.
US08206484B2
This invention is a method for fabricating fibers by melt-blowing a melt of a molecularly self-assembling material, the melt being at a temperature of from 130° C. to 220° C., thereby forming a fiber set having a distribution of fiber diameters wherein at least 95% of the fibers have a diameter of less than about 3 microns. The invention further comprises collecting the fiber set so as to form a fibrous non-woven web.
US08206478B2
The disclosure relates to a modular waste liquid separator and collector device, comprising component modules. A first module comprises a support structure, a second module comprises a droplet separator connectable to said support structure, and a third module comprises a waste liquid collector. The component modules are individually portable, and are assembled at the point of use.
US08206476B2
A cover (120) for a diesel particulate filter (106) includes a hollow chamber (128) with an open bottom (140) sized to receive the body of the diesel particulate filter (106), and a plenum (156) attached to the hollow chamber (128) to receive a supply of air, and to distribute that air to an air vent (152) formed in the top surface (150) of the hollow chamber (128) to direct the air across the top surface of the diesel particulate filter (106).
US08206468B2
An energy storage device includes a first electrode comprising a first material and a second electrode comprising a second material, at least a portion of the first and second materials forming an interpenetrating network when dispersed in an electrolyte, the electrolyte, the first material and the second material are selected so that the first and second materials exert a repelling force on each other when combined. An electrochemical device, includes a first electrode in electrical communication with a first current collector; a second electrode in electrical communication with a second current collector; and an ionically conductive medium in ionic contact with said first and second electrodes, wherein at least a portion of the first and second electrodes form an interpenetrating network and wherein at least one of the first and second electrodes comprises an electrode structure providing two or more pathways to its current collector.
US08206462B2
The present invention relates to the use of polymers comprising carboxyl groups in combination with bivalent cations for producing a protective layer on a textile sheet material and to textile treatment agents, in particular washing and cleaning agents containing said polymers in a suitable form of administration, in order to enable the formation of a protective layer on textile sheet materials.
US08206459B1
A prosthetic assembly for a residual limb that includes a sleeve for attachment to a distal portion of the residual limb, where the attachment member has a diametrically oriented magnetic field, and a prosthesis with a socket for receiving the sleeve, where the prosthesis socket has a distal end with an attachment member having a corresponding diametrically oriented magnetic field. The diametrically oriented magnetic fields of the sleeve and prosthetic attachment members may be oriented on the prosthesis and the residual limb to achieve a predetermined rotational orientation between the prosthesis and the residual limb and will facilitate removal of the prosthesis with a twisting action.
US08206458B1
A prosthetic device having a housing, an axle, at least three housing vanes, a flow medium and a valve. The axle is disposed within the housing and moveable independently of the housing. The axle has an axle reservoir and at least three axle vanes extending from the axle to contact the chamber wall. The three housing vanes extend from a chamber wall and contact the axle. A first opening and a second opening are formed in each axle vane. The flow medium is contained entirely within the chamber and the axle reservoir. The valve is disposed in the axle and operable in response to movement of the axle in a first direction relative to the housing to allow the flow medium to enter the axle reservoir from the chamber for storage under pressure.
US08206455B2
A hip prosthesis is provided for insertion into a femur. In one exemplary embodiment, the hip prosthesis includes a stem having a proximal end, a distal end, and a longitudinal axis. This stem may include anterior and posterior locking surfaces which diverge away from the longitudinal axis. A shank portion may extend distally from the anterior and posterior locking surfaces and converge at an angle distally toward the longitudinal axis.
US08206453B2
A sigmoid notch resurfacing prosthesis for application to the sigmoid notch of the distal radius. The sigmoid notch prosthesis generally includes a saddle and a radius portion for attachment to the distal radius. The saddle may be formed from ultra high molecular weight polyethylene or another durable self-lubricating material. The saddle includes an at least partially concave contoured depression having rounded edges that is securable to the radius portion. The saddle may be secured by a sliding notch snap fit design. The prosthesis may be adapted for articulation with the natural head of the ulnar or with an ulnar head prosthesis that has replaced the ulnar head.
US08206452B2
A prosthetic joint assembly supports articulation of a joint. The joint assembly includes a first component configured to be fixed to an anatomical feature. The first component includes a first impact surface and a second component that engages the first component. The second component includes a second impact surface that impacts the first impact surface as the first component moves relative to the second component. Furthermore, at least one of the first impact surface and the second impact surface includes a dampening member that dampens energy resulting from impact of the first and second impact surfaces.
US08206451B2
A posterior stabilized knee orthopaedic prosthesis includes a tibial bearing and a femoral component configured to articulate with the tibial bearing. The tibial bearing includes a spine having a concave cam surface and a convex cam surface. The femoral component includes a posterior cam having a concave cam surface and a convex cam surface. During flexion, the concave cam surface of the posterior cam contacts the convex cam surface of the spine and the convex cam surface of the posterior cam contacts the concave cam surface of the spine.
US08206449B2
An intervertebral disc placement system includes a multi part intervertebral disc, such as a mobile core disc, and an associated placement instrument. The placement instrument holds the disc securely with the disc endplates angled for ease of placement of the disc into an intervertebral disc space and quickly releases the implant within the disc space. The disc includes upper and lower plates having notches in inner surfaces for engagement of the placement instrument. The placement instrument has a rotatable key configured to fit into the first and second notches to grasp the disc from the interior and eliminate the need for an external grasping mechanism which could interfere with disc placement.
US08206447B2
A method for inserting an intervertebral disc prosthesis into a space between two vertebrae involves inserting the prosthesis partway into the space under constraint to prevent endplates of the prosthesis from articulating, releasing the prosthesis from constraint, and inserting the unconstrained prosthesis farther into the space. In some embodiments, the method involves grasping the prosthesis with a grasping device to insert the prosthesis partway under constraint, loosing the grasping device to release the prosthesis from constraint, and pushing the prosthesis farther into the disc space using the grasping device and/or one or more separate pusher devices. A system includes a grasping device, at least one separate pushing device, and optionally a vertebral spreading device and/or a vertebral midline indicator device.
US08206445B2
A method of ligament reconstruction comprising forming a femoral tunnel and a tibial tunnel, forming a plurality of supplemental femoral tunnels through a sidewall of the femoral tunnel, and forming a plurality of supplemental tibial tunnels through a sidewall of the tibial tunnel. The plurality of supplemental femoral tunnels and plurality of supplement tibial tunnels providing a basis for suture material fixation of graft tissue/material over cortical bone.
US08206438B2
Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outward from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
US08206436B2
The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to compression forces. Exemplary embodiments provide a stent that is coated in a manner that limits the amount of coating surface area that is in direct contact with the target lumen. In particular, a covered stent is provided that is coated internally such that the outer scaffolding surface of the stent is raised from the outer surface of the coating. To this end, cilia function is only partially limited and mucociliary clearance is not significantly affected. Moreover, the coating itself has anti-adherent properties such that bacteria, fungi or other microbials cannot colonize the cover in particular and the stent generally.
US08206433B2
A stent is described that is capable of expanding and thereafter recoiling to its initial coiled state within a biliary duct. A delivery system is utilized to deploy the stent in its natural coiled state into a targeted site of an occluded biliary duct. A balloon from the delivery system is positioned within a lumen defined by the inner coiled arm of the stent. The inflation of a balloon from the delivery system causes the inner coiled arm to radially move outward and engage the outer coiled arm to form an expanded stent. The expanded stent can revert back to its recoiled state by deploying a balloon through a lumen of the expanded stent. Inflation of the balloon disengages the inner coiled arm from the outer coiled arm thereby collapsing the inner coiled arm radially outward and onto the outer coiled arm to form a recoiled stent. The recoiled stent can be removed from the biliary duct.
US08206428B2
A structure and method associated with a tabbed stent that facilitates folding of its unconnected crowns over the adjacent connected crowns, to thus minimize the stent's compressed diameter. The middles of tabs and connected crowns are moved radially inwards with respect to unconnected neighbor crowns such that when in a compressed configuration the unconnected neighbor crowns overlap the connected crowns. The tabs of tabbed stent facilitate folding of the unconnected neighbor crowns over the connected crowns connected to the tabs. In this manner, the compressed profile of the tabbed stent and the crossing profile of the catheter containing the tabbed stent is minimized.
US08206425B2
A cranial fixation system and method are provided. The system includes two heads slidably connected with telescopic extensions and a spring or an elastomeric flexible component. The two heads are maintained in a distracted position by a locking mechanism until ready for cranial implantation. Once implanted, the locking mechanism is disengaged, thereby allowing the heads to compress towards each other by the spring and approximate the cranial bone flap to the skull.
US08206408B2
A surgical instrument having a shaft with a fixed handle part having a sliding part arranged thereon, and axially movable by means of a pivotable handle. The sliding part is guided on the shaft within an axial working stroke by proximal and distal guidance mechanism. A locking mechanism limit the axial displacement of the sliding part on the proximal end of the working stroke. In use, after unlocking the locking mechanism. the sliding part is movable beyond the proximal end of the working stroke into a cleaning position, in which the distal guidance mechanism are disengaged, so that the sliding part can be lifted away from the shaft.
US08206395B2
A surgical instrument for the distraction or compression of bones or bone portions comprises a pair of elongate cross members pivotally coupled for relative movement having at one end a respective pair of handles and at the other end a respective pair of jaws. The jaws are generally parallel to each other and define a first plane within which the jaws are relatively movable, the space on both sides of the plane defining a work space between the jaws. The instrument further comprises a fulcrum supported by at least one of the cross members projecting into the work space and having an axis spaced from the jaws.
US08206382B2
A surgical apparatus has a surgical instrument to treat a diseased part of a patient. An energy supply unit supplies energy for driving the surgical instrument. A sensor obtains information about states of the surgical instrument. An energy change detector detects whether magnitude of energy supplied to the surgical instrument is changed or not. A control unit controls driving of the sensor, based on a result of detection by the energy change detector.
US08206378B1
A number of parameters related to the operation of a fluid delivery device are determined based on pressures within the device sensed using multiple pressure sensors. In one example, the volume of therapeutic fluid within a reservoir of a fluid delivery device is estimated based on a measured pressure differential. In another example, the rate at which a therapeutic fluid is added to or removed from the reservoir is estimated based on the measured pressure differential.
US08206371B2
Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.
US08206363B2
The invention provides a device adapted to assist the sterilization of a limb surface, comprising a flexible tubular sleeve, closed at one end, shaped and sized so as to loosely fit, in use, around the limb of a patient whose limb surface is to be sterilized. The sleeve bas limb-sealing means, located close to or at each end of the sleeve, and each capable of forming, in use, a seal between the sleeve and the limb of a patient. The device is particularly suitable to assist in de-contamination of limbs prior to surgery thereon.
US08206357B2
A surgical portal apparatus is provided which includes a housing and a portal member. The portal member is connected to the housing which extends therefrom. The portal member has a longitudinal axis which includes a longitudinal passageway for permitting a surgical object to pass therethrough. A seal mount is mounted to the housing and has an internal seal adapted to establish a substantial sealed relation with the surgical object, the seal mount adapted to articulate relative to the housing between a first position relative to the housing and at least one second position relative to the housing, the seal mount being normally biased toward the first position.
US08206352B2
An apparatus for selecting a flow rate of a fluid includes an axle including an elongated cylindrical member having flow paths, each flow path being defined by a corresponding set of radial holes, each set of radial holes comprising at least one radial hole that extends substantially between an outer surface of the axle and an interior cavity of the axle, and a barrel including an elongated cylindrical member within which the axle is disposed, the barrel having input ports and an output port, the barrel being configured to enable the axle to rotate about an axis of rotation that extends along a length of the axle, wherein a flow rate of a fluid is selected by rotating the axle to a position so that a set of radial holes is in alignment with one or more ports of the barrel.
US08206338B2
A peritoneal dialysis system includes a dialysis machine including a pump chamber and a pump actuator moveable within the pump chamber; a pumping cassette including a rigid portion defining a pump well and a flexible membrane covering the pump well; and wherein the dialysis machine is configured to be mated with the pumping cassette so as to hold a vacuum between the pump chamber and the flexible membrane, the vacuum operable to cause the flexible membrane to follow the pump actuator as the actuator is retracted from the pump well of the rigid portion, the pump actuator operable to cause the flexible membrane to move into the pump well as the actuator is moved into the pump well.
US08206332B2
A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.
US08206327B2
A head massager includes a helmet (10) having a first parallel hoop (11) and a second parallel hoop (12) connected to each other for forming a ring surrounding the user's head. The helmet (10) has a first meridian hoop (21) and a second meridian hoop (22) connected to each other to form an arc structure and hang the head massager on user's head. The distance adjustment devices (3) are provided to connect the first parallel hoop (11), the second parallel hoop (12), the first meridian hoop (21), and the second meridian hoop (22) together for adjusting the size of the helmet (10) to provide a comfortable fit to user's head.
US08206317B2
A lancet belt has a first belt tape with a longitudinal axis and an adhesion material disposed on an adhesion side of the tape. A second belt tape has a longitudinal axis disposed on the adhesion side of the first tape with the longitudinal axes of the first belt tape and the second belt tape being substantially parallel. A plurality of lancets are disposed between the first belt tape and the second belt tape. Longitudinal axes of the lancets are substantially orthogonal to the longitudinal axes of the first and second belt tapes.
US08206305B2
Multiple twisted or rotated arrays are provided. For example, a memory alloy may allow manufacture of multiple rows of elements on a flat substrate. The memory of the alloy is activated to twist different rows in different ways, such as two adjacent substantially parallel but oppositely rotated arrays. By selecting different apertures along a given twist, different planes are scanned due to the difference in direction of the elements of the aperture. By selecting different apertures on differently rotated arrays, a larger volume may be scanned.
US08206297B2
Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.
US08206293B2
The retractor system for use in spinal surgery and other types of surgical procedures that is a simple and efficient solution for minimally invasive access to thoracolumbar spine is disclosed. The fully customizable design allows the surgeon to independently angle the retractor blades and expand the retractor in both cephalad-caudal and medial-lateral directions. With an offering of a range of blade lengths, access can be tailored to the patient's anatomy. Auxiliary instruments such as the retractor inserter, universal hex driver and blade removal instrument allow quick and controlled access to the surgical site. The retractor system provides versatility and control ensuring minimal tissue trauma.
US08206280B2
The present disclosure relates to implants having two arms and a support portion configured to support a body tissue, such as a urethra. The implants are anchored in soft tissue with tissue anchors having a plurality of barbs. The tissue anchors contain an aperture through which a portion of arm is maintained. A locking member is disposed within at least one of the arms to facilitate fixation of the arm to at least one of the anchors.
US08206276B2
A machine tool includes a headstock provided with a main spindle and movable in a direction different from a direction of axis of the main spindle, a tool post mounted on the headstock so as to be movable in the direction of axis of the main spindle, and a tool change unit configured to change a tool attached to the main spindle with another tool after an extremity of the main spindle has been moved to a predetermined tool change position. In this machine tool, when an extremity of the tool post is positioned in the tool change position by the movement of the headstock and also by the movement of the tool post, the tool change unit performs change of a tool attached to the tool post with another tool by the same tool change operation as that for the main spindle.
US08206273B2
An assembly for mounting of a hangboard includes first and second brackets each having first and second opposing end regions and a first elongate member having first and second spaced apart connection points configured for attachment to the first end regions of the first and second brackets. A second elongate member has third and fourth spaced apart connection points configured for simultaneous attachment to the first and second brackets. The second elongate member has a third connection point configured for attachment at a point along a portion of the first bracket between the first and second end regions thereof; and the fourth connection point configured for attachment at a point along a portion of the second bracket between the first and second end regions thereof. When the first and second members are so attached the assembly can be suspended within a wall opening.
US08206266B2
A trampoline exercise system that is designed to show an avatar of a user, which is jumping on a trampoline. The exercise system includes a computer module, a trampoline configured to provide a platform for a user to perform exercises thereon, and a sensor module designed to sense movements of a user performed on the trampoline. The sensor module provides information that is received by the computer module that controls the display of a users' avatar on a video monitor in response to the users' motion on the trampoline. Several types of sensor may be used to sense the movement of the user, including body mounted sensors, trampoline mounted sensors, and remote viewing sensors.
US08206265B2
The present invention provides a control system for a dual clutch automatic transmission having a torque converter. The transmission provides seven forward speeds or gear ratios and reverse. The control system includes a hydraulic pump, a pressure regulator assembly and control valves that provide and release pressurized hydraulic fluid to the torque converter, a pair of input clutches and eight synchronizer clutches. A first pair of control valves are high flow rate valves which are capable of rapidly engaging and disengaging the input clutches. A second pair of high flow rate valves, control valves and spool valves provide a branching control circuit which controls engagement and disengagement of the synchronizer clutches. A control valve linked to the shift lever blocks hydraulic fluid flow to the first pair of high flow rate valves to inhibit input clutch activation when the shift lever is in Park or Neutral.
US08206251B2
A double-cogged V-belt with the upper and lower cog profiles symmetric and having lines (“L”) and arcs (“A”) connected according to a sequence from the center of a root to the center of an adjacent cog of L1-A1-L2-A2-L3 for the upper profile and L4-A3-L5-A4-L6, and with at least one upper root and one lower root substantially aligned with each other, and with the sum of the length of L1 plus the radius of A1 equal to or within 20% of the sum of the length of L4 plus the radius of A3. The upper and lower pitches may be equal and all the roots aligned, or there may be more upper cogs than lower cogs. Some or all arcs and lines may be connected tangentially.
US08206250B1
A bat having a handle portion, a transition portion attached to the handle portion, and a barrel portion attached to the transition portion. The area(s) adjacent to the central portion of the barrel have an increased performance with respect to the central portion of the barrel to effectively enlarge the sweet spot, or preferred hitting area. At least one tubular member of the barrel is circumferential aligned and axially spaced from another tubular member.
US08206242B2
A golf club head with reinforced crown is described herein. Other embodiments are also disclosed herein.
US08206239B2
A golf club head is disclosed. The golf club head has a body member and a face insert formed of different materials. The body material is relatively soft and ductile to allow the club to be customized, and the face insert member is relatively hard and wear resistant to ensure that the face groove geometry remains substantially unaltered through use.
US08206221B2
A method for coordinate generation to be implemented using an orientation device includes the steps of: providing at least three reference marks on a target; aiming the orientation device at a target point on the target, and operating the orientation device such that the orientation device is able to capture an image of the target that contains the reference marks; assigning absolute coordinates to the reference marks in the image captured by the orientation device; and determining relative coordinates of the target point in a coordinate space of the target with reference to the absolute coordinates assigned to the reference marks. An orientation device that performs the method is also disclosed.
US08206216B2
Systems and methods for operating a gaming machine that automatically detects peripherals and enables or disables features in accordance with the detected peripherals are disclosed. One aspect of the systems and methods is that the peripheral has an identifier associated with it. The identifier may be used to identify the type of peripheral attached to the gaming machine. After determining the type of peripheral, features associated with the peripheral type may be enabled and other features may be disabled. A further aspect includes reading configuration data for the gaming machine. The configuration data may be compared to the peripheral types that are automatically detected by the gaming machine.
US08206212B2
A gaming system including a central server linked to a plurality of gaming tables. In one embodiment, the gaming system provides players with one or more loyalty incentives, such as one or more loyalty awards, utilizing one or more loyalty incentive award sequences. In one embodiment, the gaming system determines a loyalty award to provide to a player and then determines an appropriate loyalty award sequence to utilize to provide the player the determined loyalty award, wherein the loyalty award sequence is determined based on the individual gaming table at which that the player is currently playing.
US08206204B2
A method of cooling an engine control unit (ECU) coupled to an engine in a vehicle having a cabin climate control system, comprising operating the vehicle cabin climate control system according to a customer-based climate control setting during a first operating condition, and overriding said customer-based setting during a second operating condition including an ECU over-temperature condition.
US08206198B2
A wafer grinding machine and a wafer grinding method are disclosed. A barrier (60) is arranged around a holding unit (29) to hold at least a wafer (40) with a film (11) attached on the front surface (41) thereof and with the back surface (42) thereof directed upward. The upper surface (61) of the barrier unit is ground to the position between the back surface of the wafer held by the holding unit and the boundary between the wafer and the film. Then, the wafer is ground while being held with the back surface thereof up by the holding unit. As a result, the film is prevented from coming off from the wafer at the time of grinding the back surface of the wafer. Further, when the wafer is ground, a fluid may be supplied into the gap between the barrier unit and the outer peripheral portion of the wafer held by the holding unit.
US08206193B2
A buoy provided preferably for ascending in the water from an initial submerged position. The buoy comprises a buoyancy element positioned at an upper portion of the buoy in the ascending direction. Further the buoy comprises a storing structure for an elongated member positioned below the buoyancy element in the ascending direction, wherein one end of the elongated member is connected to the buoy and the other end of the elongated member is connected to an object submerged in the water. The buoyancy element is provided to obtain a rotation of the buoy around its central axis thereby paying out the elongated member while the buoy is ascending essentially vertically in the water.
US08206182B2
An electrical connector (100), comprising an insulative housing (1) defining a base portion (11) and a mating portion (12) extending from the front side of the base portion along a mating direction; a plurality of passageways (114) disposed in the base portion with an opening backwards and extending along the mating direction; a plurality of receiving spaces (121) disposed in the mating portion and communicating with the complementary passageways; a plurality of contacts (2) mounting to the insulative housing along the mating direction, and each contact including a flat base part (21) mounting to the base portion of the insulative housing, a connecting part (22) extending forwards from the base portion and received in the passageways, a mating part (23) extending from the connecting part and disposed in said receiving space, and a spacer part (24) located between the base part and the connecting part; wherein the spacer part covers the opening of the passageways.
US08206179B2
The present invention provides a modular connector system for, in some embodiments, interconnecting circuit boards. In some embodiments, the modular connector system includes a header assembly for blind mating with an adapter assembly.
US08206178B2
An electrical appliance includes a housing having a holding chamber and an insert slot, an insulation displacement connector (IDC), and an electrical component such as a battery inserted into the holding chamber. The component has an electric connector extending through the holding chamber into the insert slot. Upon insertion of the IDC into the insert slot, the IDC contacts the electric connector of the component and contacts a printed circuit board (PCB) mounted to the housing whereby the electrical component and the PCB are electrically connected via the electric connector of the component and the IDC. The holding chamber completely surrounds, at least in sections, the component within the holding chamber. The holding chamber includes a radially-pivotable latching clip which axially fixes in place the component within the holding chamber.
US08206177B2
An HDMI connector structure includes a base, a circuit board, a chassis and a metal casing. The base includes a containing space, a retaining wall formed at a front end of the containing space, and an opening formed on the retaining wall. The circuit board is installed in the containing space, and an end of the circuit board is passed through the opening and out of the retaining wall, and at least one surface of the circuit board has a plurality of conductive pins, and a transmission line segment is extended from an end of each conductive pin and electrically coupled to a conductive terminal The metal casing includes a hollow main body, and the base is installed in the empty main body, and a front end of the hollow main body is provided for exposing a port from an end of the circuit board.
US08206162B1
A connector module is disclosed in the present invention. The connector module includes a housing, a substrate whereon a first set and a second set of metal contacts are formed, and at least one conductive resilient piece piercing through the housing. The substrate is disposed inside the housing with the first set of metal contacts exposed outwardly. A first end of the conductive resilient piece is fixed on an outer surface of the housing, and the conductive resilient piece is resiliently deformed and electrically contacts the second set of metal contacts when the conductive resilient piece is pressed by a conductive component of an connector receptacle.
US08206149B2
A description is given of a burner for introducing solid, liquid or gaseous fuel into the burning zone of a kiln, such as rotary kiln for manufacturing cement clinker or “similar materials, said burner comprising a burner pipe (1) which encircles a number of ducts for conveying fuel and combustion air through the burner. The burner is characterized in that the burner pipe (1) is made up of modules (1a, 1b) which are fixed to another by fixing means (9) which will allow non-destructive assembly and disassembly of the modules. Hereby is obtained a burner in which it will be possible in a simple and non-destructive manner to disassembly the burner pipe (1) in modules (1a, 1b) in direction from the free end of the burner (7) or the burner tip. As a result, the outermost module of the burner pipe (1) which constitutes the burner tip can easily be disassembled for repair or replacement and/or for repair or replacement of components incorporated in the burner tip so that maintenance and upgrading of the burner to the latest technology can be carried out in the simple and non-destructive manner.
US08206130B2
A radial cylinder hydraulic motor comprises: oscillating hydraulic cylinders (1) driven to oscillate by means of an eccentric crankpin (2) formed on the motor shaft (3), the oscillating cylinder liners (4) being provided with trunnions (5) for oscillation about a parallel axis (C) to the axis (A) of rotation of the motor shaft which are coupled oscillably to the motor crankcase (6); reciprocating pistons (7) within said liners which are provided with a runner (8) for sliding over the outer surface (9) of said eccentric crankpin; and a rotary disk distributor (10, 23) coupled to the motor shaft for synchronized rotation therewith, adapted to place the conduits (12, 13) of the hydraulic circuit in fluid communication with the conduits (14) of the respective cylinders during the delivery and discharge strokes via ports of slanted or through-going configuration; and advantageously includes the rotating disk of the distributor formed with a connection/supply means (38, 40) to the passageway between one face (27) and the inner wall of the distributor cover (41) incorporating a seal (28), with pressurized fluid in the area outside the seal. In another embodiment, it has the trunnions (5) formed with trough-like channels (30) in their outer surface (31), at the area of rubbing contact with the trunnion journals, into a branched layout (30) having a roughly trapezoidal projected shape, the channels in the branched layout being supplied pressurized fluid through one or more supply channels (32) from within the cylinder.
US08206119B2
In one embodiment, a coverplate may be configured to axially overlay a plurality of blade retaining slots within a wheel post of a rotor wheel. The coverplate may include a tab for radially securing the coverplate within a complementary groove of the rotor wheel and an aperture configured to align with a corresponding aperture of the turbine wheel to receive a fastener for axially securing the coverplate to the rotor wheel.
US08206114B2
Gas turbine engine systems involving turbine blade platforms with mateface cooling holes are provided. In this regard, a representative turbine blade for a gas turbine engine includes: an airfoil having a leading edge, a trailing edge, a pressure side and a suction side; and a blade platform on which the airfoil is disposed, the blade platform having a pressure side mateface located adjacent to the pressure side of the airfoil and a suction side mateface located adjacent to the suction side of the airfoil, the blade platform having a cooling hole operative to direct a flow of cooling air toward an adjacent blade platform.
US08206104B2
A fan frame structure includes a plastic frame and a metal fixing frame, in which at least two support arms are disposed on the rim of the fixing frame and extended outwardly therefrom, the outwardly extended distance of each support arm shall be beyond the range of an accommodation space of the frame, the portion of the support arm beyond the accommodation space in integrally enclosed by the plastic material of the frame.
US08206102B2
A composite gas turbine engine duct receives a support ring that operates as an interface arrangement for attachment of engine system components. The support ring interfaces with the composite duct through a fastener shear load arrangement to provide a structurally sound interface which minimizes the risk of ply delamination.
US08206101B2
A turbine nozzle includes a hollow vane mounted between inner and outer bands. The inner band includes a mounting flange between forward and aft lips. An aft pocket is found in the inner band between the flange and aft lip. And, an impingement bore extends through the flange into the windward half of the pocket and is directed aft toward the opposite leeward half of the pocket for co-rotation with purge flow during operation.
US08206099B2
A fan includes at least one fan frame, at least one impeller and at least one active flow-control device. The fan frame includes at least one air inlet and at least one air outlet. The impeller is disposed in the fan frame. The active flow-control device, is disposed on the fan frame for adjusting the size of the air inlet or the size of the air outlet according to demands.
US08206089B2
A flow control device for controlling fluid flow into a turbine comprising a stator and a rotor located in a fluid flow direction downstream of the stator is provided. The stator has a plurality of vanes extending radially inwards from a casing. Nozzles are defined, with each being defined between each adjacent pair of vanes. A flow controller is arranged to control a nozzle area open for fluid flow from a stator to rotor by altering the radial length of at least one of the nozzles and comprises an actuator and baffle plates connected at first ends thereof to a periphery of the turbine and at second ends thereof to arcuate plates of the actuator. Each baffle plate extends through a corresponding nozzle from an upstream to a downstream side of the stator. The actuator may selectively move the baffle plates to adjust flow through the nozzles.
US08206084B2
A blade wheel consisting of sheet metal for use in motor vehicle refrigerant pumps has blades that are cut out of a disk and pitched and base disk segments that lie adjacent to the blades and remain between the latter. The blade wheel is formed by at least two different blade wheel elements which are provided with cut out, pitched blades, are interconnected in a fixed manner and are arranged so that their respective base disk segments are offset in relation to one another, forming a gap therebetween, the elements thus forming a common bottom disk. A hub sleeve is provided in the center of one of these blade wheel elements (the hub disk), and the center of the other blade wheel element or elements (the bore disk or disks) is provided with a hub sleeve receiving bore, which can be pushed onto the casing of the hub sleeve.
US08206082B2
In one embodiment, a packing seal has a plurality of lands that align with annular teeth. Each land has opposite axial sides relative to a rotational axis of a rotary component. Each land also has a recess in at least one of the opposite sides.
US08206079B2
An apparatus for controlling the temperature of a component, which is situated in use in a gas stream, provides a nozzle to create a jet of air at an angle to the gas stream, the jet being directed into the region of the stagnation point of the component so as to control the temperature of the component. The invention is particularly suited to preventing or reducing the formation of ice on vanes of gas turbine engines, but may also be applied to other components, and may equally be used in situations where a component is to be cooled rather than heated.
US08206072B2
A fastener is provided that may be readily threadingly engaged with and/or disengaged from a threaded shaft without the need to threadingly advance the fastener along substantially the entire length of the threaded shaft. In one exemplary embodiment, a quick release nut is provided that includes an upper body portion and a lower body portion that are rotatably connected to one another. Each of the upper body portion and the lower body portion include central apertures extending therethrough with the walls defining the central apertures of the upper and lower body portions being at least partially threaded.
US08206065B2
A recoverable gabion is disclosed. The gabion comprises opposed side walls connected together at spaced intervals by a plurality of partition walls such that spaces between neighboring pairs of partition walls define, together with the side walls, individual compartments of the gabion, adjacent side and partition walls being connected to one another by pivotal connections wherein at least one partition wail comprises at least three partition wall elements, a first partition wall element being pivotally connected to a first side wall and a second partition wall element being connected to a second side wall, and the partition wall comprising at least a third partition wall element between said first and second partition wall elements acting as a spacer element therebetween to extend the width of the gabion compartment and being releasably connected to the first and second partition wall elements.
US08206062B2
A method for in-situ reduction of contaminants in soil.
US08206061B1
A utility compactor is disclosed that includes a roller disposed on top of and connected to a base plate. The roller has two opposing vertical supports. The compactor also includes an eccentric vibratory shaft extending between and rotatably connected to the two vertical supports of the roller. The eccentric vibratory shaft includes a first rotor shaft coaxially spaced apart from a second rotor shaft. The first and second rotor shafts are coupled together by an offset shaft. The offset shaft has an I-beam cross section and includes a first angled portion, a second angled portion and a center portion disposed between and coupling the first and second angled portions together. The first angled portion is coupled to the first rotor shaft; the second angled portion is coupled to the second rotor shaft. The first and second angled portions are angled with respect to a first axis passing through the first and second rotor shafts such that the center portion has a second axis that is offset from and at least substantially parallel to the first axis.
US08206057B2
A plurality of biodegradable stakes for use as trail markers that are coated with a biodegradable coating comprised of an adhesive and a fluorescing compound for inserting into the ground such that the coated surface of the marker is exposed at various distances from each other such that the stakes glow when a source of ultra-violet light is present and thus form a route or trail by which a person can find their way to a point of interest even in low light conditions, while remaining unobtrusive so that one has difficulty seeing the stake without ultraviolet light and unless one is specifically looking for it thereby not detracting from the natural appearance of the location.
US08206055B2
A coupling mechanism secures a shaft-to-collar connection for two shafts, such as an extension shaft stub and a tractor PTO shaft. An annular locking element on the first shaft prevents an axial disconnection of an established connection. One of the shafts has a collar with a positive engagement element for a locking engagement with the other shaft. The other shaft includes a positive engagement for a locking engagement with the collar. To enable an easier handling of the axial locking of the shaft to collar connection, the locking element includes a first set of teeth which are complementarily to a second set of teeth on the second shaft. The locking element is rotatably arranged on the first shaft and can be rotated from a locked position to an unlocked position. In the locked position the teeth overlap.
US08206051B2
A cosmetic-containing applicator. The applicator is mounted, at its tip end, with an applicator body in which a flange-shaped engagement part is formed at an outer periphery at a rear end of a fiber bundle, comprising an accommodating part accommodating liquid cosmetics, a tip casing mounted on a tip end side of the accommodating part and formed with an insertion hole in which the applicator body (30) is mountable, a guiding part for guiding the cosmetics from the accommodating part to the applicator body, and a reduced-diameter part formed as an inwardly facing flange and reducing in diameter between the insertion hole and the guiding part. The reduced-diameter part is divided into claw-shaped holding pieces by slits, and its smallest-diameter part has a diameter smaller than an outer diameter of the engagement part.
US08206050B2
An elongate container includes a cylindrical chamber having an opening at one end of the container. A collar is affixed to the elongate container, and a threaded rod is axially disposed within the cylindrical chamber and coupled to the collar. The collar is adapted to rotate the threaded rod relative to the elongate container. A piston is disposed within the cylindrical chamber and is threadingly engaged with the threaded rod. The piston includes a sealing ring adapted to circumferentially seal against an inner wall of the cylindrical chamber and at least two axially aligned ribs. The ribs are disposed on a side of the piston and seated against the inner wall of the cylindrical chamber. With this arrangement, rotation of the threaded rod causes translation of the piston in the axial direction.
US08206047B1
A keyboard overlay for use on a touch screen is disclosed, as well as novel key structures for use on overlays. The keyboard overlay and key structures have novel structures which can provide finger resting resistance, deceleration during actuation, pre-actuation cues, finger positioning cues, key identification cues, and other desired aspects of a keyboard optimized for touch typing. Methods for stowing and deploying the keyboard overlay to align with the virtual keyboard of a touch screen are also disclosed. The disclosed keyboard overlay can provide optimal touch typing characteristics for use on all known types of touch screens.
US08206037B2
A linear guide, which has at least one approximately U-shaped carriage with side limbs that engage at least partially over a guide rail, at least two recirculating ball shoes for the longitudinally movable support of the carriage with respect to the guide rail and adjusting means for pressing the recirculating ball shoes against the guide rail without play. At least one component is provided which has, in cross-section, at least one wedge-shaped portion, which projects at least partially into a likewise wedge-shaped intermediate space between at least one recirculating ball shoe and one of the side limbs. It is possible to realize reliable and automatic play adjustment which can be realized in a cost-effective manner, with a compact design of the linear guide being maintained.
US08206026B2
A cooking apparatus includes a spatula assembly and a cooking container comprising an upper access opening and an inner, cooking surface having a spherical surface portion. The spatula assembly includes a spatula driver and a curved spatula pivotally mounted to the cooking container for moving along the cooking surface and about a pivot axis between first and second positions. The pivot axis passes through the center point of the spherical surface portion. The spatula assembly may be constructed so that at least one of the first and second positions is above the pivot axis. The curved spatula may also include a spatula body having an outer surface and a barrier member extending radially inwardly from the outer surface, the outer surface contacting the cooking surface of the cooking container.
US08206024B2
An ultrasonic mixing system having a particulate dispensing system to dispense particulates into a treatment chamber and the treatment chamber in which particulates can be mixed with one or more formulations is disclosed. Specifically, the treatment chamber has an elongate housing through which a formulation and particulates flow longitudinally from an inlet port to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulation and particulates within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulation and particulates being mixed in the chamber.
US08206023B2
A backlight assembly and a display device including the backlight assembly are provided for one or more embodiments, where the display device is slim, lightweight, and requires low manufacturing costs because the device integrates a receiving container and a light generating unit cover member. According to an embodiment, the backlight assembly includes a first light generating unit, a wire electrically connected to the first light generating unit, a first fixing member including a groove to fix the first light generating unit and a wire outlet, and a receiving container comprising a light generating unit cover member. The first fixing member includes a protruding portion extending outwardly from the receiving container and the wire outlet formed on the protruding portion.
US08206015B2
A light emitting diode (LED) based lamp may include a LED module having at least one LED to provide light, a housing to house the LED module, and a lens to receive the light from the LED and to direct the light in a specific direction. A microlens array may have a plurality of microlenses with a polygonal shape, and a distance between two opposing sides of one of the microlens is 0.7 mm to 1.2 mm.
US08206012B2
A layered dimmer formed of different layers. The front layer may be a scattering layer, and the back layer may be a reflective layer. The light beam is scattered prior to reflecting, to avoid reflection back to form hotspots.
US08206005B2
A light assembly is disclosed which can include an LED array and a reflector. The LED array can include a plurality of LEDs which are disposed such that each LED is substantially aligned to define a focal axis. Each LED can emit light substantially along an optical output axis, with each optical output axis being perpendicular to the focal axis. The optical output axis of the LED array can be disposed in intersecting relationship with the reflector surface. The reflector can be defined by a curve section defined with respect to a principal axis. The principal axis and the output axis of the LED array can be in non-parallel relationship with each other. The optical output axis of the LED array can be substantially perpendicular to the principal axis of the curve section of the reflector.
US08205999B2
A multi view display comprising a light emitting element having an optical cavity formed by a first and a second reflecting layer, at least said second reflecting layer being semi-transparent, and a light emitting layer arranged between said reflecting layers, wherein said optical cavity is designed so that light emitted in at least two preferred viewing directions has a higher intensity than light emitted in other directions. The invention is based on interference phenomena in the optical cavity, making it possible to realize a light emitting element that intrinsically emits more light in the preferential viewing directions than in other directions. This emission profile makes the light emitting element very useful in a multi view display, reducing the problems of cross talk.
US08205978B2
A head for ejecting a liquid from ejection holes, including: a first flow-passage member in which are formed (a) a liquid-supply passage, (b) branch passages connected to the liquid-supply passage, and (c) discharge passages each being connected to any of the branch passages; a second flow-passage member in which are formed (a) at least one common passage each communicating with at least one of the branch passages and (b) individual passages having respective pressure chambers, each individual passage being connected to any one of the at least one common passage and introducing the liquid to a corresponding one of the ejection holes via a corresponding one of the pressure chambers; a first filter disposed in the liquid-supply passage; second filters disposed between the branch passages and the at least one common passage: and at least one energy giving member for giving ejection energy to the liquid in each pressure chamber.
US08205975B2
A recording apparatus for performing recording by reciprocally moving a liquid discharge head includes the liquid discharge head, which includes a case, a connection terminal group including a plurality of connection terminals capable of electrically connecting to the recording apparatus and which is provided on one face of the case, a liquid discharge substrate for discharging a liquid from a discharge port according to a signal transmitted from the recording apparatus via the connection terminals, and a supporting substrate supporting the liquid discharge substrate, which is provided on another one face of the case. The recording apparatus includes a standby area provided on the one end of the recording apparatus where the liquid discharge head is on stand-by when recording is not performed, and a carriage including a connection terminal which can electrically connect to the liquid discharge head, is mounted with the liquid discharge head, and reciprocally moves between the standby area and another end of the recording apparatus.
US08205970B2
A method for bonding a polymer layer to an outlet plate for an inkjet print head has been developed that enables the polymer layer to be attached to the outlet plate with little or no bowing of the polymer layer. The method includes aligning recesses in a bonding plate with channels in an outlet plate, interposing a polymer layer between the bonding plate and the outlet plate, and pressing the bonding plate against the polymer layer to bond the polymer layer to the outlet plate.
US08205968B2
A liquid discharge head includes: a discharge port from which a liquid is discharged; a channel that communicates with the discharge port; and an energy generating element that is provided in the channel and generates energy used to discharge the liquid from the discharge port, wherein the channel includes a first inlet path supplying the liquid to the energy generating element; a second inlet path supplying the liquid to the energy generating element from a direction opposite to a direction in which the first inlet path supplies the liquid; and a outlet path allowing the liquid supplied to the energy generating element to run out.
US08205964B2
The present invention provides a head array unit in which a plurality of head members is easily aligned on an alignment member with a simple structure and a method for manufacturing the head array unit, and an image forming apparatus including the head array unit. The head array unit includes a head unit. The head unit includes a head member, a head member retainer, and an alignment member. The head member includes a plurality of nozzles and is configured to eject liquid droplets. The head member retainer, on which the head member is disposed and fixed thereto, includes a reference hole for aligning the head unit relative to the alignment member. The alignment member includes an opening formed at a location associated with the reference hole and relatively larger than the reference hole. The head member may be directly aligned and fixed on the alignment member.
US08205963B2
An ink jet print head, which can prevent test terminals from coming into contact with ink or moisture and thus being corroded or damaging other circuits or wires, includes a nozzle forming member that is located in the vicinity of an area with the test terminals arranged therein and is separated from a nozzle forming member located in the remaining area so as to have a reduced volume.
US08205956B2
An image recording apparatus configured to record images on front and back surfaces of a sheet, including: a head which ejects ink onto the sheet for recording; a sheet-supply roller which contacts the sheet so as to transfer the sheet for supplying to the head; a sheet-supply path which is provided between the sheet-supply roller and the head, which has a U-shape, and through which the sheet is transferred such that one of surfaces thereof opposite to the other of the surfaces contacted by the sheet-supply roller faces the head; and a sheet-stopping control section configured to control the sheet-supply roller such that the sheet transferred by the sheet-supply roller is stopped for a first time in the sheet-supply path in a state in which the sheet is deformed so as to have a U-shape, after an image has been recorded on the front surface of the sheet and before an image is recorded on the back surface thereof.