US08816323B2
The nitride-based light emitting device according to one embodiment includes a first nitride semiconductor layer doped with a first conductive impurity; a strain buffer layer formed on the first nitride semiconductor layer and comprised of InGaN; an active layer formed on the strain buffer layer and having a multi-quantum well structure in which a quantum-well layer and a quantum-barrier layer are alternately stacked one above another; and a second nitride semiconductor layer formed on the active layer and doped with a second conductive impurity opposite to the first conductive impurity, wherein the ratio B/A satisfies 1.4
US08816322B2
The present invention provides a Group III nitride semiconductor light-emitting device which is intended to relax stress applied to a light-emitting layer. The light-emitting device includes an MQW layer, and an n-side superlattice layer formed below the MQW layer. The n-side superlattice layer is formed by repeatedly depositing layer units, each unit including an InGaN layer, a GaN layer, and an n-GaN layer which are sequentially deposited from the side of the sapphire substrate. In the n-side superlattice layer, an InGaN layer more proximal to the MQW layer has a higher In compositional proportion. The In compositional proportion of the InGaN layer (which is most proximal to the MQW layer) of the n-side superlattice layer is 70% to 100% of the In compositional proportion of the InGaN layer (which is most proximal to the n-side superlattice layer) of the MQW layer.
US08816305B2
An apparatus supplies a target material to a target location. The apparatus includes a reservoir that holds a target mixture that includes the target material and non-target particles; a supply system that receives the target mixture from the reservoir and that supplies the target mixture to the target location, the supply system including a tube and a nozzle that defines an orifice through which the target mixture is passed; and a filter inside the tube through which the target mixture is passed.
US08816301B2
Germicidal lamp apparatuses are provided with lamps disposed between upper and lower bases of a support structure. In some embodiments, a longitudinal axis of a lamp is at an acute angle greater than 0° relative to a region of the lower base between the lamp and another lamp. In addition, the longitudinal axis of the other lamp is at either a right angle or an obtuse angle relative to said region. Other embodiments of apparatuses include a reflector system disposed between the upper and lower bases which is common to the lamps and which includes a reflector with slanted peripheral edge. Other germicidal lamp apparatuses are provided which include a reflector with multiple sections each contoured to manipulate directionality of light emitted from a subset of lamps. In such cases, the apparatuses are configured to move the reflector and/or collectively move the lamps during illumination of the lamps.
US08816295B2
A system and method for detecting adhesive used to produce an envelope in a mailpiece creation system. The system includes a source of ElectroMagnetic (EM) energy in at least the short UV range to illuminate a surface of the substrate material anticipated to have an adhesive deposited thereon in select regions, an EM energy detection device operative to detect energy reflected from the surface of the substrate material in the visible light range and produce a response indicative of the optical absorbance of EM energy in the short UV range; and a processor operative to analyze the response of the EM energy detection device to determine whether light energy in the visible range is below a threshold level to indicate the presence of adhesive deposited on the substrate material.
US08816288B2
In the radiation detector, a capacitor is connected between a connecting wire which is connected with a preamplifier (amplifier) and another connecting wire. Specifically, the capacitor is connected between the connecting wire and another connecting wire which has the lowest electric resistance with respect to a signal wire among connecting wires connected with a radiation detecting element. This prevents electric current produced by static electricity from flowing to the signal wire and prevents the signal wire or the preamplifier from being damaged by static electricity. A circuit element for a countermeasure against static electricity is not provided at the signal wire, and therefore input capacitance of the preamplifier is kept low. Accordingly, the radiation detector is improved by a sufficient countermeasure against static electricity while input capacitance of the preamplifier is kept low.
US08816285B2
A photosensor-equipped display device is provided having a combination of visible and non-visible light sources where a voltage drop is minimized when the non-visible light sources are turned on. The display device includes: a plurality of infrared LEDs (3b); photosensors (9) provided in a pixel region (4) for detecting reflected light originating from the infrared LEDs (3b); a sensor row driver circuit (7) configured to supply a sensor drive signal to the photosensors (9); an amplifier circuit (6) configured to amplify a signal read from the photosensors (9) in response to the sensor drive signal and output a photosensor signal; a signal processing circuit (20) configured to process the photosensor signal output from the amplifier circuit (6); and a backlight control circuit (13) configured to control on and off of the infrared LEDs (3b). The plurality of photosensors (9) are divided into a plurality of sensor groups in the pixel region (4). The light source control circuit (13) causes separate sets of infrared LEDs (3b), corresponding to the sensor groups, to be on during different time periods.
US08816277B2
An amount of pattern position displacement between observation images acquired by irradiating from two different directions is changed depending on beam deflection for moving an image acquisition position. In a pattern evaluation method that measures astigmatic difference or focus position displacement having a small amount of dose at a high speed using parallax caused by the tilted beam, a correction value obtained in advance by measurement is reflected in an amount of pattern position displacement between observation images obtained by irradiating from at least two different directions and generated in accordance with the amount of beam deflection for moving an image acquisition position. A processing unit calculates an amount of correction of an amount of pattern position displacement depending on beam deflection of a beam deflecting unit for moving an image acquisition position on the sample at a high speed.
US08816260B2
Embodiments of a flight-control system and methods of reducing the probability of a roll-control reversal in a canard-controlled flight vehicle are generally described herein. In some embodiments, the flight-control system may monitor angular velocities of the flight vehicle to detect the onset of instability and adaptively control an acceleration limit of the flight vehicle based on the detected instability to reduce the probability of a roll-control reversal. The onset of instability may be detected by persistently high angular velocities. The acceleration limit may be further adaptively controlled based on an approach of a vehicle trim limit.
US08816259B2
A system and method of restoring material properties is disclosed. A subject material may have one or more of its material properties restored by contacting a packed bed of a reactive material contained within a container with the subject material in which material properties are desired to be restored. The packed bed and the subject material may be heated to restore the material properties. The packed bed may be formed from boron, silicon or other appropriate materials. An inert atmosphere system may have an argon injection system or a helium injection system in communication with the container. A deoxidizing system may be in communication with the container for creating a vacuum within the container or injecting hydrogen into the container.
US08816255B2
Provided is a surface heater using a strip type surface heating element and a fabricating method thereof, in which the surface heater can be embodied into a thin film form using a metallic surface heating element which has a specific resistance value appropriate as a heat wire and is formed of a strip style, where the strip type surface heating element can be sequentially produced at an inexpensive cost. The surface heater includes: the strip type surface heating element in which a number of strips which are obtained by slitting a metallic thin film are arranged with an interval in parallel with each other and both ends of each adjacent strip are connected with each other; and an insulation layer which is coated on the outer circumference of the strip type surface heating element in a plate form.
US08816245B2
A method of cutting an object to be processed comprises the steps of irradiating an object to be processed with a laser light which is an elliptically-polarized light having an ellipticity other than 1 such that a direction of polarization of the laser light intersects a line to cut the object and a thickness direction of the object, while locating a converging point of the laser light within the object, so as to form a modified region within the object along the line and generate a fracture from the modified region in the thickness direction of the object, and causing the fracture to reach front and rear faces of the object so as to cut the object along the line.
US08816242B2
A method of fabricating an implantable pulse generator for generating electrical pulses for application to tissue of a patient, the method comprises: providing one or more housing components adapted to house at least pulse generating and switching circuitry of the implantable pulse generator; providing a feedthrough assembly adapted to be coupled with the one or more housing components, the feedthrough assembly comprising an array of feedthrough pins for providing respective electrical connections from a hermetically sealed enclosure formed within the one or more housing components to a location exterior to the enclosure; providing a plurality of welding components with each welding component comprising a first portion adapted to engage a respective feedthrough pin and a second portion for engaging a conductor wire; performing one or more weld operations for each welding component to connect each welding component with a respective feedthrough pin and a respective conductor wire.
US08816241B2
Together with a scanner device, an air blower is provided above a workpiece, and the air blower exhausts air in the shape of a ring toward the workpiece, the air in a ring shape surrounding an optical axis of a laser beam emitted from the scanner device. A housing of the air blower is formed in a ring shape, a ring-shaped cavity is formed in the housing, an inner ring member is attached to an undersurface of the housing, an outer ring member is attached to an outer peripheral side of the inner ring member, and a ring-shaped exhaust port is formed between the inner ring member and the outer ring member. An exhaust direction of the air is defined by inclination of an outer-peripheral-side end surface of the inner ring member and inclination of an inner-peripheral-side end surface of the outer ring member (FIG. 2).
US08816238B2
A DC balanced square wave power source, controlled in a constant voltage mode, for ESW and ESW-NG welding systems and methods can be matched with variable speed wire electrode feeders, multiple guide tubes, articulated air-cooled cooper welding shoes, and multiple pass ESW welding systems, thus gaining the following advantages, namely, controlling weld bead shape, reducing base metal dilution, reducing total heat input into the parent material, and reduction or elimination of any DC magnetic field in the weld cavity.
US08816221B2
A low resistance pathway includes a flexible member, a surface interfacing the flexible member, a sealing feature, and a fastener. The sealing feature forms an interior edge of at least one of the flexible member and the surface. The fastener compresses the flexible member to contact the surface.
US08816220B2
An enclosure that includes a box structure that includes a plurality of sides defining a sealed chamber for containing a heat producing component. At least one of the sides of the box structure includes a panel. The panel includes two outer sheets and an inner layer of material sandwiched between the two outer sheets. The two outer sheets and the inner layer of material collectively define a plurality of fluid flow channels extending from a first end of the two outer sheets to a second end of the two outer sheets. Heat generated by the heat producing component is transferred to at least one of the outer sheets which transfers the heat to fluid flowing through the fluid flow channels. The panel can be the main load bearing path of the box structure.
US08816219B2
Provided is a metal strip for an electromagnetic interference shield case. The metal strip is uniform in width and thickness. A metal clip that is integrated with at least one pair of face-to-face elastic parts and is appropriate for soldering is fitted on an end of the metal strip along a width direction of the metal strip. The metal strip is bent and cut so as to have a shape corresponding to a ground pattern disposed on a printed circuit board, and then, a bottom surface of the metal clip is soldered to the ground pattern or a solder member disposed on the ground pattern.
US08816217B2
Multilayer polyimide-fluoropolymer insulation structures exhibiting excellent copper heat seal strength and superior internal adhesion strength comprise a layer of polyimide having first and second major surfaces and at least a first fluoropolymer layer wherein the first fluoropolymer layer comprises fluoropolymer, metal oxide and ammonium salt. Protected wire or cable using the multilayer insulation structures, are also described.
US08816215B2
The present invention relates to a disk with an electrical connection element, having a substrate with a first coefficient of thermal expansion, an electrically conductive structure on a region of the substrate, and a connection element with a second coefficient of thermal expansion.
US08816209B2
A submersible motor electric wire includes a conductor including a copper wire and an enamel coating formed on the periphery of the copper wire, and an insulating sheath layer formed outside the conductor. The insulating sheath layer includes a silane graft polymer as a main constituent. The silane graft polymer is formed by a graft-polymerization that an unsaturated silane compound and an organic peroxide are added to polyethylene, and is cross-linked contacting with water in the presence of a siloxane condensation catalyst. Alternatively, the insulating sheath layer includes a composition including polyethylene as a main constituent, and the composition is cross-linked by being irradiated with an ionizing radiation.
US08816204B2
A wire connecting method and a wiring harness that allows one to utilize a single terminal for multiple core wires having various diameters thereby reducing the number and different types of terminals. The wire connecting method allows the larger wire cores first to be ultrasonic pressed such that the diameter of the larger core wires are reduced to sizes that are small enough to utilize the single terminal used on smaller core wires.
US08816203B2
A fitting for coupling an end of a first insulated conductor to an end of a second insulated conductor is described. The fitting includes a first splice housing placed over the end of the first insulated conductor and coupled to the first insulated conductor. The fitting also includes a second splice housing placed over the end of the second insulated conductor and coupled to the second insulated conductor. A sleeve is located over the end of the second insulated conductor and adjacent to the second splice housing. An interior volume of the fitting is substantially filled with electrically insulating material. The interior volume of the fitting is reduced such that the electrically insulating material substantially filling the interior volume is compacted.
US08816201B1
An electrical device cover includes a base with a wall structure having at least two pairs of opposing walls located perpendicular to each other and an opening in a back side large enough to receive an electrical device. An exterior surface of at least a first wall has at least one rail running perpendicular to a plane in which the back side of the base resides and the base of a detachable hinge component is slidably coupled to the at least one rail. The detachable hinge component has at least one hinge member that is parallel to the base of the hinge component and a lid with at least one hinge tab in which the at least one hinge member seats such that the lid is pivotally coupled to the hinge component.
US08816199B1
A cable routing system includes a longitudinally-expanding body positionable within an IT rack having a frame and two or more NEMA rails coupled to the frame. A pair of mounting brackets are positioned proximate each distal end of the longitudinal-expanding body and configured to directly engage the frame of the IT rack. A cable routing tray is longitudinally affixed to the longitudinally-expanding body and configured to rout cables longitudinally along at least a portion of the longitudinally-expanding body. One or more vertical radiused supports are configured to define a minimum vertical bend radius for cables routed through the cable routing tray.
US08816197B2
A pressure-balanced electrical cable assembly including a connector body, an electrical conductor positioned within the connector body, an interior chamber defined within the connector body, a dielectric fluid medium contained within the chamber, and a shuttle delimiting at least a portion of the chamber to prevent the escapement of the dielectric fluid from the chamber. The shuttle is moveable in response to differences between a pressure within the chamber and a pressure outside of the chamber.
US08816194B2
A photoelectric conversion device with a novel anti-reflection structure. In the photoelectric conversion device, a front surface of a semiconductor substrate which serves as a light-receiving surface is covered with a group of whiskers (a group of nanowires) so that surface reflection is reduced. In other words, a semiconductor layer which has a front surface where crystals grow so that whiskers are formed is provided on the light-receiving surface side of the semiconductor substrate. The semiconductor layer has a given uneven structure, and thus has effects of reducing reflection on the front surface of the semiconductor substrate and increasing conversion efficiency.
US08816192B1
An improved efficiency thin film solar cell is disclosed. Nanoscale indentations or protrusions are formed on the cross sectional surface of a carrier layer, onto which a thin metal film is deposited. Additional layers, including semiconductor absorber and collector layers and a window layer, are disposed on the metal film, thereby completing the solar cell. The nanostructure underlying the metal film serves to reduce the work function of the metal and thereby assists in the absorption of holes created by solar photons. This leads to more efficient electricity generation in the solar cell. In a further embodiment of the present invention the cross sectional surface of the semiconductor absorber layer is also modified by nanoscale indentations or protrusions. These indentations or protrusions have the effect of altering the size of the semiconductor band gap, thereby optimizing the radiation absorption properties of the solar cell.
US08816191B2
Novel structures of photovoltaic cells (also treated as solar cells) are provided. The cells are based on nanometer or micrometer-scaled wires, tubes, and/or rods, which are made of electronic materials covering semiconductors, insulators, and may be metallic in structure. These photovoltaic cells have large power generation capability per unit physical area over the conventional cells. These cells will have enormous applications such as in space, commercial, residential and industrial applications.
US08816178B2
A system of removing undesirable overtones and rings in an acoustic drum includes a drum, a tuning port, and an attachment mechanism. The tuning port is attached to the drum by the attachment mechanism, and three different attachment mechanisms are used within the system to attach the tuning port. A plurality of dimples is positioned on the inner surface of the tuning port, and the tuning port includes a first, second, and third alternative embodiments. The first alternative embodiment, which has a flared end and a cylindrical end, can be attached with a drum shell of the drum by the first and second attachment mechanisms. The second alternative embodiment, which has two flared ends, can be attached with the drum shell by the first and second attachment mechanisms. The third alternative embodiment, which has two flared ends, can be attached with the drum shell by the third attachment mechanism.
US08816173B1
A novel maize variety designated PH1DBM and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1DBM with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1DBM through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1DBM or a locus conversion of PH1DBM with another maize variety.
US08816170B2
A pepper hybrid designated E 490264 is disclosed. The invention relates to the seeds of pepper hybrid E 490264, to the plants of pepper hybrid E 490264, and to methods for producing a hybrid plant, either inbred or hybrid, by crossing the pepper hybrid E 490264 with itself or another pepper plant. The invention further relates to methods for producing a pepper plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other pepper lines, cultivars or hybrids derived from the pepper hybrid E 490264.
US08816159B1
The present invention provides novel lettuce cultivar Inferno and plant parts, seed, and tissue culture therefrom. The invention also provides methods for producing a lettuce plant by crossing the lettuce plants of the invention with themselves or another lettuce plant. The invention also provides lettuce plants produced from such a crossing as well as plant parts, seed, and tissue culture therefrom.
US08816157B2
This invention provides modified, insecticidal Cry34 proteins with enhanced properties as compared to wild-type Cry34 proteins. The modifications to these proteins were based in part on an analysis of the three-dimensional (3D) structure of this protein and other proteins in the Cry34 class. The subject invention also includes polynucleotides that encode these modified proteins, and transgenic plants that produce these modified proteins. This invention further provides methods of controlling plant pests, including rootworms, with these modified proteins. The modified proteins of the subject invention include chimeric toxins involving exchanged segments, domains, and motifs as discussed herein. The subject invention also provides methods of modifying Cry34 proteins.
US08816155B2
Long-day onion plants of variety I37853B, I37554A, or I37554B variety capable of producing onion bulbs comprising ‘high soluble solids’ combined with a ‘sweet taste’ as a result of low pungency, are provided. Such onions can be stored for long periods without a loss in quality and without an increase in pungency.
US08816148B2
A process comprising receiving a hydrocarbon feed stream comprising carbon dioxide, separating the hydrocarbon feed stream into a light hydrocarbon stream and a heavy hydrocarbon stream, separating the light hydrocarbon stream into a carbon dioxide-rich stream and a carbon dioxide-lean stream, and feeding the carbon dioxide-lean stream into a hydrocarbon sweetening process, thereby increasing the processing capacity of the hydrocarbon sweetening process compared to the processing capacity of the hydrocarbon sweetening process when fed the hydrocarbon feed stream. Included is an apparatus comprising a first separation unit that receives a hydrocarbon feed stream containing carbon dioxide and produces a heavy hydrocarbon stream and a light hydrocarbon stream, and a second separation unit that receives the light hydrocarbon stream and produces a carbon dioxide-rich stream and a carbon dioxide-lean stream, wherein the apparatus is configured to feed the carbon dioxide-lean stream to a physical solvent, membrane, or carbon dioxide recovery process.
US08816132B2
The present invention relates to a process for accelerated preparation of polyglycerol from crude glycerol using microwave irradiation as the heat element in the presence of soap as the catalyst. The process includes the steps of (a) heating the crude glycerol that contain soap to an elevated temperature for a certain reaction time by using a microwave technology, (b) acidifying the crude polyglycerol with mineral acid at a specific temperature and centrifuging acidified crude product obtained from step (b) at a specific temperature for a certain duration of time.
US08816125B2
The invention relates to a multi-stage process for the continuous, phosgene-free preparation of (cyclo)aliphatic diisocyanates that comprises the conversion of (cyclo)aliphatic diamines into the corresponding (cyclo)alkylene biscarbamates and the thermal cleaving of the latter into the (cyclo)alkylene diisocyanates and alcohol. The urea used in accordance with the invention and also the urea employed for the preparation of urea equivalents (e.g. alkyl carbonates, alkyl carbamates) as a possible precursor for the synthesis of the (cyclo)aliphatic biscarbamates is unconditioned.
US08816124B2
Disclosed is an energetic reactive plasticizer for a plastic bonded explosive (PBX), and specifically an energetic reactive plasticizer for PBX which has high performance and insensitiveness without a plasticizer leak by being bonded with a polymer binder for a plastic bonded explosive.
US08816123B2
A decarboxylation reaction of a (3-methyl-3-butenyl)malonic acid dialkyl ester, carried out by heating in the presence of water and a base, produces an alkyl 5-methyl-5-hexenoate. The decarboxylation reaction produces the alkyl 5-methyl-5-hexenoate inexpensively and effectively. The base can optionally be a tertiary amine compound or a heterocyclic amine compound. Producing the alkyl 5-methyl-5-hexenoate can optionally further include removing an alcohol.
US08816122B2
Embodiments of the present disclosure provide for prostratin analogs, bryostatin analogs, prodrugs of prostratin and prostratin analogs, methods of making prostratin analogs, and methods of making prodrugs of prostratin and prostratin analogs, methods of use of prostratin analogs, bryostatin analogs, and prodrugs thereof, and the like.
US08816116B2
A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF3)2C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CH2CH═CH—) and trimethylene group (—CH2CH2CH2—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH2)n—, —(OCH2CH2)m—, and —(Si(CH3)2O)p—Si(CH3)2—(CH2)q—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF3)2(OH), wherein Z represents a thiol protecting group.
US08816115B2
Provided herein are metal nanoparticles, metal nanopowders, methods of synthesizing the same, and radiation shields using the same.
US08816113B2
A novel bidentate catalytic ligand of general formula (I) is described. R represents a hydrocarbyl aromatic structure having at least one aromatic ring to which Q1 and Q2 are each linked, via the respective linking group, if present, on available adjacent atoms of the at least one aromatic ring. The groups X3 and X4 represent radicals joined via tertiary carbon atoms to the respective atom Q1 and the groups X1 and X2 represent radicals joined via primary, or substituted aromatic ring carbon atom(s) to the respective atom Q2. A and B represent an optional lower alkylene linking group. Q1 and Q2 each represent phosphorus, arsenic or antimony. A process for the carbonylation of ethylenically unsaturated compounds comprising reacting the compound with carbon monoxide in the presence of a source of hydroxyl groups, optionally, a source of anions and catalyst system obtainable by combining a metal of Group 8, 9 or 10 or a compound thereof and the bidentate ligand of general formula (I) is also described.
US08816106B2
The present invention relates to enzymes which possess desaturase, conjugase, epoxidase and/or hydroxylase activity that can be used in methods of synthesizing fatty acids.
US08816102B2
A method of modulating the flavor of an orally-receivable product, such as a foodstuff, beverage, dentifrice or medicine, comprising the addition thereto of a flavor-modulating proportion of at least one compound of the formula I in which X is selected from CHOH, C═O, CH2—CO and CH═C(OH), Y is selected from C1-C7 linear and branched alkyl and CH2CH2OH, Z is selected from CH3 and a moiety of the formula II in which the wavy bond represents bond linking Z to X and R1 and R2 are selected from the possibilities (i) both hydrogen; (ii) independently OH and OCH3; and (iii) R1 and R2 together with their bonds to the phenyl ring form a ring of the formula —O—CH2—O—; such that, when Z is CH3, X is C═O and Y is CH2CH2OH.
US08816091B2
The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
US08816090B2
This invention relates to compounds of the formula (I): wherein A, B, R1, R4, m, and n are each as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central 10 nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.
US08816086B2
A process for the preparation of compounds of formula (I) or a salt thereof wherein X1, X2, X3, X4, Rx, u, R2, R1g, z, and A1 are as defined in the specification is disclosed.
US08816085B2
The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
US08816080B2
Described herein are platinum and palladium compounds with geometrically distorted charge transfer state, applications and methods for the preparation thereof. The platinum and/or palladium compounds described herein are capable of emitting light and can be used in light emitting devices.
US08816078B2
Compositions and methods related to the removal of acidic gas. In one embodiment, compositions and methods are provided for the removal of acidic gas from a gas mixture using an aqueous amine solvent comprising water, a first amine, and a second amine, wherein the first amine contributes at least 50% by weight of the solvent's total amine concentration.
US08816074B2
The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses.
US08816073B2
The present invention relates to β-hydroxy and amino-substituted carboxylic acids, which act as matrix metalloproteinase inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for their synthesis, and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune, and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase.
US08816068B2
The invention relates to an improved process for the production of a sugar alcohol from the corresponding sugar through catalytic hydrogenation. Especially, the invention relates to a process for reducing the interference of sugar-derived aldonic acids in the hydrogenation process by adjusting the hydrogenation conditions so that the activity of the catalyst is maintained. In one embodiment of the invention, the process of the invention is carried out by adjusting the hydrogenation temperature by starting the hydrogenation at a lower temperature and then gradually rising the temperature to the final hydrogenation temperature. In another embodiment of the invention, the process of the invention is carried out by adding small-molecular monocarboxylic acids to the hydrogenation solution.
US08816049B2
There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): where R1 represents an aliphatic group having 9 to 23 carbon atoms; R2, R3, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a —(CH2)n—X group, and at least one of R2, R3, R4 and R5 represents a —(CH2)n—X group; n represents the number of 1 to 4; X represents a guanidino group, a —CONH2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and m represents 1 or 2, and a hydrogel comprising the lipid peptide.
US08816046B2
Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further embodiments relate to compositions, methods and uses of CaMKIIN-derived molecules and other CaMKII inhibitor molecules that inhibit autonomous CaMKII activity. In accordance with these embodiments, compositions that inhibit autonomous CaMKII activity may be used for treating conditions causing neuronal cell death, for treating cancer or for treating neurodegenerative disorders.
US08816043B2
The present invention relates to solar cells and discloses a difluoro benzotriazolyl solar cell material and preparation method and use thereof. The solar cell material is represented by formula (I), wherein both R1 and R2, are C1 to C20 alkyl, and n is an integer from 10 to 50. In the difluoro benzotriazolyl solar cell material, since the 1,2,3-benzotriazole solar cell material contains two fluorine atoms, the HOMO energy level is reduced by 0.11 eV, while the fluorine-substituted 1,2,3-benzotriazole has two imido groups with electron-withdrawing ability; the fluorine-substituted 1,2,3-benzotriazole is a heterocyclic compound with strong electron-withdrawing ability, and an alkyl chain can be easily introduced to the N-position of the N—H bond of the benzotriazole. The functional group of the alkyl chain can improve the solar energy conversion efficiency, thus solving the low efficiency problem of solar cells made of the solar cell material.
US08816037B2
The invention relates to moisture-curing compositions which comprise at least one aromatic isocyanate group-bearing polyisocyanate and at least one dialdimine of formula (I). The compositions according to the invention have a longer open time and at the same time a shorter curing time, they are storage-stable and cure without forming bubbles. They are especially suitable as adhesives, sealing agents, potting compounds or coating materials, the use as sealing agents being especially advantageous.
US08816032B1
The present invention is directed to a copolymer derived from an acyclic conjugated diene monomer and a 1-vinylcycloalkene monomer of formula I where n is an integer ranging from 0 to 4, R is hydrogen or a linear or branched alkyl group of one to four carbon atoms, with the proviso that R may be appended at the 3 to (n+5) positions on the carbon ring.
US08816023B2
Disclosed are particles that have an exterior surface coated with a thin polymeric coating, such as a coating that includes a sulfur-containing polymer. Also disclosed are compositions, such as fuel-resistant sealant and coating compositions, which include such particles. Aerospace vehicles having an aperture at least partially sealed with a sealant deposited from such a sealant composition are also disclosed.
US08816020B2
A method of producing liquid polymeric polyols from epoxidized plant oils by ring-opening polymerization in an organic solvent in the presence of a catalyst to yield the desired polyols at room temperature. The properties of the polymeric polyols depend on the type of plant oil used as starting material. Typically, polymeric content of the purified plant oil based polyols ranges from 65% to 90%. The hydroxyl value and the acid value ranges from 30 to 90 mg KOH/g sample and 1 to 14 mg KOH/g sample respectively. The average molecular weight Mn ranges from 800 Da to 16000 Da. The liquid plant oil based polymeric polyols are reacted with excess diisocyanate to produce isocyanate terminated prepolymer. Subsequently, the prepared prepolymer is reacted with diol or diamine to polyurethane and polyurea respectively.
US08816016B2
A curable composition, useful as a thermosetting binder, having an emulsion (co)polymer, a polyol, and a water soluble polyacid or salt thereof.
US08816001B2
This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2′-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1). Purified GFP-1 was then used as an initiator under standard ATRP conditions with oligo(ethylene oxide)monomethyl ether methacrylate, efficiently producing a polymer-GFP bioconjugate wherein the polymer is connected at a specifically selected site on GFP.
US08815991B2
The present invention relates to a polymer composition comprising polylactide and, based on the weight of this polymer, from 17 to 25 wt % of a chain modifier, from 30 to 55 wt % of an elastomeric polymer and from 20 to 45 wt % of a plasticizer. The invention also relates to the method of preparing said composition as well as to the method of manufacturing an article starting from said composition and the article per se.
US08815986B2
This invention relates to a method for storing a naphthol aralkyl type cyanate ester resin solution, which is difficult to precipitate due to long term storage in a solution state, and particularly relates to a method for storing a naphthol aralkyl type cyanate ester resin solution (AB), which comprises: preparing (i) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a naphthol aralkyl type cyanate ester resin (A), a maleimide compound (B) and a solvent, (ii) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a prepolymer of a naphthol aralkyl type cyanate ester resin (A), a maleimide compound (B) and a solvent, or (iii) a naphthol aralkyl type cyanate ester resin solution (AB) comprising a prepolymer of a naphthol aralkyl type cyanate ester resin (A) and a maleimide compound (B), and a solvent, and; storing the resin solution (AB).
US08815985B2
An object of the present invention is to provide a curable composition which is made mainly of a polymer having one or more reactive silicon groups, has good curability even when filler is used while a non-organotin catalyst is used, and is further high in industrial practicability. The object is solved by a curable composition, comprising, as constituents, a polymer (A) having one or more reactive silicon groups on average per molecule thereof, the reactive silicon group(s) being (each) a group which can be crosslinked by forming a siloxane bond, a Lewis acid and/or derivative thereof (B), an amine compound (C), a compound (D) having a reactive silicon group, and filler (E), and obtained by mixing the constituents with each other.
US08815984B2
An elastomeric composition containing a rubber polymer, an acid acceptor, and a silane-modified needle-like/acircular mineral additive. Compositions according to the present invention have superior heat resistance, compression set resistance, and improved processability (lower compound Mooney) compared to known rubber compositions.
US08815980B2
The invention provides an ink composition for inkjet recording, including: a component (A) that is a compound having two or more groups each of which having a specific structure; a component (B) that is at least one selected from the group consisting of organic solvents each of which having a specific structure; and (C) a colorant.
US08815974B2
[Problems] To provide a liquid dental adhesive composition which contains a phosphoric acid-type compound having a hydrogenphosphoric diester group as an acidic group-containing polymerizable monomer and, further, contains polyvalent metal ions, effectively preventing not only the gelation but also the formation of precipitates (cloudiness) during the storage.[Means for Solution] A dental adhesive composition which is acidic and contains an acidic group-containing polymerizable monomer (A), polyvalent metal ions (B), water (C), a water-soluble organic solvent (D) and fluoride ions (E), wherein at least 35% by mole of the acidic group-containing polymerizable monomer (A) is a phosphoric acid-type compound having a hydrogenphosphoric diester group, and the contents of the fluoride ions (E) and the polyvalent metal ions (B) are so set that a valence number ratio (RF) defined by the following formula (1): RF=VF/TVP (1) wherein VF is a valence number of the fluoride ions (E) contained in the composition, and TVP is a total valence number of the polyvalent metal ions (B) contained in the composition, satisfies a range of 0.2 to 2.0.
US08815966B2
Disclosed is a sheet for use as a packaging material having a low percentage thermal shrinkage, outstanding flexibility and outstanding properties as a packaging material for solar cells. The sheet for use as a packaging material for solar cells according to the present invention is a resin sheet having air spaces obtained by the hot-melt bonding of a portion of a dispersed hot-bonding resin powder, wherein the apparent density of the sheet is no less than 20(%) and no more than 70(%) of the net density of the hot-bonding resin, such that the sheet is adequately flexible.
US08815952B1
A composition comprising a mixture of chlorohexidine, a surfactant, and a cationic quaternary ammonium compound is suitable for use as an antiseptic and is surprisingly effective against difficult-to-kill organisms such as Mycobacterium tuberculosis and against Methicillin-resistant Staphylococcus aureus (MRSA) while still being suitable for topical application. The composition may include a chelating agent.
US08815943B2
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
US08815942B2
The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., Plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.
US08815941B2
Compounds of structural formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza are provided Pharmaceutical preparations thereof and methods for their preparation are also described. The therapeutic effect is achieved via inhibition of viral neuraminidases, also known as viral sialidases. These neuraminidases are classified under the GH34 family of viral enzymes.
US08815937B2
The present invention relates, in various embodiments, to a compound represented by Structural Formula (I), pharmaceutically acceptable salts or prodrugs thereof, and compositions comprising said compounds, or pharmaceutically acceptable salts or prodrugs thereof. Methods of using compounds of Structural Formulas (I) and (la) or compositions comprising compounds of Structural Formulas (I) and (la), or pharmaceutically acceptable salts or prodrugs thereof, to treat ischemia or ischemia-reperfusion injury are also disclosed.
US08815932B2
Substituted tricyclic diproline analogues of the formula (I): wherein the variables are as defined herein. Also disclosed are methods for the production thereof, the use thereof for the induction of an alpha-helix conformation in peptides and/or proteins, pharmaceuticals containing said compounds, methods for the production of a peptide library containing said compounds, and peptide libraries containing said compounds.
US08815931B2
Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.
US08815928B2
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with the compounds.
US08815927B2
The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs). The invention also relates to the use of bivalent diazo bicyclic Smac mimetics for inducing or sensitizing cells to the induction of apoptotic cell death. Thus, compounds of the invention are useful in the treatment, amelioration, or prevention of hyperproliferative diseases such as cancer.
US08815926B2
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
US08815923B2
Disclosed herein is a compound having a structure compositions, methods, and medicaments related thereto are also disclosed.
US08815916B2
The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.
US08815907B2
The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
US08815903B2
The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.
US08815902B2
The present invention is directed to tetrahydroquinoline amide compounds of formula (I) (Formula should be inserted here) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
US08815901B2
The invention relates to compounds of formula (I) wherein the substituents are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester, N-oxide thereof; processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
US08815897B2
Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers:
US08815894B2
Novel [1,2,4]triazolo[1,5-a]pyridinyl-6-yl-substituted tetrahydroisoquinolines are described in the present invention. These compounds and crystalline forms SA1 and N-2 are used in the treatment of various neurological and physiological disorders. Methods of making these compounds and crystalline forms SA-1 and N-2 are also described in the present invention.
US08815878B1
Substituted spiro hemiaminals and methods for their use in the treatment of viral diseases, including hepatitis C viral infections, are described herein.
US08815870B2
The present teachings provide a compound of Formula (I-B): wherein R1-R10 are as described herein; a pharmaceutically acceptable salt of the compound, a geometric isomer of the compound, or a pharmaceutically acceptable salt of the geometric isomer. Also described are methods of preparing the same, as well as methods for preparing vilazodone using the same.
US08815864B2
The present invention relates to compounds of general formula I, wherein the group (Het)Ar is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
US08815847B2
The present invention describes [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutically acceptable salts thereof, which are useful in lowering serum uric acid in a patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a [1,2,4]thiadiazine 1,1-dioxide compound.
US08815845B2
The present invention provides novel chemical compounds characterized as Rho kinase (ROCK) inhibitors, methods for their discovery, and their therapeutic, research, and diagnostic use. In particular, the present invention provides 1,4-benzodiazepine-2,5-dione compounds and related compounds having ROCK inhibitory activity, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with ROCK activity.
US08815840B2
The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
US08815839B2
Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, r, R2 and Z are defined herein.
US08815831B2
The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer. The Acinetobacter may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with Acinetobacter. In another aspect the method can be used to combat Acinetobacter contamination of a site e.g., for disinfection and cleaning purposes.
US08815825B2
This invention relates to compounds, compositions, and methods useful for reducing β-catenin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.
US08815820B2
The present invention provides a method of identifying host cell molecules which may be modulated to inhibit viral replication and method of testing antiviral compounds. In addition, the invention provides compositions, methods and medicaments for treating viral infections and/or diseases or conditions caused or contributed to by viruses.
US08815815B2
Methods are provided for obtaining phytoextracts from vegetation waters and pomaces coming from olive milling. Such methods may be based on combining physical-chemical and enzymatic pre-treatment methods, membrane tangential filtration and vacuum evaporation. Such methods allow eco-sustainable and efficient extraction of the active ingredients involved. Compositions resulting from such methods are also provided.
US08815805B2
The teachings provided herein generally relate to a combination therapy and are directed to pharmaceutical compositions and methods for administering a combination of an α5β1 antagonist with an α2β1 antagonist to a subject. The methods are for use in inhibiting, preventing, or reversing angiogenesis, as well as in treating cancer. In some embodiments, the compositions and methods include a combined administration of VLO4 and VP12 (ECL12).
US08815802B2
The invention relates to a GLP-1 analog which comprises a histidine (H) residue at a position corresponding to position 31 of GLP-1(7-37) (SEQ ID NO: 1), a glutamine (Q) residue at a position corresponding to position 34 of GLP-1 (7-37) (SEQ ID NO: 1), and a maximum of ten amino acid modifications as compared to GLP-1 (7-37) (SEQ ID NO: 1); wherein the H residue is designated H31, and the Q residue is designated Q34; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to derivatives thereof, as well as the pharmaceutical use of these analogs and derivatives, for example in the treatment and/or prevention of all forms of diabetes and related diseases. The invention furthermore relates to corresponding novel side chain intermediates. The derivatives are suitable for oral administration.
US08815801B2
A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
US08815800B2
The invention is directed to skin moisturizing compositions comprising an aminopeptide mixture. The composition replenishes the skins natural moisturization factor and delivers excellent sensory benefits. The composition is not unpleasantly viscous during and after application.
US08815793B2
Adhesive polymeric compositions which can comprise dihydroxyphenyl moieties and derivatives thereof, and related methods of use.
US08815792B2
The present invention concerns a compound of formula wherein R represents a hydrogen atom or a C1-2 alkyl or alkoxyl group; each R1, R2 or R3 represents a hydrogen atom or a methyl or ethyl group; and X represents a CHO, COOR4 or CN group, R4 being a methyl or ethyl group; and at least one of said R, R1 or R2 represents a group containing at least one carbon atom; and it use as perfuming ingredient, for instance to impart odor notes of the floral and/or anis type.
US08815790B2
Foaming light duty liquid detergent formulations that contain at least one cleaning solvent, at least one anionic surfactant and at least foam stabilizing surfactant are disclosed. The compositions of the presently described technology are useful for soil removal applications including, but not limited to, washing dishes by hand and cleaning bathroom and kitchen articles and/or surfaces.
US08815787B2
Provided is a skin cleanser, including the following components (A) to (D): (A) 1 to 30% by weight of a higher fatty acid or a salt thereof; (B) 0.5 to 10% by weight of a polyoxyethylene alkyl ether carboxylic acid or a salt thereof; (C) 0.1 to 10% by weight of an amphiphilic substance having an IOB of 0.25 to 1.2; and (D) 1 to 25% by weight of a water-insoluble particle having an average particle diameter of 50 to 500 μm, in which a weight ratio between the components (A) and (B) “(A)/(B)” is 1/2 to 10/1.
US08815785B2
Methods for creating a fluid diverting barrier in a zone of a subterranean formation are provided. Certain methods comprise providing a treatment fluid that comprises an aqueous base fluid, a viscoelastic surfactant, and a soap component; placing the treatment fluid in a subterranean formation penetrated by a well bore; and allowing the soap component of the treatment fluid to interact with a metal ion present in the subterranean formation to form a precipitate.
US08815782B2
Provided herein is method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in the initial sample, thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage.
US08815781B2
The present patent application introduces methods for generating mixture compound libraries from a drug lead. The mixture compound libraries are then screened for the discovery of modified drug lead compounds which possess desired improved drug properties. The process utilizes a non-selective reaction to modify the drug lead compound structure. Compared to existing methods of modifying a drug lead compound, this new method can modify more structural positions of a drug lead compound. As a consequence, there will be greater probability of finding a product with improved drug properties.
US08815779B2
This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be used in assays to identify conditions that modulate activity of the biological response.
US08815778B2
The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.
US08815775B2
Bis(difluoromethyl)pyrazole derivatives of the formula (I) in which the symbols R1, X, Y and Q are each as defined in the description, and agrochemically active salts thereof, and use thereof for controlling phytopathogenic harmful fungi, and also processes for preparing compounds of the formula (I).
US08815771B2
A mechanochromic coating composition is disclosed comprising a polymeric network incorporating a plurality of ring-opening mechanophores each bound at two positions thereof within said polymeric network.
US08815769B2
A process for conditioning a high efficiency silver catalyst used to manufacture ethylene oxide from ethylene, oxygen, and at least one organic chloride is described. A non-reactive conditioning gas comprising at least one of ethylene, oxygen, and a ballast gas is introduced to the catalyst at a conditioning temperature ranging from 150° C. to 180° C. for a selected period of at least 4 hours.
US08815767B2
Mixed oxides catalysts usable in particular in the full oxidation to CO2 and H2O of volatile organic compounds (VOC), in the decomposition of nitrogen protoxide to nitrogen and oxygen and the combustion of CO, H2 and CH4 off gases in fuel cells, comprising oxides of manganese, copper and La2O3 and/or Nd2O3, having a percentage composition by weight expressed as MnO, CuO, La2O3 and/or Nd2O3 respectively of 35-56%, 19-31% and 20-37%. The oxides are supported on inert porous inorganic oxides, preferably alumina.
US08815766B2
Embodiments include metal (102) containing composites (100) and methods of forming metal containing composites. A metal containing composite can be formed by contacting an oxide support surface (104) with coordination compounds having metal atoms for a first predetermined time, where the metal atoms of the coordination compounds deposit on the oxide support surface; contacting the oxide support surface with a first reagent for a second predetermined time; and contacting the first reagent with a second reagent for a third predetermined time, where the first reagent and the second reagent react to form another layer of the oxide support surface.
US08815764B2
A process is presented for the formation of a SAPO-34 catalyst product. The process, that involves treatment with water or optionally at least one dissolved solid selected from the group consisting of ammonium chloride, ammonium phosphate, ammonium sulfate, ammonium acetate, ammonium carbonate, ammonium nitrate and mixtures thereof creates a SAPO-34 catalyst that has an increased selectivity for production of ethylene and propylene.
US08815760B2
The subject of the present invention relates to obtaining a zirconia sintered body having excellent in both properties of a translucency and a mechanical strength. The present invention relates to obtaining a high-strength zirconia sintered body having a translucency of an in-line transmission of 50% or more at a sample thickness of 1 mm for visible light at a wavelength of 600 nm and an average flexural strength of 300 MPa or more by subjecting a zirconia primary sintered body having an average grain size of 1 μm or less and a relative density of 92% or more and the crystal phase composed of cubic crystals only to HIP treatment at a temperature of 1,250° C. to 1,600° C. and a pressure of at least 50 MPa. The primary sintered body is obtained by maintaining a molded body of a zirconia powder containing 7 mol % to 30 mol % of yttria at 1,100° C. to 1,300° C. for at least 5 hrs or by heating the molded body at a high rate of temperature rise of 500° C./hr or more.
US08815758B2
The present application relates to a silica-based nonflammable material and to a method for preparing same. More particularly, the application relates to a silica-based nonflammable material which contains silica, limestone, and albite as main ingredients, which is obtained by a series of processes including grinding, melting, spraying, and molding, and which can replace asbestos, as well as to a method for preparing same. As functional building materials which are nonflammable even at high temperatures can be prepared using silica-based nonflammable materials consisting of silica-based minerals, and as only natural minerals may be used as main ingredients. The materials used as building materials may not be harmful to the human body and can replace asbestos that has been widely used as a conventional building material for thermal insulation, soundproofing, etc.
US08815753B2
Methods for sealing a porous dielectric are presented including: receiving a substrate, the substrate including the porous dielectric; exposing the substrate to an organosilane, where the organosilane includes a hydrolysable group for facilitating attachment with the porous dielectric, and where the organosilane does not include an alkyl group; and forming a layer as a result of the exposing to seal the porous dielectric. In some embodiments, methods are presented where the organosilane includes: alkynyl groups, aryl groups, fluoroalkyl groups, heteroaryl groups, alcohol groups, thiol groups, amine groups, thiocarbamate groups, ester groups, ether groups, sulfide groups, and nitrile groups. In some embodiments, method further include: removing contamination from the porous dielectric and a conductive region of the substrate prior to the exposing; and removing contamination from the conductive region after the forming.
US08815739B2
One illustrative device disclosed herein includes at least one fin comprised of a semiconducting material, a layer of gate insulation material positioned adjacent an outer surface of the fin, a gate electrode comprised of graphene positioned on the layer of gate insulation material around at least a portion of the fin, and an insulating material formed on the gate electrode.
US08815735B2
A semiconductor device comprises a substrate, a dielectric layer, an undoped silicon layer, and a silicon material. The substrate comprises a doped region. The dielectric layer is formed on the substrate and comprises a contact hole, and the contact hole corresponds to the doped region. The undoped silicon layer is formed on the doped region. The silicon material fills the contact hole from the undoped silicon layer.
US08815720B2
A workpiece is implanted to a first depth to form a first amorphized region. This amorphized region is then etched to the first depth. After etching, the workpiece is implanted to a second depth to form a second amorphized region below a location of the first amorphized region. The second amorphized region is then etched to the second depth. The implant and etch steps may be repeated until structure is formed to the desired depth. The workpiece may be, for example, a compound semiconductor, such as GaN, a magnetic material, silicon, or other materials.
US08815716B2
A semiconductor device includes a semiconductor layer (1) containing GaN and an electrode. The electrode includes an electrode main body (6), a connection-use electrode (8) containing Al and formed at a position farther from the semiconductor layer (1) than the electrode main body (6), and a barrier layer (7) formed between the electrode main body (6) and the connection-use electrode (8), the barrier layer (7) containing at least one selected from the group consisting of W, TiW, WN, TiN, Ta, and TaN. A surface roughness RMS of the barrier layer (7) is 3.0 nm or less.
US08815711B2
A manufacturing apparatus for a semiconductor device, including: a reaction chamber configured to perform film formation on a wafer; a process gas supplying mechanism provided in an upper part of the reaction chamber and configured to introduce process gas to an interior of the reaction chamber; a gas discharging mechanism provided in a lower part of the reaction chamber and configured to discharge gas from the reaction chamber; a supporting member configured to hold the wafer; a cleaning gas supplying mechanism provided in an outer periphery of the supporting member and configured to emit cleaning gas in an outer periphery direction below an upper end of the supporting member; a heater configured to heat the wafer; and a rotary driving mechanism configured to rotate the wafer.
US08815704B2
A method of forming a substrate with isolation areas suitable for integration of electronic and photonic devices is provided. A common reticle and photolithographic technique is used to fabricate a mask defining openings for etching first and second trench isolation areas in a substrate, with the openings for the second trench isolation areas being wider than the openings for the first trench isolation areas. The first and second trench isolation areas are etched in the substrate through the mask. The second trench isolation areas are further etched to the deeper than the first trench isolation areas. The trench isolation areas are filled with oxide material. Electrical devices can be formed on the substrate and electrically isolated by the first trench isolation areas and photonic devices can be formed over the second trench isolation areas and be optically isolated from the substrate.
US08815703B2
A fabricating method of a shallow trench isolation structure includes the following steps. Firstly, a substrate is provided, wherein a high voltage device area is defined in the substrate. Then, a first etching process is performed to partially remove the substrate, thereby forming a preliminary shallow trench in the high voltage device area. Then, a second etching process is performed to further remove the substrate corresponding to the preliminary shallow trench, thereby forming a first shallow trench in the high voltage device area. Afterwards, a dielectric material is filled in the first shallow trench, thereby forming a first shallow trench isolation structure.
US08815692B2
A thin film transistor array substrate having excellent characteristics and a method for manufacturing the same are disclosed. The thin film transistor array substrate includes a substrate, a gate electrode positioned on the substrate, a gate insulating layer positioned on the gate electrode, an active layer which is positioned on the gate insulating layer and includes a channel, an ohmic contact layer positioned on the active layer, and a source electrode and a drain electrode which are respectively connected to both sides of the active layer through the ohmic contact layer. The gate insulating layer includes a phosphorus-doped layer positioned adjacent to the active layer.
US08815683B2
A nonvolatile memory electronic device including nanowire channel and nanoparticle-floating gate nodes, in which the nonvolatile memory electronic device, which comprises a semiconductor nanowire used as a charge transport channel and nanoparticles used as a charge trapping layer, is configured by allowing the nanoparticles to be adsorbed on a tunneling layer deposited on a surface of the semiconductor nanowire, whereby charge carriers moving through the nanowire are tunneled to the nanoparticles by a voltage applied to a gate, and then, the charge carriers are tunneled from the nanoparticles to the nanowire by the change of the voltage that has been applied to the gate, whereby the nonvolatile memory electronic device can be operated at a low voltage and increase the operation speed thereof.
US08815680B2
A method for making a non-volatile memory device provides a semiconductor substrate including a surface region and a tunnel dielectric layer overlying the surface region. Preferably the tunnel dielectric layer is a high-K dielectric, characterized by a dielectric constant higher than 3.9. The method forms a source region within a first portion and a drain region within a second portion of the semiconductor substrate. The method includes forming a first and second nanocrystalline silicon structures overlying the first and second portions between the source region and the drain region to form a first and second floating gate structures while maintaining a separation between the first and second nanocrystalline silicon structures. The method includes forming a second dielectric layer overlying the first and second floating gate structures. The method also includes forming a control gate structure overlying the first and second floating gate structures.
US08815673B2
In some embodiments of the inventive subject matter, methods include forming an oxide layer on a semiconductor substrate, injecting nitrogen into the oxide layer to form a nitrogen injection layer and to change the oxide layer to an oxynitride layer, removing a part of the oxynitride layer to leave a portion of the oxynitride layer in a first area and expose the nitrogen injection layer in a second area and forming an insulating layer comprising a portion on the portion of the oxynitride layer in the first area and a portion on the nitrogen injection layer in the second area. The insulating layer may have a higher dielectric constant than the oxide layer.
US08815670B2
A FinFET structure is formed by forming a hardmask layer on a substrate including a silicon-containing layer on an insulating layer. The hardmask layer includes first, second and third layers on the silicon-containing layer. An array of fins is formed from the hardmask layer and the silicon-containing layer. A gate is formed covering a portion but not all of a length of each of the array of fins. The portion covers each of the fins in the array. The gate defines source/drain regions on either side of the gate. A spacer is formed on each side of the gate, the forming of the spacer performed to remove the third layer from portions of the fins in the source/drain regions. The second layer of the hardmask layer is removed from the portions of the fins in the source/drain regions, and the fins in the source/drain regions are merged.
US08815658B2
The present invention provides a method of forming a transistor. The method includes forming a first layer of a first semiconductor material above an insulation layer. The first semiconductor material is selected to provide high mobility to a first carrier type. The method also includes forming a second layer of a second semiconductor material above the first layer of semiconductor material. The second semiconductor material is selected to provide high mobility to a second carrier type opposite the first carrier type. The method further includes forming a first masking layer adjacent the second layer and etching the second layer through the first masking layer to form at least one feature in the second layer. Each feature in the second layer forms an inverted-T shape with a portion of the second layer.
US08815652B2
The present invention is a manufacturing method for a semiconductor device having steps of; aligning a program head 80 having a program dot array corresponding to each OTP-ROM cell array 21 provided in areas 12 to be a plurality of semiconductor chips arranged in a semiconductor wafer to the OTP-ROM cell array 21 in one of the areas to be the plurality of semiconductor chips 12; and programming the OTP-ROM cell array 21 with a different pattern for each of the areas to be the plurality of semiconductor chips 12 by using the program head 80.
US08815650B2
A method of manufacture of an integrated circuit packaging system includes: providing a substrate; mounting an integrated circuit above the substrate with an interconnect directly connecting between the substrate and the integrated circuit; and forming an under-fill between the integrated circuit and the substrate having a cast side.
US08815648B1
A method of assembling semiconductor devices includes applying a metal paste including a plurality of metal particles having an average size less than 50 nanometers and a binder material onto a metal terminal of a package substrate. The metal paste is processed including a heat up step in a reducing gas atmosphere and then a vacuum sintering step at a temperature of at least 200° C. for forming a sintered metal coating. A semiconductor die is attached onto a die attach area of the package substrate. A bond wire is then connected between a bond pad on the semiconductor die and the sintered metal coating on the metal terminal.
US08815636B2
Solar cell contacts having good electrical performance are made by a process involving: (a) providing a silicon wafer substrate; (b) providing a paste comprising: (i) aluminum, (ii) glass frit, and (iii) a separate and distinct amount of at least one oxide, such that, together with the aluminum, the glass frit and oxide forms a paste having an exothermic reaction peak, at a temperature of at least 660° C. to less than 900° C., (c) applying the paste to the silicon wafer substrate to form a coated substrate, and (d) firing the coated substrate for a time and at a temperature sufficient to sinter the aluminum and fuse the glass frit and oxide.
US08815634B2
Dark currents within a photosensitive device are reduced through improved implantation of a species during its fabrication. Dark currents can be caused by defects in the photo-diode device, caused during the annealing, implanting or other processing steps used during fabrication. By amorphizing the workpiece in the photo-diode region, the number of defects can be reduced thereby reducing this cause of dark current. Dark current is also caused by stress induced by an adjacent STI, where the stress caused by the liner and fill material exacerbate defects in the workpiece. By amorphizing the sidewalls and bottom surface of the trench, defects created during the etching process can be reduced. This reduction in defects also decreases dark current in the photosensitive device.
US08815633B1
A method of fabricating a 3-dimensional structure on a copper-indium-gallium-diselenide material comprises steps: preparing a CIGS (Copper Indium Gallium Diselenide) substrate, and defining two types of regions complementary to each other on the CIGS substrate; providing a mold absorbing an etching solution that can etch the CIGS substrate instead of the mold; aligning the mold to the two types of regions, and allowing the etching solution to flow out from the mold and contact with the two types of regions to etch the two types of regions for generating a level drop between the two types of regions and forming a 3-dimensional (3D) structure on the CIGS substrate. As a result, the present invention can fabricate a large-area 3D structure on a CIGS substrate rapidly without using expensive equipments or complicated processes.
US08815628B2
A complementary metal oxide semiconductor (CMOS) device and a method for fabricating the same are provided. The CMOS image sensor includes: a first conductive type substrate including a trench; a channel stop layer formed by using a first conductive type epitaxial layer over an inner surface of the trench; a device isolation layer formed on the channel stop layer to fill the trench; a second conductive type photodiode formed in a portion of the substrate in one side of the channel stop layer; and a transfer gate structure formed on the substrate adjacent to the photodiode to transfer photo-electrons generated from the photodiode.
US08815627B2
A method for manufacturing an ionizing radiation detection device having a block of a semiconductor material adapted to undergo local separations of charges between positive and negative charges under the effect of ionizing radiation. The device including a first series of at least two collecting electrodes formed on the surface of the semiconductor block, and a second series of at least two non-collecting electrodes formed on a support and separated from the semiconductor block by an insulating layer. During processing, after forming the insulating layer on the support so as to cover the non-collecting electrodes, the block of semiconductor material bearing the collecting electrodes and the support bearing the non-collecting electrodes and the insulating layer are assembled.
US08815620B2
In a flexible organic light-emitting display device and a method of manufacturing the same, a photolysis layer and an electrostaticity prevention layer are sequentially formed on a carrier substrate, a first flexible substrate is formed on the electrostaticity prevention layer, a display unit is formed on the first flexible substrate, the display unit is covered with the second flexible substrate, and light is irradiated so as to decompose the photolysis layer and to remove the carrier substrate. The formed flexible organic light-emitting display device may have improved flexibility because a flexible substrate is used instead of a typical strong and thick glass substrate. In addition, occurrence of electrostaticity during the separation of the carrier substrate is suppressed by the electrostaticity prevention layer, and thus, damage of the display unit due to electrical impacts is also reduced.
US08815611B2
A functional group and spacer group modified polymer composition, articles incorporating the composition, and methods for label-independent-detection using the articles, as defined herein.
US08815609B2
A lateral flow device includes a sample compressor and a test strip comprising a diverting zone. The diverting zone, which may include a barrier and/or a gap or ditch, stops or impedes flow. Flow is reinitiated and diverted into an alternate plane by compression of a sample compressor. Flow returns to the original, lateral plane, at the end of the diverting zone.
US08815606B2
A thin-layer chromatography method for detection and identification of common military and peroxide explosives in samples includes the steps of provide a reverse-phase thin-layer chromatography plate; prepare the plate by marking spots on which to deposit the samples by touching the plate with a marker; spot one micro liter of a first standard onto one of the spots, spot one micro liter of a second standard onto another of the spots, and spot samples onto other of spots producing a spotted plate; add eluent to a developing chamber; add the spotted plate to the developing chamber; remove the spotted plate from the developing chamber producing a developed plate; place the developed plate in an ultraviolet light box; add a visualization agent to a dip tank; dip the developed plate in the dip tank and remove the developed plate quickly; and detect explosives by viewing said developed plate.
US08815603B2
A chemochromic indicator is provided that includes a hypergolic fuel sensing chemochromic pigment that change from a first color to a second color in the presence of a hypergolic fuel. In a first embodiment, a chemochromic indicator is provided for detecting the presence of a hypergolic fuel such that the irreversible hypergolic fuel sensing chemochromic pigment includes potassium tetrachloroaurate (KAuCl4). There are several types of chemochromic indicators, for example, the article used to form the chemochromic indicators include, but are not limited to, wipe materials, silicone/TEFLON tape, manufactured parts, fabrics, extruded parts, and paints.
US08815598B2
The present inventors discovered that genes could be introduced specifically into trophectodermal cells with high efficiency, by infecting blastocysts with viral vectors carrying an arbitrary polynucleotide, or by using a nucleic acid transfection reagent in blastocysts, from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from infection of viruses and the like) is removed. This method has no risk of infecting cells of the inner cell mass, which develops into a fetus in the future, with the introduced polynucleotide because the trophectoderm serves as a barrier. The present invention provides methods for introducing foreign genes into only placenta but not fetus, which enables rescue of genetically mutant animals from embryonic lethality due to placental abnormality and allows their birth. Furthermore, it is possible to analyze expression and effect of genes that regulate placental formation or placental function by using these methods.
US08815594B2
A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.
US08815592B2
A method of differentiation stem cells cells by contacting stem cells with a dopaminergic differentiation agent is provided in certain aspects. For example, the agent may comprise substituted benzoxazole. These methods and compositions may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound or treatment of neurological disorders.
US08815582B2
Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.
US08815578B2
Disclosed is a cell culture tube, having in opposite end walls two respective eccentric openings which communicate with each other through an inner straight passage formed in the cell culture tube, in which the inner straight passage is tilted at an angle relative to a longitudinal axis of the cell culture tube to allow a culture medium to smoothly flow into and out of the inner passage through the openings. Also, provided is a multiple cell culture system using a plurality of the culture tubes.
US08815572B2
The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material.
US08815563B2
Modified viral particles wherein the viral particles, typically adenoviral particles, are modified by glycosylation and the use of the modified viral particles to deliver heterologous nucleic acid to cells. Also disclosed are pharmaceutical compositions comprising the same and method of treatment using the same.
US08815561B2
Methods and composition for biofuel processing are provided. For example, in certain aspects methods for using metal compounds to enhance cellulose enzymatic hydrolysis are described. Furthermore, the invention provides integrated processes with fewer lignin removal steps to improve efficiency.
US08815555B2
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
US08815549B2
The invention relates to a method for the ozonolysis of unsaturated fatty acids and derivatives thereof, comprising a) ozonolysis of a fatty acid or of a derivative thereof in an organic phase comprising an organic solvent, and b) contacting the organic phase with an aqueous phase comprising catalase and preferably a buffer, where the fatty acid or the derivative thereof has a linear chain having at least eight carbon atoms, and the use of catalase for removing reactive oxygen species from a reaction mixture comprising ozonolysis products of an unsaturated fatty acid.
US08815548B2
The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
US08815542B2
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
US08815541B2
The invention provides an improved method for producing polypeptides with a C-terminal glycine in a yeast transformant being characterized in having a non functional KEX1 gene. The method is in particular well suited to produce polypeptides with an aromatic amino acid residue attached to the C-terminal glycine. The yeast strain may have further non-functional protease genes selected from PEP4, YPS1, MKCI, YPS3, YPS5, YPS6, YPS7, PRB1, STE13 and KEX2.
US08815540B2
The present invention provides a method for preparing a non-adenoviral target virus or target proteins utilizing a potent expression cell line having stably integrated into its genome a gene encoding a specific heterologous regulator protein.
US08815533B2
A method is provided for purifying a protein comprising the steps of providing a heme tag with an open coordination site and tagging the recombinant protein of interest with the heme tag. A resin framework is used, wherein a base that binds to heme is immobilized to the resin, and the open coordination site of the heme tag is capable of reversibly binding to the base immobilized to the resin. The tagged protein is reversibly bound to the resin, then eluted from the resin and quantified. The method enables the tagged protein to be tracked during protein expression or purification, and can be used to identify secretion of a protein to the periplasm or to tag proteins in the cytoplasm.
US08815520B2
The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16INK4a based detection of anogenital lesions in cytological testing procedures.
US08815498B2
The present invention provides a method of forming tight-pitched patterns. First, a target pattern is provided, wherein the target pattern comprises a plurality of first stripe patterns, and each of the first stripe patterns has a first width and a first length. Then, a photomask comprising a plurality of second stripe patterns corresponding to the first stripe patterns is provided, and each of the second stripe patterns has a second width and a second length. Then, a first exposure process with the photomask is provided in an exposure system, wherein the first exposure process uses a first light source that can resolve the second width of each of the second stripe patterns. Lastly, a second exposure process with the photo-mask is provided in the exposure system, wherein the second exposure process uses a second light source that cannot resolve the second width of each of the second stripe patterns.
US08815477B2
A color filter manufacturing method for forming a filter segment and a black matrix by repeating at least a coating step of coating a substrate with a photosensitive resin layer, a pattern exposure step of curing the photosensitive resin layer by pattern exposure, a developing step of developing the exposed photosensitive resin layer, and a sintering step of thermosetting the developed photosensitive resin layer, in this order a plurality of number of times, characterized in that in the exposure step, a laser is used as a light source, and proximity exposure is performed by repetitively emitting the laser via photomask such that a cumulative exposure amount is 1 to 150 mJ/cm2.
US08815470B2
It is a main object of the present invention to provide a fuel cell catalyst in which a support for supporting a metal catalyst has electrical conductivity in itself and which can prevent agglomeration of the metal catalyst during long term use of the fuel cell. In the present invention, the object is achieved by providing a fuel cell catalyst for use in a cathode-side catalyst electrode layer of a solid polymer electrolyte fuel cell, comprising a metal catalyst and a perovskite-type complex oxide (ABO3).
US08815467B2
The present invention relates to a membrane electrode assembly comprising at least two electrochemically active electrodes separated by at least one polymer electrolyte membrane, the aforementioned polymer electrolyte membrane having fibrous reinforcing elements which at least partly penetrate the polymer electrolyte membrane, wherein at least some of the fibrous reinforcing elements have functional groups which have a covalent chemical bond between the fibers and the polymer of the polymer electrolyte membrane.The membrane electrode assembly is suitable for applications in fuel cells, especially in high-temperature polymer electrolyte fuel cells.
US08815464B2
A fuel cell includes a membrane electrode assembly and a metal separator. The metal separator is stacked with the membrane electrode assembly. A reactant gas passage is provided between the membrane electrode assembly and the metal separator to supply a reactant gas along an electrode surface. The metal separator includes a reactant gas communication hole to communicate with the reactant gas passage. The metal separator further includes a plurality of groove groups each having a plurality of grooves press-formed to allow the reactant gas communication hole to communicate with the reactant gas passage. The grooves adjacent to each other are spaced apart by a first distance. The groove groups adjacent to each other are spaced apart by a second distance larger than the first distance.
US08815463B2
Deterioration of an electrolyte and a sealing member is suppressed taking account of the durable temperature characteristics thereof, while enhancing the starting performance of a fuel cell. For this realization, in a system comprising a gas piping system for supplying a reactant gas to a fuel cell, and a gas supply controller for altering the supply state of the reactant gas in response to a power generation request, a gas supply quantity is altered in accordance with the temperature of the fuel cell. Preferably, the gas supply quantity is altered in accordance with the durable temperature characteristics of a passage member forming a gas passage of the reactant gas. Furthermore, the differential pressure of the gas supply state between the anode side and the cathode side of the fuel cell is preferably taken into account and the differential pressure between both poles is suppressed by altering the gas supply quantity on the cathode side as the case may be.
US08815459B2
A fuel system including a fuel cell including a plurality of unit cells supplied with a prescribed gas to generate electricity, a stoichiometric ratio calculating apparatus calculating the stoichiometric ratio of the prescribed gas for each unit cell, and a gas flow increasing apparatus increasing the supply of the prescribed gas when the stoichiometric ratio falls below a prescribed value.
US08815452B2
The present invention relates to one or more electrode plates, which are installed with current collecting terminals at two or more sides thereof, and joined to an auxiliary conductor made of a material having a conductivity that is higher than that of the electrode plates. Current collecting terminals are installed at two or more sides of the auxiliary conductor, for linking with current collecting terminals installed at two or more sides of the electrode plates, and at least one of linked terminals is used as a general current collecting terminal to output current to an external part or to receive input current from the external part. Finally, insulators installed between the auxiliary conductor and the electrode plates to constitute an electrode unit.
US08815451B2
A negative-electrode plate 22 for use in a cylindrical cell, intended to be laid over a positive-electrode plate 21 with a separator 23 interposed between and rolled to form a cylindrical electrode body 20, with the positive-electrode plate 21 inside, the electrode body being arranged in a bottomed cylindrical outer can 10 to form the cylindrical cell, comprises a first negative-electrode part 22a which is to face the positive-electrode plate 21 on either side, with the separator 23 between, when formed into the electrode body 20, and a second negative-electrode part 22b which is to form the innermost circumference of the electrode body 20 and face the positive-electrode plate 21 only on one side, with the separator 23 between, when formed into the electrode body 20, the second negative-electrode part 22b being lower in negative-electrode active material density than the first negative-electrode part 22a.
US08815447B2
The present invention aims to provide a fuel cell anode, a membrane electrode assembly and a fuel cell, so as to obtain high electric power. The fuel cell anode has an electrode catalyst layer, and the electrode catalyst layer comprises a supported catalyst comprises electrically conductive carriers and fine catalytic particles supported thereon, a proton-conductive inorganic oxide supporting SiO2 on its surface, and a proton-conductive organic polymer binder. The SiO2 supported on the inorganic oxide prevents the oxide particles from growing, to ensure the high electric power. It is necessary to control the mixing ratios among the supported catalyst, the proton-conductive oxide and the proton-conductive binder in particular ranges.
US08815444B1
Composite current collectors containing coatings of metals, alloys or compounds, selected from the group of Zn, Cd, Hg, Ga, In, Tl, Sn, Pb, As, Sb, Bi and Se on non-metallic, non-conductive or poorly-conductive substrates are disclosed. The composite current collectors can be used in electrochemical cells particularly sealed cells requiring a long storage life. Selected metals, metal alloys or metal compounds are applied to polymer or ceramic substrates by vacuum deposition techniques, extrusion, conductive paints (dispersed as particles in a suitable paint), electroless deposition, cementation; or after suitable metallization by galvanic means (electrodeposition or electrophoresis). Metal compound coatings are reduced to their respective metals by chemical or galvanic means. The current collectors described are particular suitable for use in sealed primary or rechargeable galvanic cells containing mercury-fee and lead-free alkaline zinc electrodes.
US08815442B2
The invention relates to an electrode comprising (a) an electron collector containing one or more transition metals from the groups 4 to 12 of the Periodic Classification of the Elements, and (b) a material that is electrochemically active, present on the surface of the electron collector in the form of a nano-structured conversion layer containing nano-particles or agglomerates of said nano-particles, wherein the nano-particles have a mean diameter of between 1 and 1000 nm, preferably between 10 and 300 nm, wherein said electrochemically active material contains at least one compound of the transition metal or transition metals present in the electron collector, characterized by the fact that the electrode is a textile formed by metallic wires or fibers. The invention also relates to a half-accumulator and an accumulator containing such a textile electrode.
US08815441B2
A secondary battery includes an electrode assembly for generating electricity, a can for accommodating the electrode assembly, and a cap assembly. The can has an open top and the cap assembly seals the open top. The electrode assembly has a plurality of electrode tabs through which electricity is supplied. The cap assembly includes an insulating case that has a plurality of tab drawing grooves. Each of the tab drawing grooves is capable of being occupied by one of the electrode tabs. A number of the tab drawing grooves is greater than a number of the electrode tabs. One of the electrode tabs can be drawn through one of the tab drawing grooves. Other tab drawing grooves are left as spare grooves, and therefore it is not necessary to change the shape of the insulating case even though the structure of the secondary battery is changed.
US08815437B2
A rechargeable battery is disclosed. In one embodiment, the battery includes: i) a first current collecting plate, ii) a plurality of electrode assemblies electrically connected in parallel with each other via the first current collecting plate, wherein each of the electrode assemblies comprises two opposing ends and an outer side formed between the two ends, and wherein the first current collecting plate is electrically connected to one of the two ends of the electrode assemblies and iii) a can configured to accommodate the first current collecting plate and the plurality of electrode assemblies, wherein the can comprises at least one non-linear portion, and wherein an inner surface of the non-linear portion faces the outer side of at least one electrode assembly.
US08815435B2
An object of the present invention is to provide a separator for a nonaqueous secondary battery having excellent heat resistance and excellent ion permeation as well as shut-down properties. The first invention is a separator for a nonaqueous secondary battery, comprising a porous composite membrane which includes a substrate comprising a polyolefin microporous membrane and a heat-resistant porous layer comprising a heat-resistant resin, the heat-resistant porous layer being formed on at least one surface of the substrate, wherein the separator is characterized in that the sheet resistance (A) of the substrate, the Gurley value (B) of the substrate, the sheet resistance (C) of the porous composite membrane, and the Gurley value (D) of the porous composite membrane satisfy a specific relationship. The second invention is characterized in that the heat-resistant porous layer has an average pore size of 0.1 to 0.2 μm as measured by mercury intrusion porosimetry. The third invention is characterized in that the heat-resistant resin fibrils have an average fibril diameter of 10 to 80 nm, and the pores in the heat-resistant porous layer have an average pore size of 50 to 250 nm.
US08815433B2
Disclosed is a method for manufacturing a separator. The method includes (S1) preparing a porous planar substrate having a plurality of pores, (S2) preparing a slurry containing inorganic particles dispersed therein and a polymer solution including a first binder polymer and a second binder polymer in a solvent, and coating the slurry on at least one surface of the porous substrate, (S3) spraying a non-solvent incapable of dissolving the second binder polymer on the slurry, and (S4) simultaneously removing the solvent and the non-solvent by drying. According to the method, a separator with good bindability to electrodes can be manufactured in an easy manner. In addition, problems associated with the separation of inorganic particles in the course of manufacturing an electrochemical device can be avoided.
US08815424B2
A process of controlling the temperature of a battery pack includes the steps of determining the operating mode and present temperature of the battery pack. Optimal temperature for the battery pack depends on the operating mode and the difference between the present temperature and the previously identified optimal temperature. The battery pack is warmed if the temperature difference (measured minus optimal) is large. The optimal time interval over which the battery pack should be warmed is a function of the operating mode and the previously calculated temperature difference. A heater is switchably operated enabling and disabling the heat generating element to warm the pack to the previously identified optimal temperature.
US08815422B2
A battery pack and a method for fabricating the same are provided. The battery pack includes a plurality of battery cells connected in series or in parallel to each other, a protective circuit module (PCM) controlling charging and discharging of the plurality of battery cells, and a coverlay electrically connecting the plurality of battery cells to the PCM, wherein the coverlay includes a plurality of wires, each of the plurality of wires includes battery connecting pads provided at its one end, the battery connecting pads connected to the battery cells, and module connecting pads provided at it's the other end, the module connecting pads connected to the PCM, and a solder layer is formed on the battery connecting pads.
US08815416B2
Disclosed is an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and of simple constitution. Also disclosed is a compound useful for the fabrication of said organic electroluminescent device. This compound for organic electroluminescent device is a bipyrimidyl compound which has a basic skeleton of 2,2′-bipyrimidyl and is substituted by an aromatic hydrocarbon group, an aromatic heterocyclic group, or a substituted amino group. The aforementioned organic electroluminescent device has a light-emitting layer between an anode and a cathode which are piled one upon another on a substrate and the light-emitting layer contains a phosphorescent dopant and the aforementioned bipyrimidyl compound as a host material.
US08815410B2
It is an object of the present invention to provide a light emitting element, which is resistant to repetition of an oxidation reaction. It is another object of the invention to provide a light emitting element, which is resistant to repetition of a reduction reaction. An anthracene derivative is represented by a general formula (1). In the general formula (1), R1 represents hydrogen or an alkyl group having 1 to 4 carbon atoms, R2 represents any one of hydrogen, an alkyl group having 1 to 4 carbon atoms and an aryl group having 6 to 12 carbon atoms, R3 represents any one of hydrogen, an alkyl group having 1 to 4 carbon atoms, and an aryl group having 6 to 12 carbon atoms, Ph1 represents a phenyl group, and X1 represents an arylene group having 6 to 15 carbon atoms.
US08815409B2
An organic electroluminescent device including at least one organic layer between a pair of electrodes, wherein the at least one organic layer includes a luminescent layer, at least one layer of the at least one organic layer includes at least one metal complex containing a tri- or higher-dentate ligand, and a compound represented by formula (I) is contained in an organic layer containing the metal complex and/or in other organic layer(s). In formula (I), R11 to R14 each independently represent a hydrogen atom or a substituent group, and at least one of R11 to R14 represents an aryl or heteroaryl group.
US08815404B2
Disclosed herein is a protective film. The protective film is produced by alternate coating of a polysilazane-based polymer and a flexible polysiloxane-based polymer. The polysilazane-based polymer is cured at low temperature to form silica, thereby achieving high hardness and high light transmittance. The protective film has improved interfacial adhesion between the respective coating films, which prevents permeation of moisture and oxygen. In addition, the protective film can be easily produced by low-temperature wet processes. Also disclosed herein is an encapsulation material comprising the protective film.
US08815399B2
Provided is a carbon nanotube (CNT) transparent conductive layer having a loop pattern in which a plurality of loops are at least partially connected to one another, and a fabrication method thereof. The loops in the pattern are generated by a spray-coating method and partially connected with one anther, and thus improving transparency and conductivity of the CNT transparent conductive layer. In Addition, the CNT transparent conductive layer has conductivity and sheet resistance highly suitable for a transparent electrode.
US08815396B2
Improved silicon carbide particles, improved silicon carbide abrasive particles, and abrasive slurry compositions for use chemical mechanical planarization (CMP) processes. The particles can comprise nano-sized silicon carbide particles, particularly silicon carbide particles having a surface chemistry similar to silica.
US08815392B2
A process is disclosed for producing a doped gallium arsenide single crystal by melting a gallium arsenide starting material and subsequently solidifying the gallium arsenide melt, wherein the gallium arsenide melt contains an excess of gallium relative to the stoichiometric composition, and wherein it is provided for a boron concentration of at least 5×1017 cm−3 in the melt or in the obtained crystal. The thus obtained crystal is characterized by a unique combination of low dislocation density, high conductivity and yet excellent, very low optic absorption, particularly in the range of the near infrared.
US08815379B2
A coated article includes a substrate, a first layer formed on the substrate, and a second layer deposited on the first layer. The substrate comprises a first outer surface. The substrate defines a plurality of first convexes in the first outer surface. The first layer comprises a second outer surface away from the first outer surface. The second outer surface of the first layer defines a plurality of second convexes corresponding to the first convexes in the position. The second layer substantially includes substance M, O, and N, wherein M is Al or Si.
US08815376B2
A surface treatment agent for hydraulic transfer to perform hydraulic transfer decoration with high adhesion onto an olefin-type substrate with poor adhesion. They are provided by a surface treatment agent for hydraulic transfer to a polyolefin-type substrate to be used in a hydraulic transfer method for forming a decorative layer, by coating an activator to a dried print pattern on a water-soluble film to recover adhesion of said print pattern, and then by hydraulic transferring said print pattern onto the surface of a surface treatment layer of the polyolefin-type substrate treated with the surface treatment agent, characterized in that said surface treatment agent for hydraulic transfer is consisted of a resin composition including a modified polyolefin (a), a polyfunctional isocyanate (b) and a solvent (c), and a blending ratio of (b)/(a) is 0.005 to 0.5, in weight ratio.
US08815370B2
A decorative floor tile including at least one decorative layer and a backing layer having an array of resilient annular projections. Each annular projection includes a concave top surface, an outside wall surface, and an inside wall surface. The inside wall surface defines a central, blind passageway area. When the decorative floor tile is installed over an underlying surface, and pressure is applied to the decorative floor tile, a vacuum is created within the blind passageway and the underlying surface. The vacuum increases the amount of frictional drag between the surface covering and the underlying surface, and thus allows the surface covering to remain in place without the need for an adhesive.
US08815368B2
A composite sheet and a method of making a composite sheet. A core having end walls is provided. Continuous fibers or a continuous fiber mat is secured to the core such that the continuous fibers align with the end walls of the core.
US08815366B2
Reinforced concrete component with at least one upper and at least one lower longitudinal reinforcement layer, and one transverse force reinforcement. Transverse force reinforcement being passed to the upper and lower longitudinal reinforcement in its extension. The transverse force reinforcement is formed by at least 20 L-shaped sheet metal components made from structural steel with stirrups attached thereto. Each sheet metal component thereby comprises a chamfer.
US08815359B2
Provided is a multi-layer container excellent in delamination resistance and gas barrier property, which can be manufactured without employing any molding method involving a special apparatus, which increases a production cost, and a complicated step. Specifically, the multi-layer container includes a laminate structure of three or more layers having at least a gas barrier layer between an innermost layer and an outermost layer, in which the gas barrier layer in a site formed of the laminate structure has a portion having a thickness 0.01 to 0.9 times as large as the maximum thickness of the gas barrier layer. Further, provided are a mold suitable for manufacturing the multi-layer container, and a manufacturing method for a multi-layer container using the mold.
US08815348B2
The present invention relates to modified geopolymer compositions, geopolymer-coated organic polymer substrates, and methods of manufacturing and articles comprising same.
US08815343B2
The invention relates to a process for the synthesis of conducting polymer films by vapor phase polymerization. The invention relates particularly to the synthesis of polymerized thiophene films, for example poly(3,4-ethylenedioxythiophene) (PEDOT) films.
US08815342B2
The present invention relates to a process for forming on the surface of a metal part a protective coating containing aluminium and zirconium, in which process said part and a cement made of an aluminium alloy are brought into contact with a gas at a treatment temperature in a treatment vessel, the gas comprising a carrier gas and an activator, the activator reacting with the cement to form a gaseous aluminium halide that decomposes on the surface of the part, depositing metallic aluminium thereon, the activator containing a zirconium salt such as ZΓO (¾ obtained from granules of a zirconium salt), disassociation reactions of said zirconium salt taking place within a disassociation temperature range with formation of a Zr metal coating on the surface of the part, the assembly comprising the part, the cement and the zirconium salt granules is progressively heated in the chamber from room temperature up to the treatment temperature, the process being characterized in that the treatment chamber is maintained at an overpressure with no carrier gas flow throughout the temperature range corresponding to the disassociation reactions of the zirconium salt.
US08815341B2
Processes for growing carbon nanotubes on carbon fiber substrates are described herein. The processes can include depositing a catalyst precursor on a carbon fiber substrate, optionally depositing a non-catalytic material on the carbon fiber substrate, and after depositing the catalyst precursor and the optional non-catalytic material, exposing the carbon fiber substrate to carbon nanotube growth conditions so as to grow carbon nanotubes thereon. The carbon nanotube growth conditions can convert the catalyst precursor into a catalyst that is operable for growing carbon nanotubes. The carbon fiber substrate can remain stationary or be transported while the carbon nanotubes are being grown. Optionally, the carbon fiber substrates can include a barrier coating and/or be free of a sizing agent. Carbon fiber substrates having carbon nanotubes grown thereon are also described.
US08815340B2
The subject of the invention is a heat treatment process by flame treatment of at least one thin film deposited on a glass substrate (1) running in the path of at least one flame treatment device comprising at least one burner (2), said treatment being able to increase the degree of crystallization of said at least one thin film and/or to increase the size of the crystallites in said at least one thin film, said process being characterized in that the maximum transient bending “b” is less than 150 mm and respects the following condition: b≦0.9×d where the bending “b” corresponds to the distance, expressed in mm, between the plane of the substrate without heating (P1) and the point of the substrate closest to the plane (P2) passing through the tip (6) of the burner (2) and parallel to the plane of the substrate without heating (P1), “d” corresponds to the distance between the plane of the substrate without heating (P1) and the tip (6) of the burner (2), expressed in mm, the width of the substrate “L” in a direction perpendicular to the run direction (5) being greater than or equal to 1.1 m.
US08815338B2
A method for producing a composite lithium iron phosphate material, which comprises formulating lithium iron phosphate material and purified water at a weight ratio of 1:5-15 into a suspension solution, slowly adjusting the pH value of the suspension solution to 1-3 with phosphoric acid at a concentration of 5-30% in weight, adding an analytically pure soluble chloride in an amount of 0.05-2% based on the molar amount of the lithium iron phosphate material; then adding ammonia water into the solution to adjust the pH value of the solution to 5-6 to obtain hydroxide colloid; drying liquid through spraying to prepare powder, and calcining at 300-450° C. for 3-6 hours under an inert atmosphere; coating the oxide with high conductivity obtained by thermally decomposing the hydroxide colloid on the surface of the lithium iron phosphate material grains; ball milling and sieving the calcined material into a finished product. Also disclosed is the composite lithium iron phosphate material produced by such a method.
US08815336B2
According to one embodiment, there is provided a magnetic recording medium manufacturing method including forming a resist layer on a magnetic recording layer, patterning the resist layer, forming a magnetic pattern by performing ion implantation through the resist layer, partially modifying the surface of the magnetic recording layer, removing the resist, applying a self-organization material to the surface of the magnetic recording layer and forming a dotted mask pattern, and patterning the magnetic recording layer.
US08815335B2
One exemplary embodiment may include a method comprising: depositing a solution comprising an organometallic compound on a substrate, drying the solution to provide a film of the organometallic compound and at least partially oxidizing an organic component of the organometallic compound to provide nanoparticles including metal oxides on the substrate which would have multiuse industrial applications.
US08815332B2
An apparatus, comprising two conductive surfaces or layers and a nanostructure assembly bonded to the two conductive surfaces or layers to create electrical or thermal connections between the two conductive surfaces or layers, and a method of making same.
US08815330B2
The following is included: loading cells spatially defined by partitions with a dispersion liquid containing electrophoretically mobile particles and a dispersion medium for dispersing the electrophoretically mobile particles, and covering the exposed surface of the dispersion liquid loaded in the cells with a sealing coating to seal the dispersion liquid in the cells. The dispersion medium is a lipophilic hydrocarbon solvent, and the sealing coating is made from a material containing a water-soluble polymer.
US08815323B2
There is described a method for the prevention, mitigation or slowing of the discoloration of produce (fruit) the method comprising: (i) an optional first step of pre-dipping the produce in a chelating agent; and (ii) treating the optionally pre-dipped produce with an enzyme inhibitor.
US08815280B2
The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.
US08815266B2
The invention relates to peptide derivatives of general formula (I): R1-AA1-AA2-R3-AA4-R2 (I) their stereoisomers, mixtures thereof, and their cosmetically or pharmaceutically acceptable salts, a method for obtaining them, cosmetic or pharmaceutical compositions containing them and their use for the treatment, care and/or cleansing of those conditions, disorders and/or pathologies of the skin, mucosae, scalp and/or nails resulting from microorganism proliferation or being at risk of microorganism proliferation.
US08815261B2
[Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has been enabled for the first time by appropriately combining aripiprazole and an organic acid (particularly fatty acid with low lipophilicity). That is, it has been found that more superior transdermal absorbability can be achieved by forming a salt by using a compound showing lipophilicity within the range of −1.5-2, such as fatty acid and the like. It has been further found that the transdermal absorbability is remarkable improved by appropriately selecting the solvent composition. As a result, since a new dosage form of aripiprazole other than oral preparation has been developed, a new transdermal absorption preparation of aripiprazole can be provided.
US08815259B2
The invention describes nanotextured super hydrophobic coatings that contain active agents which can elute from the coating over a period of time.
US08815256B2
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.
US08815250B2
The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
US08815245B2
A medicament based on antibodies contains an activated form of monoclonal, polyclonal, or natural antibodies to interferon in low or ultra-low doses prepared by multiple consecutive dilutions and exposure to external factors, preferably in accordance with homeopathic technology. In order to obtain antibodies, human or heterologous interferon alpha, beta, or gamma, including recombinant interferon, is used; a mixture of various, mostly centimal, homeopathic dilutions being employed. A method of treating a pathologic syndrome, whose formation is affected by interferon, consists in the use of activated forms of antibodies to interferon alpha, beta, or gamma in low or ultra-low doses obtained by multiple consecutive dilutions and exposure to external factors.
US08815240B2
The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
US08815232B2
The present invention is based, in part, on our discovery of compositions and methods that can be used to systemically deplete arginine and thereby treat arginine-dependent cancers. Our studies indicate that administering a composition that depletes arginine directly to the patient's small intestine will provide effective treatment for arginine-dependent cancers. Moreover, the methods can be carried out in such a way that various sources of arginine are restricted and side effects are minimized. For example, to deplete arginine, one can not only administer an arginine-depleting enzyme directly to the intestinal lumen but can also inhibit endogenous production of arginine, reduce arginine production by intestinal bacteria and limit arginine intake. To minimize side effects, one can inhibit protein breakdown, which may occur as a compensatory mechanism, provide systemic NO from a nitric oxide donor, provide a pressor peptide, and/or provide prostacycline or an analog thereof.
US08815225B2
The invention relates to hair care compositions comprising an effective amount of a condensation polymer having at least one, optionally quarternized or protonated, dialkylamide end-group connected through the polymer backbone to a unit derived from an alkylamide, the connection comprising at least one ester linkage.
US08815221B2
A composition used for skin whitening includes: an effective amount of spermidine derivative, wherein a structure of the spermidine derivative is shown as Structure (I): where R1-R5 individually includes H, OH, or OCH3 and at least one of R1-R5 is OH, and the spermidine derivative has tyrosinase inhibition activity; and a cosmetically or pharmaceutically acceptable vehicle, wherein the composition used for skin whitening whitens skin.
US08815220B2
Sunscreen compositions containing an extract of Curcuma longa L. are provided, the sunscreens having an absorption that spans the UVA and UVB ranges in a manner that meets updated FDA recommendations without requiring the addition of titanium dioxide. The sunscreens can also include an extraction solvent that is at least substantially non-toxic and useful also as a pharmaceutically acceptable carrier in liquid dosage forms. Microemulsions and nanoemulsions are also provided to enhance the bioavailability and stability of the extracts in the sunscreens.
US08815215B2
A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier.
US08815214B2
Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
US08815211B2
An object of the present invention is to provide a radioactive metal anti-cadherin antibody which is highly accumulated specifically in cancer tissue. Another object is to provide a cancer therapeutic agent having high anti-cancer effect and safety and a cancer diagnostic agent. The radioactive metal-labeled anti-cadherin antibody is obtained by binding a radioactive metallic element to an anti-cadherin antibody via a metal-chelating reagent.
US08815203B2
A process for removing sulfur from a gas stream is provided in which a plurality of reactor units, each comprising a condenser and reactor, are selectively operable under Claus reaction and cold bed adsorption conditions. The arrangement of reactor units within the plant is periodically changed following a front-middle-back sequencing scheme. This ensures that the final reactor unit in the series utilizes fully cooled catalyst which is most efficient for operation under cold bed adsorption conditions. In addition, the condenser of the final reactor unit in the series operates at or below the freezing point of sulfur thereby permitting even greater sulfur recovery.
US08815196B2
A method for reducing NOx emissions from a lean burn combustor equipped with a NOx reducing exhaust catalyst, includes at least the following steps: (i) generating a computer based model of the geometry of an exhaust system of the combustor; (ii) computing at least one of flue gas velocity profiles and mass flow stream lines for exhaust gas flow through the exhaust system; (iii) inputting injector data comprising at least droplet size and velocity; (iv) modeling droplet trajectories for a plurality of injector locations; (v) modeling at least one flow conditioning device in the exhaust system; and (vi) manipulating the computer based model until an injector location is identified that provides a predicted root mean square (RMS) of reagent at the face of the catalyst that is less than 15%.
US08815184B2
A process for treating spent catalyst containing heavy metals, e.g., Group VIB metals and Group VIII metals is provided. In one embodiment after deoiling, the spent catalyst is treated with an ammonia leach solution under conditions sufficient to dissolve the group VIB metal and the Group VIII metal into the leaching solution, forming a leach slurry. After solid-liquid separation to recover a leach solution, chemical precipitation and solids repulping is carried out to obtain an effluent stream containing ammonium sulfate (Amsul), ammonium sulfamate, Group VB, Group VIB and Group VIII metals. Following sulfidation, the Group VIII metal is fully removed and Group VB and Group VI metals are partially removed from the Amsul stream. In the additional steps of oxydrolysis and iron precipitation, an effective amount of ferric ion at a pre-select pH is added to form insoluble complexes with the Group VB and Group VIB metals, which upon liquid-solid separation produces an effluent ammonium sulfate stream containing less than 10 ppm each of the Group VB and Group VIB metals.
US08815181B2
A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.
US08815179B2
An automated liquid collection workstation is provided. The workstation includes a processor, a peristaltic pump, a valve actuator, and an algorithm. The peristaltic pump and the valve actuator are in electrical communication with the processor. The valve actuator can move a plurality of valves, when disposed therein, among an off position, a flush position, and a collection position. The algorithm is resident on the processor and is configured to: move all of the valves to the off position and place the pump in an off state when no sampling or flushing is required, move all of the valves to the flush position and place the pump in an on state for a predetermined flush time period when flushing is required, and move a respective one of the valves to the collection position, move any of the valves upstream of the respective valve to the flush position, and place the pump to the on state for a predetermined collection time period when collection is required.
US08815168B2
A carbon nanotube synthesizing apparatus in which the state of generated plasma can be stabilized is provided. A carbon nanotube synthesizing apparatus 1 comprises a chamber 2, an antenna 3 including a tip 3a, a microwave conductor 4, a gas introducing unit 5, a gas discharging unit 6, a substrate holding unit 7, and a heating unit 8. The shape of the inner wall of the chamber 2 is symmetrical with respect to the tip 3a of the antenna 3.
US08815161B2
A gas-sensing element configured to measure a concentration of a specific component of a gas is mounted to a first circuit board which includes a driving circuit configured to drive the gas-sensing element. A moisture-proof material is disposed over at least one side of the first circuit board disposed in a tubular gas-sensing element case fixed to a sensor case. A gas-sensing chamber is defined by the first circuit board and an inner tubular surface of the gas-sensing element case, and opens at an open end of the gas-sensing element case to receive the gas to be monitored. A second circuit board which includes a control circuit configured to control the gas-sensing element via the driving circuit is fixed to a sensor case, and disposed in a position separate from the gas-sensing chamber such that the second circuit board is kept out of contact with the gas to be monitored.
US08815155B2
A diagnostic tape cassette is disclosed that includes an analytical test tape, a supply spool for winding off unused test tape and a take-up spool for winding used test tape, a housing and a rotational lock for the take-up spool at least against inadvertent unwinding of test tape. The rotational lock includes one of a locking teeth arrangement, friction elements, and a catch spring and spring latch arrangement.
US08815150B2
Methods of producing metal nanowires, compositions, and articles are disclosed. Such methods allow production of metal nanowires with reproducibly uniform diameter and length, even in the presence of catalyst concentration variation. Such metal nanowires are useful for electronics applications.
US08815148B2
Multi-component magnesium-based alloy consisting essentially of about 1.0-15.0 wt. % of scandium, about 0.1-3.0 wt. % of yttrium, about 1.0-3.0 wt. % of rare-earth metal, about 0.1-0.5 wt. % of zirconium. Purity degree of magnesium base is not less of 99.995 wt. %. Impurities of Fe, Ni and Cu do not exceed 0.001 wt. % of everyone, the contents of other impurity in an alloy does not exceed 0.005 wt. %. The alloy demonstrates an improved combination of strength, deformability and corrosion resistance at room temperature. The alloy does not contain harmful and toxic impurities. The alloy can be used in the various practical applications demanding a combination of high strength, deformability and corrosion resistance, preferably in the field of medicine.
US08815142B2
Provided is a method of manufacturing a resin molded gear, which is to be integrally formed by injection molding, and includes: a tooth portion formed along an outer peripheral surface of a rim; a web extending along an inner peripheral surface of the rim; and a gate portion arranged at a boss, which joins to at least part of the web and is formed on a core portion located at a center axis, the method using a synthetic resin having a melting temperature of Tm° C., the method including: injecting and loading the synthetic resin molten at the melting temperature of Tm° C. into a cavity of a mold for forming the resin molded gear; and setting, when the gate portion is solidified, a thickness center temperature T1 of the web to (Tm−20)° C. or more to (Tm+20)° C. or less and a surface temperature T2 of the tooth portion to (T1−50)° C. or less.
US08815139B2
A method for forming a flare in the end of a flexible tube comprises heating the end of the flexible tube to a near-melted state, inserting the end of the flexible tube into a flare-forming die with a flare forming portion, and pressing a mandrel into the end of the flexible tube, thereby pressure forming a flare in the end of the flexible tube.
US08815138B2
A recoil pad having a pad in which the elastomer contains a plurality of pockets having one or more pocket characteristics adjustable over the entirety or portions of the pad to achieve recoil pad characteristics which can be incrementally variably matched to the recoil energy characteristics and recoil energy transfer characteristics of a particular target stock.
US08815137B2
A method of incorporating an anti-counterfeiting device into a multi-walled container is provided. The multi-walled container includes an inner wall having an outer surface, an outer wall adjacent to the inner wall, and an anti-counterfeiting device sandwiched between the inner and outer walls. The method includes forming the inner wall from a polymeric composition, adhering the anti-counterfeiting device to the outer surface of the inner wall either during, or after formation of the inner wall, and then over molding the outer wall about the inner wall to form the multi-walled container. Suitable anti-counterfeiting devices for incorporation into the multi-walled container include RFID, printed or foil antennae, conductive inks, metal spheres, and x-ray readable foils.
US08815135B2
A high-throughput process for the manufacture of absorbent unexpanded glass-like polysaccharides is disclosed. The process comprises the use of a twin screw extruder having turbulence and kneading sections, the kneading sections being located downstream from the turbulence sections.
US08815118B2
A method and system for assembling building blocks of colloidal particles and also for shaping of colloids for self-assembly for manufacturing, processing and formation of compositions of matter. A first type of particle is selected as a “key” particle constructed to mate with a “lock” particle, the binding arising from depletion forces. A variety of shapes can be used to carry out this method and system to create compositions of matter. Colloids can be shaped by controlled deformation of multiphase colloid particles.
US08815113B2
The invention relates to a biodegradable halogen-free flame retardants composition used for fire-safety and prevention, that limits and extinguishes fires by means of increased resistance to ignition, slowing down burning rates and the rate of heat, smoke and toxic gas release from polymers with different physical and chemical properties and structure, such as textiles, wooden materials, paper, cardboard, corrugated board, leather, cellular polystyrene, foamed polyurethane, and items made of them. The composition according to the invention contains orthophosphoric acid, urea, triethanolamine, ammonia water, polydimethylsiloxane, surfactant, which may be anionic, cationic, amphoteric, non-ionic or mixtures thereof and water.
US08815111B2
The substrate treatment method is for treating a substrate with a chemical liquid in a treatment chamber. The method includes a higher temperature chemical liquid supplying step, and a rinse liquid supplying step after the higher temperature chemical liquid supplying step. The rinse liquid supplying step includes: a peripheral edge portion treating step of supplying the rinse liquid selectively onto a center portion of the front surface of the substrate so that a chemical liquid treatment is inhibited on the center portion while being allowed to proceed on a peripheral edge portion of the front surface of the substrate; and an entire surface rinsing step of spreading the rinse liquid over the entire front surface of the substrate to replace the chemical liquid with the rinse liquid on the entire front surface of the substrate after the peripheral edge portion treating step.
US08815109B2
A computer implemented method of monitoring a polishing process includes, for each sweep of a plurality of sweeps of an optical sensor across a substrate undergoing polishing, obtaining a plurality of current spectra, each current spectrum of the plurality of current spectra being a spectrum resulting from reflection of white light from the substrate, for each sweep of the plurality of sweeps, determining a difference between each current spectrum and each reference spectrum of a plurality of reference spectra to generate a plurality of differences, for each sweep of the plurality of sweeps, determining a smallest difference of the plurality of differences, thus generating a sequence of smallest difference, and determining a polishing endpoint based on the sequence of smallest differences.
US08815106B2
A method of supplying an etching gas includes: supplying a first etching gas used in an etching process into a processing container; and supplying a second etching gas used in the etching process into the processing container, in which, when the first etching gas and the second etching gas are switched therebetween, only a small amount of a gas, which is needed as an etching gas before the switching and is not needed as an etching gas after the switching, is continuously supplied into the processing container.
US08815103B2
A method of preparing an optical preform includes the steps of: a) etching an optical preform to remove a portion of an oxide material deposited on the preform by using a gas comprising an etchant gas containing fluorine at a sufficient temperature and gas concentration to create a redeposited germanium containing compounds contamination such as GeOx in the remaining oxide material; and b) cleaning the etched preform using a cleaning gas containing at least one halogen gas at a sufficient temperature and gas concentration to remove the redeposited germanium containing compound contamination without any substantial further contamination of the remaining deposited oxide material. Preferably the halogen is either chlorine or bromine.
US08815101B2
This invention relates generally to the field of separation of heterogeneous mixtures and, more particularly to a solid-liquid separating tank and system.A settlement tank including: a tank wall defining a tank inner space; an internal wall structure in the inner space and defining a fluid flow path from a center of the inner space to a fluid outlet at the tank wall; and a plurality of drainage pipes having an open internal end and an outer end connected to a drainage manifold, wherein the open internal end is positioned at a bottom of the inner space to remove gravity decanted sediment and hydrostatically decanted water from the inner space.
US08815079B2
An electrochemical test sensor for detecting the analyte concentration of a fluid test sample includes a base, a dielectric layer, a reagent layer, a light guide area, and a lid. The base provides a flow path for the test sample having on its surface a counter electrode and a working electrode adapted to electrically communicate with a detector of electrical current. The dielectric layer forms a dielectric window therethrough. The reagent layer includes an enzyme that is adapted to react with the analyte. The lid is adapted to mate with the base and to assist in forming a capillary space with an opening for the introduction of the test sample thereto. The light guide area transmits light towards the capillary space.
US08815077B2
An electrochemical sensor for measuring the oxygen partial pressure in a process fluid, comprises an electrolyte-filled sensor body, which is covered on one side charged with the process fluid by an oxygen-permeable membrane, a cathode on the membrane, an annular guard electrode surrounding the cathode, which in measuring operation lies at the same potential as the cathode, an anode charged by the electrolyte in the sensor body, a reference electrode charged by the electrolyte in the sensor body, wherein between the anode and cathode a voltage can be applied, which is controlled between the cathode (8) and reference electrode at a constant polarization voltage and the measuring sensor current flowing in measuring operation between the cathode and anode is a measure for the oxygen partial pressure in the process fluid, and a test voltage source which can be switched in a testing mode between the cathode and guard electrode for producing test oxygen in the electrolyte and/or in the process fluid between the cathode and guard electrode for testing the function of the sensor.
US08815074B2
A method for reducing carbon dioxide with use of a device for reducing carbon dioxide includes steps of (a) preparing the device. The device includes a vessel, a cathode electrode and an anode electrode. An electrolytic solution is stored in the vessel, the cathode electrode contains a copper rubeanate metal organic framework, the copper rubeanate metal organic framework is in contact with the electrolytic solution, the anode electrode is in contact with the electrolytic solution, and the electrolytic solution contains carbon dioxide. The method further includes step of (b) applying a voltage difference between the cathode electrode and the anode electrode so as to reduce the carbon dioxide.
US08815072B2
A process is provided for roughening both sides of a copper plate by forming protrusions with fine bump shapes on both sides of the copper plate in an electroplating solution for plating copper while reducing deterioration of the electroplating solution. Opposed pairs of negative electrodes (3c) and positive electrodes (3a) are provided in an electroplating copper solution (2), and a copper plate (4) is arranged between the pair of negative electrodes (3c). An anodic treatment for generating copper fine particles on both surfaces of the copper plate (4) is carried out by performing an electrolytic process for three to ten minutes with the copper plate (4) as a positive electrode between the negative electrodes (3c). Then a cathodic treatment is carried out by moving the copper plate (4) between positive electrodes (3a) and performing an electroplating of copper for three to ten minutes with the copper plate (4) as a negative electrode for fixing the copper fine particles onto the surfaces of the copper plate (4). The cycle of anodic and cathodic treatment may be performed more than one time.
US08815070B2
Disclosed herein is a device A device of the microelectrode array architecture, comprising: (a) a bottom plate comprising an array of multiple microelectrodes disposed on a top surface of a substrate covered by a dielectric layer; wherein each of the microelectrode is coupled to at least one grounding elements of a grounding mechanism, wherein a hydrophobic layer is disposed on the top of the dielectric layer and the grounding elements to make hydrophobic surfaces with the droplets; (b) a field programmability mechanism for programming a group of configured-electrodes to generate microfluidic components and layouts with selected shapes and sizes; and, (c) a system management unit, comprising: (i) a droplet manipulation unit; and (ii) a system control unit.
US08815069B2
A disposable capillary electrophoresis detecting device includes a fixing device, a capillary electrophoresis microchip, and an electrochemical sensor microchip. The fixing device includes two chip-fixing bases having a first chip-holding cavity horizontally arranged and a second chip-holding cavity vertically arranged. The second chip-holding cavity is substantially perpendicular to the first chip-holding cavity and faces an end portion thereof. The capillary electrophoresis microchip is horizontally placed in the first chip-holding cavity. The electrochemical sensor microchip is vertically placed in the second chip-holding cavity. In the electrochemical sensor microchip, a patterned insulation layer is located on a detecting electrode, exposes a sensor area of the detecting electrode, and is extended to two sides of the sensor area. The outlet of the separation capillary of the capillary electrophoresis microchip is aligned to the sensor area, and the distance between the outlet and the sensor area is the thickness of the patterned insulation layer.
US08815060B2
A method for applying a protective layer to an electronic device such as the ABS of a slider, magnetic head, etc. for reducing paramagnetic deadlayer thickness includes selecting an etching angle for minimizing formation of a paramagnetic deadlayer at an interface of an electronic device and an adhesive layer subsequently formed on the electronic device, etching a surface of an electronic device at the selected angle, the selected angle being less than about 75 degrees from an imaginary line extending perpendicular to the surface, forming an adhesive layer on the etched surface of the electronic device, and forming a protective layer on the adhesive layer. A magnetic head formed by the process is also disclosed.
US08815058B2
Arsenic can be an impurity in phosphorous pentafluoride production processes. It is desirable to remove arsenic from phosphorous pentafluoride prior to using of the phosphorous pentafluoride in the production of lithium hexafluorophosphate. The present technology provides methods of removing arsenic from phosphorous pentafluoride by extractive distillation.
US08815050B2
Processes and systems for drying liquid bromine utilizing two fractionators to produce a substantially dry liquid bromine stream and a substantially bromine-free water stream. Wet bromine liquid may be conveyed to a first fractionator wherein a substantially dry bromine liquid is produced, while a vapor stream from the first fractionator may be condensed into a first liquid phase comprising bromine saturated with water and a second liquid phase comprising water saturated with bromine. The water saturated with bromine may be conveyed to a second fractionator to produce at least substantially bromine-free water.